Hot off the press! We demonstrate in @theaacr.bsky.social that the αv integrin- and neuropilin-1 (NRP-1)-dual targeting iRGD peptide (in phase II clinical trials) reverses some of these tumor microenvironment features by inhibiting TGF-β activation in the tumor aacrjournals.org/cancerres/ar...

Congratulations to Tappara on the win once again! 🏆 We’re proud to see one of our researchers Raine Sihvonen celebrating with the team as Tappara’s doctor. Our researchers do many things, and supporting sports is one of them! #Tappara #Research #IceHockey #Orthopedics

With some big delays, but it's nice to see the fruitful collaboration with @terojarvinen.bsky.social and @carolinacabalin.bsky.social out in a nice package!

MedicalResearch.com now interview with Teppo Järvinen, Professor of Orthopaedics and Traumatology, University of Helsinki and HUS. You can find more information about the interview here: medicalresearch.com/nejm-arthros...

In the FIDELITY trial of arthroscopic partial meniscectomy for degenerative medial meniscal tear in adults, participant-reported and radiologic outcomes over 10 years of follow-up suggested no benefit and possible harm from the procedure. Full trial results: https://nej.md/48Pkwww #Orthopedics

Three must-read articles that sparked major news coverage in April.

Over the moon to see this work from my PhD finally published in Development! Using a combination of structural biology and genetics we identify an avidity-driven mechanism of BMP signal control in the extracellular space. (1/11)

In 2002, I watched hundreds of surgeons jump out of their seats to blast a speaker. @nejm.org Arthroscopic Partial Meniscectomy for Degenerative Tear — 10-Year Outcomes | New England Journal of Medicine www.nejm.org/doi/full/10....

Hot off the press! ☝️ Arthroscopic Partial Meniscectomy for Degenerative Tear — 10-Year Outcomes | New England Journal of Medicine www.nejm.org/doi/full/10....

The FIDELITY 10-year results have been published in the New England Journal of Medicine. You can find the full article through the link in the comments. #FIDELITY #NEJM #MedicalResearch

A significant milestone for the field and a proud moment for everyone involved. ✨

Dr. Tuomas Komulainen, M.D. wrapped up his PhD Thesis demonstrating that the recruitment of anti-inflammatory M2 macrophages are important for keloid resolution after corticosteroids therapy. A double-blinded, randomized, controlled trial. @thejidjournal.bsky.social www.jidonline.org/article/S002...

Have you heard about this? #TBT #ThrowBackThursday #EBM #placebo #RCT #FIDELITYtrial

#TBT to one of our most widely recognized publications: the 1-year results of FIDELITY. Find the publication link in the comments.

Since our research programme began, we have invested an average of £500,000 a year in pioneering EB research - £24 million so far. This sustained commitment is accelerating treatment breakthroughs, improving quality of life & bringing us closer to a world where EB no longer limits lives. 🦋

Welcoming a new junior researcher Venla-Linnea Karjalainen to the team. Venla-Linnea is a medical student at Tampere University and alongside her medical studies, she works on research in hand surgery and orthopaedics in FICEBO.

www.tuni.fi/en/news/tero... Honored to receive this recognition from Tampere Univ.🏆 This award belongs to the incredible team behind the work: Marianne Karlsberg, Toini Pemmari, Soili Lehtonen, and Ulrike May. Thanks to collaborators at @unitartupress.bsky.social (Teesalu Lab) and NYMC (Liao Lab).

In conversation with Jarkko Jokihaara. Interview by Alan Cassels. Read more on our website: www.ficebo.com/post/meet-dr...

Interview is particularly interesting, as Jarkko Jokihaara reflects on the history of trapeziectomy — and once again this reminds us why it is important to study the effectiveness of procedures already used in clinical practice.

Our work is out @eurjimmunol.bsky.social Dynamic Thymic Stromal Lymphopoietin and Its Receptor Complex Expression on Skin Langerhans Cells in Skin Inflammation - González‐Rodríguez - 2026 - European Journal of Immunology - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...

So much grift in stem cell space. Seeing more influencers leverage “regenerative” rhetoric. We been studying stem cell hype and unproven therapies for almost 20 yrs! And it just gets worse and worse. tbh, the phrase “stem cells” now a big red flag for BUNK! 🚩 🚩 🚩 🚩 🚩 🚩

Great to be part of the team!✨

In this testing & data obsessed time, studies like this good reminder often useless & harmful! Over 40? Your rotator cuff probably looks a little rough www.sciencenews.org/article/shou... Study: "RC abnormalities nearly universal after age 40 years & routine imaging should NOT guide diagnosis..."

“Almost as Common as Grey Hair” Recent study from our group finds that after midlife, rotator cuff changes on MRI are almost as expected as grey hair. Now the lead author Thomas Ibounig explains the recent FIMAGE study findings in depth: www.ficebo.com/post/almost-...

You may have noticed a shift in our social media posts lately. That’s because Hongfei has joined our team to help share our research with a wider audience! Read more about Hongfei on our website: www.ficebo.com/people/hongf...

Milloin valita olkamurtuman hoidoksi ortoosi ja milloin leikkaus? Tutkijamme arvioivat eri hoitomuotojen kustannusvaikuttavuutta FISH-tutkimuksessa, heidän kommenttinsa tuloksista voit lukea HUS uutisesta. ➡️ Verkkosivulla myös linkki alkuperäiseen tutkimusartikkeliin www.hus.fi/ajankohtaist...

We welcome our newest researcher to the team, Dr Amir Sobhani, bringing fresh perspectives and expertise to drive our work forward. Check out his full bio on our website: www.ficebo.com/people/amir-...

Shouldering uncertainty open.substack.com/pub/unrelent...

#RotatorCuff abnormalities on #MRI were found in 99% of adults aged 41–76, including 96% of asymptomatic shoulders, indicating most findings are age-related rather than disease. ja.ma/4aiQPVU

Incidental Rotator Cuff Abnormalities on Magnetic Resonance Imaging url: jamanetwork.com/journals/jam...

Macrocyclic vascular homing peptide CAR not only works as drug delivery vehicle, but as a drug by itself; CAR homes to skin wound, binds to syndecan 4, which activates cytohesin 2 to activate small GTPase Arf6 to accelerate skin wound closure. www.nature.com/articles/s41... @natcomms.nature.com

Macrocyclic vascular homing peptide CAR not only works as drug delivery vehicle, but as a drug by itself; CAR homes to skin wound and binds to syndecan 4, which activates cytohesin 2 to activate small GTPase Arf6 to accelerate skin wound closure. www.nature.com/articles/s41... @natcomms.nature.com

We have developed a new way of performing in vivo phage display screens by introducing microdialysis catheter into the in vivo screen to capture the macrocyclic homing and tissue penetrating peptides for efficient drug delivery www.life-science-alliance.org/content/8/5/... @lsajournal.org

Remarkable clinical RCT series on ankle fractures keeps changing the treatment of these common injuries. Cast immobilisation versus surgery for unstable lateral malleolus fractures (SUPER-FIN): randomised non-inferiority clinical trial www.bmj.com/content/392/...

Together w. Morgan Lab, we demonstrated that the vascular homing peptide CAR, not only works as drug delivery vehicle, but as a drug by itself; CAR binds to syndecan 4, which activates cytohesin 2 to activate small GTPase Arf6 to stimulate skin wound closure. www.nature.com/articles/s41...

We published the potential future way of performing in vivo phage display screens by introducing microdialysis catheters into the in vivo screen to capture the homing and tissue penetrating phages clones www.life-science-alliance.org/content/8/5/...

NEW @bmj.com research assesses the long term efficacy of arthroscopic subacromial decompression versus placebo surgery and exercise therapy in patients with subacromial pain syndrome www.bmj.com/content/391/...

Dr. K. Kanto - Remarkable job! 👍👏 www.bmj.com/content/391/...

Fall Prevention Integrated Into Primary Health Care url: jamanetwork.com/journals/jam... Dr. Pekka Kannus was right; fall prevention should be a high priority. Remarkable results with simple intervention.

Here is my interview for the Innovation Award by the Finnish Medical Foundation: laaketieteensaatio.fi/tero-jarvise...

Honored to be considered (and proposed by someone) for this prestigious award. www.sttinfo.fi/tiedote/7160...

The protein LRG1 acts as a critical player in the initial onset of diabetic retinopathy by disrupting TGF-beta signaling in pericytes and triggering pathological constriction of capillaries, according to new #ScienceTranslationalMedicine work in mice. https://scim.ag/3Jx6NRu

Dr. Tuomas Komulainen, M.D. wrapped up his PhD Thesis demonstrating that the recruitment of anti-inflammatory M2 macrophages are important for keloid resolution after corticosteroid injections. A double-blinded RCT. J Invest Dermatol www.jidonline.org/article/S002... @thejidjournal.bsky.social