Fabrice Senger
@senger.bsky.social
📤 736
📥 366
📝 479
Mechanobiology / Multi-cellular assemblies
reposted by
Fabrice Senger
Ewerslab
about 8 hours ago
We are starting at
#GEF25
with a plenary lecture by none other than Markus Sauer
@sauer-lab.bsky.social
and yes, there is ExM-STORM!
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Typical "I know that story" and yes the biorixv was allready stunning... Makes me wonder about cells degrading the ECM...
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about 4 hours ago
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www.biorxiv.org/content/10.1...
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Motile cilia spin the Reissner fiber, a tensioned and anchored extracellular thread essential for body morphogenesis
The Reissner fiber (RF) is an extracellular thread composed of the glycoprotein SCO-spondin (Sspo) that forms within cerebrospinal fluid (CSF) in the brain ventricles and central canal (CC) of vertebr...
https://www.biorxiv.org/content/10.1101/2025.09.25.678623v1
about 5 hours ago
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I would have lost bets on that one
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about 21 hours ago
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reposted by
Fabrice Senger
Naba Lab UIC
1 day ago
“The integrin odyssey – a journey full of fundamental discoveries” by Fässler and Sonnenberg in
@jcellsci.bsky.social
, worth a read!
journals.biologists.com/jcs/article/...
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The integrin odyssey – a journey full of fundamental discoveries
Summary: This Perspective highlights the key discoveries in integrin research that laid the foundation for a successful field.
https://journals.biologists.com/jcs/article/138/18/jcs263999/369272/The-integrin-odyssey-a-journey-full-of-fundamental
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Fabrice Senger
Florian Schur
2 days ago
Huntingtin binds and bundles F-actin! Thrilled to team up with the Humbert (Sorbonne Université) and Song (KAIST) labs on this discovery. We had a blast doing cryo-ET on this unexpected complex — and now so many new questions lie ahead!
#TeamTomo
#CryoET
#HTT
#actin
doi.org/10.1126/scia...
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Fabrice Senger
Maik Bischoff
3 days ago
1/12 A very special moment for me! 🎉 My first paper as corresponding author—a
@jcb.org
Perspective on how contact-based decision-making in collective cell migration can itself encode blueprints for complex patterns and shapes.
rupress.org/jcb/article/...
#cellbio
#devbio
#science
🧵for details
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3 days ago
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Fabrice Senger
Rockefeller University Press
4 days ago
New perspective in
@jcb.org
by
@maikbischoff.bsky.social
&
@mayorlab.bsky.social
about how mesenchymal cells use contact-dependent rules to generate swarm-like behaviors, patterns & organ forms.
rupress.org/jcb/article/...
#CellBio
#CellMigration
#Morphogenesis
#Development
#Science
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Fabrice Senger
Biophysical Paris
4 days ago
at the ENS de Lyon (Amphi Descartes) in Lyon on Tuesday 3rd of February 2026. two CNRS GDRs, 'Approches Quantitatives du Vivant' and 'Micro Nano Fluidique'. 'Microfluidics for biological characterisation and diagnosis' and 'Organs-on-a-chip / Cell biology on a chip'.
mnfaqv2026.sciencesconf.org
)
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Journée Commune GdR MNF et AQV - 3 févr. 2026 Lyon - Sciencesconf.org
Presentation
https://mnfaqv2026.sciencesconf.org/
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Fabrice Senger
Robert Grosse @ grosselab
5 days ago
we found that nuclear envelope rupture triggers rapid DIAPH3 formin influx to generate a actin mesh to prevent further chromatin leakage from damaged nuclei. thanks to Pitter Huesgen
@degradomics.bsky.social
and
@cibss.bsky.social
,
@chrkam.bsky.social
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Fabrice Senger
Denis Wirtz
5 days ago
We have developed a new workflow to map whole human organs at single-cell resolution, while integrating spatial transcriptomics, proteomics, and metabolomics. We applied this workflow to map precancerous lesions of the fallopian tubes. More here:
www.biorxiv.org/content/10.1...
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Fabrice Senger
Nature Methods
10 days ago
A new Perspective discusses the challenges of sharing annotated image datasets and offers advice for improving bioimage annotation and reuse, particularly for AI applications.
www.nature.com/articles/s41...
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Fabrice Senger
Peter Jelinek
7 days ago
"Solange wir gehorchen, wird alles gut. Das ist Freiheit. Das ist Amerika." Starke Anti-Trump-Kampagne.
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Fabrice Senger
Marco Dalla Vecchia
7 days ago
In preparation for our annual microscopy course I used
#NotebookLM
to gather resources about light-sheet microscopy and get ideas for teaching and get a better understanding. Then I listened to the audio summary, and I got mad at how decently good it was!
notebooklm.google.com/notebook/3b5...
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Sign in - Google Accounts
https://notebooklm.google.com/notebook/3b54c00a-06e2-4ba1-b58b-6d051173739c/audio
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Fabrice Senger
Daniel Alber
9 days ago
A ring of cells deforms into a triangular keyhole in just 15 minutes. Meet the hindgut, a model for boundary-driven morphogenesis! Out now in
@pnas.org
at
doi.org/10.1073/pnas...
with
@zhaoshh.bsky.social
, Alex Jacinto, Eric Wieschaus, Stas Shvartsman,
@lepuslapis.bsky.social
(1/8)
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Fabrice Senger
Lars Hubatsch
8 days ago
Amazing!!! 🧪 The 2025 Ig Nobel prize goes to scientists from the
@mpipks.bsky.social
for discovering a bullet proof version to make the classic pasta alla cacio e pepe! Including a deep understanding of the pasta sauce in terms of phase separation physics 😃 Congrats
@gbart.bsky.social
et al! Links👇
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Fabrice Senger
Benoit Ladoux
10 days ago
Happy to share our new study
@ijmonod.bsky.social
and
@mpi-scienceoflight.bsky.social
with C. Duclut and J. Prost. on forces generated by active fluid transport in epithelia and their role in tissue dynamics. Congrats to Huiqiong Wu, G. Arkowitz and R. Chilupuri!
www.biorxiv.org/content/10.1...
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Regulation of epithelial tissue homeostasis by active trans-epithelial transport
Epithelia are intricate tissues whose function is intimately linked to mechanics. While mechanobiology has primarily focused on factors such as cell-generated contractility and mechanical properties o...
https://www.biorxiv.org/content/10.1101/2025.09.17.676587v1
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Fabrice Senger
Ryota IINO 飯野亮太
10 days ago
A self-assembled nanoscale robotic arm controlled by electric fields | Science
www.science.org/doi/10.1126/...
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A self-assembled nanoscale robotic arm controlled by electric fields
An electrically driven DNA origami arm can exert piconewton forces and transport fluorophores and nanoparticles.
https://www.science.org/doi/10.1126/science.aao4284
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Fabrice Senger
Al Jord Lab
10 days ago
🌟 We’re happy to share that
@adelaljord.bsky.social
will be speaking at the upcoming
@embo.org
Workshop taking place at
@icfo.eu
next February: "Intracellular Mechanics and Organelle Mechanobiology » 👉 Don’t miss it - applications are now open❗
meetings.embo.org/event/26-org...
@crg.eu
@prbb.org
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Intracellular mechanics and organelle mechanobiology
Mechanobiology is an interdisciplinary field that emerges at the cross-section of biology, physics and engineering. It aims to understand how living cells, tissues and animals sense and respond to me…
https://meetings.embo.org/event/26-organelle-mechanobiology
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Fabrice Senger
Christophe 🔬 L
10 days ago
Check the full preprint and its movies for more details:
www.biorxiv.org/content/10.1...
Congrats
@wiesner-t.bsky.social
and the whole team!
@inp-marseille.bsky.social
@ncis-marseille.bsky.social
@univ-amu.fr
@cnrsbiologie.bsky.social
@agencerecherche.bsky.social
@neuromarseille.bsky.social
11/11
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Non-synaptic exocytosis along the axon shaft and its regulation by the submembrane periodic skeleton
Neuronal communication relies on signaling molecules transferred via exo- and endocytosis throughout the brain. Historically, studies have focused on vesicle exo- and endocytosis and their release mac...
https://www.biorxiv.org/content/10.1101/2025.09.17.676728v1
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Fabrice Senger
Biophysical Journal
10 days ago
Introducing a new tool for lipid nano-mapping: Savoye et al. combine single-molecule localization microscopy with lipid order probes to compare marked point clouds, capturing both spatial and biophysical features of the membrane.
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Measuring the similarity of single-molecule localization microscopy derived marked point clouds
Cellular membranes are dynamic, heterogeneous structures where lipid nanodomains (e.g., lipid rafts) play key roles in signaling, membrane trafficking, and protein function. Single-molecule…
https://www.cell.com/biophysj/fulltext/S0006-3495(25)00484-9
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Fabrice Senger
SWC/GCNU Neuroinformatics Unit
10 days ago
Lovely talk by Open Software Week participant
@ishratz25.bsky.social
on the challenges of using
@brainglobe.info
tools to identify very small regions, in very large images.
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Fabrice Senger
Joachim Goedhart
12 days ago
If you want to get started, here's a tutorial that I made:
github.com/JoachimGoedh...
Reach out if you have questions or want advice!!
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GitHub - JoachimGoedhart/A_Shiny_start: A beginners tutorial on Shiny apps
A beginners tutorial on Shiny apps. Contribute to JoachimGoedhart/A_Shiny_start development by creating an account on GitHub.
https://github.com/JoachimGoedhart/A_Shiny_start
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Fabrice Senger
Mark Peifer (He, him)
12 days ago
If you are interested in the latest advances in Imaging Cell Dynamics, check out the 2026
@jcellsci.bsky.social
Meeting. These small meetings are a terrific way to meet key people in the field and get feedback on your own work. Highly recommended!
www.biologists.com/meetings/jcs...
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Fabrice Senger
Garcia-Mata Lab
12 days ago
The protocol describes an easy way to segment hundreds of junctions and analyze the distribution of different protein both horizontally, across the junction, and vertically, apical to basal. It combines imageJ scripts, with R Studio. Check it out!!!
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Fabrice Senger
The BioImage Archive
12 days ago
🎉 Our paper “MIFA: Metadata, Incentives, Formats and Accessibility guidelines to improve the reuse of AI datasets for bioimage analysis” is out in
@natmethods.nature.com
! Community-driven standards to make bioimage data AI-ready & reusable. 👉
www.nature.com/articles/s41...
#AI
#Bioimaging
#FAIRdata
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Fabrice Senger
James Manton
12 days ago
We present a simple method to easily increase the imageable depth of an expansion microscopy gel on a typical inverted microscope ten-fold, using some carefully placed FEP film and a water dipping objective lens:
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Fabrice Senger
A/Prof Sam Stehbens PhD (She/Her)
14 days ago
Exciting new work from the
#Schaedel
lab on the limits of microtubule self repair > will help us understand how
#microtubules
experiencing extreme compression in crowded 3D environments resist or give way.
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Fabrice Senger
Ronja Houtekamer
14 days ago
A bit delayed, but excited to still share our latest paper, showing that intercellular forces transduced by E-cadherin activate EGFR-ERK signaling in epithelia by inducing EGFR ligand shedding! Mechanical and biochemical signals can act together within a single, linear cascade!
tinyurl.com/mr9mj9j2
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E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand shedding
Epithelial stretching promotes the release of EGF receptor ligands that stimulate ERK activation.
https://tinyurl.com/mr9mj9j2
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Fabrice Senger
epithelial mechanics fan club
14 days ago
How can we use cell shapes and geometry to study mechanics of tissues? I'm
@juliaeckert.bsky.social
, and with this thread, I would like to show you the secrets of cells and tissues. Let’s connect biology with a little bit of physics. Don't be scared and get inspired 😀.
#EpithelialMechanics
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Fabrice Senger
BioCytoLab
16 days ago
Happy to share that our paper on Tau- Microtubule interaction is now published in Nature Physics!🥳 We show that Tau isn’t just a microtubule stabiliser - it promotes removal of defects in the microtubule lattice. Congratulations
@subhambiswas.bsky.social
!
www.nature.com/articles/s41...
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15 days ago
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Very interesting indeed, whatever you track, actually
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16 days ago
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Fabrice Senger
Mechanobiology Institute
16 days ago
Order matters! Aurelien Roux
@rouxlab.bsky.social
studied the formation of multi-cellular tornado-like structures and regeneration of heads in hydra to share with us how stress fields, topology and geometry of initial tissue organization set the sequence of morphogenesis.
#MBIMPG2025
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Fabrice Senger
Guillaume Jacquemet
17 days ago
Come and work with us 5-year position available for a University Researcher in Bioimaging 1.11.2025-31.12.2030
abo.rekrytointi.com/paikat/index...
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University Researcher in Bioimaging / Universitetsforskare med inriktning bioimaging, 1.11.2025-31.12.2030
https://abo.rekrytointi.com/paikat/index.php?jid=935&key=&o=A_RJ&rspvt=tg3h4dpqsbkkk4wwwwg4o4o8woggw4c
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Prof Sam Illingworth
18 days ago
🦟 World’s biggest mosquito factory In Brazil, a new facility will produce 100 million Wolbachia-infected mosquitoes weekly. These harmless insects cut dengue spread by passing the bacterium to wild populations, reducing cases by 69% in trials. 🔗
doi.org/10.1038/d415...
#SciComm
🧪
#Dengue
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This is the world’s largest ‘mosquito factory’: its goal is to stop dengue
Raising millions upon millions of disease-fighting mosquitoes per week is no easy task, Nature learnt during its visit to the facility.
https://doi.org/10.1038/d41586-025-02728-y
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Fabrice Senger
Jean-Yves Tinevez
17 days ago
Save the date! The
@pasteur.fr
Pasteur course on image analysis is announced: It will happen from the 1st of June to the 5th 2026. This year there will be only one track: the Early Career Investigator track (beginners). 👇
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Julia Eckert
about 1 month ago
Want to test your multicellular system? I have created a GitHub repository, ‘3D_SurfProps’, where you can download the MATLAB codes of our 3D surface analysis method: 👉
github.com/Julia-Eckert...
Any questions, suggestions, or ideas for improvements? Please DM or email me. Have fun testing!
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GitHub - Julia-Eckert/3D_SurfProps: These MATLAB scripts determine the nematic orientation field on the entire surface of 3D tissues of arbitrary shape, based on z-stack images, identify topological d...
These MATLAB scripts determine the nematic orientation field on the entire surface of 3D tissues of arbitrary shape, based on z-stack images, identify topological defects, and quantify signals of f...
https://github.com/Julia-Eckert/3D_SurfProps
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Fabrice Senger
Pierre Haas
19 days ago
Another
#preprint
: "Elasticity and plasticity of epithelial gap closure", from the
#PhD
work of Maryam Setoudeh:
arxiv.org/abs/2509.05110
This one required a lot of (I think) beautiful
#mechanics
!
@mpipks.bsky.social
@mpi-cbg.de
@csbdresden.bsky.social
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Fabrice Senger
Erdinc Sezgin
19 days ago
Previous preprint is now published in RSC Chemical Biology. If you are interested in plasma membrane labeling, see the paper! 👇
pubs.rsc.org/en/content/a...
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Fabrice Senger
Barbara Marte
21 days ago
new out in Nature
www.nature.com/articles/d41...
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Compression causes cancer cells to start spreading
The switch between proliferation and invasion is triggered by mechanical force.
https://www.nature.com/articles/d41586-025-02768-4
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Fabrice Senger
Mohamed-Ali HAKIMI
21 days ago
Zeus had his Hydra ⚔️, now Toxoplasma has its own. Meet Hydra: not a monster, but a brand-new protein domain. It multimerizes like crazy & rewrites the chromatin landscape 🧬 in Toxoplasma. Our team and colleagues from
@embl.org
#Grenoble
just dropped the preprint 👉
www.biorxiv.org/content/10.1...
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Fabrice Senger
Eugene Katrukha 🇺🇦
22 days ago
Our new preprint is about the airway epithelium microtubule network, cilia, basal body protein composition, averaging of volumetric fluorescence data, and expansion microscopy. Four years of very hard work from our very talented Emma van Grinsven.
www.biorxiv.org/content/10.1...
(1/N)
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Fabrice Senger
EMBL
26 days ago
📢 Recruitment for the EMBL International PhD Programme is officially open! At EMBL, we train young scientists to become skilled and creative future leaders in academia and other sectors. Join us and get a head start on your career in life sciences!
bit.ly/47mmiFF
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Fabrice Senger
Gaëlle Letort
23 days ago
We (with
@nicolasdray.bsky.social
@zenlabpasteur.bsky.social
) are happy to release officially FishFeats, our
#napari
plugin to streamline 3D smFish/RNA quantification! 🎊 Available here:
github.com/gletort/Fish...
user documentation:
gletort.github.io/FishFeats/
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Martin Humphries
23 days ago
Venkatesh B, et al. (
@tanentzapflab.bsky.social
lab) Inside-out integrin activation is essential for early mammalian development. Mol Biol Cell. 2025 Sep 3;:mbcE25030106. [Epub ahead of print]. PMID: 40901728
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Fabrice Senger
Jonatan Alvelid
25 days ago
Excited to share my postdoc work from the Eggeling lab in Jena (
@leibnizipht.bsky.social
,
#FSUJena
,
#KTHuniversity
) on bringing smart microscopy to super-resolution MINFLUX: event-triggered MINFLUX microscopy.
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Fabrice Senger
Philipp Niethammer
26 days ago
www.nature.com/articles/s41...
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Cell tumbling enhances stem cell differentiation in hydrogels via nuclear mechanotransduction - Nature Materials
Minutes-scale whole-cell movements fuelled by fast cytoskeletal dynamics and nuclear activity regulate mesenchymal stem cells differentiation into chondrocytes in hydrogels, being another process modu...
https://www.nature.com/articles/s41563-024-02038-0
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Fabrice Senger
Christian Simon
about 1 month ago
Bonjour à tous
#ESR
Est-ce que vous connaissez les outils de « La Suite Numérique » de la DINUM ? Le tchat, le transfert de fichier, les espaces collaboratifs ? Les utilisez vous ? Si non, pourquoi ?
@sorbonne-universite.fr
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