Allways a good read, even for the lay

Optogenetic SH3 nanoclustering of SRC and HCK uncovers the functional specificity of these redundant kinases in macrophages. https://www.biorxiv.org/content/10.64898/2025.12.27.692121v1

💻 Get direct access to 3D CAD models for Nikon microscope components! ✏️Our CAD request page puts detailed, ready-to-use files at your fingertips, so you can design with total precision and speed. 👉 Explore the page and grab your CAD files today: https://bit.ly/3Y4gzOV #NikonMicroscopy

📣 Paper alert A great collaboration with my colleagues from Toulouse 🤝 ANR MOLIERE Big up to Angélique Ala for computing & modelling and Camille Douillet for experimental work @cnrs.fr @univbordeaux.bsky.social @universitetoulouse.bsky.social @agencerecherche.bsky.social doi.org/10.1016/j.ac...

🔬📊 PhD (100%) – Statistics & ML for self-driving microscopy Joint PhD with David Ginsbourger (Stats) & Pertz Lab (Cell Biology). Gaussian Processes, Bayesian design, active learning on live-cell experiments. ohws.prospective.ch/public/v1/jo... #PhD #Statistics #MachineLearning #Bayesian

Now that you have gathered you raw data from a cell migration assay, how do you analyze that data? In our review, we describe methods - including AI methods - to track migrating cells and extract as much information as possible. Read our paper here: www.nature.com/articles/s41...

New video: more examples showing deep learning segmentation failure modes—and how to detect them with Napari. I show how Napari’s layer system compares images, ground truth, and results, and how Appose enables comparison across incompatible DL packages. www.youtube.com/watch?v=c369...

🚀📰 End-of-year news for #RxivMaker =). Now it generates both #pdf and #docx from #markdown. Docx makes it easier to collaborate on a document for non-markdown users, making it simple to loop between docx and #RxivMaker to a professional-looking #preprint Preprint updated: arxiv.org/abs/2508.00836

rdcu.be/eVrRs What i most like here is the concept of prompt engineering as a basis to use SAM ...

We wrote two reviews on cell migration, published today in Nature Methods. They provides practical guidelines how to select a cell-migration assay and how to analyze cell-migration data Review 1: nature.com/articles/s41... Review 2: nature.com/articles/s41...

Good to see the peer reviewed version of this published A chemo-optogenetic system for spatiotemporal control of gene expression We use it to: - Reconstruct SHH mediated neural tube patterning in vitro - Measure extracellular half-life of Shh www.cell.com/developmenta...

I am putting together a collection of video-protocols we (will) use in tissue mechanics research🌀 I hope to help consolidate established methods, but also showcase a few up-and-coming ones in our blooming field. Abstract submission by March 2026! Get in touch✨ #JoVETissueMech #ReproducibleTissueMech

Here we go

Do you know how far phototoxicity can hinder your experiments?🤔 @mariodelr.bsky.social and @gomez-mariscal.bsky.social have just published their work on #PhotoFiTT in @natcomms.nature.com where they explain how to quantitatively measure it in live-cell imaging.⚡🧫🔬 Read more at: shorturl.at/ly9Zn

New paper out! Combining single-objective light-sheet microscopy and time-resolved SPAD array detection, we massively accelerate fluorescence lifetime imaging (FLIM) compared to confocal FLIM, making FLIM applicable to 3D specimen such as organoids and embryos. www.nature.com/articles/s42...

AutoSTED: An automated workflow for STED super-resolution imaging of cell nuclei https://www.biorxiv.org/content/10.64898/2025.12.11.693650v1

Cells can sense the geometry of their environment, from tiny subcellular features to whole-tissue patterns. How can we engineer environments to systematically probe these responses? 🧵 I'm @lhinderling.bsky.social from @olivierpertz.bsky.social lab, let’s do a short tour on microfabrication!

Pleased to say that Jonas Hartmann (bs-less) and I have finally released DySTrack (“diss track”) - Dynamic Sample Tracking. It’s a Python-based, modular tool that brings smart microscopy to everyday imaging on commercial systems. Preprint: www.biorxiv.org/content/10.6... [1/6]

If you want to learn more about Appose, check out the hands-on Appose workshop from "Halfway to I2K" 2025: fiji.github.io/i2k-2025-app... – along with the reference implementation of the demo project at github.com/ctrueden/uns.... New releases of python and java flavors coming before year's end.

The scikit-bio paper in online in Nature Methods! Many thanks to our collaborators, community contributors and reviewers! We couldn’t have done it without you. www.nature.com/articles/s41... #Bioinformatics #OpenSource

Hot off the press at EMBO Journal. The culmination of several years of work and hopefully useful to people in the field! BIG Shout-out to Review Commons, who handled the submission. It's a sensible and efficient model and all the journals I like (Society and NFP) are already participating. 🙏

Minin, A., Semerikova, T., Belousova, A.V., Karavashkova, O., Pozdina, V., Tomilina, M., & Zubarev I. (2025). MSLASpheroidStamp: 3d cell spheroids for everyone. Bioprinting, 49, e00416. #EpithelialMechanics buff.ly/gwERE1P

Hello, here is a review I wrote about how cells sometimes try to synchronise with surrounding cells so that they can do a good job of building tissues during development. It is called "Keeping up with the neighbours" link.springer.com/article/10.1... #DevBio 🧪

Isn't it that biorixv is on fire ?

Yep exactly. SAMJ is based on the preview off a brand new technology called appose that does everything transparently (download etc) TrackMate 9 will be based on that Summoning @ctrue.bsky.social

@simonecoppola.bsky.social has made micromorph, the first native Python application and library for measuring bacterial morphology. It runs interactively in napari or can be easily integrated into automated Python scripts. It integrates deep learning cell segmentation and is easily extended 🔬🦠🧫

🧪⚛️ “Turing foams” in the Min system—now seen in experiment. Non-equilibrium protein currents create foam-like interfaces obeying Plateau laws and even splitting like tiny dividing cells. Stunning video from Petra Schwille’s lab; the whole story is here: www.nature.com/articles/s41...

Latest from the lab "Filopodome proteomics identifies CCT8 as a MYO10 interactor critical for filopodia functions " www.biorxiv.org/content/10.6... Work driven by @anagracanin.bsky.social A great collaboration with @ivaskalab.bsky.social and @bengoult.bsky.social

This is going to be breathtaking

Meet the Epithelial Mechanics Fan Club @epimechfc.bsky.social Nimesh Chahare @onenimesa.bsky.social and Julia Eckert @juliaeckert.bsky.social introduce us to the Epithelial Mechanics Fan Club. Learn how you can get involved with this community: focalplane.biologists.com/2025/12/04/e...

Cells can hunt prey, solve mazes, and learn from past experience. Does this mean they can think, at some level? Find out more at our upcoming session on "Cell Behavior and Cognition" at the ASCB/EMBO #cellbio2025 meeting, Saturday 1-3 pm rm 115.

Too fluid, too rigid, no patterning. Garner et al. identify tissue fluidity—how freely cells move within a tissue—as a critical regulator of adhesion-based cell sorting. Read their study to learn how tissues can tune their fluidity to enable patterning.

In the latest issue of Lab on a Chip: Reversible and reusable compartmentalized thermoplastic chip for coculture of dorsal root ganglion neurons. Hugo Salmon, Sophie Bernard et al @hugsalmon.bsky.social @upcite.bsky.social pubs.rsc.org/en/content/a...

Are you interested in cytoskeleton and looking for a postdoc position? I will be advertising positions in the new year but happy to chat in person if you are attending ASCB @ascbiology.bsky.social in Philadelphia. Just drop me a line.

We used CODA to generate 3D single-cell immuno maps around pre-cancer lesions of the human pancreas. Highly heterogeneous. Work by Prof. Ashley Kiemen and colleagues. Read more about 3D immuno maps around pre-cancer lesions here: www.biorxiv.org/content/10.1...

The EMBO Practical Course "Hack your microscope" in Oeiras, PT, 20–25 Apr 2026 aims to innovate, democratize advanced #imaging technologies and shape the future of open-source #microscopy – Apply now! Deadline: 12 Dec https://meetings.embo.org/event/26-microscope#imaging#microscopy#EMBOmicroscope #EMBOevents 🧪

SPIN90 and #YanCao strike again! First NPF to only activate a subset of Arp2/3 iso-complexes to regulate lamellipodial actin & protrusion efficiency. Great collaboration with @romet-jegou-lab.bsky.social #ManosMavrakis polarized fluorescence microscopy rocks 🤘💥🎉 www.biorxiv.org/content/10.6...

So exciting to see this in print! Ever wondered how embryonic cells know what (fate) to become during early development? In particular when they might see different signaling cues? We investigated this! And a lovely cover from Zoe Ruiz and @oliveringe.bsky.social! www.cell.com/developmenta...

Ultrack on the cover of Nature Methods! Thanks @alexandredizeux.bsky.social for helping us with the beautiful cover art! 😍

i surprised myself preaching about data structure after being fed up with labels like : Ctrl , ctrl, CTRL etc

Tissue stress measurements — our latest preprint is out: arxiv.org/abs/2512.00550 (publication coming soon!) Fantastic work by the three musketeers — @luanger.bsky.social, @andreasschoenit.bsky.social and @fanny-wodrascka.bsky.social — in collaboration with P. Marcq!

In their Tools and Resources article, Nina Grishchenko, Michael Olson and colleagues present Toogle-Untoogle, a cell segmentation tool with an interactive user verification interface. journals.biologists.com/jcs/article/...

Our latest work is out in biorxiv! 😊 We show that human spastin, a microtubule severing enzyme, behaves completely differently in presence of free tubulin - it forms tubulin ring stack and promotes de novo microtubule nucleation. www.biorxiv.org/content/10.1...

Our paper is out in Nature Communications! We combine two-photon microscopy and active foam modeling to show how cell-scale mechanics control the viscoelasticity and fusion of tissue spheroids, linking single-cell behavior to tissue-level properties. 🔗 www.nature.com/articles/s41... #ActiveMatter

Hi everyone, Which compagnie to you recommand to purchase siRNA ?? Thank you for your replies! Don't hesitate to share

New must-read review article for all lovers of #centrioles and #centrosomes 😍👇