Tomorrow! Come hear me rambling for an hour about neurons, dev bio, transcription factors, colorful dots and fun speculations of galactic proportions 🧪

✅ Open source ✅ Gradient-based optimisation via backpropagation ✅ Works on tissues too large to fully image ✅ Applied to 5 mouse epithelial tissues 💡 The ratio of apical to lateral surface tension predicts cell shape across epithelial subtypes: single parameter yields broad morphological diversity

The paper is now published in Current Protocols!! 🎉🥳 currentprotocols.onlinelibrary.wiley.com/doi/abs/10.1... Some personal story below 👇 , and technical details in the linked post that featured the preprint 👉

On Friday, NCIS facility manager @bertrandvernay.bsky.social presented an overview of our microscopes to the whole @inp-marseille.bsky.social, focusing on updates and future instruments. Check them all here: inp.univ-amu.fr/en/node/55

MAIIA go go go

easytrack: A napari plugin for automated parameter tuning in cell tracking #micropublication #biology #data #caltechlibrary #Other #ComputationalBiology #ImagingSoftware #Methods #Methodology https://micropublication.org/journals/biology/micropub-biology-002090

Here’s the last major paper from the PhD of @paulknabl.bsky.social. We were trying to understand what BMP signaling does in the sea anemone Nematostella when it is not patterning its second body axis. Check out Part 1 in BMC Biol. 2025; and here's is our Part 2 journals.plos.org/plosbiology/...

Spotlight: New work by Zheng et al. (rupress.org/jcb/article/...) elucidates how #adhesion proteins are rapidly moved along the cell edge to vertices in response to mechanical forces. Jiarui Jiang and @krothphd.bsky.social discuss the findings: rupress.org/jcb/article/... #Mechanobiology

🚨🧠 Our paper is out! We introduce a simple computational model that generates macroscopic, long-timescale dynamics as seen in large-scale neural recordings. #neuroscience #dynamics @marius10p.bsky.social @zhong-lin.bsky.social @hhmijanelia.bsky.social Link: go.nature.com/4tRNjIu

Am I famous now?!? 😉 Jokes aside… I am stoked to start this new research direction with some of the most amazing scientists I know! What a team we already are… and… it will only get better from here!!! ❤️

The MOSAIC swiss army knife microscope (its previous name) has been published in @natmethods.nature.com: www.nature.com/articles/s41...

Oskar Schlemmer

A day in the life of a growing hiPSC spheroid expressing endogenously mStayGold-tagged histone 3.3 for #FluorescenceFriday and the #Snouty aficionados. 28 hours (and >50,000 exposures) later and they are still going! Home-brewed volume projection.

Development of Micro-Manager code has accelerated quite a bit with availability of the new generation of AI coding tools (and the need to provide functionality for microscopes in our core at UCSF). Follow these developments here: nicost.github.io/microscope-t...

Interdisciplinary course on Artificial Cells next fall in Paris. Registrations are open : www.edu.bio.ens.psl.eu/spip.php?art... For masters, PhD students and postdocs. Every wednesday, 5 to 7 PM, @espciparispsl.bsky.social from September to December. See below for the list of great teachers!

Happy to share our new review on biophysical principles of cell competition and elimination: www.cell.com/trends/cell-... With @bladoux.bsky.social and @rmmege.bsky.social, we discuss mechanical fitness, how loser cells are removed through various strategies and how forces can effect their fate

🔈 PhD offers! 2 PhD positions available at the BiOf-lab 🎓 Fancy 3D biology? Microscopy? Microfabrication? Bordeaux? 🧫 🔬 🛠️ 🍷 the first one is already online, the other will be out soon! (stay tuned) adum.fr/as/ed/voirpr...

Extremely happy and proud about this one - a tour de force and a scientific marathon by our outstanding PhD student Ziao Wang, Kilian Muller, and many collaborators in particular @krzakalaf.bsky.social @ldaudet.bsky.social and many at @lightonai.bsky.social,

Surprisingly (to me, at least), CODA 3D mapping shows that the density of cells in a pancreatic tumor is massively lower than in healthy tissues. Tumors are first and foremost WMDs: they destroy acini and ducts.

Our latest preprint list is now up on FocalPlane. Here, we focus on new tools and techniques in imaging. Let us know if you have any recommendations to add to our list. focalplane.biologists.com/2026/05/15/m...

Glad to see this out in its final form! www.nature.com/articles/s41... What changed since the preprint? Wonderful experiments disentangling the effect of receptor binding vs tissue porosity on Nodal diffusion, plus one of the smoothest review experiences! Thanks @natcellbio.nature.com & reviewers 🙏

This

Kayal, S., Nguyen, A. Q., & Bi, D. (2025). The Rheology of Living Tissues: From Cells to Organismal Mechanics. Annual Review of Condensed Matter Physics, 17. #EpithelialMechanicsReview buff.ly/3GjxT0B

Off to a flying start on the final day of #JCSimaging with @christlet.bsky.social. He described work on clathrin-coated pits and exocytic events in “clearings” in the membrane-associated periodic skeleton in axons.

Check the little video they made from the interview (with the “Rolex” Rave skateboards tee-shirt 😆)

quite a dense reading : infoscience.epfl.ch/entities/pub...

1/ Our new preprint is out today.🎉 It started from a surprising control experiment while studying how talin binds vinculin. We were using the widely adopted A50I vinculin mutant to disrupt talin binding — but unexpectedly, it still bound talin. www.biorxiv.org/content/10.6...

thinking aloud : what would be great is posting on Biorixv and get labs proposing to perform experiments to improve the science

and this one : mmv-lab.github.io/Agentic-J/

The kind of paper that makes you love this job. Amazing and very complete study! Galvanin, a direct electric-field sensor during cell migration www.biorxiv.org/content/10.1...

The Cimini lab is hiring for both postdocs and interns! The postdoc role will cover bioimage analysis projects and educational material creation; the intern will be working on our Bilayers project for helping distribute and access deep learning tools for bioimage analysis. Click below to learn more!

Localized actin cortex perturbation generates cell-scale membrane tension gradients https://www.biorxiv.org/content/10.64898/2026.05.06.721853v1

👏🏆 @emiglietta.bsky.social reports finding the golden egg in Doom for ImageJ, illustrating bioimage analysts' perseverance in navigating the maze of bioimage tools. Well done!

The 2026 Open Hardware Summit is just a few weeks away! Join us at TU Berlin for a weekend of celebrating all things open, from talks to drag shows #OHS2026 has got it all.

📣 We are organising the workshop "Phases of Collective Cellular Behavior: Rheology, Order & Feedback" from 5.-9. October 2026 at the MPI-PKS in Dresden, Germany. This workshop at the interface between physics and biology is about the collective behaviour of cells. More info: www.pks.mpg.de/colcel26

Registration for the Cell Biology and Cancer course at Institut Curie is now open! Explore how biological forms emerge across scales, from intracellular organization to tissues. 📅 November 16th-20th, 2026 (Paris) ⏳ Deadline: September 10th, 2026 🔗 training.institut-curie.org/cours/biolog...

Save the date! We have an exciting conference coming up next year for the UK Mechanobiology community!

Outstanding highlight of the Campàs Lab @poldresden.bsky.social 🐟

Hey y’all 👋 repost magic appreciated. The Solecki lab is recruiting multiple postdocs at St. Jude for a chromatin imaging project at the edge of live-cell imaging, neuronal cell biology, chromatin regulation, and quantitative image analysis. Ever dreamed of touring chromatin like this? We CAN 🔥

Question of the day : Can SAM embeddings become the shared representation space for interactive learning? If you have thoughts, feedback is welcome

Don’t reach for ChatGPT Images or Nano Banana as your first option when creating scientific images There are multiple free and open-source images, icons, and tools for creating scientific illustrations. #plantscience @stephenturner.us blog.stephenturner.us/p/free-open-...

Hey, if anyone wants to support my SpliceCraft project, where proceeds go to paying for Claude Code Max, I set up a Ko-Fi account. No pressure, of course. This project is born free and will remain free forever. TYIA! 💚 ko-fi.com/atinygreencell

I'm convinced heterogeneity is still totally underrated and most "classical" statistical tests even hide the importance of that parameter

Our latest preprint list is now up on FocalPlane. This week, bioimage analysis takes centre stage! focalplane.biologists.com/2026/05/01/m... #microscopy #bioimageanalysis #preprints

Self-supervised denoising avoids the need for clean ground truth, but training can be unstable. We recently release an adaptive intensity normalization method for more stable training @PhotoniX Life, 1, 7 (2026), with strong generalization across methods. #SN2N

Sorti il y a... 30 ans

#microtubules in orange hot, #F-actin greyscale, Fibroblast, spinning disc. @marcoenriquez18.bsky.social @aibnatuq.bsky.social #fluorescenceFriday

After 9 years, I am finally finishing the story about normalized cross-correlation (and reviving my blog). The new blog post about deep technical details on the most used image registration technique. I know y'all have been waiting. katpyxa.info/feedbacks/?p...