Peeking inside a cellular galaxy #cellfie 🧪

A cell biology professor of mine used to use this picture as an allegory of science: when we look at the pic, we're not seeing the camels, we're seeing the shadow of the camels. We do the same when we do an immuno, a western, or we measure the transcriptome.

This is finally out in J Neuroscience! A micropatterned presynapse-on-glass approach to resolve the nanoscale architecture and function of presynapses www.jneurosci.org/content/earl...

We are pleased to announce that the 4th Sino-French BioImaging Symposium (SFBS 2026) will be held in Bordeaux from 14 to 21 October 2026! 🔹An advanced thematic school (14-16 October 2026) 🔹A three-day international symposium (19-21 October 2026)

Si vous cherchez les enseignements chercheurs (et étudiants) de @univ-amu.fr en ce jour pluvieux vous aurez une chance de les croiser au salon de l’étudiant @letudiant-fr.bsky.social @inp-marseille.bsky.social @facpharmarseille.bsky.social @cnrsbiologie.bsky.social

🚨The Neurocyto lab is branching out in our latest preprint! We used tubulin microinjection to directly visualize microtubule turnover in developing hippocampal neurons, demonstrating the presence of in-lattice repair and a selective stabilization in the nascent axon. Check below, or read on 🧵 1/9

Direct labeling of microtubule turnover reveals in-lattice repair and stabilization patterns in developing neurons https://www.biorxiv.org/content/10.64898/2026.01.11.698892v1

Super exciting news for the #OligOld team 🤩😱: our project Epiglia has been awarded an #ERCCog! Ready to dive into the epigenetics of oligodendroglial cells in Alzheimer for the next 5 years with our amazing group and collaborators @inp-marseille.bsky.social @univ-amu.fr

Our new preprint is up! This is the main postdoc work of @wiesner-t.bsky.social focusing on exocytosis along the axon shaft and its regulation by the sub membrane actin-spectrin scaffold: www.biorxiv.org/content/10.1... Read the thread below for a summary of our findings 🧵1/11

Back to work! To dive right in, our team invites you to read our new review just published: ApoE-calypse tau talking about the interaction between tau and apoE proteins in the pathophysiology of Alzheimer’s disease. Congratulations to the team and our collaborators! @inp-marseille.bsky.social

The 2025 @cnrs.fr medal are out! Bronze medals for early career researchers: congrats to Aurélie Tchoghandjian at our institute @inp-marseille.bsky.social, and to @alexandra-colin.bsky.social who was nominated by the Cell biology section 🎉

🎉 It's such a pleasure to congratulate Nicolas Jullien, full-stack ingénieur, CRISPR wizard in the NeuroCyto team, software developer extraordinaire and more, who was awarded the @cnrs.fr crystal medal! Thank you @nico-juulien.bsky.social 🙏https://www.insb.cnrs.fr/fr/personne/nicolas-jullien/

Super happy to announce that together with @stefvass.bsky.social , we will have the honor to join 1st authors Florian Wernert and @moparthisk.bsky.social to present our recent work (www.science.org/doi/10.1126/...) to the French Academy of Sciences @academiesciences.bsky.social!

L’Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC – Strasbourg-Illkirch) recherche son/sa futur(e) responsable du centre d’imagerie. Pour postuler: pro.inserm.fr/rubriques/no... Contacts: [email protected] et [email protected]

🔥 We've already received over a third of pre-registrations! #Mifobio2025 is already shaping up to be a highly attractive event... Don't delay in pre-registering! 👉 imabio-cnrs.fr @cnrs.fr @cnrsbiologie.bsky.social @cnrsingenierie.bsky.social @cnrs-inist.bsky.social

By democratizing bioimage analysis, BiaPy is paving the way for faster, more inclusive scientific breakthroughs, bringing us closer to understanding the building blocks of life. https://mappingignorance.org/2025/05/15/biapy-analising-bioimages-made-easy/

A universal AI-powered pipeline enables precise 3D analysis of cell morphology and topology within organoid structures. www.nature.com/articles/s41...

Thank you #neubiaspasteur2025 for the great energy! My slides on AI-based bioimage analysis pipelines (and SAMJ!) are now up on Zenodo. I hope you took away something new! 💡 🔗 zenodo.org/records/1539...

🧵5 Top Free Alternatives to BioRender for Scientific Illustrations! These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs. Save and share the post!

Hehe, finally had time to revamp a bit Warpy. It's now possible to concatenate a series of transformed sections in a 3D stack for #QuPath. Computed on the fly and with reasonable performance (image and transform field caching).

🚀🔬🦠 Releasing 🤖Cellpose-SAM🤖, a cellular segmentation algorithm with superhuman generalization 🦸‍♀️. Try it now on 🤗 huggingface.co/spaces/mouse... paper: www.biorxiv.org/content/10.1... w/ @computingnature.bsky.social 1/n

INP lunch break … @inp-marseille.bsky.social @univ-amu.fr @facpharmarseille.bsky.social @cnrsbiologie.bsky.social @cnrs.fr

PREPRINT OUT ✨ "hack" your microscope to work as a 3D printer! print micrometer sized features at cm scale. a method for easy and cheap microfabrication, with a focus on biological applications. THREAD ↓ www.biorxiv.org/content/10.1...

Do you LOVE organelles?? Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social! Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy 🧵1/N

Scientists have designed an “ingenious” side-view device that lets them observe the structural changes of 3D tumour spheroids more comprehensively. https://elifesciences.org/articles/101886?utm_source=bluesky&utm_medium=social&utm_campaign=organic

Finally, a new release for Aligning Big Brains and Atlases! A preprint 🎉 + plenty of small improvements, have a look at the forum thread for details! forum.image.sc/t/abba-align...

Bluetorial: The path to a new pain medication with little potential for addiction Perhaps a good story to share with folks who want to learn about how biomedical research works and where advances come from.

Timothy Wong, Ismail Khater, Ghassan Hamarneh, Ivan Nabi and colleagues present SuperResNET, a pipeline for analysis of point cloud data generated by SMLM, and use it to examine clathrin structures. journals.biologists.com/jcs/article/...

🚨 Opportunities at our Institute 🚨 Check the ad in the link below and join our vibrant community, an ideal place to start a lab 🎯

At the INP, we seek new group leaders to run their teams in a brilliant, competitive, friendly and sunny environment. Want to study the fundamental organization of neural cells, basis of brain diseases or explore therapeutic strategies? Apply before March 20th! 👉 euraxess.ec.europa.eu/jobs/304107

Our next micro_sam release is here! We have a new model for light microscopy, that massively improves for automatic segmentation! See the qualitative and quantitative comparison in the images, v2 is our previous version, v3 is the new one.

Our first deposition of synaptic vesicles segmentations is now in the Cryo ET Portal! We segmented vesicles in over 50 tomograms to enable analysis of membrane proteins and more. cryoetdataportal.czscience.com/depositions/...

From @kmonier007.bsky.social et al. at Institut NeuroMyoGene in Lyon: optimization of SIM² and correlation with STORM for promyeocytic leukemia nuclear bodies imaging - nice use of multimodal calibration spheres 🌐 www.sciencedirect.com/science/arti...

Almost there

Ca va bien se passer ...

#flurorescencefriday cooking at NCIS.

monArch, a near-infrared fluorescent voltage indicator, is developed via directed molecular evolution in HEK cells and characterized by several-fold higher baseline fluorescence compared to other Arch-based GEVIs. Plasmids are available from WeKwikGene wekwikgene.wllsb.edu.cn/publications...

Our NCIS facility and Nikon Center of Excellence for Neuro-nanoimaging is on Bluesky! Follow @ncis-marseille.bsky.social for your stunning images and microscopy news fix by @bertrandvernay.bsky.social and me

Announcing PathoSAM, our foundation model for nucleus segmentation in histopathology. PathoSAM supports interactive and automatic nucleus segmentation (instance and semantic). See segmentation on a WSI from openslide, check out arxiv.org/abs/2502.00408 or read on for details.

The AX confocal with NSPARC super-resolution module arrives for a month-long demo at the NCIS facility! Looks like the crate was designed juuuust right for our elevator @christmachu.bsky.social

1/5 🚀 Excited to share our latest preprint from: 𝗦𝗶𝗥-𝗫𝗔𝗰𝘁𝗶𝗻: 𝗔 𝗳𝗹𝘂𝗼𝗿𝗲𝘀𝗰𝗲𝗻𝘁 𝗽𝗿𝗼𝗯𝗲 𝗳𝗼𝗿 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 𝗮𝗰𝘁𝗶𝗻 𝗱𝘆𝗻𝗮𝗺𝗶𝗰𝘀 𝗶𝗻 𝗹𝗶𝘃𝗲 𝗰𝗲𝗹𝗹𝘀 on #bioRxiv! www.biorxiv.org/content/10.1... #JohnssonLab and #ArndtLab with valued collaborators

I'll be in Nice tomorrow to give a keynote seminar at Institut de Biologie Valrose (iBV), please come at 11 to here about the neuronal cytoskeleton!

New actin probe from @veselin-nasufovic.bsky.social et al! SiR-XActin and its variants are more photostable and less perturbative than SiR-actin or FastAct. And it's already available from @spirochrome.com! With some beautiful data from @chillinwithpfn1.bsky.social: www.biorxiv.org/content/10.1...

The 14th International Conference on Image Processing Theory, Tools and Applications will be held on October 13-16 at @galatasaray.bsky.social University 🇹🇷 #IEEEconference 👉For researchers, innovators, educators & practitioners in Image Processing & Applications 🧐More Info on ipta-conference.com

"Imagine a DAPI-like stain, but for the extracellular matrix." That's basically how this work was pitched to me by Kayvon and Antonio a year or so ago. Now the final product really delivers. Read about their versatile label for ECM in living tissues here: www.nature.com/articles/s41...

Ten simple rules for developing good reading habits during graduate school and beyond journals.plos.org/ploscompbiol...

🆕 Now that the bugs have been fixed 🙃, we have a new video 📹 tutorial on how to import pretrained models from the BioImage Model Zoo 🦒 into your #BiaPy workflow using our friendly GUI 🖥️, by @iarganda.bsky.social: youtu.be/Zq50Ew1s8ag

👏 Félicitations à Thomas Baumert, lauréat d’un prestigieux ERC Proof of Concept Grant délivré par l’Union européenne. Ce financement lui permettra de développer avec son équipe une approche thérapeutique novatrice pour traiter la forme la plus courante de cancer du pancréas.

Brilliant work by Takeharu Nagai and team: Creating coveted bioluminescence colors for simultaneous multi-color bioimaging www.science.org/doi/10.1126/...