🦠💡 Bacteria have millions of secret weapons against viruses! Researchers used AI to uncover millions of new bacterial proteins likely involved in antiviral defense — suggesting immunity genes make up ~1.5% of the genome, 3× more than thought. 🔗 www.pasteur.fr/en/research-... @audeber.bsky.social

🦠 New preprint! We detect and profile individual SARS-CoV-2 particles by flow virometry, directly from cultures & patient swabs, no purification needed. Opens new doors for viral heterogeneity & diagnostics. 📄 www.medrxiv.org/content/10.6...

🚀 New review out! How viruses hijack host proteases to evade antibodies: shedding decoys, reshaping antigens & cutting Fc-effector pathways. 👉 journals.asm.org/doi/10.1128/... #Virology #Immunology

Keratinocyte VISTA attenuates UV light-induced skin injury by suppressing cutaneous type I interferon (IFN-I) response https://www.biorxiv.org/content/10.64898/2025.12.04.692370v1

Inhibitory potential of autologous neutralizing antibodies sets quantitative limits on the rebound-competent HIV-1 reservoir https://www.biorxiv.org/content/10.64898/2025.12.07.692769v1

Spike conformational and glycan heterogeneity associated with furin cleavage causes incomplete neutralization of SARS-CoV-2 www.nature.com/articles/s41...

Eliminating interactions with the viral Fc receptor improves antibody-mediated protection against neonatal HSV infection in mice www.science.org/doi/10.1126/...

Human antibody targeting of coronavirus spike S2 subunit is associated with protection mediated by Fc effector functions journals.asm.org/doi/10.1128/...

Effects and mechanisms of monoclonal and polyclonal human antibodies in protection of humanized mice from HIV-1 challenge https://www.biorxiv.org/content/10.1101/2025.11.12.688003v1

The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling @natcomms.nature.com www.nature.com/articles/s41...

Our latest work on #COVID immunity and imprinting in humans. Led by Ale Tortorici and Kaiti Sprouse with @aminaddetia.bsky.social and several others! www.biorxiv.org/content/10.1...

Bat sarbecovirus WIV1-CoV bears an adaptive mutation that alters spike dynamics and enhances ACE2 binding journals.plos.org/plospathogen...

« A lineage that is virtually unchanged since 1976 challenges assumptions about Ebola's evolution and exposes the blind spots of surveillance. »

#NewResearch Dipeptidase 1 is a functional receptor for a porcine coronavirus @virusfusion007.bsky.social @jeremydufloo.bsky.social #microsky www.nature.com/articles/s41...

Dipeptidase 1 is a functional receptor for a porcine coronavirus www.nature.com/articles/s41...

« Our findings strongly implicate VZV reactivation as a modifiable risk factor for dementia. » www.nature.com/articles/s41...

Re-infection with SARS-CoV-2 is associated with increased antibody breadth and potency against diverse sarbecovirus strains https://www.biorxiv.org/content/10.1101/2025.10.03.679858v1

After years in the making, Joe McKellar @viroscope.bsky.social’s final PhD paper is finally out today in PNAS! 🎉 🎉🎉 www.pnas.org/doi/10.1073/...

New paper (micro) from our lab : “No evidence for human or rodent deltavirus replication in yeast”. A collaboration with Dom helmlinger’s lab .

Read the associated research article here: www.nature.com/articles/s41...

Epstein–Barr virus exploits desmocollin 2 as the principal epithelial cell entry receptor @natmicrobiol.nature.com Microbiol www.nature.com/articles/s41...

Congrats to @summabibby.bsky.social @naphakm.bsky.social Daniel Watterson et al. here at SCMB on the first high-res cryo-EM structures of yellow fever virus! Striking vaccine vs virulent particle differences and a single R380 residue shaping antigenicity & neutralisation. doi.org/10.1038/s414...

HIV infection of CD4 T cells drives KLF2 and p53 signaling, which downregulate MYC and proliferation pathways, resulting in proviral transcriptional silencing to enhance latent reservoir formation @natmicrobiol.nature.com @saba-valadkhan.bsky.social www.nature.com/articles/s41...

« Chromatin profiling revealed that IRF1 and IRF2 occupy the same ISG regulatory sites, but as a weaker transcriptional activator, IRF2 limited ISG transcription by IRF1. » How to repress with an activator. What a stunning study. Reaching that level of mechanistic details is very inspiring!

The anti-virus T cell response dominates the anti-cancer response in oncolytic virus therapy https://www.biorxiv.org/content/10.1101/2025.09.22.677905v1

Establishment of reverse genetics systems for Colorado tick fever virus. Remind me never to complain about monopartite reverse genetics systems. journals.plos.org/plospathogen...

Big news in tick-borne flaviviruses: www.nature.com/articles/s41...

#Comment A cross-continental joint lab model brings together diverse knowledge, skill sets, working cultures and ideas to tackle the complexity and interdisciplinary nature of research questions in the current science landscape. #MicroSky #AcademicChatter www.nature.com/articles/s41...

An immune-competent lung-on-a-chip for modelling the human severe influenza infection response @natbiomedeng.nature.com @vanderbilt.edu www.nature.com/articles/s41...

Non-neutralizing antibodies to influenza A matrix-protein-2-ectodomain are broadly effective therapeutics and resistant to viral escape mutations www.science.org/doi/10.1126/...

Vientovirus capsid protein mimics autoantigens and contributes to autoimmunity in Sjögren’s disease www.nature.com/articles/s41...

Really excited to have been a small part of this work investigating sarbecovirus host range, receptor usage and antigenicity! www.biorxiv.org/content/10.1101/2025.09.03.673949v1

These editors handled only 1.3% of all articles published by the journal from 2006 to 2023, but the papers they accepted accounted for more than 30% of the 702 retractions that Plos One issued by early 2024.

B and T cell receptor repertoires as well as nasal and systemic immune responses correlate with length of viral shedding after influenza challenge www.science.org/doi/10.1126/...

@vijayrathinam.bsky.social @vinnieviruses.bsky.social ‪@raflynn5.bsky.social‬ discovers why RNA undergoes glycosylation: N-glycans on glycoRNAs hide self-RNA from endosomal TLRs promoting ‘silent’ clearance of dead cells @nature.com www.nature.com/articles/s41...

THREAD Not all attention is good attention In July 2025 the book "Mastering Machine Learning: From Basics to Advanced" made headlines after it was discovered that a large part of its citations were made up or substantively incorrect. Suboptimal. www.inkl.com/news/bo... 1/9

New in @science.org We built a safe, atomic-resolution version of the Powassan virus—a deadly tick-borne #flavivirus with no vaccine. ✅ First structure ever ✅ Safe to handle (BSL-2) ✅ Platform for vaccines & antivirals Let me show you 🧵 (1/5) Link: www.science.org/doi/10.1126/...

Feline infectious peritonitis epizootic caused by a recombinant coronavirus www.nature.com/articles/s41...

Loss of FCoV-23 spike domain 0 enhances fusogenicity and entry kinetics www.nature.com/articles/s41...

A thread- resolving the Omicron Paradox.

Still playing with PDB files and my pen plotter 👌

Playing with a PDB structure of SARS-CoV-2 (7DF3), the amazing blnkhz.github.io tool, and an iDraw pen plotter 😀

🔴 EXCLUSIF. L'appel des trois grands instituts de recherche français : "Trump ne cible pas la science par hasard" ⬇️ ✍️ @stephaniebenz.bsky.social, @ericchol.bsky.social et Thomas Mahler

#Medsky 🧪 #IDsky #immunosky #publichealth The spike protein of many #sarbecoviruses binds to ACE2 receptor & facilitates viral entry. The diversification of 🦠 spike gene & the mammalian ACE2 gene suggests that s.viruses & their hosts have co-evolved .Another excellent study frim Kei Sato San et al👇🏿

One of life’s greatest tragedies is losing a child. And yet, 1 child under 5 dies somewhere in the world every 18 seconds - mostly from preventable causes like 💔 Birth complications 💔 Pneumonia 💔 Diarrhoea 💔 Malaria This amounts to 4.8 MILLION deaths each year. NEW report: bit.ly/4kTTBUV

There is a human tissue that builds itself up and breaks itself down every 28 days (on average) using non-scarring wound healing and instead of studying that and learning everything we can about it we think it's gross and look for other less relevant models to understand wound healing.

#TheMoreTheMerrier! Wu, Yan &co show @cp-immunity.bsky.social that antiviral OAS alerts neighboring cells by producing 2-5A which via gap junctions or exporter/importer activates RNaseL, protecting against infection or tumor growth! #ScienceSavesLives dlvr.it/TJB0nT

Although the yellow fever vaccine is highly effective, supply is limited. In a trial in Africa, lower doses of vaccine were noninferior to a standard dose for producing seroconversion within 28 days. Full NIFTY trial results: nej.md/3D9rAY9 #MedSky #IDSky

Most of the fellows in CDC’s highly competitive Laboratory Leadership Service were fired last weekend. The ultracompetitive, 2-year program, which trains Ph.D. scientists in the intricacies of public health laboratory work. scim.ag/4gPy0te

🚨 New preprint alert! 🚨 How does SARS-CoV-2 use as much of its genome as possible to evade our immune response? Our latest study dissects how Orf9b, which is encoded in an alternate reading frame from the N(ucleocapsid) protein, can regulate interferon signaling. www.biorxiv.org/content/10.1... 🧵👇