Rhys Parry
@rhyshparry.bsky.social
📤 1920
📥 770
📝 49
Virologist at the University of Queensland.
#virology
#virusevolution
#rnavirology
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Rhys Parry
Alain Kohl
14 days ago
Dear colleagues - the international meeting on arboviruses and their vectors planned in Hamburg, Germany for 2026, is going to be moved to Liverpool instead. Logistical reasons beyond our control necessitated this move. Still the same dates- see you on Merseyside!
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Chris McMillan
17 days ago
Great to share the story behind our recent paper on needle-free DNA vaccine delivery! Microarray patches like the one being developed by Vaxxas may help unlock the pandemic preparedness potential of DNA vaccines - read more
microb.io/48PTJ2l
Manuscript:
www.microbiologyresearch.org/content/jour...
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Patching up pandemic preparedness: a needle-free approach to influenza vaccination
Chris McMillan and Chloe Entriken of the University of Queensland, Australia, take us behind the scenes of their latest publication <a href="http://doi.org/10.1099/jgv.0.002179">'Improved eff...
https://microb.io/48PTJ2l
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Used
@plasmidsaurus.bsky.social
RNA-seq for the first time. $50USD a sample. Sent 42 samples from Australia. Dropped off 50uL cells in Zymo shield on Dec 5th at RT. Just got data back, almost all at or above 10million reads. Online analysis tool fine but will do own analysis. Spread the word.
17 days ago
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It’s starting to feel a lot like Christ(Flavi)mas.
about 1 month ago
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Prof Gavin Yamey
about 1 month ago
Yup, Colin is right & that NYT piece is infuriating, painting an unreal picture of Kennedy & his band of extreme anti-vaccine activists & conspiracy theorists—who cause suffering & death—as a group of compassionate folks trying to give grieving parents meaning when their unvaxxed kids die of measles
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Out now in Microbial Genomics
@microbiologysociety.org
MCMV-infected dendritic cells switch off MHC-II (via Ciita) while turning on migration via viral GPCR M33 – converting DCs into stealth couriers for viral spread. Work with Helen Farrell lab and
@chrismcmillan.bsky.social
doi.org/10.1099/mgen...
about 1 month ago
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Society for Molecular Biology and Evolution
about 1 month ago
SMBE Australasian Protein Structural Phylogenetics Meeting 📄 Abstract submission deadline: Nov 28 Please submit your abstracts by Friday! Registration is free, but limited to 50 in-person attendees. ✈️ Travel grant applications deadline: Nov 28 🔗
biosig.lab.uq.edu.au/strphy26/str...
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APSPM 2026: Structural Phylogenetics Meeting
A pivotal SMBE regional meeting in Brisbane on the interface of protein structure, function, and evolution.
https://biosig.lab.uq.edu.au/strphy26/strphy26/
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Are influenza B viruses really “human only”? New review synthesises evidence from serology & metagenomics for
#IBV
/ IBV-like viruses in animals and aquatic hosts. One Health gaps remain. With
@marioskoutsakos.viralvaxlab.com
@duckswabber.bsky.social
www.mdpi.com/1999-4915/17...
about 1 month ago
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Starting to say “publish or perish” less fatalistically and more threateningly.
about 1 month ago
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Rhys Parry
about 1 month ago
Was my pleasure to present our brain organoid model of flavivirus infection at Organoid Nexus symposium in sunny Melbourne.
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New preprint from the Khromykh/
@slonchak.bsky.social
/Short lab 👇 In primary human nasal epithelia,
#Omicron
BA.5 & XBB show enhanced ciliated-cell tropism and a striking cilia-gene shutdown plus apoptosis/inflammation, unlike ancestral virus or BA.1. Preprint:
www.biorxiv.org/content/10.1...
about 1 month ago
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ARC Tracker
about 1 month ago
Where to start, with a statement like this? "Tim Ayres said the cuts were aimed at refocusing … CSIRO towards research priorities, such as critical minerals, iron & steel production in Australia." From some rando down the bus stop, one would brush it off. But this is from our Science Minister 🤯
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CSIRO to cut up to 350 research jobs in major overhaul
After 440 positions were slashed last year, the CSIRO has announced more staff cuts across the country in a bid to remain financially viable.
https://www.abc.net.au/news/2025-11-18/csiro-cuts-350-research-jobs/106024498?utm_medium=social&utm_content=sf279182680&utm_campaign=abc_news&utm_source=m.facebook.com&fbclid=IwY2xjawOJMLRleHRuA2FlbQIxMQBicmlkETFPd3ZWaUxMYkExZmpHTHN0c3J0YwZhcHBfaWQQMjIyMDM5MTc4ODIwMDg5MgABHr05IYxchUYmoo_37e8Zo9QHOyF3KOKUvXCtxpYXCVQcy_x7jJP0fYcBrP54_aem_JyKjyU-rUuXTm9ie8qHFXA
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Ed Hutchinson
about 1 month ago
If you'd like to celebrate the biology of viruses - or the fight against viral diseases - this winter, try out our free and updated
#VirusSnowflake
designs. Please share, and if you have any photos of Virus Snowflakes in your area it would be lovely to see them!
cvr-engagement.co.uk/virus-snowfl...
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Colin Carlson
about 2 months ago
🚨 NEW: The majority holder of the world's genetic sequence data is a bad actor who can cut off access to critics and competing services. We've tolerated this for years, and now it threatens the pandemic treaty. Time for WHO to step in. With
@ctrlalttim.com
:
www.thinkglobalhealth.org/article/to-f...
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To Finish the Pandemic Agreement, WHO Needs a Trustworthy Viral Database | Think Global Health
Online platforms for sharing virus sequences are in disarray. The World Health Organization has a chance to build something new
https://www.thinkglobalhealth.org/article/to-finish-the-pandemic-agreement-who-needs-a-trustworthy-viral-database
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Dr Emma Hodcroft
about 2 months ago
I want to spell this out in case the implications aren't clear: This means all public tools/webapps of GISAID data (all the ones you've been used to seeing thru the pandemic, as far as we can tell) are prohibited. The file allowed this. Cut that - cut off all tools the public & others were using.
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ASM QLD Branch
2 months ago
🧬 MiM2025 — ASM Queensland Annual Meeting Join us for a full day of microbiology at Griffith Uni, Gold Coast! 📅 Sat 22 Nov 2025 | Free for members 🎙 Featuring keynote speakers Greg Cook,
@duckswabber.bsky.social
Michelle Wille & Subir Sarker. 🔗 Register:
www.trybooking.com/DGRHL
#ASM
#Micro
#MiM2025
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Had a wonderful time at
#HCVFLAVI2025
in Singapore presenting our Flavi ncRNA work from the Khromykh lab and was chuffed to pick up a short talk award. Here I am with other awardees demonstrating a normal distribution. Hope to see you again at
#HCVFLAVI2026
3 months ago
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Final day of
#HCFLAVI2025
with a great talk from
@maringerlab.bsky.social
on 3D models of dengue microvascular dysfunction, using gorgeous liver microvascular spheroids, to unpack
#dengue
vascular pathology.
3 months ago
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Rhys Parry
ASM QLD Branch
3 months ago
🚨 SAVE THE DATE 🚨 MiM2025 — ASM QLD’s annual microbiology meeting 🧫✨ 📍 Gold Coast | 🗓️ 22 Nov 2025 🧪 Talks & 5-min
#Microbites
for students 📨 Abstracts due 20 Oct — send to
[email protected]
@aussocmic.bsky.social
#MiM2025
#microbiology
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Haunted lately by
@galaxyproject.bsky.social
CO₂e estimates for jobs. This one MEGAHIT assembly: ~450g CO2e. I've run this ~150k times on HPC, ~75 tonnes of CO2e 😬. Perhaps ARC/NHMRC would accept Australian Carbon Credit Units as part of the grant cost for offset? What others are doing in AUS/INT?
3 months ago
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Merja Joensuu
3 months ago
🌟 Thrilled to share that my lab’s first publication is now out in
@natmetabolism.nature.com
. Congrats to the team 🎉 🧠 We discovered that neurons use endogenous fatty acids as an energy fuel, challenging long-standing models of sugars being the exclusive energy source for neurons. 1/3
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Tamanash Bhattacharya
3 months ago
New preprint alert! 🦟 <-> 🦠 <-> 🧑 I am thrilled to share our latest study on alphavirus host adaptation. More specifically, on how a single codon helps blunt alphavirus-induced host innate immune responses in mosquito and human cells. Continue reading for more!
www.biorxiv.org/content/10.1...
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The Sindbis virus nsP3 opal codon protects viral RNA and fitness by maintaining replication spherule integrity
Most alphaviruses encode an in-frame opal stop codon between nsP3 and nsP4 in their nsP ORF. This opal stop codon mediates a temperature-dependent balance between viral polymerase production and prote...
https://www.biorxiv.org/content/10.1101/2025.09.27.679005v1
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Joe Grove
3 months ago
🚨 New Web Resource Alert! 🚨 We're delighted to share Viro3D a database of >85000 viral protein structure predictions from >4400 human & animal viruses. 🔗
viro3d.cvr.gla.ac.uk
📄
www.embopress.org/doi/full/10....
@molsystbiol.org
@cvrinfo.bsky.social
@uofgmvls.bsky.social
#Virology
#AlphaFold
🧪 🦠
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Viro3D
https://viro3d.cvr.gla.ac.uk
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Congrats to
@summabibby.bsky.social
@naphakm.bsky.social
Daniel Watterson et al. here at SCMB on the first high-res cryo-EM structures of yellow fever virus! Striking vaccine vs virulent particle differences and a single R380 residue shaping antigenicity & neutralisation.
doi.org/10.1038/s414...
3 months ago
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The use of attenuated SC2 JN.1 as a bivalent vaccine vector. Mutate (D130A) in nsp16, delete FCS in spike, delete accessory ORFs, and/or modify transcription regulatory sequences, then add prefusion RSV F. Successfully protects, although modified TRS seem to over-attenuate.
doi.org/10.1126/scia...
3 months ago
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Rhys Parry
Germán Bonilla-Rosso
3 months ago
🧪🦠🖥️🧬🧫🔬 The Roadmap for equitable use of public microbiome data -including the Data Reuse Information Tag (DRI)- by the
#DataReuseConsortium
. Must read if you use or produce microbiome data! Kudos to the Data Reuse Core Team for their hard work!
doi.org/10.1038/s415...
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Establishment of reverse genetics systems for Colorado tick fever virus. Remind me never to complain about monopartite reverse genetics systems.
journals.plos.org/plospathogen...
3 months ago
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Impressive work on the effect of
#Wolbachia
in 60! strains of DENV. Like earlier reports, DENV-1,2,4 was strongly inhibited. DENV-3 isolates had more variable & weaker inhibition. Given the range of genotypes, this is a strong foundation to examine viral genetic determinants of susceptibility.
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3 months ago
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Rhys Parry
Thelonevirologist
4 months ago
Transcriptomic response of mosquitoes to Japanese encephalitis virus and identification of its potential entry factors
www.nature.com/articles/s44...
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Transcriptomic response of mosquitoes to Japanese encephalitis virus and identification of its potential entry factors - npj Viruses
npj Viruses - Transcriptomic response of mosquitoes to Japanese encephalitis virus and identification of its potential entry factors
https://www.nature.com/articles/s44298-025-00151-8
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Rhys Parry
Hugo Perdomo
5 months ago
How can mosquitoes tolerate viral infections? In our latest preprint we show that mosquitoes that can regulate their metabolism after infection can tolerate viral infections better. Thanks to all the authors for all your ideas and contributions
www.biorxiv.org/content/10.1...
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Metabolic homeostasis favors tolerance to persistent viral infection in Aedes aegypti mosquitoes
The mosquito Aedes aegypti harbors a wide range of persistent viral infections, including both medically important arboviruses and insect-specific viruses (ISVs). However, the mechanisms underpinning ...
https://www.biorxiv.org/content/10.1101/2025.07.23.666353v1
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Rhys White
4 months ago
🚨Call for abstracts
#OneHealth
Aotearoa Symposium 2025 📍Wellington + online 🗓️2–3 Dec 2025 Submit an abstract by 30 Sept Themes:
#AMR
,
#Zoonoses
,
#HealthEquity
,
#TeAoMāori
,
#ClimateHealth
& more More info👉
onehealth.org.nz/one-health-a...
📩
[email protected]
🖥️🧬💻
#AcademicSky
#MicroSky
🧪🧫🦠
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One Health Aotearoa Symposium 2025 - One Health Aotearoa
Our 11th annual symposium will be held on 2-3 December 2025 at the University of Otago, Wellington campus and online. Registrations will open soon! Venue Information Nordmeyer Lecture Theatre – Univer...
https://onehealth.org.nz/one-health-aotearoa-symposium-2025/
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Rhys Parry
MicroSeq2025
4 months ago
Until next year,
@mozztacular.bsky.social
, Asad,
@royalfizzbin.bsky.social
, Mozammel,
@wytamma.bsky.social
, Bec, and
@rhyshparry.bsky.social
out!
#MicroSeq2025
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Jennifer Barr
4 months ago
Our research describing the isolation and characterisation of a novel henipavirus, Salt Gully virus, discovered in Australian bats has been published in the September edition of Emerging Infectious Diseases.
wwwnc.cdc.gov/eid/article/...
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Novel Henipavirus, Salt Gully Virus, Isolated from Pteropid Bats, Australia
Novel Henipavirus Isolated from Bats, Australia
https://wwwnc.cdc.gov/eid/article/31/9/25-0470_article
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Rhys Parry
MicroSeq2025
4 months ago
Your
#MicroSeq2025
committee -
@mozztacular.bsky.social
, Asad Prodhan,
@royalfizzbin.bsky.social
, Mozammel Hoque,
@wytamma.bsky.social
, Rebecca Roach, and
@rhyshparry.bsky.social
- are all here and ready to go! 🫡 Please feel free to reach out to any of us w/ questions or concerns at any time ♥️
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MicroSeq2025
4 months ago
✨
#MicroSeq2025
Plenary Highlight! ✨ Dr Jackie Mahar is an evolutionary virologist & bioinformatician based at CSIRO, managing projects on NGS-based phylogenomics of zoonotic & animal viruses for pathogen discovery, surveillance & viral ecology. Register👇
trybooking.com/events/landing/1424679
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Rhys Parry
Mine Altinli
4 months ago
RNAi is a powerful tool for mosquito control, but delivery remains difficult. Could symbiotic bacteria be the key? Mixed results so far highlight the complexity and the gaps in our understanding of RNAi, bacterial delivery, and host–symbiont interactions. Read more in our recent review👇
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Rhys Parry
MicroSeq2025
5 months ago
We are delighted to announce our plenary speakers for
#MicroSeq2025
! Dr Rose Collis, Dr Jackie Mahar, Dr Peter Mee, and Dr Leah Roberts! We’ll be treated to four excellent talks across September 3-4. We can’t wait! Register below👇
trybooking.com/events/landing/1424679
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Ian M. Mackay, PhD (he/him) 🦠🤧🧬📑🦟🧀
5 months ago
What crap is this? "The Queensland government says it wasn't "confident" a doctor was suitable to be the state's chief health officer" -do they not know the last 2 two Qld CHOs were medical doctors (and so stand-ins)?? The need is in the title guys.
www.abc.net.au/news/2025-08...
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MP calls for transparency over Qld health head appointment
Sources told the ABC an offer for the state's top health job was made and quickly scrapped.
https://www.abc.net.au/news/2025-08-14/chief-health-officer-appointment-scrapped-krispin-hajkowicz-/105655530?utm_source=abc_news_app&utm_medium=content_shared&utm_campaign=abc_news_app&utm_content=other
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Brennan Lab CVR
5 months ago
📢 Thrilled to share our NEW PREPRINT! SFTSV NSs is a novel tick antiviral RNAi suppressor! 🦠 🧫 NSs essential for tick but not mammalian infection 🧬 Binds 22-nt viral siRNAs to block RNAi 🕷️ Reveals host-specific viral immune evasion 📖
doi.org/p2vf
#lovevirology
#bunyavirus
#tickborne
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SFTSV NSs protein is a novel tick antiviral RNAi response suppressor
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne phenuivirus causing high mortality in humans. While the non-structural protein NSs is dispensable for replication in...
https://doi.org/p2vf
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Rhys Parry
International Bat Research Conference 2025
5 months ago
IBRC delegates protest visa denials of 8 researchers from Africa and Asia.
#ibrc2025
#batresearch
www.theguardian.com/environment/...
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Eight bat researchers mostly from Asia and Africa refused entry into Australia to attend global scientific event
Organisers say move will damage nation’s scientific standing as government refuses to comment on why group of scientists were refused entry
https://www.theguardian.com/environment/2025/aug/09/eight-bat-researchers-mostly-from-asia-and-africa-refused-entry-into-australia-to-attend-global-scientific-event
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Is bisegmentation cheating in the ssRNA length race?
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5 months ago
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Eddie Holmes
5 months ago
You’ve been badly misled over COVID origins
theconversation.com/how-conspira...
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How conspiracy theories about COVID’s origins are hampering our ability to prevent the next pandemic
The COVID pandemic likely began when the virus jumped from animals to humans, and didn’t start in a lab. But false narratives continue to circulate.
https://theconversation.com/how-conspiracy-theories-about-covids-origins-are-hampering-our-ability-to-prevent-the-next-pandemic-261475
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A pleasure to host A. Prof Aaron Irving
@batresearch.bsky.social
today at the SCMB Infection & Immunity seminar. Wild genetic diversification and antiviral immune adaptations in Chinese horseshoe bats. Great to see large-scale genomics paired with functional in vitro molecular
#virology🦇🧬
5 months ago
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MicroSeq2025
5 months ago
🚨Abstract submission & registration for
#MicroSeq2025
is OPEN! 🚨Get in quick! The first 50 registrations are FREE for PhD students and ECRs who are current ASM members, thanks to
@aussocmic.bsky.social
. Head to our website to register now 👇
www.microseqconference.com/registration...
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Alain Kohl
5 months ago
Interested in applying for a EU MSCA fellowship? Happy to discuss projects in the arbovirology/parasite virology fields. Get in touch and join the group in Liverpool!
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Seth Cheetham
7 months ago
To accelerate
#mRNA
vaccine and therapy research, we're excited to share our end-to-end protocol for mRNA design, synthesis and encapsulation in
@natprot.nature.com
. Protocol development led by
@laura-leighton.bsky.social
, Natasha Chaudhary and Tim
[email protected]
rdcu.be/eqiF1
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The design, manufacture and LNP formulation of mRNA for research use
Nature Protocols - This protocol describes simple, small-scale laboratory production of mRNA for research and preclinical use. This includes sequence design, DNA template production, mRNA synthesis...
https://rdcu.be/eqiF1
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Rhys Parry
MicroSeq2025
6 months ago
📣Calling Australian/NZ ECRs and PhD Students 📣 Abstract submission and registration for MicroSeq2025 opens July 21! Abstracts for both medium-length and lightning talks will be welcome.
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Stuart Turville
6 months ago
1-Here is the work under discussion
www.biorxiv.org/content/10.1...
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Replication of SARS-CoV-2 Omicron lineages is defined by TMPRSS2 use in environments where ACE2 is complexed with solute carriers SLC6A19 and SLC6A20.
The Omicron variant of SARS-CoV-2 emerged in late 2021 and since then Omicron subvariants have continued to evolve and dominate globally. The viral S protein evolved towards highly efficient antibody evasion and replicative capacity in the upper respiratory tract resulting in high transmissibility. At the same time, the mutations acquired in the S protein diminish infection of the lung epithelium and pathogenic potential. The changing entry requirements for Omicron sub-lineages that lead to this shift in tropism remain poorly understood. We resolve the changing replication requirements of SARS-CoV-2 to be related to two distinct pools of ACE2. The first pool relates to ACE2s role in the renin angiotensin system (RAS) and this pool can complex with TMPRSS2 (RAS-ACE2). The second pool relates to ACE2s role as a protein solute carrier chaperone than cannot complex with TMPRSS2 (Chaperone ACE2). Here, we demonstrate that pre-Omicron lineages replicate in a TMPRSS2 dependent manner across both ACE2 pools, whilst Omicron lineages can only spread and replicate using chaperone ACE2. This provides a mechanistic basis for the evolving infectivity requirements of SARS-CoV-2 and furthermore provides approaches to track and monitor ACE2 utilizing coronaviruses. ### Competing Interest Statement The authors have declared no competing interest. New South Wales Department of Health, https://ror.org/03tb4gf50 National Health and Medical Research Council, https://ror.org/011kf5r70 Medical Research Future Fund, AU
https://www.biorxiv.org/content/10.1101/2025.07.07.663433v1
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Nature Structural & Molecular Biology
6 months ago
New online: A nanobody-based therapeutic targeting Nipah virus limits viral escape
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A nanobody-based therapeutic targeting Nipah virus limits viral escape
Nature Structural & Molecular Biology, Published online: 08 July 2025; doi:10.1038/s41594-025-01598-2Here, Isaacs, Nieto and Zhang et al. discover a potent nanobody and engineer a dual-action antibody that targets two viral proteins, offering strong protection against Nipah and Hendra viruses while preventing viral escape, potentially contributing to future treatments.
https://go.nature.com/46uSUfG
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Jennifer Barr
6 months ago
Great to see this hard work finally published, led by UQ colleagues Ariel Isaacs & Dan Watterson 👏 We assessed the nanobody and engineered bispecific nanobody-MAb at BSL4 with live virus and found superior neutralization capability
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