🎉 Our new study of CD4 TFH quality is now online @ebiomedicine.bsky.social! We know that TFH are critical for germinal centres and antibody production, but want to understand whether all CD4 responses can be equally helpful to B cells. www.thelancet.com/journals/ebi...

Are influenza B viruses really “human only”? New review synthesises evidence from serology & metagenomics for #IBV / IBV-like viruses in animals and aquatic hosts. One Health gaps remain. With @marioskoutsakos.viralvaxlab.com @duckswabber.bsky.social www.mdpi.com/1999-4915/17...

Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis @science.org @yiweichang.bsky.social www.science.org/doi/10.1126/...

Happy to be able to contribute to this very cool preprint Characterization of the glycoproteins of novel fish influenza B-like viruses #glycotime #lovevirology @uu-cbdd.bsky.social www.biorxiv.org/content/10.1...

In unexposed adults, frequency of memory B cells with cross-reactive recognition of H5 + H7 low, & lower in unexposed vs humans w seasonal H1N1/H3N2 HA-specific B cells. Boosting B cell responses against HPAI following seasonal immunisation = sporadic. 👉 www.biorxiv.org/content/10.1...

Happy to finally share this work!

Check out the latest from @viralvaxlab.bsky.social postdoc Wen Shi Lee, developing monoclonal antibodies that neutralise the NL63 coronavirus!

Happy to report that Mitchell's paper on CD4 T cells and AIM assays is now available online at Science Advances! www.science.org/doi/10.1126/... Thanks to all our collaborators in @viralvaxlab.bsky.social and @thedohertyinst.bsky.social, including @assocprofashhaque.bsky.social lab

New preprint alert 🚨 My team and I are pleased to share our most recent story about how bacterial pathogen (Streptococcus pyogenes, Strep A) exposure induces antibody responses against glycan and protein antigens. For paper: SSRN ssrn.com/abstract=519... biorxiv : doi: doi.org/10.1101/2025...

Today @natmedicine.bsky.social published our study showing the older individuals born prior to 1968 have more antibodies that cross-react to #H5N1 relative to younger individuals. If H5N1 causes a pandemic, children will likely be the most susceptible. 1/2 www.nature.com/articles/s41...

The Virology Unit at IPC has 3 positions open in #OneHealth: *Postdoc – Reconstructing Past Outbreaks *Postdoc – Environmental Surveillance *Clinical Manager These aren’t just jobs. They’re front-row seats to global health in action. Ready? tinyurl.com/57rvxcau #ViroSky #IDSky 🦠🔬🧬🥼🧪

1/ Hot off the press in @jimmunol.bsky.social. We investigated how same side (ipsilateral) vs alternate side (contralateral) prime-boost vaccination impacts germinal center (GC) dynamics & antibody responses against SARS-CoV-2 spike in mice.💉🦠#immunology #vaccines @thedohertyinst.bsky.social

New research from @thedohertyinst.bsky.social suggests that receiving multiple doses of a vaccine in the same limb leads to faster antibody development, an important strategy for providing #immunity quickly during a pandemic or disease #outbreak. #ReadTheJI #immunology ow.ly/c28N50VeRGR

Antigenic map of H5 influenza viruses spanning their evolutionary history. 3 clusters (surprisingly few!) w no cross immunity. 6 key aa identified. 2344b, 2321a, 2344h in different clusters. Big jump in antigenicity from 234 to 2344b important finding. 👉 www.researchsquare.com/article/rs-6...

Negative-Strand RNA Virus meeting #NSV2025 registration is now open! Visit www.negativestrandvirus.org/home

Really proud to share our preprint describing early adaptation of H5N1 to US dairy cattle, and showing how these mutations enhance the ability of the virus to infect other mammals, such as pigs and humans. With @influenzal.bsky.social @vidhid.bsky.social @drclairesmith.bsky.social and many more!

8/9 In short, we suggest in vitro stimulation activates ag-specific T cells, which secrete cytokines and activate Treg and Th17/22 cells. Without careful phenotyping, all of these cells can get picked up as AIM+, accounting for the Th17-like memory cells found in many virus-specific AIM datasets.

Thanks @ausvirologysoc.bsky.social for a great meeting. Where else can you turn the evolution of flu A vs flu B strains as described by @marioskoutsakos.bsky.social into a dance move. Having Jenna Guthmiller here from the US was a highlight for me! See you all in Adelaide in 2026

I have a few brief thoughts on this just released Science paper on the adaptation potential of bovine #H5N1 HA. Its very good work by very good group at Scripps! Think people need to be cautious in assessing the actualized risk out of this one study. #influenza www.science.org/doi/10.1126/...

Next up is Marios Koutsakos @marioskoutsakos.bsky.social who is presenting Antigenic evolution of the influenza B virus HA over 80 years of circulation in humans. Marios has apologised for only including one phylogenetic tree in his talk in this evolutionary virology session. #AVS12

I've made a starter pack for Aussie virologists joining Bluesky at #AVS12. Let me know if you would like to be added- please share 🤗 @ausvirologysoc.bsky.social go.bsky.app/FgBEzfc