@slonchak.bsky.social
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I'm excited that our review paper on superinfection exclusion in insect-specific flaviviruses is now published. This comprehensive review summarizes the experimental data on the ability of different ISFs to cause SIE and suggests future pathways in SIE research:
www.mdpi.com/1999-4915/18...
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https://www.mdpi.com/1999-4915/18/1/115
about 1 month ago
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Festive season at Systems Virology Lab
@qimrb.bsky.social
🎄🍷 Thank you York and
@michaelleitner.bsky.social
for organising this on my last day at work this year.
3 months ago
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Last scRNA-Seq run of the year at Systems Virology lab feels special 🎄🧬🦠 Featuring
@michaelleitner.bsky.social
and
@10xgenomics.bsky.social
Chromium X
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3 months ago
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Celebrating an epic year with an even more epic team. Grateful to my team for the science through the year and the laughs at the lab Christmas party and to Ukrainian Club Brisbane for fantastic food and flavoured vodkas 🎄🧬🥂
3 months ago
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Congratulations to
@rhyshparry.bsky.social
on award of DECRA by ARC
3 months ago
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Had fantastic time enjoying two days of
#organoid
talks and engagement with research and industry leaders in the field. Also congratulations to
@leitnerm.bsky.social
for successful presentation of his first results in our new lab at
@qimrb.bsky.social
3 months ago
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Was my pleasure to present our brain organoid model of flavivirus infection at Organoid Nexus symposium in sunny Melbourne.
3 months ago
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reposted by
Rhys Parry
3 months ago
New preprint from the Khromykh/
@slonchak.bsky.social
/Short lab 👇 In primary human nasal epithelia,
#Omicron
BA.5 & XBB show enhanced ciliated-cell tropism and a striking cilia-gene shutdown plus apoptosis/inflammation, unlike ancestral virus or BA.1. Preprint:
www.biorxiv.org/content/10.1...
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Excited to learn about the most recent advances in organoid technologies at
#MonashOrganoidSymposium
3 months ago
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Amazing night celebrating 80 years of
@qimrb.bsky.social
at gala dinner with a fantastic cohort of distinguished guests!
4 months ago
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reposted by
Nature Microbiology
4 months ago
The IFIT2–IFIT3 antiviral complex targets short 5’ untranslated regions on viral mRNAs for translation inhibition By Dustin Glasner, Matthew Daugherty & colleagues.
#microsky
www.nature.com/articles/s41...
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The IFIT2–IFIT3 antiviral complex targets short 5’ untranslated regions on viral mRNAs for translation inhibition - Nature Microbiology
Viruses generally have compact genomes, resulting in many viral mRNAs with short 5’ untranslated regions. An antiviral complex exploits this feature of viral mRNAs to selectively inhibit viral protein...
https://www.nature.com/articles/s41564-025-02138-w
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Probes for multicoloured RNA FISH look so vibrant! Can’t wait to see the beautiful slide scans! Made by
@carlaprvieira.bsky.social
at Systems Virology Lab.
4 months ago
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Team work makes dream work. Especially when setting up a new lab
@qimrb.bsky.social
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8 months ago
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Systems virology team has arrived to our new amazing home at
@qimrb.bsky.social
It was an exciting first day unpacking and unboxing and thank you to my fantastic team for their effort in getting setup!
8 months ago
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Today was my farewell party at Khromykh’s lab, which felt like an end of an era. I definitely had amazing time working alongside all the amazing people there and developing my leadership with Alex’s help. Thank you
@rhyshparry.bsky.social
for organising this.
8 months ago
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reposted by
Lach De Hayr
9 months ago
@slonchak.bsky.social
presenting his work on viral pathogenesis in human brain organoid models using single cell sequencing. Hisnlast presentation at
#uqscmb
before he heads to
@qimrb.bsky.social
to head his own lab
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Today I’m learning about most recent innovations in single cell and spatial technologies from
@10xgenomics.bsky.social
experts and users at Brisbane’s Single Cell and Spatial Symposium. Very exciting how quickly this field is developing blinking new opportunities to researchers and clinicians.
11 months ago
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It’s always a plus when the conference is being held in a place of stunning natural beauty. On the last day of
#lorneiandi
a got to get my drone up to capture the beauty of the location from the birds eye view. What an amazing place!
@theviin.bsky.social
about 1 year ago
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reposted by
Connor Scott
about 1 year ago
Feeling very grateful to receive an early career development and ECR oral presentation award at Lorne I&I
@theviin.bsky.social
An amazing few days in Lorne learning about all types of pathogens and host responses. Great science at a stunning location!
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Host tRNAs as novel player in antiviral response. Presented by
@lachdehayr.bsky.social
at Lorne I&I conference
@theviin.bsky.social
about 1 year ago
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reposted by
Lach De Hayr
about 1 year ago
@slonchak.bsky.social
's excellent presentation on his work studying WNV neuropathology using state of the art human brain organoids and single cell sequencing
#UQSCMB
add a skeleton here at some point
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What was happening in my hotel room while I was attending the sessions at Lorne I&I conference
@theviin.bsky.social
Cheeky
#cockatoos
!
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about 1 year ago
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reposted by
Lach De Hayr
over 1 year ago
Our paper and the first from our PhD student talking about the current state of flavivirus vaccines. Are our current strategies failing, and are their other options? Maybe new targets are needed. Read it below.
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The Flavivirus Non-Structural Protein 5 (NS5): Structure, Functions, and Targeting for Development of Vaccines and Therapeutics
Flaviviruses, including dengue (DENV), Zika (ZIKV), West Nile (WNV), Japanese encephalitis (JEV), yellow fever (YFV), and tick-borne encephalitis (TBEV) viruses, pose a significant global emerging threat. With their potential to cause widespread outbreaks and severe health complications, the development of effective vaccines and antiviral therapeutics is imperative. The flaviviral non-structural protein 5 (NS5) is a highly conserved and multifunctional protein that is crucial for viral replication, and the NS5 protein of many flaviviruses has been shown to be a potent inhibitor of interferon (IFN) signalling. In this review, we discuss the functions of NS5, diverse NS5-mediated strategies adopted by flaviviruses to evade the host antiviral response, and how NS5 can be a target for the development of vaccines and antiviral therapeutics.
https://www.mdpi.com/2076-393X/12/8/865
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Very clever way of tricking the immune system into production of extremely specific neutralising antibody against Japanese encephalitis virs by presenting JEV proteins on the surface of an insect virus. Presented today by Connor Scott at Lorne I&I conference
@theviin.bsky.social
about 1 year ago
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Early but exciting morning today. 6am flight to Melbourne to attend my first Lorne Infection and Immunity Conference by
@theviin.bsky.social
Looking forward for meeting my colleagues from all fields of microbiology and immunology
about 1 year ago
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