Rahel Woldeyes
@rahelwoldeyes.bsky.social
📤 1636
📥 911
📝 16
A Structural systems/cell biologist
#teamtomo
#cryoET
#cryoem
https://orcid.org/0000-0003-0737-8383
pinned post!
Very excited to share our paper.
www.biorxiv.org/content/10.1...
We combine cutting-edge developments in cryo-electron tomography with hiPSC-cardiomyocytes to visualize cardiac proteins in their cellular context in health and disease.
#cryoem
#teamtomo
#cryoet
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about 2 years ago
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AI x Bio Discovery
22 days ago
IsoNet2 determines cellular structures at submolecular resolution without averaging
[new] 3D cryo-ET recon: self-sup. DL refines struct., revealing details in situ.
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Manuel Thery
28 days ago
#LivingArchitectures
We put cells and cytoskeleton filaments on the architecture of the musée d'Orsay.
www.musee-orsay.fr/fr/agenda/ev...
Scientists of the
#CytoMorphoLab
adapted their protocols to illustrate the questions that keep them awake at night. -> Two shows on the 24th and 25th of January.
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Utz Ermel
about 2 months ago
Hi
#teamtomo
! Want to use OME-Zarr for your tilt series but can't integrate it with your existing sub-tomogram averaging pipelines? Try zarr-particle-tools - RELION-style extraction & reconstruction built for OME-Zarr-based workflows! 📦 pip install zarr-particle-tools 🔗
github.com/czimagingins...
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GitHub - czimaginginstitute/zarr-particle-tools: Particle extraction and reconstruction from OME-Zarr tilt series.
Particle extraction and reconstruction from OME-Zarr tilt series. - czimaginginstitute/zarr-particle-tools
https://github.com/czimaginginstitute/zarr-particle-tools
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Raúl Padrón
3 months ago
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Edward T Eng
3 months ago
Muyuan Chen has turned structural biology into an immersive experience with his new video game Meowtabolism, now available on Steam. Try the demo here:
store.steampowered.com/app/4045010/...
Give Muyuan feedback:
steamcommunity.com/app/4045010
#ScienceGaming
#StructuralBiology
#CryoEM
#STEMOutreach
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bioRxivpreprint
4 months ago
Correlative MS Imaging for cellular identification and analysis of in situ cryo-ET
https://www.biorxiv.org/content/10.1101/2025.09.16.676641v1
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Brittany Trang
6 months ago
NEW from me at STAT: We've learned that DeepMind is going to fund CASP, the protein structure competition that brought Google DeepMind's
#AlphaFold
to prominence (and a Nobel Prize), as its NIH funding runs out. More
@statnews.com
:
www.statnews.com/2025/07/21/c...
🖥️🩺🧪🧬
#bioML
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AlphaFold developer Google DeepMind to fund CASP as NIH funding falls short
Protein structure prediction contest CASP gets temporary funding from Google DeepMind as NIH grant runs out.
https://www.statnews.com/2025/07/21/casp-new-funding-from-alphafold-developer-google-deepmind-after-nih-grant-runs-out/
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Anthony Shiver
6 months ago
A future perspective article on the next 10 years in microbial molecular biology and physiology is online now.
journals.asm.org/doi/10.1128/...
🧵👇
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An exciting future for microbial molecular biology and physiology | mBio
The first two bacterial genomes were sequenced nearly 30 years ago (1, 2). The cost of one of those sequences, that of Haemophilus influenzae, was over 1,000,000 U.S. dollars and took multiple years (...
https://journals.asm.org/doi/10.1128/mbio.00694-25
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www.nature.com/articles/d41...
#heartmusclecells
:)
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Can AI build a virtual cell? Scientists race to model life’s smallest unit
Several groups hope to develop artificial-intelligence models that can predict how cells behave.
https://www.nature.com/articles/d41586-025-02011-0
6 months ago
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Marcus Brubaker
6 months ago
Ever wonder why SGD, which works so well for ab initio cryo-EM, never seems to get to high resolution on its own? Well, we have the answer: conditioning!
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European Research Council (ERC)
7 months ago
🎉 Congratulations to Wolfgang Baumeister
@maxplanck.de
, awarded the 2025
#ShawPrize
in Life Science & Medicine for pioneering work in cryo-ET! Learn more 👉
europa.eu/!JBXDBG
#FrontierResearch
#ERCSyG
#CryoET
#StructuralBiology
#shawprize2025
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ERC grantee wins the Shaw Prize in Life Science and Medicine
2025 Shaw Prize honours ERC-funded research in molecular imaging
https://europa.eu/!JBXDBG
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Rita Strack
8 months ago
I was awestruck by the work I saw presented at the CZI Imaging Institute today. They are pursuing difficult problems head on with great ideas and the right people, and it's paying off in progress. In situ structural biology is going to be a solved problem. A million thanks to my host Shawn Zheng.
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Daniel Hurdiss
9 months ago
I’m delighted that we could contribute the
#cryoEM
data to this incredible antiviral discovery project from the group of
@neytsjohan.bsky.social
💊 "A coronavirus assembly inhibitor that targets the viral membrane protein"
www.nature.com/articles/s41...
A huge congrats to everyone involved! 🎉
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Bil Clemons
9 months ago
A new paper from our lab is available at
doi.org/10.1101/2025...
. The work describes how ArsA, which is involved in arsenic detoxification, utilizes nucleotides to drive dramatic conformational changes—multiple EM structures of a 64kDa protein. Congratulations to Shivansh Mahajan.
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Nucleotide and metalloid-driven conformational changes in the arsenite efflux ATPase ArsA
A common mechanism of arsenic detoxification in bacteria is arsenite (AsIII) efflux facilitated by the ArsAB pump that couples metalloid transport to ATP hydrolysis. The cytoplasmic ATPase component, ...
https://doi.org/10.1101/2025.03.21.644500
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Rahel Woldeyes
9 months ago
The Mechanisms and Innovations in Cardiovascular Disease T32 Training Grant is currently recruiting PhD and MD scientists to join its postdoctoral training fellowship. To apply, please follow this link:
stanforduniversity.qualtrics.com/jfe/form/SV_...
.
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cryoEM papers
10 months ago
AreTomoLive: Automated reconstruction of comprehensively-corrected and denoised cryo-electron tomograms in real-time and at high throughput
www.biorxiv.org/content/10.1101/2025.03.11.642690v1
#cryoem
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www.biorxiv.org/content/10.1...
#teamtomo
#cryoET
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Structure of the Thin Filament in Human iPSC-derived Cardiomyocytes and its Response to Heart Disease
Cardiovascular diseases are a leading cause of death worldwide, but our understanding of the underlying mechanisms is limited, in part because of the complexity of the cellular machinery that controls...
https://www.biorxiv.org/content/10.1101/2023.10.26.564098v2
10 months ago
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Christophe 🔬 L
10 months ago
Notre Dame is so back
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Randy Read 🇨🇦🇬🇧
10 months ago
Watch out for an upcoming bluetorial/tweetorial on this work from the amazing
@alisiafadini.bsky.social
!
www.biorxiv.org/content/10.1...
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AlphaFold as a Prior: Experimental Structure Determination Conditioned on a Pretrained Neural Network
Advances in machine learning have transformed structural biology, enabling swift and accurate prediction of protein structure from sequence. However, challenges persist in capturing sidechain packing,...
https://www.biorxiv.org/content/10.1101/2025.02.18.638828v1
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www6.slac.stanford.edu/news/2025-02...
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Innovative target design leads to surprising discovery in laser-plasma acceleration
Scientists studying laser-plasma proton acceleration made an unexpected breakthrough, simultaneously resolving multiple long-standing problems although they had only aimed to address one.
https://www6.slac.stanford.edu/news/2025-02-10-innovative-target-design-leads-surprising-discovery-laser-plasma-acceleration
11 months ago
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Alushin Lab
11 months ago
My heart goes out to all my NIH people. Unbelievable.
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Sri Kosuri
11 months ago
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
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Rahel Woldeyes
11 months ago
Deeply saddened by the passing of Prof. Mike Sheetz, a true leader in Mechanobiology. His groundbreaking work on Kinesin, membrane organization, and mechanotransduction has left an indelible mark. A tremendous loss to science.
#Mechanobiology
#Science
#LaskerAward
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Jeremy Berg
11 months ago
A special Bluetorial about one of my mentors Ruth Kirschstein Among Ruth Kirschstein’s many contributions to American science was the development and expansion of programs intended to increase participation of people from groups underrepresented in biomedical research.
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Bjorkman Lab @ Caltech
11 months ago
@caltech.edu
asked Dr. Pamela Bjorkman "if overusing antibiotics can be harmful. Should we worry about overusing vaccines too?" The short answer is no. Swipe to learn more from Caltech's Pamela Bjorkman.
#AskCaltech
at
caltech.edu/AskCaltech
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Jeremy Berg
11 months ago
Let me give a concrete example of the importance of applications with high risk-high reward as well as the role of NIH staff in taking risks. Decades ago, a physical chemist proposed ideas about doing mass spectrometry on proteins (when this was deemed probably impossible). 1/n
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Kresten Lindorff-Larsen
12 months ago
I've been hoping that someone would attempt to train a structure prediction model against experimental data (rather than 3D coordinates), and hopefully this is a step in that direction SFCalculator: connecting deep generative models and crystallography
doi.org/10.1101/2025...
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Joachim Frank
12 months ago
You want to build an apparatus for time-resolved cryo-EM? Easy:
bio-protocol.org/en/bpdetail?...
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https://bio-protocol.org/en/bpdetail?id=5193&type=0
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Sam Rodriques
12 months ago
The info session for our FutureHouse fellowship is TOMORROW, Tuesday, 9:00am Pacific time. Come get all your questions answered! Details are on our website:
www.futurehouse.org/fellowship
Now for an AI generated image that we present as an offering to the Algorithms, may they Boost our Post.
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Nogales Lab
12 months ago
The Cryo-EM: the next 50 years Symposium held yesterday at
@ucberkeleyofficial.bsky.social
was a smashing success!!
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Sarah Reisman
12 months ago
Thanks to those who’ve reached out the last few days. I am grateful that my family and home are safe. Many of my friends and colleagues have lost homes. If you want to help Caltech/JPL faculty/students/staff, a relief fund has been established:
giving.caltech.edu/areas-to-sup...
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The Caltech and JPL Disaster Relief Fund
https://giving.caltech.edu/areas-to-support/relief
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RCSB Protein Data Bank
12 months ago
After a remarkable 300 columns, David Goodsell has retired from the Molecule of the Month. We are very grateful for his service. @jiwasa.bsky.social will continue the series, beginning with January's article on Assembly Line Polyketide Synthases Details:
cdn.rcsb.org/rcsb-pd...
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EDUCATION CORNER: Molecule of the Month: Celebrating 25 Years of Storytelling and Announcing New Beginnings
After a remarkable 300 columns, David Goodsell has retired from the Molecule of the Month series. Janet Iwasa will be continuing the series for PDB-101.
https://cdn.rcsb.org/rcsb-pdb/general_information/news_publications/newsletters/2025q1/corner.html
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Ben Engel
12 months ago
Towards community-driven visual proteomics! Excited to finally share this large-scale curated & annotated dataset of 1829 high-quality
#cryoET
tomograms of the little green alga that just keeps giving— Chlamydomonas! 🧪🧶🧬🌾🌊🌍 Preprint📜:
www.biorxiv.org/content/10.1...
A short thread🧵👇
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Miriam B. Goodman, PhD
12 months ago
Curious to learn more, but need a guide to this interdisciplinary study? I've got you... 1n
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Rui Zhang
about 1 year ago
4/n) We discover a sperm-specific axoneme-tethered TRiC chaperone that likely contributes to constructing or maintaining the long flagella of mammalian sperm.
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cryoEM papers
about 1 year ago
Towards community-driven visual proteomics with large-scale cryo-electron tomography of Chlamydomonas reinhardtii
biorxiv.org/cgi/content/short/2024.12.28.630444v1
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Derek Lowe
about 1 year ago
A look at how some drug molecules are peculiarly slow-moving once they get into the cell:
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Drugs Inside Cells - A Bit of Light
https://www.science.org/content/blog-post/drugs-inside-cells-bit-light
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Kresten Lindorff-Larsen
about 1 year ago
Another great thread; this time on the classic “Stryer” biochemistry textbook. Incidentally, I’m currently teaching a biochemistry course using the 10th edition. The quote below is golden
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Rachael Kretsch
about 1 year ago
We discovered 3 RNA families that form homo-oligomeric RNA-only complexes! Studying nature continues to expand my wildest imagination. Read about it:
doi.org/10.1101/2024...
Vivian Wu, Svetlana Shabalina, Hyunbin Lee, Grace Nye, Eugene Koonin, Alex Gao, Rhiju Das, Wah Chiu
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euanashley
about 1 year ago
A really exciting day for the scientists, inventors, biotechnologists, and, most importantly, patients who made this possible.
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bioRxivpreprint
about 1 year ago
Naturally ornate RNA-only complexes revealed by cryo-EM
https://www.biorxiv.org/content/10.1101/2024.12.08.627333v1
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Cornelius Gati
about 1 year ago
Sharing highly encouraged: My lab has an opening for a postdoc, to study structural biology, biophysics and pharmacology of GPCRs in neuro- and immunobiology. Come join our diverse and collaborative team in sunny SoCal - please reach out with any questions!
dornsife.usc.edu/gati/
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Micha Rapé Lab
about 1 year ago
Very excited to present the structural and mechanistic basis for stress response silencing by the monster E3 ligase SIFI.
www.biorxiv.org/content/10.1...
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Torsten Schwede
about 1 year ago
CASP would not be possible without the great work of our expert assessors. Here is the list of
#CASP16
assessors for the different categories:
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blog.google/around-the-g...
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Google launches the London AI Campus
Google has launched the AI Campus in Somers Town, Camden, home to a two-year education pilot aimed to help inspire, inform, and educate local sixth form students in the …
https://blog.google/around-the-globe/google-europe/united-kingdom/google-launches-ai-campus-london/?s=09https://blog.google/around-the-globe/google-europe/united-kingdom/google-launches-ai-campus-london/
about 1 year ago
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Frances Arnold
about 1 year ago
We have a great PhD program across many disciplines, including
#proteinengineering
,
#directedevolution
,
#machinelearning
,
#biocatalysis
,
#enzymes
, and much more.
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Ben Engel
about 1 year ago
It took us seven years, but our collaboration with
@profmattjohnson.bsky.social
on the molecular architecture of plant thylakoids is finally online. Check it out!
#PlantScience
#TeamTomo
🧪🔬🧶🧬🌾
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Alexey Amunts
about 1 year ago
Faster and more accurate protein modeling with CryFold. By focusing on nearby points (Local Attention) and employing map masking, CryFold excels in generating models from challenging maps regions. It enables a more cost-efficient model building. 🧵 💾
github.com/SBQ-1999/Cry...
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Prakash Lab at Stanford
about 1 year ago
My favorite NPR story blog - “Goats and Soda” sent a writer and photographer to a rural school in India; an early adopter of Foldscope. A wonderful photo story of kids “reading nature”. In this current challenging climate - the kids show us the way with joy and wonder.
www.npr.org/sections/goa...
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