Bil Clemons
@profbilc.bsky.social
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Hanisch Memorial Professor of Biochemistry at Caltech Program Officer in Science at CZI
reposted by
Bil Clemons
13 days ago
Second, from the Clemons lab at Caltech, we determined high-resolution cryo-EM reconstructions for human and bacterial phosphoglycosyltransferase orthologs with a common inhibitor.
www.biorxiv.org/content/10.6...
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Structures of bacterial and human phosphoglycosyltransferases bound to a common inhibitor inform selective therapeutics
Glycoconjugates facilitate myriad biological processes, including cell–cell recognition and immune response, and they are generated by enzymes that transfer glycans. The orthologs MraY and DPAGT1 are ...
https://www.biorxiv.org/content/10.64898/2025.12.16.694696v1
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A new paper from our lab is available at
doi.org/10.1101/2025...
. The work describes how ArsA, which is involved in arsenic detoxification, utilizes nucleotides to drive dramatic conformational changes—multiple EM structures of a 64kDa protein. Congratulations to Shivansh Mahajan.
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Nucleotide and metalloid-driven conformational changes in the arsenite efflux ATPase ArsA
A common mechanism of arsenic detoxification in bacteria is arsenite (AsIII) efflux facilitated by the ArsAB pump that couples metalloid transport to ATP hydrolysis. The cytoplasmic ATPase component, ...
https://doi.org/10.1101/2025.03.21.644500
10 months ago
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It was a fun day. Thanks everyone!
add a skeleton here at some point
about 1 year ago
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reposted by
Bil Clemons
Anirban Banerjee
about 1 year ago
A privilege to host Bil Clemons
@profbilc.bsky.social
at the NIH Intramural Program for the Wednesday Afternoon Lecture Series. A fantastic talk about how phages use proteins to target bacterial cell wall biosynthesis machinery and a truly insightful lesson about inequity in science and society.
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