🧵Antibiotic resistance is a public health crisis. But viruses called phages have been solving this problem for millennia. New research in @nature.com reveals how 3 different phages attack the same weak spot—a protein called MurJt—potentially leading to a new class of antibiotics.

Second, from the Clemons lab at Caltech, we determined high-resolution cryo-EM reconstructions for human and bacterial phosphoglycosyltransferase orthologs with a common inhibitor. www.biorxiv.org/content/10.6...

A new paper from our lab is available at doi.org/10.1101/2025.... The work describes how ArsA, which is involved in arsenic detoxification, utilizes nucleotides to drive dramatic conformational changes—multiple EM structures of a 64kDa protein. Congratulations to Shivansh Mahajan.

It was a fun day. Thanks everyone!

A privilege to host Bil Clemons @profbilc.bsky.social at the NIH Intramural Program for the Wednesday Afternoon Lecture Series. A fantastic talk about how phages use proteins to target bacterial cell wall biosynthesis machinery and a truly insightful lesson about inequity in science and society.