Susan Gregurick
@sgregurick.bsky.social
📤 160
📥 68
📝 193
I’m the Associate Director for Data Science at the NIH. All views, posts, and retweets are my own.
www.jci.org/articles/vie...
🧪. Great review evaluating the translational evidence of GLP-1RAs as candidate disease-modifying therapies for NDDs, including mechanistic pathways linking metabolic dysfunction to neuronal vulnerability, and outlining remaining challenges.
loading . . .
JCI - The promise of GLP-1 receptor agonists for neurodegenerative diseases
https://www.jci.org/articles/view/194745
about 12 hours ago
0
0
2
www.nature.com/articles/s41...
Supported by our office this work combines deep, convolutional neural network training to detect microneuromas with an uncertainty quantification mechanism that allows the model to communicate when it is unsure about a given image.
loading . . .
Development and validation of a deep learning model for diagnosing neuropathic corneal pain via in vivo confocal microscopy - npj Digital Medicine
npj Digital Medicine - Development and validation of a deep learning model for diagnosing neuropathic corneal pain via in vivo confocal microscopy
https://www.nature.com/articles/s41746-025-01577-3
2 days ago
1
2
2
Preparing clinical research data for artificial intelligence readiness: insights from the National Institute of Diabetes and Digestive and Kidney Diseases data centric challenge url:
academic.oup.com/jamia/articl...
🧪. happy to have supported the Data Centric Challenge
loading . . .
Preparing clinical research data for artificial intelligence readiness: insights from the National Institute of Diabetes and Digestive and Kidney Diseases data centric challenge
AbstractObjectives. The success of artificial intelligence (AI) and machine learning (ML) approaches in biomedical research depends on the quality of the u
https://academic.oup.com/jamia/article/32/10/1609/8211965
5 days ago
0
0
0
academic.oup.com/nar/article/...
. 🧪. Supported by my office The Complex Portal (
www.ebi.ac.uk/complexportal
) (1) serves as a unifying resource, linking information on protein complexes across multiple resources by providing summaries of the molecular composition, topology (when known) and function
loading . . .
Complex portal 2025: predicted human complexes and enhanced visualisation tools for the comparison of orthologous and paralogous complexes
Abstract. The Complex Portal (www.ebi.ac.uk/complexportal) is a manually curated reference database for molecular complexes. It is a unifying web resource
https://academic.oup.com/nar/article/53/D1/D644/7903366
5 days ago
0
1
0
www.nature.com/articles/s41...
in press release includes annotations and a detailed analysis of segmentations of diseased plants. Great resource
loading . . .
A Large-Scale In-the-wild Dataset for Plant Disease Segmentation - Scientific Data
Scientific Data - A Large-Scale In-the-wild Dataset for Plant Disease Segmentation
https://www.nature.com/articles/s41597-025-06513-4
8 days ago
0
0
0
reposted by
Susan Gregurick
Ele Willoughby
9 days ago
Happy birthday to Russian
#chemist
Dmitri Mendeleev (1834 – 1907) who published the periodic table. 🧪🐡
#histsci
Born in Siberia, the youngest child of a large family, his father was a school principal until he lost his sight & job. His mother then restarted her family’s abandoned glass factory 🧵
2
69
32
www.sciencedirect.com/science/arti...
. 🧪 tool to predict polypeptide helicity from amino acid sequence. Also training data available. Nice.
loading . . .
ABSEIL: A Polypeptide Helicity and Ensemble Prediction Tool
Nascent helicity in polypeptides and unfolded proteins arises from local structure formation and represents one of the earliest events in a protein fo…
https://www.sciencedirect.com/science/article/abs/pii/S0022283626000483
9 days ago
0
2
1
www.nature.com/articles/s41...
🧪. Impressive GWAS meta-analysis from the Anxiety Disorders Working Group of the Psychiatric Genomics Consortium
loading . . .
Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling - Nature Genetics
Genome-wide association meta-analysis identifies 58 independent risk loci for major anxiety disorders among individuals of European ancestry and implicates GABAergic signaling as a potential mechanism...
https://www.nature.com/articles/s41588-025-02485-8
12 days ago
0
5
2
www.nature.com/articles/s41...
🧪. Exciting work on spatiotemporal modulation of Gs signaling
loading . . .
Inhibitory probes for spatiotemporal analysis of Gαs protein signaling - Nature Chemical Biology
Broadly applicable genetically encoded probes and peptide-based compounds specifically inhibit Gαs, the prototypical signal transducer of G-protein-coupled receptors, providing new mechanistic insight...
https://www.nature.com/articles/s41589-025-02138-1
12 days ago
0
3
1
www.nature.com/articles/s41...
🧪. Looks pretty amazing.
loading . . .
A flexible digital compute-in-memory chip for edge intelligence - Nature
A flexible digital artificial intelligence chip with a compute-in-memory architecture is fabricated using a commercial low-temperature polycrystalline silicon thin-film transistor process and shows hi...
https://www.nature.com/articles/s41586-025-09931-x
19 days ago
0
3
0
www.nature.com/articles/s41...
🧪. DeepMind AlphaGenome, trained on 1 Mb of DNA sequence from human and mouse and predicts thousands of functional genomic tracks including gene expression, transcription initiation, chromatin accessibility, histone modifications, transcription factor binding etc
loading . . .
Advancing regulatory variant effect prediction with AlphaGenome - Nature
AlphaGenome, a deep learning model that inputs 1-Mb DNA sequence to predict functional genomic tracks at single-base resolution across diverse modalities, outperforms existing models in variant effect...
https://www.nature.com/articles/s41586-025-10014-0
20 days ago
0
4
3
link.springer.com/article/10.1...
would like to see more on the implementation of the framework.
loading . . .
Shaping the Future of Evidence Generation: Real-World Data to Drive Healthcare Transformation and Patient-Centered Decisions - Pharmaceutical Medicine
The increasing complexity of healthcare decision making and the demand for real-world evidence call for a transformation in how Medical Affairs departments generate and communicate evidence. In respon...
https://link.springer.com/article/10.1007/s40290-025-00599-2
20 days ago
0
1
0
www.nature.com/articles/s41...
🧪. Very cool
loading . . .
A filamentary soft robotic probe for multimodal in utero monitoring of fetal health - Nature Biomedical Engineering
A soft robotic probe enables continuous in utero monitoring of fetal physiological parameters, including heart rate, blood oxygen saturation, temperature and electrocardiogram data, during open or fet...
https://www.nature.com/articles/s41551-025-01605-3
22 days ago
1
2
1
Temperature‐Dependent Chain Structures during Solution‐Grown Crystallization via Atomic Force Microscopy - Wang - Macromolecular Rapid Communications - Wiley Online Library
onlinelibrary.wiley.com/doi/10.1002/...
🧪. Neat study of crystallization and polymer chain folding.
loading . . .
Temperature‐Dependent Chain Structures during Solution‐Grown Crystallization via Atomic Force Microscopy
AFM-based single-molecule force spectroscopy was employed to investigate temperature-dependent single-chain folding structures of semi-crystalline PEO. Force–volume measurements enabled correlation o...
https://onlinelibrary.wiley.com/doi/10.1002/marc.202500842
22 days ago
0
1
0
www.ahajournals.org/doi/10.1161/...
🧪
loading . . .
2026 Guideline for the Early Management of Patients With Acute Ischemic Stroke: A Guideline From the American Heart Association/American Stroke Association | Stroke
AIM: The “2026 Guideline for the Early Management of Patients With AIS” replaces the “2018 Guidelines for the Early Management of Patients With AIS” and the 2019 update to reflect recent advances in e...
https://www.ahajournals.org/doi/10.1161/STR.0000000000000513
22 days ago
0
2
1
SAIGE-GPU — Accelerating Genome- and Phenome-Wide Association Studies using GPUs url:
academic.oup.com/bioinformati...
🧪 really good news for biomedical researchers using NIH STRIDES clouds.
loading . . .
SAIGE-GPU — Accelerating Genome- and Phenome-Wide Association Studies using GPUs
AbstractMotivation. Genome-wide association studies (GWAS) at biobank scale are computationally intensive, especially for admixed populations requiring rob
https://academic.oup.com/bioinformatics/article/doi/10.1093/bioinformatics/btag032/8438945
26 days ago
1
7
3
www.nature.com/articles/s41...
. Awesome work
loading . . .
Holistic evaluation of large language models for medical tasks with MedHELM - Nature Medicine
MedHELM, an extensible evaluation framework including a new taxonomy for classifying medical tasks and a benchmark of many datasets across these categories, enables the evaluation of large language mo...
https://www.nature.com/articles/s41591-025-04151-2
28 days ago
0
1
1
Mental Disorders as a Risk Factor of Acute Coronary Syndrome url:
jamanetwork.com/journals/jam...
. 🧪 interesting meta analysis indicates PTSD and sleep disorders emerged as significant risk factors for ACS
loading . . .
Mental Disorders as a Risk Factor of Acute Coronary Syndrome
This systematic review and meta-analysis investigates the association between mental disorders and acute coronary syndrome.
https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2843974?utm_source=bluesky&utm_campaign=content-shareicons&utm_content=article_engagement&utm_medium=social&utm_term=011526
about 1 month ago
0
4
1
Exciting study just out 🧪
www.cell.com/hgg-advances...
loading . . .
https://www.cell.com/hgg-advances/pdf/S2666-2477(26)00006-0.pdf?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2666247726000060%3Fshowall%3Dtrue
about 1 month ago
1
2
1
reposted by
Susan Gregurick
Zebrafish Rock!
about 1 month ago
Immune cell response to spinal cord injury in a zebrafish larva. Credit to
@beckergroup.bsky.social
.
#ZebrafishZunday
🧪
loading . . .
1
70
12
academic.oup.com/bib/article/...
. 🧪. Work illustrates knowledge graphs gene–gene interactions within oligogenic combinations. Very thoughtful study.
loading . . .
Benchmarking knowledge graph embedding models for the prediction of oligogenic combinations
Abstract. Identifying the potential oligogenic causes of rare diseases remains a challenge, notwithstanding the advancements made in the last decade. While
https://academic.oup.com/bib/article/27/1/bbaf712/8419939
about 1 month ago
0
5
1
Uncovering regional atrophy not explained by tau deposition using Additional Pathology Inference (AddiPath) - Binding - 2025 - Alzheimer's & Dementia - Wiley Online Library
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
🧪
loading . . .
Uncovering regional atrophy not explained by tau deposition using Additional Pathology Inference (AddiPath)
Background Mixed pathology is prevalent in Alzheimer's disease (AD) but difficult to detect in vivo as biomarkers for several additional pathologies are in their infancy. Cortical thickness (CT) atr...
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz70856_105447
about 1 month ago
0
15
1
www.nature.com/articles/s41...
. This is exciting illustrating feasibility of remote biomarker assessment using capillary blood, obtained by fingerstick collection
loading . . .
A minimally invasive dried blood spot biomarker test for the detection of Alzheimer’s disease pathology - Nature Medicine
This multicenter study demonstrates use of dried and capillary blood as a minimally invasive, scalable approach for Alzheimer’s biomarker testing in research, with potential as a widely scalable popul...
https://www.nature.com/articles/s41591-025-04080-0
about 1 month ago
0
1
1
pubmed.ncbi.nlm.nih.gov/41491993/%F0...
loading . . .
OMG! A proteomic determinant of neurodegenerative resiliency - PubMed
Our findings implicate OMG as a mechanistic determinant of neurodegenerative resiliency among older adults, which is reliably captured by its abundance in peripheral circulation.
https://pubmed.ncbi.nlm.nih.gov/41491993/
about 1 month ago
0
1
1
pubs.acs.org/doi/10.1021/...
.
loading . . .
https://pubs.acs.org/doi/10.1021/jasms.5c00304
about 1 month ago
0
0
0
academic.oup.com/nargab/artic...
. Neat. Authors integrate disease-association information from DisGeNET and tissue-specific gene expression data from GTEx to identify key tissues involved in complex diseases.
loading . . .
DEDUCE: statistical inference on disease-associated genes uncovers tissue–disease associations
Abstract. Accurate identification of affected tissues of human diseases is important for the derivation of disease etiology and the development of new trea
https://academic.oup.com/nargab/article/7/4/lqaf205/8407650
about 2 months ago
0
1
1
🧪
doi.org/10.1111/acel...
. The paper from the October 22nd, 2025 Brain Aging Symposium is out!
loading . . .
The Right Person, the Right Treatment, at the Right Time in Alzheimer's Disease: Insights From the 2025 Brain Aging Symposium
The Brain Aging Symposium highlighted how early detection and longitudinal tracking, enabled by multimodal biomarker integration, reveal critical roles for lipid metabolism, sex differences, and popu...
https://doi.org/10.1111/acel.70351
about 2 months ago
0
4
3
Informative Co‐Data Learning for High‐Dimensional Horseshoe Regression - Busatto - 2026 - Biometrical Journal - Wiley Online Library
onlinelibrary.wiley.com/doi/10.1002/...
loading . . .
Informative Co‐Data Learning for High‐Dimensional Horseshoe Regression
High-dimensional data often arise from clinical genomics research to infer relevant predictors of a particular trait. A way to improve the predictive performance is by incorporating information about...
https://onlinelibrary.wiley.com/doi/10.1002/bimj.70105
about 2 months ago
0
1
0
www.nature.com/articles/s41...
. Interesting article 🧪
loading . . .
Context matching is not reasoning when performing generalized clinical evaluation of generative language models - npj Digital Medicine
npj Digital Medicine - Context matching is not reasoning when performing generalized clinical evaluation of generative language models
https://www.nature.com/articles/s41746-025-02253-2
about 2 months ago
0
4
2
🧪
add a skeleton here at some point
about 2 months ago
0
3
0
www.nature.com/articles/s43...
. Exciting multimodal LO-VLM that learns from both images and descriptions written by experts to enable analysis optical coherence tomography scans.
loading . . .
https://www.nature.com/articles/s43856-025-01293-9_reference.pdf
about 2 months ago
0
1
1
Integrating Event‐Based and Network Diffusion Models to Predict Individual Tau Progression in Alzheimer's Disease - Sandell - 2025 - Alzheimer's & Dementia - Wiley Online Library
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
. 🧪. Neat article
loading . . .
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz70855_107645
about 2 months ago
0
1
1
www.nature.com/articles/s41...
. Preliminary study illustrates potential of GPT models in accurately detecting subtle linguistic markers indicative of SLDs, such as echolalia, pronoun reversal, and atypical pragmatic language usage.
loading . . .
Exploiting large language models for diagnosing autism associated language disorders and identifying distinct features - npj Digital Medicine
npj Digital Medicine - Exploiting large language models for diagnosing autism associated language disorders and identifying distinct features
https://www.nature.com/articles/s41746-025-02133-9
2 months ago
0
2
0
isevjournals.onlinelibrary.wiley.com/doi/10.1002/...
. New work by AstraZeneca on hybrid Extracellular vesicles. Very cool.
loading . . .
Hybrid Extracellular Vesicles for Efficient Loading and Functional Delivery of mRNA
Hybrid extracellular vesicles (HEV) produced by EV-LNP fusion enable efficient loading and functional delivery of mRNA. HEV integrated properties of both EV and LNP contributing to their excellent ce...
https://isevjournals.onlinelibrary.wiley.com/doi/10.1002/jev2.70201
2 months ago
0
3
0
reposted by
Susan Gregurick
PLOS Biology
2 months ago
What underlies the dynamics of
#RedBloodCell
production? Nicola Wilson explores a
@plosbiology.org
study that suggests a broadly applicable mechanism able to balance the maintenance of the steady-state with an effective stress response 🧪
#erythropoiesis
Paper:
plos.io/3KDskbX
Primer:
plos.io/4j4QBV1
0
4
2
onlinelibrary.wiley.com/doi/10.1002/...
🧪. polarization-entangled photon pairs can analyze monolayer cells and distinguish between two types of cell layers
loading . . .
Probing polarization response of monolayer cell cultures with entangled photon pairs
Innovative optical detection using polarization and quantum techniques is presented for biological sample analysis. This method utilizes non-classical light, specifically entangled photon pairs, for ...
https://onlinelibrary.wiley.com/doi/10.1002/jbio.202400018
2 months ago
0
6
3
link.springer.com/article/10.1...
. 🧪. Neat study to check if grass could serve as effective bioindicators for detecting changes in As and Se soil contamination profiles and provide an evaluation of three technologies used for evaluating plant health.
loading . . .
Grass is a tattletale: using grass as a biomonitoring tool for remote sensing of coal combustion residue contamination - Environmental Monitoring and Assessment
Coal-fired power plants generate coal combustion residuals (CCRs), which are typically disposed of in landfills and surface impoundments that must be monitored to ensure that hazardous constituents su...
https://link.springer.com/article/10.1007/s10661-025-14719-7
2 months ago
0
3
0
pubmed.ncbi.nlm.nih.gov/41343214/%F0...
loading . . .
COVID-19 mRNA Vaccination and 4-Year All-Cause Mortality Among Adults Aged 18 to 59 Years in France - PubMed
In this national cohort study of 28 million individuals, the results found no increased risk of 4-year all-cause mortality in individuals aged 18 to 59 years vaccinated against COVID-19, further supporting the safety of the mRNA vaccines that are widely used worldwide.
https://pubmed.ncbi.nlm.nih.gov/41343214/
2 months ago
0
1
0
link.springer.com/article/10.1...
🧪 neural network-based DNAm aging clock using Korean population data that enables precise age prediction and offers potential opportunities for advancing aging-related research in Korea. Cool.
loading . . .
KoMethylNet: a novel epigenetic clock based on neural network analysis of DNA methylation data and epigenetic age acceleration in a Korean population - BMC Medicine
Background Epigenetic clocks have been extensively investigated in individuals of European ancestry and may be suboptimal in East Asians. We developed a novel epigenetic clock (KoMethylNet) using neur...
https://link.springer.com/article/10.1186/s12916-025-04564-3
3 months ago
0
1
1
🧪
add a skeleton here at some point
3 months ago
0
3
2
reposted by
Susan Gregurick
www.nejm.org/doi/full/10....
loading . . .
A Threat to Evidence-Based Vaccine Policy and Public Health Security at the FDA | NEJM
Twelve former commissioners of the FDA express concern that the agency’s recent moves will undermine a regulatory model designed to ensure vaccine safety, effectiveness, and availability.
https://www.nejm.org/doi/full/10.1056/NEJMp2517497
3 months ago
0
1
4
www.nejm.org/doi/full/10....
loading . . .
A Threat to Evidence-Based Vaccine Policy and Public Health Security at the FDA | NEJM
Twelve former commissioners of the FDA express concern that the agency’s recent moves will undermine a regulatory model designed to ensure vaccine safety, effectiveness, and availability.
https://www.nejm.org/doi/full/10.1056/NEJMp2517497
3 months ago
0
1
4
cdt.amegroups.org/article/view...
🧪. A thoughtful article on the need for policies regarding AI use for manuscript writing assistance.
loading . . .
Artificial intelligence for manuscript writing: policies and implementation in cardiovascular journals
Artificial intelligence for manuscript writing: policies and implementation in cardiovascular journals
https://cdt.amegroups.org/article/view/144694/html
3 months ago
0
2
0
Excited and grateful to be awarded HPCwire 35 legends this year. Bittersweet as I am unlikely to be able to attend SC25 due to the furlough. Congratulations to my esteemed colleagues and wishing you a great conference.
#SC25
www.hpcwire.com/35-hpc-legen...
loading . . .
35 HPC Legends - HPCwire
We are proud to announce the HPCwire 35 Legends Class of 2025. Our second annual list recognizes 35 luminaries who have made HPC what it is today. The High Performance Computing (HPC) market is distin...
https://www.hpcwire.com/35-hpc-legends/
3 months ago
0
4
0
Beyond the Secretory Pathway: New Insights Into Protein Release - Chen - 2025 - Traffic - Wiley Online Library
onlinelibrary.wiley.com/doi/10.1111/...
. Thank you all for publishing a wonderful scientific summary on inaugural conference on Molecular Mechanisms & Physiology of Unconventional Secretion
loading . . .
Beyond the Secretory Pathway: New Insights Into Protein Release
While proteins bearing N-terminal signal or leader sequences are secreted via the ER-Golgi-plasma membrane axis of the conventional secretion pathway, many cytosolic proteins lacking signaling sequen...
https://onlinelibrary.wiley.com/doi/10.1111/tra.70022
3 months ago
0
2
0
reposted by
Susan Gregurick
UK Centre for Ecology & Hydrology (UKCEH)
3 months ago
Long-term monitoring tells a story of change. For 80 years scientists have monitored Windermere and nearby lakes in Cumbria, tracking how climate change and pollution are reshaping our freshwater ecosystems. It’s one of the longest lake datasets anywhere in the world! 🌎 🧪 1/
loading . . .
1
23
13
The updated Global Naturalized Alien Flora (GloNAF 2.0) database - Davis - 2025 - Ecology - Wiley Online Library
esajournals.onlinelibrary.wiley.com/doi/10.1002/...
nice to see updates improving accessibility, standards and support for data reuse in GloNAF 2.0 a resource for invasive vascular plants
loading . . .
The updated Global Naturalized Alien Flora (GloNAF 2.0) database
GloNAF is a continuously updated, curated compilation of alien naturalized vascular plant inventories for geographic regions worldwide. Building on its predecessor, GloNAF 2.0 now contains 16,429 tax....
https://esajournals.onlinelibrary.wiley.com/doi/10.1002/ecy.70245
3 months ago
0
1
0
Artificial Intelligence Networks Combining Histopathology and Machine Learning Can Extract Axon Pathology in Autism Spectrum Disorder . Authors developed custom transfer learning processes and protocols to distinguishing high-resolution microscopic images of myelinated axons in white matter pathways
loading . . .
Artificial Intelligence Networks Combining Histopathology and Machine Learning Can Extract Axon Pathology in Autism Spectrum Disorder
Axon features that underlie the structural and functional organization of cortical pathways have distinct patterns in the brains of neurotypical controls (CTR) compared to individuals with Autism Spe....
https://onlinelibrary.wiley.com/doi/10.1002/aur.70135
4 months ago
0
0
0
The relationship between obesity and chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference - Kidney International
www.kidney-international.org/article/S008...
🧪 just out and worth reading.
loading . . .
The relationship between obesity and chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference
Obesity and chronic kidney disease (CKD) are complex diseases that are interlinked directly and indirectly. In October 2024, Kidney Disease: Improving Global Outcomes (KDIGO) held a Controversies Conf...
https://www.kidney-international.org/article/S0085-2538%2825%2900774-4/fulltext
4 months ago
0
0
0
pubs.acs.org/doi/10.1021/...
neat work on a probabilistic machine learning framework to estimate total or partial RDFs with uncertainty quantification from background and inelastic corrected scattering data. The results could help with folks interested in molecular force field optimization.
loading . . .
Physics-Informed Gaussian Process Inference of Liquid Structure from Scattering Data
We present a nonparametric Bayesian framework to infer radial distribution functions from experimental scattering measurements with uncertainty quantification using nonstationary Gaussian processes. The Gaussian process prior mean and kernel functions are designed to mitigate well-known numerical challenges with the Fourier transform, including discrete measurement binning and detector windowing, while encoding fundamental yet minimal physical knowledge of the liquid structure. We demonstrate uncertainty propagation of the Gaussian process posterior to unmeasured quantities of interest. Experimental radial distribution functions of liquid argon and water with uncertainty quantification are provided as both a proof of principle for the method and a benchmark for molecular models.
https://pubs.acs.org/doi/10.1021/acs.jpcb.5c05024
4 months ago
0
1
0
Load more
feeds!
log in