www.ahajournals.org/doi/10.1161/.... Study finds ACE2 is causally protective for hypertension and diabetes. This suggests that ACE2 treatment may provide additional protection from these cardiovascular diseases.🧪

www.frontiersin.org/journals/nut.... Really interesting review. 🧪

onlinelibrary.wiley.com/doi/10.1002/.... Nice study on a mobile health app for Chronic low back pain treatment 🧪

www.jacc.org/doi/10.1016/.... Import results “the evidence linking inflammation with atherosclerotic CVD is no longer exploratory but is compelling and clinically actionable.” 🧪

Allergen Chip Challenge: a nationwide open database supporting allergy prediction algorithms - Journal of Allergy and Clinical Immunology www.jacionline.org/article/S009.... nationwide, open database of allergen chip, demographic and clinical information

iopscience.iop.org/article/10.3... 🧪. Very exciting article on exoplanetary atmospheres

www.nature.com/articles/s41... 🧪. Large study of over 1m quantifies the independent associations of albuminuria and eGFR with the incidence of overall cancer, and among selected site-specific cancers, using data from eligible cohorts in the Chronic Kidney Disease Prognosis Consortium (CKD-PC).

www.cell.com/biophysj/abs.... 🧪 nice work from Jeremey smith at ORNL discuss the role of MD and ML/AI to overcome lignocellulose recalcitrance by designing pretreatment methods to efficiently produce solubilized cellulose/lignin/hemicellulose, and improve energy-intensive manufacturing challenges.

www.nature.com/articles/s41... 🧪. this study provides evidence indicating S. mutans can colonize the gut and affect PD pathology via microbial UrdA and its metabolite, imidazole propionate.

Study reveals 90%^+ agreement between real-world amyloid-PET visual reads and quantification, aiding cognitive impairment diagnosis! 🧠 PMID:40720133, JAMA Neurol 2025, @JAMANeuro https://doi.org/10.1001/jamaneurol.2025.2218 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

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link.springer.com/article/10.1... Neat study finds that cholesterol metabolism was clearly altered in the TDP-43 proteinopathies of effected brains, pointing towards an accumulation of cholesterol esters and triglycerides in the form of lipid droplets

link.springer.com/article/10.1... Neat study finds that cholesterol metabolism was clearly altered in the TDP-43 proteinopathies of effected brains, pointing towards an accumulation of cholesterol esters and triglycerides in the form of lipid droplets

What causes viral transmission bottlenecks? This study uses barcoded virions to show that in the case of #influenza A #virus, early within-host replication dynamics (rather than a reduced inoculum population) drive loss of diversity during transmission @plosbiology.org 🧪 plos.io/4ngicDK

ojrd.biomedcentral.com/articles/10..... A good read. 🧪

movementecologyjournal.biomedcentral.com/articles/10.... Neat article on tiger adaptation and movement.

Cardiovascular and kidney outcomes of GLP‐1 receptor agonists in adults with obesity: A target trial emulation study - Tang - Diabetes, Obesity and Metabolism - Wiley Online Library dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/... 🧪

www.nature.com/articles/s43... 🧪 Interesting article on deep active optimization for low data problems. The back propagation out of local minima and benchmarks on finding tricky global minima using DNN is cool. The discussion on tradeoffs between Bayesian optimization and active optimization is cool

www.nature.com/articles/s41... 🧪

www.nature.com/articles/s41... what a nice article highlighting deep learning methods to detect brood disease in honeybees

link.springer.com/article/10.1... 🧪. Really interesting in particular the section on blood pressure control post thrombectomy

direct.mit.edu/imag/article... 🧪. Researchers illustrate that the presence of information is far more distributed across the brain than previously thought and that information is fairly accessible

open-research-europe.ec.europa.eu/articles/5-1... 🧪 unexpected and really fun read. I enjoyed the discussion on developing the ontology and use of Protégé. Makes me want to travel and try this out.

American College of Rheumatology Guidance Statement for Diagnosis and Management of VEXAS Developed by the International VEXAS Working Group Expert Panel - Mekinian - Arthritis & Rheumatology - acrjournals.onlinelibrary.wiley.com/doi/10.1002/... 🧪 new clinical guidance for this rare disease

GLP-1 RAs and Ophthalmic Complications in Patients With Type 2 Diabetes url:https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2837378?utm_source=bluesky&utm_campaign=content-shareicons&utm_content=article_engagement&utm_medium=social&utm_term=081225 🧪

www.nature.com/articles/s41... 🧪. Article highlights lithium depletion increases amyloid accumulation and Replacement therapy with Li salt prevents pathological changes and memory loss as seen in AD mouse models and ageing wild-type mice.

onlinelibrary.wiley.com/doi/10.1002/... 🧪. lncRNAs have a fairly diverse set of functions and this is a good overview.

Integrating Generative Pretrained Transformer and Genetic Algorithms for Efficient and Diverse Molecular Generation - Xu - 2025 - onlinelibrary.wiley.com/doi/10.1002/... Happy to see optimization with genetic algorithms and generative pretrained transformer for drug discovery 🧪

aacrjournals.org/cancerres/ar... 🧪

www.jmir.org/2025/1/e74976. 🧪. Very much worth a read.

www.nature.com/articles/s41... Might be of interest for biomarkers for diagnosis, therapeutic response prediction, and risk assessment

www.sciencedirect.com/science/arti... Interesting article on the ability of retinal imaging to detect the association of increased aging related to the prevalence of diabetes in schizophrenia patients

bmcmedicine.biomedcentral.com/articles/10.... Nice work using TEDDY data for a predictive model of type 1 diabetes risk validated in the TrialNet.

www.nejm.org/doi/full/10.... 🧪

www.sciencedirect.com/science/arti... 🧪. I wonder if the work has broader applications beyond river networks

genomebiology.biomedcentral.com/articles/10.... 🧪

United States Food and Drug Administration Regulation of Clinical Software in the Era of Artificial Intelligence and Machine Learning - Mayo Clinic Proceedings: Digital Health www.mcpdigitalhealth.org/article/S294... 🧪 helpful article with thoughts on gen AI device regulation

NIH’s CIT and ODSS are co-hosting a session on Cyberinfrastructure and Emerging Technologies. If you’ll be attending, please join us on Monday, July 21, for our session: NIH Track on GenAI, Cyberinfrastructure, Digital Twins, and Quantum Computing. #ISMB 🧪

jamanetwork.com/journals/jam... 🧪

cardiab.biomedcentral.com/articles/10.... 🧪 another interesting GLP-1 paper supports the role of GLP-1RA as part of therapy in cardiovascular events risk reduction, especially with high BMI.

ccforum.biomedcentral.com/articles/10.... 🧪 really interesting review discussing the complex interplay between adiponectin, obesity, and sepsis outcomes and GLP -1.

fluidsbarrierscns.biomedcentral.com/articles/10.... 🧪review article illustrates compromised brain barriers are ubiquitous pathological features across brain disorders. In fact, at least ~ 41% of brain disorders display dysfunctions and/or structural alterations of brain barriers.

genomebiology.biomedcentral.com/articles/10.... 🧪. Researchers integrate genetic, epigenetic, and cytokine response data from the same individuals demonstrating that dynamic DNA methylation results in immune-related memory

www.frontiersin.org/journals/car... 🧪. Thoughtful review raising many points of ai assisted patient outcomes including patient adherence to ai alerts from wearables.

www.nature.com/articles/s41... 🧪. Neat article that the illustrates the potential of slice Transformers for explainability and 3d medical imaging analysis.

diabetesjournals.org/care/article... 🧪

genomebiology.biomedcentral.com/articles/10.... Researchers describe a model of gene regulation that involves positioning active cis-regulatory elements on domain surfaces.

Early diagnosis of vascular Ehlers-Danlos syndrome through AI-powered facial analysis: Results from the Montalcino Aortic Consortium - Genetics in Medicine Open www.gimopen.org/article/S294... 🧪 really neat work

Diagnosis and Treatment of Type 2 Diabetes in Adults: A Review url:https://jamanetwork.com/journals/jama/fullarticle/2835629?utm_source=bluesky&utm_campaign=content-shareicons&utm_content=article_engagement&utm_medium=social&utm_term=062525 🧪

pubmed.ncbi.nlm.nih.gov/40550582/ 🧪