Well done!

Woah! store.steampowered.com/app/4045010/...

One of my scientific heroes. journals.biologists.com/dev/article/...

The first 1 million prime numbers vizualized in 2D according to their prime factors (Umap) Source: johnhw.github.io/uma...

🚂 The T2T train keeps rolling: "The formation and propagation of human Robertsonian chromosomes" with Gerton and Garrison labs is out! What's a Robertsonian chromosome? Let Jen tell you herself in this great video, or read our paper: [1/3] 📺 youtu.be/JmlY5omxQVc 📄 www.nature.com/articles/s41...

Useful reminder from Peter Kellner on the problems we refuse to acknowledge are getting better, and the politics of hopelessness that this breeds open.substack.com/pub/kellnerp...

Delighted to finally announce a preprint describing the Q100 project! “A complete diploid human genome benchmark for personalized genomics” For which we finished HG002 to near-perfect accuracy: www.biorxiv.org/content/10.1... 🧵[1/14]

🤯

Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...

🤯 www.nature.com/articles/s41...

I’m most definitely a ‘mellow’ guy!

Here, we show that bacterial ribosomes—often viewed as conserved drug targets—actually vary across species due to extensive sequence variation in their drug-binding residues. In some cases, this divergence may lead to intrinsic drug resistance in certain bacterial clades: doi.org/10.1016/j.ce...

Very happy to have been awarded a NIRG from the MRC. Stay tuned for some exciting (I think, but being biased) postdoc positions within our lab!

#OnThisDay in 1858, a seminal journal article comprised of papers by Alfred Russel Wallace FRS and Charles Darwin FRS on the theory of evolution by natural selection was published by the Linnean Society, the first public announcement of the theory of evolution. bit.ly/3k8fq4u

Beautiful work.

Very nice!

Just submitted a large grant application. Getting funding these days is so difficult that even a acknowledgement of receipt counts as a win! 😅

📣 New publication from our group! 📣 Our work showing that the leukemia mutated genes PHF6 and PHIP act as a chromatin complex to repress AML stemness is now out in @genesdev.bsky.social. Congratulations to first author @aishwarya2510.bsky.social, who defended her PhD on this work this month!

Hmmm….an Iron Maiden poster with a biscuit offering in the institute where I work??

The difference between Knowledge and Experience

Nature research paper: Mapping and engineering RNA-driven architecture of the multiphase nucleolus https://go.nature.com/44Tib11

Telomere-to-telomere DNA sequencing is set to transform the field of human genetics in coming years. For a flavour of what's coming, see this exciting work on nearly complete genomes of 65 individuals from diverse populations, out today in @nature.com by @glennislogsdon.bsky.social & colleagues. 👇🧬🧪

Scientists have corrected gene mutations in mice causing an ultra-rare disease by editing DNA directly in the brain with a single injection, a feat with profound implications for patients with neurological diseases. 🧬🧠🔬🧪

Paper in Nature 150 years ago. Beats reading any single-cell experiment…

Ha ha ha! 😂

Definitely worth watching!!

Our Evolutionary Biology and Ecology of Cancer Summer School #EBECancer2025 in full swing @eventswcs.bsky.social in sunny Hinxton, Cambridge. @florentmouliere.bsky.social giving a deep dive into tracking cancer evolution with cfDNA. @amyboddy.bsky.social @yosoykit.bsky.social @afrankell.bsky.social

Hello! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @cp-cellreports.bsky.social, @mardakheh.bsky.social and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit! tinyurl.com/ydn6e3ac

Excited to contribute to the Mitoribosome collaborative study led by @wredenberglab.bsky.social in @natcomms.nature.com🎉 "The mitochondrial methylation potential gates mitoribosome assembly" The assembly starts before the completion of the rRNA gene cluster processing🧵 www.nature.com/articles/s41...

Just out in Science: we demonstrate a micro-evolutionary shift in a single generation, involving thousands of genomic loci, giving younger ash trees more resistance to ash dieback, on average, than their parents www.science.org/doi/10.1126/science.adp2990

Woah!

Excited to launch our AlphaGenome API goo.gle/3ZPUeFX along with the preprint goo.gle/45AkUyc describing and evaluating our latest DNA sequence model powering the API. Looking forward to seeing how scientists use it! @googledeepmind

I've wanted to write this article for years. About my and other's struggles to even survive sometime in #academia. Thank you to the amazing editors at @plosbiology.org that gave me the forum to write this piece. #science

Happy Father's day as well to all the bug dads. Male water bugs, Belostomatidae, carry their partner's eggs around on their backs until they hatch, making sure the temperature and oxygen levels are acceptable, and the predators are at bay.

Fantastic study and preprint.

Wow!

🔎 Despite failed experiments as a student, alumnus Professor Azim Surani has spent his entire career trying to understand early mammalian development. 🔬 This year marks the 40th anniversary of his discovery of genomic imprinting — the process that tags specific genes, turning

It was such a great meeting. So proud to be part of this vibrant community. We keep going from strength to strength.

A reminder in these hard times. #sciencestrong

It was great to catch up with many friends and meet new people. Thank you all for participating in this event.

Thank you everyone for participating in the QMUL epigenetics centre launch event. It was a great success. Special thanks to SAB @deborahbourchis.bsky.social @lab-turner.bsky.social Bas Heijmans and @elisaoricchio.bsky.social for interaction with our centre.

Check out our latest work‼️Fantastic study with really cool data and findings led by @allancarbal.bsky.social in collaborarion with Stephan’s lab. The one and many ways of getting a belly…

New from our lab @crick.ac.uk, in collaboration with the Enchev and Bukau labs. By studying a protein that is difficult to fold, we discover fascinating new mechanisms by which the ribosome supports protein biogenesis. www.biorxiv.org/content/10.1...

Very excited to share our latest work in #MolCell showing NPM1 stabilizing the association of nucleolus associated domains (NADs) and recruiting G9a to establish their repressive chromatin states. www.sciencedirect.com/science/arti...

New paper from the lab: Our teeth arose as sensory organs on the outside of the body of ancient jawless fish.!! Congrats to Yara Haridy and the team! Background and video: phys.org/news/2025-05... Open Access Paper: www.nature.com/articles/s41... News and Views: www.nature.com/articles/d41...