At #ICON? – Join us tomorrow to hear about novel measurement & manipulation approaches for neuromodulatory systems! 🗓️Sept 19, 🕚11:45 am 🏫Room Sé #ICON2025 #CogNeuro #AcademicSky #LocusCoeruleus #neuroskyence

We showed previously that chemogenetic activation of the LC rescues spatial reversal learning in the TgF344-AD rat. New paper follows up and reports that optogenetic stimulation of LC terminals in CA1 also rescues cognitive deficits in 3xTg mouse model of AD. link.springer.com/article/10.1...

Adaptive learning is coordinated across behaviour, time and neurobiology (from synapses and dendrites, to astrocytes and the systems level). If you’ve ever wondered how noradrenaline helps shape these multiscale learning processes, you might like this: www.cell.com/trends/cogni...

New study out in Nature Medicine: Education does not protect against age-related decline of memory. Read more here: Reevaluating the role of education on cognitive decline and brain aging in longitudinal cohorts across 33 Western countries www.nature.com/articles/s41...

Great (and lots of) work from Mike David and many colleagues using #pupillometry #EEG #MRI to understand arousal and #locuscoeruleus changes in #AlzheimersDisease. Out now in @braincomms.bsky.social academic.oup.com/braincomms/a...

Beyond happy & proud to have our paper on peptidergic neuromodulation of the #LC out! This is a project that started with naive intentions & silly curiosity, withstood 1 pandemic & 2 lab moves & made us fall in ❤️ with the most beautiful brain regions of all!! 🔵 www.science.org/doi/10.1126/...

Our oscillations consensus paper is finally out as a preprint 🤩 thanks to everyone involved arxiv.org/abs/2507.15639

Call For Papers! Alzheimer's & Dementia Special Issue: Neuromodulatory Subcortical Systems in Alzheimer's Disease Research on the intersection of the Neuromodulatory Subcortical Systems and AD are welcome! #AlzResearch ⏰Deadline: Aug. 30, 2025 alz-journals.onlinelibrary.wiley.com/hub/journal/...

Super happy to see our latest work out in @plosbiology.org : N2 sleep during short naps increased the likelihood of insight in a decision task. The steepness of the spectral slope best predicted insight, beyond sleep stages alone. With dream team @maritpetzka.bsky.social @nicoschuck.bsky.social

Pulsed taVNS elicits pupil dilation. However, if sham feels as intense, there is not much left. Based on our comparatively large sample (94 participants, single-blind crossover), we show that a highly variable sham response explains this. #neuroskyence 🩺 www.biorxiv.org/content/10.1...

After years of hard work, @hashimsat.bsky.social's big one is out! Huge thanks to co-authors Katharina Wille, Matt Nassar, Radek Cichy, @nicoschuck.bsky.social & Peter Dayan - and to @haukeren.bsky.social for his invaluable support!

Excited to share that the astrocyte-centered half of my thesis work is now out @science.org ! With @mishaahrens.bsky.social and @marcduque.bsky.social science.org/doi/10.1126/... 1/8

www.nature.com/articles/s41... Excited to see this out in @natcomms.nature.com today! This paper builds on the lab's work on self-regulation of arousal through pupil-based biofeedback. We assessed several markers of cortical and cardiac arousal in a pure self-regulation and dual task setting.

A wonderful day for science, to see the (peri) #LC in all its glory. A ginormous effort from all involved, and a fantastic resource for the field. Chapeau 🎩 🧠 🔵 www.nature.com/articles/s41...

A time window for memory consolidation during NREM sleep revealed by cAMP oscillation: Neuron www.cell.com/neuron/fullt...

My paper reviewing how different neurodegenerative diseases affect autonomic function was just published.

Transcutaneous auricular vagus nerve stimulation (taVNS) and fMRI: a great combination to test the mechanism of action driving stimulation effects 🧠 But how to use the stimulation safely within the magnetic field? We looked into this! #neuroskyence doi.org/10.31234/osf...

👉👉new paper alert from @labluthi.bsky.social - so proud for talented and determined Dr.Najma Cherrad who opened the lab‘s access to brain-body communication! #sleep #locuscoeruleus #parasympathetic @fbm-unil.bsky.social

Check out a new lab paper from Mayumi Watanabe's thesis work showing how different subregions of medial prefrontal cortex differentially regulate extinction of aversive memories through projections to the locus-coeruleus-noradrenaline system: doi.org/10.1038/s413...

With support from @istaart.bsky.social, we are organizing the first Integrative Neuromodulatory Subcortical Systems meeting in collab with Sleep and Circadian Rhythms PIA! WHEN/WHERE: Boston, MGH/Martinos Center on July 17-18; info, register & submit your abstract: education.martinos.org/inss2025/

In our new @commspsychol.bsky.social review, we explore how humans adjust learning to different types of uncertainty, why biases arise, and what this reveals about learning and psychiatric conditions. 📖 Read more: nature.com/articles/s44... With Matt Nassar & @haukeren.bsky.social

Fun time recording with Crowd Science by @BBCWorldService alongside @tjryan.bsky.social Why can't I remember my early childhood? Listen here: www.bbc.co.uk/programmes/w... #CrowdScience #BBCScience @lipmpib.bsky.social

Does tVNS elicit replicable effects beyond BOLD responses in the brainstem? Yes, pulsed, but not conventional tVNS leads to robust pupil dilation in our new meta-analysis. Published in Brain Stim w/ @cecivez.bsky.social @akuehnel.bsky.social #neuroskyence 🩺 www.sciencedirect.com/science/arti...

Check out our review highlighting the importance of monoamines towards understanding Alzheimer's disease. We describe promising neuroimaging and daily life sampling approaches to better elucidate the neurobiological mechanisms underlying AD.

📢 New preprint from the lab: We are very excited to report the discovery of an oscillation in the Central Thalamus using rare direct recordings of human thalamic electrophysiology. The novel oscillation is tightly coupled to specific, natural states of consciousness.🧵

Happy 30th birthday year to SPM!! 🎈🍰 To get the party started, we are delighted to announce SPM 25.01, a major new version of the open-source neuroimaging software. Read the preprint to discover what's new arxiv.org/pdf/2501.12081 and download SPM for free from Github github.com/spm/spm/rele...

My colleague Andreas Wutz (not yet on bluesky) is co-organizing a special issue in @therealspr.bsky.social on "Bridging Neural and Bodily Signals: Techniques, Methods, and Theoretical Advancements"! onlinelibrary.wiley.com/page/journal...

I am very much looking forward to this week with 2 meetings of the Neuromodulatory Subcortical System PIA: 📌 Tiny dots 21.01.25 12.30am CT (USA) - Noradrenergic Axon Loss Drives Hyposmia in AD alz-org.zoom.us/webinar/regi... 📌 Year in Review 24.01.25 10am CT (USA) alz-org.zoom.us/webinar/regi...

Excited to share our function-oriented vision for the cognitive neuroscience of human aging, now out in Neuron: www.cell.com/neuron/fullt... #neuroscience #aging

*How* does the hippocampus encode the world around us? Leo Waschke and Fabian Kamp bring the 🔥, showing that single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans. Our latest in Nature Communications: www.nature.com/articles/s41...

Brief, seconds-long microarousals during deep sleep “ride on the wave” of locus coeruleus activity and correlate with periods of waste clearing and memory consolidation, new research suggests. By @shaena.bsky.social www.thetransmitter.org/sleep/fleeti...

With so many great tau researchers like @leatgrinberg.bsky.social @lucbuee.bsky.social @sjorsscheres.bsky.social @selinawray.bsky.social @karchlab.bsky.social on #SciSky could not help but put together my 1st starterpack⤵️ We are all fighting for you @curemaptftd.bsky.social 💙 go.bsky.app/KHno2VG

🚨Short bursts of taVNS ⚡ & 👁️ pupil dilation - as an indirect measure of #LocusCoeruleus (?!) #vagusnerv #taVNS Link to publication: www.nature.com/articles/s41... I systematically tested different frequencies (10 & 25 Hz) and intensities (3 & 5 mA) during 3 sec of short bursts of taVNS

🔵 #LocusCoeruleus alert! Holy cow... I'm supposed to do something else, but this paper looks amazing! I mean the concept, the implications... wow. www.cell.com/cell/fulltex...

Aging-related losses in dopamine D2/3 receptor availability are linked to working-memory decline across five years doi.org/10.1093/cerc... #neuroscience

Uncertainty contexts require flexible control. (How) does our ability to manage task uncertainty differ in the aging brain? Multimodal EEG/fMRI evidence (w. @garrettneuro.bsky.social, U. Lindenberger and U. Mayr) is now out in Nature Communications. www.nature.com/articles/s41...

Arousal effects on oscillatory dynamics in the non-human primate brain doi.org/10.1093/cerc... #neuroscience

Our review out in TiCS spearheaded by Mathilde Bonnefond on the latest ideas on the functional role of alpha oscillations and distractor inhibition - e.g. we highlight that alpha increases might reflect perceptual target load rather than distractor anticipation authors.elsevier.com/a/1kFXN_V1r-...

I know what I am reading on the plane today 🤩👇👇👇 www.nature.com/articles/s41...

Hello #neuroskyence! 👋 I am new here and excited to connect! 🎉 I wanted to share my first paper, published recently. We explore ways to strengthen the connections between human research and animal models of brain plasticity. Check it out here: tinyurl.com/5fbbhs69 Happy to engage with you!

After popular demand (thanks @martinowk.bsky.social 😅) here a small representation of our #bluespot crowd! Please share and let me know if I missed someone! go.bsky.app/DyBTCRF

🔵 blue spot alert: Anita Luethi's team reports a dual role of #locuscoeruleus in #sleep in Nature Neuroscience @natureportfolio.bsky.social 1) high LC activity facilitates cortical microarousals 2) low LC activity is required for NREMS-to-REMS transitions doi.org/10.1038/s415...

New work from our postdoc Elouise Koops just got published: #locuscoeruleus metabolism is elevated in preclinical Alzheimer’s disease, and provides resilience against cognitive decline! In collaboration with Joyita Dutta (UMass) alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

📣 Come join us for the #MindBrainBody Symposium 2025! 📆 March 10-12, 2025 📍 Berlin & online 🔎 mindbrainbody.de Keynotes: - Ivan de Araujo - Nadine Gogolla - Maria Ribeiro @ribeironeuro.bsky.social - Markus Ullsperger - Tor Wager - Veronica Witte @veronicawitte.bsky.social #interoception

Looking for a PhD in Cognitive Science, Cognitive Neuroscience or related in Germany? One week left to apply for the Max Planck School of Cognition: cognition.maxplanckschools.org/en/application #PsychSciSky #compneurosky #neuroskyence #NeuroAI #Neuroimaging

Out now in TiCS - our opinion piece arguing that rt variability is an informative characteristic of human and primate performance, and is likely governed at least in part by ACC, DLPFC and OFC. OA to read here: www.sciencedirect.com/science/arti... #psychscisky #neurskyence

Following a week of big emotions, I declare a celebration of a part of your brain that's been on overdrive but you've barely heard of: the Insula! Each day, I'll pass along a fascinating something about the Insula. In 7 days it just might be your new favorite brain region (it's mine). Day 1 ...

How do DA and 5HT drugs alter reinforcement learning? Join us next Wednesday for talks by @anahitm.bsky.social, Diego Pizzagalli, Michael Browning, Roshan Cools, Emma Robinson, Yael Niv, Cath Harmer, Isabel Berwian, @nathanieldaw.bsky.social and Anne Collins. Links etc: acplab.org/2024/11/15/r...

Very happy to share that our work is now published in PNAS! 🎉 It's a systematic look into how demographic and psychological factors are associated with misinformation susceptibility. @arc-mpib.bsky.social Thread below and can be read in full here: www.pnas.org/doi/10.1073/...