Claire O'Callaghan
@claireocallaghan.bsky.social
๐ค 1292
๐ฅ 1285
๐ 58
Working in neuroscience etc. Sydney, Australia
reposted by
Claire O'Callaghan
OHBM Australia
about 17 hours ago
๐ Registration is now OPEN for the 2026 OHBM Australian Chapter Annual Meeting! ๐ฆ๐บ๐ง ๐ฆ๐บ Get your ticket now! ๐๏ธ๐๏ธ๐๏ธ Registration:
events.humanitix.com/ohbm-austral...
๐ Submit your abstract:
docs.google.com/forms/d/e/1F...
๐ Nominate a colleague (or yourself) for an award:
ohbm-aus.github.io/awards/
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OHBM Australia Meeting 2026
Uniting the Australian human brain mapping community.
https://events.humanitix.com/ohbm-australia-meeting-2026
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Claire O'Callaghan
Bohan Zhao
13 days ago
So I built a small tool that merges Allen CCFv3 with the traditional bregma-relative coordinate system (calibrated with Paxinos & Franklin's Atlas). Click any coronal or sagittal section, and get coordinates instantly.
bohanzhao.com/Atlas
Hope it saves someone a headache ๐ญ
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Mouse Brain Stereotaxic Coordinate Viewer
Free interactive tool: enter bregma-relative AP/ML/DV coordinates to navigate Allen Mouse Brain Atlas coronal and sagittal sections. Brain regions identified in real time.
https://bohanzhao.com/Atlas
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Claire O'Callaghan
Jรถrn Diedrichsen
18 days ago
SUITPy 2.1 is here - a Python-version of our toolbox for cerebellar isolation, normalization, atlassing, and flatmap visualization. The processing pipeline now works fully automatically from birth to old age.
suitpy.readthedocs.io
www.biorxiv.org/content/10.6...
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Claire O'Callaghan
Peter Rupprecht
21 days ago
In this new blog post, I review some several recent studies on dendritic voltage and calcium imaging in hippocampus:
gcamp6f.com/2026/05/19/d...
Great work by
@bhlee1117.bsky.social
, Xiang Wu,
@adamezracohen.bsky.social
, Attila Losonczy, Balazs Rosza, Kevin Gonzalez, and others!
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Dendritic imaging of pyramidal neurons in mouse hippocampus
Dendrites are the tree-like arborizations of neurons through which they receive input from other neurons. This compartmentalized anatomy has given rise to the idea that individual dendrites processโฆ
https://gcamp6f.com/2026/05/19/dendritic-imaging-of-pyramidal-neurons-in-mouse-hippocampus/
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Claire O'Callaghan
Alex Fornito
20 days ago
Frustrated with DSM? Interested in
@hitop-system.bsky.social
as a potential alternative? Check our latest, led by J Tiego, using a bottom-up approach in a transdiagnostic twin sample evaluating the validity & heritability of the HiTOP model:
osf.io/preprints/ps...
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Claire O'Callaghan
Eduardo Maristany de las Casas
about 1 month ago
1/10 When the going gets tough, the dendrites get going. Here is a summary on our new paper just published in
@science.org
on flexible learning in frontal motor cortex. With
@mattlark.bsky.social
๐ฌ.
#neuroskyence
#neuroscience
๐
doi.org/10.1126/scie...
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Tuft dendrites in frontal motor cortex enable flexible learning
Flexible learning relies on integrating sensory and contextual information to adjust behavioral output in different environments. The anterolateral motor cortex (ALM) is a frontal area critical for ac...
https://doi.org/10.1126/science.adx4358
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Claire O'Callaghan
Melissa Cooper, PhD
about 2 months ago
Astrocytes do so much more than any of us thought - they even communicate among specific brain regions across hemispheres! The journey to this paper spanned nearly a decade, but I'm most excited to see what everyone else does with the tools we've built. There's so much for all of us to explore!
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Astrocytes connect specific brain regions through plastic networks - Nature
Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.
https://www.nature.com/articles/s41586-026-10426-6
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Claire O'Callaghan
Mike Le Pelley
about 2 months ago
We're hiring! Looking for a postdoc to work at UNSW Sydney, studying impacts of reward and information on attention, using eye-tracking, EEG, and modelling - with Kelly Garner, Daniel Pearson and me. Application link below, please spread the word!
external-careers.jobs.unsw.edu.au/cw/en/job/53...
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Research Associate - Psychology
The Research Associate (Level A) is expected to contribute towards the research effort of UNSW and to develop their research expertise through the pursuit of defined projects relevant to their particu...
https://external-careers.jobs.unsw.edu.au/cw/en/job/539535/research-associate-psychology
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reposted by
Claire O'Callaghan
Jeremiah Cohen
about 2 months ago
Delighted to share our discoveries about one of the brain's neurotransmitter systems:
www.biorxiv.org/content/10.6...
Together with colleagues at the
@alleninstitute.org
, we have learned a lot about a tiny cluster of neurons in the brainstem locus coeruleus (LC) that releases norepinephrine (NE). 1
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https://www.biorxiv.org/content/10.64898/2026.04.10.717727v1
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Claire O'Callaghan
Fleur Zeldenrust
2 months ago
What do
#neuromodulators
do in the
#brain
? Two recent papers give new insights:
@nishantjoshi.bsky.social
shows they do not only reshape individual cellular properties, but also the architecture linking them, thereby expanding the computational repertoire.
www.biorxiv.org/content/10.6...
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https://www.biorxiv.org/content/10.64898/2026.03.13.711516v1
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Claire O'Callaghan
Tommaso Patriarchi
2 months ago
Waitโฆ localized norepinephrine transients in the awake visual cortex?! Who would have guessed this neuromodulatory signal is that spatially precise, right where visual processing is happening. Brain state control just got a lot more local.
@ruedigersarah.bsky.social
www.nature.com/articles/s41...
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reposted by
Claire O'Callaghan
Micah G. Allen
3 months ago
New paper in PNAS! When the mind wanders, it often drifts to the body. We call this "body-wandering". These thoughts are often negative, but are associated with reduced ADHD & depression symptoms, driven by a distinct interoceptive-allostatic brain signature.
pnas.org/doi/10.1073/pnas.2520822123
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reposted by
Claire O'Callaghan
Richard Naud
3 months ago
We've created a tool to visualize the map of electric signals (LFPs) in the whole mouse brain. Different brain areas have electrical fluctuations that look more like a select number of areas, thus creating a map.
nebulawang.github.io/brain-viz/
Details in this paper
doi.org/10.1101/2025...
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brain-viz
https://nebulawang.github.io/brain-viz/
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Claire O'Callaghan
Jaan Aru
3 months ago
Did someone want systematic reviews of the effects of psychedelics? We have two: A review of electrophysiology, out now in Neuroscience and Biobehavioral reviews
www.sciencedirect.com/science/arti...
And a review of cognitive effects in J of Psychopharmacology
journals.sagepub.com/doi/full/10....
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Electrophysiological Mechanisms of Psychedelic Drugs: A Systematic Review
Serotonergic psychedelics are known for their profound effects on consciousness and are gaining renewed interest as potential psychiatric treatments. โฆ
https://www.sciencedirect.com/science/article/pii/S0149763426001065
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reposted by
Claire O'Callaghan
Gaspar Jekely
3 months ago
Registration is now open for our two-day **"Heidelberg Wild Thinking Workshop - The organism, its self and its environment: from philosophy to physics"**, https://www.cos.uni-heidelberg.de/en/wild-thinking-workshop-1 an interdisciplinary event on **19-20 [โฆ]
[Original post on biologists.social]
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reposted by
Claire O'Callaghan
Tommaso Patriarchi
3 months ago
Norepinephrine imaging, pushed further. Our latest NE sensors enable highly sensitive monitoring across recording modalities, Have you been using GRABNE2 sensors? the toolkit just got a major upgrade. Interested in trying them in your system? Reach out.
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reposted by
Claire O'Callaghan
Matt Perich
3 months ago
New paper hot off the (pre-)press! We dig into the evolutionary origins of neural computations for behavioral control across mice, monkeys, and humans:
www.biorxiv.org/content/10.6...
. As our lab's first foray into comparative analysis of neural dynamics, Iโm super excited about this work! 1/18
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Claire O'Callaghan
Andreas Horn
4 months ago
"You see what you look for, and you look for what you know." We are proud to release FOCUS: a 100 ฮผm deformable human subcortical atlas precisely registered to MNI space.
www.biorxiv.org/content/10.6...
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Claire O'Callaghan
Gaspar Jekely
4 months ago
In
@eLife
: Neural connectome of the ctenophore statocyst
https://doi.org/10.7554/eLife.108420
Version of record of our ctenophore nerve-net connectome paper.
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Neural connectome of the ctenophore statocyst
Volume EM and connectome reconstruction of the apical organ of a ctenophore combined with high-speed imaging reveals a neuronal coordination of balancer cilia in the gravisensory organ.
https://elifesciences.org/articles/108420
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reposted by
Claire O'Callaghan
4 months ago
Excited to share newly minted PhD Anu Korukonda's tour de force thesis work describing the impact of pathogenic tau on
#locuscoeruleus
function in a mouse model of early
#Alzheimers
. A must for
#BlueSpot
researchers!
www.biorxiv.org/content/10.6...
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https://www.biorxiv.org/content/10.64898/2026.01.30.702923v1
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Claire O'Callaghan
Giulia Baracchini
4 months ago
Now in press one of my last PhD projects! We traced the neurobiological profile of fMRI BOLD signal variability, a measure that has been related to age, behaviour, disease status, but had not yet been fully contextualised within the brain's multiscale architecture.
www.nature.com/articles/s41...
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The biological role of local and global fMRI BOLD signal variability in multiscale human brain organization - Nature Communications
Baracchini et al. reveal that temporal variability in fMRI brain signals encodes biologically meaningful information across spatial and temporal scales, highlighting its role in healthy brain function...
https://www.nature.com/articles/s41467-026-68700-0
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Claire O'Callaghan
Alex Fornito
4 months ago
Our latest preprint on how regional cellular, molecular, and other forms of heterogeneity shape macroscopic wave dynamics is now out:
www.biorxiv.org/content/10.6...
For a full thread, see:
x.com/_victorbarne...
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Claire O'Callaghan
Annie G. Bryant
4 months ago
The extended version of my thesis procrastination project/subcortex visualization package is out now in both Python and R, now that Iโve graduated ๐ค This figure shows the 9 atlases included (and counting)! Preprint:
www.biorxiv.org/content/10.6...
Website:
anniegbryant.github.io/subcortex_vi...
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reposted by
Claire O'Callaghan
James Lightfoot
5 months ago
Why do some worms graze on bacteria while others hunt and kill? Our study, published today in Nature, reveals how predatory aggression evolved in nematodes. Led by
@gunizgozeeren.bsky.social
and
@leoboeger.bsky.social
across the
@jameslightfoot.bsky.social
and
@monikakscholz.bsky.social
labs.
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Predatory aggression evolved through adaptations to noradrenergic circuits - Nature
Noradrenergic circuits support and balance aggressive behavioural states in predatory nematodes, distinguish predatory from non-predatory nematode species and are associated with the evolution of comp...
https://www.nature.com/articles/s41586-025-10009-x
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Claire O'Callaghan
Peter Rupprecht
5 months ago
Excited to share our new preprint! We explore the link between the locus coeruleus (LC) and arousal for astrocytes, pyramidal cells, interneurons in the hippocampus. A fantastic collaboration with
@sianduss.bsky.social
@bohaceklab.bsky.social
, and many others:
www.biorxiv.org/content/10.6...
1/5
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reposted by
Claire O'Callaghan
5 months ago
What is the computational role of dendritic excitations? Byung Hun Lee and team mapped voltage dynamics throughout the dendritic trees of CA1 pyramidal neurons in mice navigating in virtual reality.
www.biorxiv.org/content/10.6...
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Claire O'Callaghan
Anthony Hannan
5 months ago
A major part of our future health & prosperity lies in medical research. There are billions of available dollars that can be used for vital medical science. Please join the campaign for our government to act urgently to fully disperse these funds:
aamri.org.au/mrff/
www.theage.com.au/politics/fed...
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Most researchers miss out on innovation grants while medical fund sits on $25b
Nine in 10 Australian researchers had their โideas grantโ applications rejected last year, even as Australiaโs medical investment fund sits on $5 billion more than it was designed to hold.
https://www.theage.com.au/politics/federal/most-researchers-miss-out-on-innovation-grants-while-medical-fund-sits-on-25b-20251230-p5nqp9.html
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reposted by
Claire O'Callaghan
Lindsay Schwarz
6 months ago
Thrilled this is out, led by former PD Cameron Ogg (now with her own lab at
@rhodescollege.bsky.social
!). It was a driven by a desire to see, in real-time, how LC activity/NE release influences downstream targets in behaving animals. SO hard to do, but Cameron did it!
www.cell.com/cell-reports...
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Locus coeruleus norepinephrine neurons facilitate orbitofrontal cortex remapping and behavioral flexibility
Ogg et al. use in vivo imaging techniques to record activity in the locus coeruleus (LC) and the orbitofrontal cortex (OFC) during a reversal learning task in freely moving rodents. They show that man...
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01459-7
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Claire O'Callaghan
Alex Fornito
6 months ago
Exciting announcement! Our Institute is calling for applications for a EMCR 2-year fellowship . Come and join a great team @turnerinstitute! Details here:
careers.pageuppeople.com/513/ci/en/jo...
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Monash University - Sign In
Sign in with your account to access PageUp
https://careers.pageuppeople.com/513/ci/en/job/687062/turner-impact-research-fellow-level-a-or-level-b-psychology
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Claire O'Callaghan
Stuart Oldham
6 months ago
My very normal, by the book presentation from this years OHBM is now available. So if you weren't at OHBM, were there but happened to miss it, or if you did see it and just want to relive it all over again, here is your chance :) I'm quite fond of this one.
www.youtube.com/watch?v=lP86...
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OHBM 2025 | Oral Session | Stuart Oldham | Only a matter of time: developmental heterochronicity cโฆ
YouTube video by Organization for Human Brain Mapping
https://www.youtube.com/watch?v=lP86m8q-k5Q
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Excellent read for a clear take on the current state of Australian scientific research funding
add a skeleton here at some point
6 months ago
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Claire O'Callaghan
Gavan McNally
6 months ago
substack.com/@gavanmcnall...
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Gavan McNally (@gavanmcnally)
Australia is sleepwalking into scientific irrelevance ย Australia is living through a dangerous contradiction: we publicly praise science while systematically dismantling the conditions required for...
https://substack.com/@gavanmcnally/note/c-184374386?r=17ja05
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Claire O'Callaghan
Alex Kwan
6 months ago
We used rabies virus ๐พ to map how
#psilocybin
modifies long-range circuits ๐ง , revealing network-specific reorganization that we didnโt expect. The full study is now online at Cell.
@cp-cell.bsky.social
Paper ๐
www.cell.com/cell/fulltex...
Thread for a synopsis ๐
bsky.app/profile/alex...
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reposted by
Claire O'Callaghan
Alex Fornito
6 months ago
Very important! If you are an Australian researcher, please complete
add a skeleton here at some point
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reposted by
Claire O'Callaghan
Alan White
6 months ago
Amazing letter in The Times (also an unbelievable play fwiw)
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Claire O'Callaghan
Alex Fornito
6 months ago
๐ฅ๐ฅThe Program for the 2026 Noosa Brain Workshop is now Available!!! ๐ฅ๐ฅ We have an incredible line up of confirmed speakers! Commuter registrations are still available, but places are limited. Check the website for details:
www.monash.edu/turner-insti...
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Claire O'Callaghan
bioRxiv Neuroscience
7 months ago
Rapid neocortical network modifications via dendritic plateau potential induced plasticity
https://www.biorxiv.org/content/10.1101/2025.11.19.689338v1
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Claire O'Callaghan
Matilde Vaghi
7 months ago
๐ We're hiring ! ๐ต๏ธ Seeking a postdoc to study the development & individual-level organization of brain circuits supporting (in)flexible behavior in psychiatric populations. ๐ง Precision functional mapping, fMRI, normative modelling Details ๐
tinyurl.com/3h8tcv2e
๐๏ธ Apply by Dec 10! Please RT ๐
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Postdoctoral Researcher (2288) - Birkbeck, University of London
Birkbeck
https://cis7.bbk.ac.uk/vacancy/postdoctoral-researcher-599088.html
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reposted by
Claire O'Callaghan
Alex Fornito
7 months ago
๐ฅ๐ฅGreat news!๐ฅ๐ฅ The registration deadline for the Noosa Brain Workshop is extended to Nov 17. Register by this date to guarantee accomodation:
monash.edu/turner-insti...
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Claire O'Callaghan
Sarah Heilbronner
8 months ago
Suzanne Haber was just elected to the National Academy of Medicine! Her work on the organization of the cortex and basal ganglia has had a huge impact. Please take the opportunity to congratulate her the next time you see her.
www.urmc.rochester.edu/news/story/u...
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University of Rochester Neurobiologist Suzanne Haber Elected to National Academy of Medicine
An internationally recognized scientist, her work has transformed our understanding of the brain networks that play a central role in many mental health disorders, including obsessive compulsive disor...
https://www.urmc.rochester.edu/news/story/university-of-rochester-neurobiologist-suzanne-haber-elected-to-national-academy-of-medicine
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Claire O'Callaghan
Christopher Whyte
8 months ago
The final paper of my PhD is now out as a preprint. This is a follow-up piece in series of two companion papers modelling awareness and suppression in a new variant of continuous flash suppression.
arxiv.org/abs/2510.17154
๐งต 1/3
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A Minimal Quantitative Model of Perceptual Suppression and Breakthrough in Visual Rivalry
When conflicting images are presented to either eye, binocular fusion is disrupted. Rather than experiencing a blend of both percepts, often only one eye's image is experienced, whilst the other is su...
https://arxiv.org/abs/2510.17154
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reposted by
Claire O'Callaghan
Sam Gershman
8 months ago
Really interesting work by Bakhurin and colleagues challenging the reward prediction error hypothesis of dopamine:
www.nature.com/articles/s41...
I love this figure which both echoes and undermines the famous figure from Schultz et al. (1997).
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Claire O'Callaghan
Jack Ashby
8 months ago
As I argue in
#PlatypusMatters
, Australia has the world's best mammals, but is sadly the worst place on Earth to be a mammal, with the planet's worst
#extinction
rate. The Christmas Island shrew is now the latest species to be officially declared extinct.
www.theguardian.com/environment/...
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And then there were none: Australiaโs only shrew declared extinct
The tally of Australian mammals extinct since 1788 is now 39 species โ far more than for any other country
https://www.theguardian.com/environment/commentisfree/2025/oct/11/and-then-there-were-none-australias-only-shrew-declared-extinct?CMP=Share_AndroidApp_Other
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Claire O'Callaghan
Kurzgesagt โ In a Nutshell
8 months ago
AI-generated content is flooding the internet, and we're entering a new era of information overload. Watch our latest video to find out how AI slop affects the internet and why kurzgesagt videos will always remain human-made:
https://kgs.link/AISlop
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Claire O'Callaghan
Choong-Wan (Wani) Woo
8 months ago
Our new paper is out in Current Opinion in Behavioral Sciences; a perspective paper on the DMN, titled "Embodying the default mode network: self-related processing from an embodied perspective"
www.sciencedirect.com/science/arti...
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Embodying the default mode network: self-related processing from an embodied perspective
Self-related processes in the default mode network (DMN) have been viewed predominantly through a cognitive lens, often overlooking the embodied dimenโฆ
https://www.sciencedirect.com/science/article/pii/S2352154625001263
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Claire O'Callaghan
Masud Husain
8 months ago
The current environment is making it near impossible to run clinical trials in the UK. One key issue discussed in
@brain1878.bsky.social
is the duplication - or worse - of regulatory oversight at NHS hospitals & universities. My views on how to change the system
academic.oup.com/brain/articl...
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Claire O'Callaghan
Kira Poskanzer
8 months ago
Congrats to Charlotte Taylor and team for dissecting how astrocyte networks integrate histamine to modulate adenosine over sleep and wake in unexpected ways:
dx.plos.org/10.1371/jour...
@vincenttse.bsky.social
@maxine.science
@trishavv.bsky.social
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Cortical astrocyte histamine-1-receptors regulate intracellular calcium and extracellular adenosine dynamics across sleep and wake
While histamine-1-receptor (H1R) signaling in neurons regulates arousal, these receptors are also abundant on cortical astrocytes. This study shows that astrocytic H1R signaling modulates calcium acti...
https://dx.plos.org/10.1371/journal.pbio.3003376
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Claire O'Callaghan
Mathew Summers
8 months ago
Check out our resource for navigating and analyzing spatial transcriptomics data in the thalamus, which we fondly call "the THALMANAC" (๐๐๐๐amus ๐ERFISH ๐๐alysis and ๐๐cess), now live on bioRxiv:
www.biorxiv.org/content/10.1...
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Exploring the correspondence between gene expression and thalamic nuclei using the THALMANAC resource
The thalamus connects the sensory organs and major subcortical brain regions with the neocortex. The thalamus has long been divided into multiple discrete nuclei, based on cytoarchitecture, histochemi...
https://www.biorxiv.org/content/10.1101/2025.09.30.679413v1
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Claire O'Callaghan
Boris Bernhardt
8 months ago
๐จ New paper in Nature Methods: HippoMaps: multiscale cartography of the human hippocampus Open-source tools & data to explore structure and function of the ๐ค๐ง (histology, in/ex vivo MRI, iEEG) Led by
@jordandekraker.bsky.social
docs:
hippomaps.readthedocs.io
paper:
doi.org/10.1038/s415...
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Claire O'Callaghan
Hugo Spiers
8 months ago
You can sign up for the early access to the new Sea Hero Quest:
seaheroquest.com
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