Thanks to @ashleyingiosi.bsky.social for this thoughtful primer about our recent astrocyte/sleep paper!

🧠📈 Evidence is mounting for all the ways the astrocyte network—that “second brain” woven between neurons—integrates modulatory signals to shape neural dynamics & brain state. It was awesome to collab on this investigation on the intricate interplay between histamine and other signals in astrocytes!

What's the function of #histamine -1-receptors (H1Rs) on cortical astrocytes? @kiraposkanzer.bsky.social & co show that astrocytic H1R signaling modulates Ca2+ activity, extracellular adenosine & REM #sleep, revealing a key #astrocyte role in sleep-wake regulation @plosbiology.org 🧪 plos.io/4gRj9Ap

Really excited to see this work from my postgrad days come out of its "slumber" 💤 If you are interested in how astrocytes interact with neuromodulatory systems to regulate cortical states, this is for you!

Congrats to Charlotte Taylor and team for dissecting how astrocyte networks integrate histamine to modulate adenosine over sleep and wake in unexpected ways: dx.plos.org/10.1371/jour... @vincenttse.bsky.social @maxine.science @trishavv.bsky.social

Brainbow

Fast, accurate, and versatile data analysis platform for the quantification of molecular spatiotemporal signals: Cell www.cell.com/cell/fulltex...

Watch the videos

Unexpected glia reference alert!

Capacitance compensation

Lipid droplets

YFP

Marin mushrooms

My what

Ultrastructure

A Photoactivatable Norepinephrine for Probing Adrenergic Neural Circuits https://www.biorxiv.org/content/10.1101/2023.11.13.566764v1

SF moon

Ocular dominance columns

Check out a recent @arcadiascience.bsky.social project looking for viruses in human brains 🧠: https://research.arcadiascience.com/pub/result-viral-search-brain-seq-data