Functional imaging of nine distinct neuronal populations under a miniscope in freely behaving animals

Spread the word: We’re hiring a Director of Operations to lead scientific support at the FMI. This senior role enables cutting-edge research by partnering with scientists, overseeing technology platforms, ensuring safety & compliance, and representing the FMI externally: www.fmi.ch/education-ca...

I find AI incredibly useful in the scientific hiring process. For example, if I see an obviously LLM-written application, it saves me a ton of time to just immediately reject that candidate.

Excited to announce big steps for electrical imaging in the brain! In 4 preprints, we and collaborators present 2 new GFP-based voltage sensors: ASAP6c for high-throughput spike recordings, and ASAP7y for subthreshold 1P and 2P imaging bit.ly/4x3k3kX bit.ly/3RKZhq3 bit.ly/4o4fKl3 bit.ly/4uHXuk3 🧵

"No matter how much we tell ourselves AI is like spell-check, it isn’t. When we use AI to flesh out ideas, we lose the most important part of the writing process: thinking...the effort and the hang-ups are a feature of the human thought process, not a bug" www.theatlantic.com/technology/2...

Ok this is a truly great tweet

Uber’s COO has said that it’s getting “harder to justify” its AI costs because there was no way to show a link between AI spend and any meaningful increase in useful features. This is the first time I’ve seen a company say this directly. www.businessinsider.com/uber-coo-and...

A link to the study

How can light precisely control neural activity? 🧠💡 This review from RIKEN & Science Tokyo, published in #Neurophotonics, outlines advances in two‑photon optogenetic stimulation, enabling targeted activation of neurons with high spatial precision. ⚛️ 🔗: https://bit.ly/3PEnbCo

3i Ltd is looking for a Technical Support Specialist to join its team in London, England. The ideal candidate has earned a bachelor's degree and has experience with optics. Familiarity with multiphoton, confocal, imaging analysis, advanced microscopy and fluorescent microscopy is preferred. 1/n

We are hiring! Join the BioOptics team as a Microscopy Specialist with a focus on multiphoton intravital microscopy. Link below.👇

Apply for our Paris Miniscope Workshop this summer: July 1-3, 2026. Come learn to record and analyze calcium imaging data with open source Miniscopes! Applications due this Friday May 22. Apply here: docs.google.com/forms/d/e/1F...

Google I/O for those that didn't watch.

In this new blog post, I review some several recent studies on dendritic voltage and calcium imaging in hippocampus: gcamp6f.com/2026/05/19/d... Great work by @bhlee1117.bsky.social, Xiang Wu, @adamezracohen.bsky.social, Attila Losonczy, Balazs Rosza, Kevin Gonzalez, and others!

Niemand muss ChatGPT nutzen. Man kann es einfach sein lassen und das Leben wird dadurch kein bisschen schlechter. Aber die Welt ein winziges bisschen besser.

How does #vision shape spatial maps in the hippocampus? Check out our brand new preprint 👇 As someone who did a PhD on the #hippocampus & postdoc on visual cortex and superior colliculus, it's such a joy to start closing the loop - especially with such a great team! 😊

We are hiring a postdoc! We study neural activity and movement using holographic optogenetics, imaging, and recordings in awake mice. My first postdoc, Masashi, is starting his own lab, so now we have an opening. Seeking candidates excited about circuits, optics, coding, or ephys. oldenburglab.com

🧠We offer 1-2 Postdoc positions in Circuit Neuroscience!🧠 Join us at @dandrite.bsky.social to study thalamic circuits for visual processing, funded by an ERC starting grant and the Lundbeck foundation. Deadline: 14. Juni 2026 Apply here: international.au.dk/about/profil...

Bitter: Innenminister:innen, die jahrelang kein Verbotsverfahren gegen rechtsextreme #noAfD auf den Weg bringen wollten, warnen jetzt also vor dem Frontal-Angriff auf den Rechtstaat, falls die AfD in Sachsen-Anhalt die Regierung übernimmt. 1/2 #KipppunktOst www.handelsblatt.com/politik/deut...

Scientific funding is under attack in both the US and the UK. In the US the attack is intentional, with a tinge of evil. In the UK it's apparently unintentional and just due to utter stupidity. Not sure which one is better.

New low for the BBSRC @ukri.org this week - 596 ECRs put their blood, sweat, tears and Easter vacation into a -pretty involved- postdoc fellowship preapplication only for the ALL to be rejected because they *didn’t foresee* applicant numbers and will therefore impose institution caps. Not cool.

I desire more in life than to be the “don’t summarise with AI”-guy on bluesky 😅 but reports like this keep coming in, so I’ll repeat ad nauseam, don’t summarise with ‘AI’! www.tue.nl/en/our-unive...

New voltage indicators from St-Pierre lab and collaborators: - FORCE1s: www.biorxiv.org/content/10.6... - JEDI3sub and JEDI3hyp: www.nature.com/articles/s41... Blog post about voltage imaging: spikesandbursts.wordpress.com/2018/11/06/v...

📢 Applications are open! Join us in October to explore next-generation fluorescent proteins, biosensors & imaging advances + machine learning and computational approaches to accelerate design. 🛏️ Meals & lodging covered; no registration fee Apply by May 21 ➡️ janelia.news/FPS26 @agtebo.bsky.social

Anstatt Menschen mit Behinderung fair zu bezahlen, vergeben Unternehmen Aufträge an Werkstätten für behinderte Menschen - für unter 2 Euro pro Std. Ist das grundrechtskonform? Antworten geben Sozialrechtler Felix Welti und @raulkrauthausen.bsky.social von @sozialhelden.bsky.social. 🎧 #GrundifürAlle

“You would hope that German officials would support scientists’ advice, but they have ignored it,” says one marine biologist who asked not to be identified because they feared repercussions. Must-read story by @martinenserink.bsky.social in @science.org. Feels like an encapsulation of our times 🧪

I have actually looked through all of them at this point (and laughed hysterically). This one is the clear winner and may well make it into a lecture powerpoint for next semester.

Calling AI use “gambling behavior” is so right in so many ways. I hadn’t quite clocked it such a manner but boy that ain’t wrong.

For inserting grin lenses/prisms in thick tissue pieces, do people use automatic/robotic manipulators to produce slow movement? If so, which actuator and how do you hold them? @spencerlaveresmith.bsky.social ? #neuroscience

flagging for everyone that @labrigger is a gold mine of info for things like this labrigger.com/blog/2011/11...

PinkyCaMP is finally published!! My first paper co-first authored with @sikmys.bsky.social where we make a great optogenetic and multiplex compatible red calcium indicator. Thank you to @massecklab.bsky.social and @campbell-lab.bsky.social for guiding this journey www.nature.com/articles/s41...

We’re really excited to announce our next international, hands-on #Miniscope workshop covering everything from microscope design to experiments to analysis! Applications are now open for the 2026 Paris Miniscope Workshop (July 1–3, ESPCI). Apply by May 22: forms.gle/4CWh7MeMchLS...

Open-source modular FPGA system for two-photon mesoscope: multiarea, multidepth neural activity recording. @riichirohira.bsky.social et al. present high throughput 2p calcium and what is maybe the largest field-of-view 2p fluorescence lifetime imaging (FLIM) data. doi.org/10.1117/1.NP...

Finally online @natmethods.nature.com www.nature.com/articles/s41... This was a fun collaboration with @finkryan.bsky.social @massecklab.bsky.social @tpatriarchi.bsky.social @martinfuhrmann.bsky.social @campbell-lab.bsky.social @jangrundemann.bsky.social 🧪🧠🔬🧬

Ich glaube es nicht! Aus einer besorgniserregenden Studie über steigende Zahlen von Hitzetoten und Tagen mit Extremhitze durch den Klimawandel macht ARD/tagesschau: „Pollensaison wird länger und stärker“ 🤦‍♂️

isn't that cool : www.eurobioimaging.eu/news/innovat...

We are recruiting a post-doc to study olfactory processing and decision-making in rodents, combining quantitative behavior with neurophysiology. www.oist.jp/careers/post... Please share with interested colleagues and trainees 🙏

Don't be shy to take on a little two-week side project. These five months will be the most precious three years of your academic journey.

How does blood flow relate to brain activity? We discovered that it reflects two neural populations affected oppositely by arousal. Together, they explain neurovascular coupling in all brain regions and brain states! Out today in Nature: rdcu.be/fdC2A @uclbrainscience.bsky.social

This is beautiful data. 2p optical reporting of subthreshold voltage, validated with simultaneous patch clamp. www.biorxiv.org/content/10.6... FORCE1s by François St-Pierre's group, with a bunch of great people joining in.

I'm not joking when I say mRNA technology is more important than "AI" and it's a tragedy we're throwing billions into one while our government is aggressively defunding the other.

New post, on the value of prospective predictions when it comes to our ability to judge AI: kucharski.substack.com/p/are-you-ov...

Happy #FluorescenceFriday!

Thank you Georg! Very happy to have worked on this. Here is a short 🧵 on what ECT-triggered CSD looks like, and why we think it is going to help shape the future of ECT research. (1/12)

Out in @natmethods.nature.com: More dyes. They work. Quite well. And blink. Pick the one that fits your target, your technique, and your labeling density. With too many collaborators and institutes to list, but anchored at @hhmijanelia.bsky.social www.nature.com/articles/s41...

For nearly a century, we believed the therapeutic effect of ECT is the seizure. Our latest research suggests we may have been looking at the wrong event. A thread on why cortical spreading depression (CSD) might be the driver of therapeutic benefit. Work led by @therehugolad.bsky.social

📢 #CancerNeuroscience Online Seminar with Ofer Yizhar, from Weizmann Institute of Science, Israel. Title: “Optogenetic modulation of neural circuits” This virtual seminar takes place on April 28, from 5-6 PM CEST, please register here: us06web.zoom.us/meeting/regi...

This week, the #VirtualPub is in collaboration with the Image Data Community Days! We welcome Carsen Stringer, HHMI Janelia, for a talk on "Cellpose-SAM: superhuman generalisation for cellular segmentation." @hhmi-science.bsky.social 🗓️ Fri, April 17 @ 1 pm CEST www.eurobioimaging.eu/our-events/t...

If you ever wanted to do FLIM, this may be a helpful read