Reunion with past and present Cai lab & Shuman lab members (and collaborators). Spending time with you guys is easily the best part of my job. @tristanshuman.bsky.social @sinaibrain.bsky.social @sfn.org

If you are at SFN this week come to our SFN dance party! Monday night at Parq nightclub. Open to everyone. @denisejcai.bsky.social, Kay Tye, and I are giving out VIP bracelets at SFN all weekend!

See you on the dance floor! @tristanshuman.bsky.social

Excited to share that I landed my dream job!🎉🎉🎉 The Pennington Lab will be opening at the University of British Columbia in January 2026! @ubcpsych.bsky.social @dmcbrainhealth.bsky.social

We're looking forward to the first annual New York Memory Hub conference later this week! Can't wait for all the talks and discussion about all things learning and memory 🧠

🚨New preprint alert🚨 We used closed-loop optogenetics to causally test the importance of inhibitory spike timing in network function and found that manipulating PV+ cell theta phase locking in the dentate gyrus can shift seizure susceptibility (both ways!)

Check out new work from our lab! We developed a new way to directly control the precise timing of interneurons during behavior and found that theta phase locking is a causal mediator of seizure susceptibility in both healthy and epileptic mice.

Check out our latest paper today in Nature: “Goal specific hippocampal inhibition gates learning” www.nature.com/articles/s41... By Nuri Jeong, Xiao Zheng, Abby Paulson, Steph Prince and colleagues.

🚨 New lab paper!🚨 A dream study of mine for nearly 20 yrs not possible until now thanks to NIH 🧠 funding & 1st-author lead @seeber.bsky.social We tracked hippocampal activity as people walked memory-guided paths & imagined them again. Did brain patterns reappear?🧵👇 www.nature.com/articles/s41...

Grid cells have a geometry in time. Thanks to @azvollan.bsky.social l & @rjgardner.bsky.social for this heroic discovery. @ercresearch.bsky.social #KiloNeurons @m-bmoser.bsky.social @kavlintnu.bsky.social @nature.com @kavlifoundation.bsky.social www.nature.com/articles/s41...

New paper out in Cell Reports! Led by @susieyufeng.bsky.social, we found that chronic epilepsy in mice drives distinct synchronization deficits in hippocampus and MEC, with early changes in HPC and late-onset changes in MEC that align with progressive memory impairment. www.cell.com/cell-reports...

My boss has been in DC a lot longer than I have - and deep inside. He has taught me a lot about how DC works. (I hope I've taught him some things about academia.). Here's what he posted on LinkedIn with our News story.

Interested in how neural communication breaks down in a model of Alzheimer's pathology? In a new preprint, we found desynchronization in medial entorhinal–hippocampal circuits that coincided with the onset of spatial memory deficits in 3xTg mice. (1/6) www.biorxiv.org/content/10.1...

New preprint from the lab! @laurenmvetere.bsky.social found disrupted MEC-hippocampal synchronization that paralleled the emergence of memory deficits in the 3xTg mouse model of AD pathology! Check it out and let us know what you think.

Did 2024 feel LONG to anyone else? A little 2024 recap from me: I defended my PhD and submitted a first author paper describing my thesis work! Look out for a preprint very soon. (1/6)

Hey #ACNP2024!!! I’ve been inspired by y’all to start a new thread to capture the amazing #FashionsOfACNP! Please add on🙏🏼💃🏻🕺 First up: the one and only @jaredwyoung.bsky.social! The shoes. The kilt. The vest. Perfection 🧑‍🍳😘

Thank you to NIH Director Dr. Bertagnolli for sharing our recent work in her latest blog post! I’m so proud of the team and first author @joezaki.bsky.social for all their hard work on these exciting new findings examining stress & memory-linking 🧠 Read here 👇 directorsblog.nih.gov/2024/12/05/s...

SO EXCITED to share our latest work demonstrating that the anterior hypothalamic nucleus (AHN) regulates stress vulnerability!!!

This is going to be a great conference! Excited to join!

A thread on NIH Reorganization and the Scientific Management Review Board (SMRB) Disclosure: I was involved with the SMRB since its inception and have very strong feelings about how it was used, misused, and abandoned. My passion on these issues will undoubtably show through. 1/n

🌟 Cai Lab Nature (@natureportfolio.bsky.social) paper alert! In work led by Joe Zaki, we find that rest periods after learning not only stabilize new memories BUT ALSO integrate new memories with older ones from days past! (1/10) Read it here: www.nature.com/articles/s41...

xcited to share our new results! We (huge team effort led by post-doc extraordinaire Sylvie Lesuis) examined the effects of acute stress on threat memory generalization and engram ensemble architecture. www.sciencedirect.com/science/arti...

Come work with us at Mount Sinai! We have an open search for tenure-track faculty in the Department of Neuroscience focusing on Computational and Systems Neuroscience. Feel free to reach out to me with questions. neuroscience.mssm.edu/docs/Faculty... Initial review will begin next week!

go.bsky.app/LdtUYZS I created a starter pack for the growing community of hippocampus physiologists that have joined the great migration. Also included the physiology-adjacent. Tell me who I haven’t found yet

Open faculty search at Mount Sinai in Computational and/or Systems Neuroscience. Deadline is November 15th, 2024 neuroscience.mssm.edu/pdf/faculty-...

NEW PREPRINT! Led by recent PhD Susie Feng, we characterized memory impairment and entorhinal-hippocampal desynchronization in epileptic mice. We found early hippocampal deficits and late-onset MEC deficits that emerged with progressively worse cognitive impairment. www.biorxiv.org/content/10.1...