Interested in how neural communication breaks down in a model of Alzheimer's pathology? In a new preprint, we found desynchronization in medial entorhinal–hippocampal circuits that coincided with the onset of spatial memory deficits in 3xTg mice. (1/6) www.biorxiv.org/content/10.1...

📣 As promised, here is our protocol paper on chemotagging! This new technique combines calcium imaging with chemogenetics to identify cell types in commonly used Miniscope recordings & can be used to tag ANY CELL TYPE! #Neuroskyence Read about the technique here: www.biorxiv.org/content/10.1...

A special thanks to NIH Director Dr. Monica Bertagnolli for featuring the Icahn School of Medicine's @denisejcai.bsky.social's & lead author @joezaki.bsky.social's latest research in the NIH Director's Blog👉 tinyurl.com/bdf8y2vt SEE THE PAPER HERE👉 www.nature.com/articles/s41...

Thank you to NIH Director Dr. Bertagnolli for sharing our recent work in her latest blog post! I’m so proud of the team and first author @joezaki.bsky.social for all their hard work on these exciting new findings examining stress & memory-linking 🧠 Read here 👇 directorsblog.nih.gov/2024/12/05/s...

❓ Do you know what the anterior hypothalamic nucleus (AHN) does? No? Neither did we! 🧠 In a new preprint from the Cai Lab, learn how we discovered the AHN’s central role in regulating stress vulnerability. Read the paper here: www.biorxiv.org/content/10.1... (1/6)

Honored to be featured alongside @sjo09.bsky.social in a recent article from The Transmitter! We love studying #memory stability & flexibility and how #stress can modify these processes! 🧠 Thank you for writing a lovely piece highlighting my lab’s work, @claudia-lopez.bsky.social!

🌟 Cai Lab Nature (@natureportfolio.bsky.social) paper alert! In work led by Joe Zaki, we find that rest periods after learning not only stabilize new memories BUT ALSO integrate new memories with older ones from days past! (1/10) Read it here: www.nature.com/articles/s41...