Is alcohol just a depressant? Not quite. Our new study, now published in final form in #JNeurosci, shows that alcohol rapidly activates neurons in the prefrontal cortex (PFC), and this effect depends on dopamine. www.jneurosci.org/content/46/2...

New voltage indicators from St-Pierre lab and collaborators: - FORCE1s: www.biorxiv.org/content/10.6... - JEDI3sub and JEDI3hyp: www.nature.com/articles/s41... Blog post about voltage imaging: spikesandbursts.wordpress.com/2018/11/06/v...

Tuft dendrites in frontal motor cortex enable flexible learning: www.science.org/doi/10.1126/...

A functional influence based circuit motif that constrains the set of plausible algorithms of cortical function elifesciences.org/reviewed-pre...

Finally online @natmethods.nature.com www.nature.com/articles/s41... This was a fun collaboration with @finkryan.bsky.social @massecklab.bsky.social @tpatriarchi.bsky.social @martinfuhrmann.bsky.social @campbell-lab.bsky.social @jangrundemann.bsky.social 🧪🧠🔬🧬

How does blood flow relate to brain activity? We discovered that it reflects two neural populations affected oppositely by arousal. Together, they explain neurovascular coupling in all brain regions and brain states! Out today in Nature: rdcu.be/fdC2A @uclbrainscience.bsky.social

Molecular and functional dissection using CaMPARI-seq reveals the neuronal organization for dissociating optic flow-dependent behaviors: www.nature.com/articles/s41...

Infant Brains Tick at 4Hz – Resonance Properties of the Developing Visual System A ~4 Hz EEG response in infants (8-month-olds) emerges independently of visual stimulation frequency. elifesciences.org/reviewed-pre...

Developmental characteristics of spontaneous activity and functional connectivity in the fetal brain "As the fetal gestational age increased, spontaneous brain activity ↓ in the bilateral thalamus and ↑ in the bilateral anterior cingulate cortex." academic.oup.com/cercor/artic...

I don’t know if you saw the MASSIVE news announced by @erc.europa.eu today: from now on, if you get a B at step 1 you are eligible to apply at N+3(!!!) years. Say you got a B in STG2026 step 1, you thought you could apply in STG2028, but no: only in STG2029! erc.europa.eu/news-events/...

What happens in the prefrontal cortex when alcohol kicks in? Our new paper is out! We show that acute alcohol activates layer 5 pyramidal neurons in the prefrontal cortex, and that this activation requires dopaminergic signaling from the ventral tegmental area. www.jneurosci.org/content/earl...

Functional synaptic connectivity shapes spine stability in the hippocampus "Spines with large responses exhibited larger volume and higher stability compared to unresponsive spines." www.nature.com/articles/s41...

Millimeter-scale selective amplification in the developing visual cortex "cortical networks are preferentially activated by inputs aligned to endogenous recurrent subnetworks" in the immature ferret visual cortex. www.biorxiv.org/content/10.6...

New paper (with lots of cute animal videos!) Ever watch your dog "run" while asleep and wonder what’s going on in their brain? In Current Bio we suggest that those twitches aren't just leaky dreams—they’re a vital maintenance system for the most precise movements www.cell.com/current-biol...

Wanna do neuroscience in Paris but can't find interesting lab? Want to come do a sabbatical but don't know who to collaborate? Check this webpage aggregating ~all the neuroscience labs (+200) in Paris. ⚠️only the information of 'verified' profiles is reliable⚠️ Please retweet 🙏 parisneuro.fr

Full online version of our AnkG E35a paper is finally out! E35a is a microexon highly included in GABAergic neurons. Surprisingly, deleting E35a increases their excitability and Ca²⁺ activity without AIS changes, pointing instead to disruption of intracellular Ca²⁺. www.nature.com/articles/s41...

The subiculum: cell-type-specific composition, computation, and function: www.cell.com/trends/neuro... "The subiculum, the primary hippocampal output region, exhibits rich excitatory neuron diversity that contributes to organizing information flow to downstream brain regions."

Youthful antics predict lifespan? Using machine learning & continuous recordings of #killifish behavior from adolescence until death, @brunetlab.bsky.social & @deisseroth.bsky.social find early-life behavior predicted future lifespan! Now published @science.org: www.science.org/doi/10.1126/... 🧪 1/2

Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation elifesciences.org/reviewed-pre...

New blog post: Resources for faculty job applications and starting a new lab Suggestions are welcome! spikesandbursts.wordpress.com/2026/03/15/r...

Take a look at the new "Python4Neuro_2026" notebooks with basic tutorials and exercises for patch-clamp and two-photon calcium imaging analysis in Python. You can launch the notebooks in Google Colab using the links in the README. github.com/dav1dcg/neur...

If you like AnkG and alternative splicing, check out how this newly identified Ank3 microexon mainly affects GABAergic neurons’ excitability without altering the AIS! Sincerely happy to have been part of this collaborative project captained by Chaolin Zhang! www.nature.com/articles/s41...

A human electrophysiological signature of Fragile X pathophysiology is shared in V1 of Fmr1-/y mice "...show in males with fragile X syndrome (FXS) that alpha oscillations in humans and alpha-like oscillations in the visual cortex of Fmr1-/y mice are slowed..." www.nature.com/articles/s41...

Triggering action potentials of a single neuron by multiphoton excitation elicits visually guided behavior "disruption of a single neuron within the ensemble temporarily paralyzes the entire ensemble and suspends behavioral responses to visual stimuli" www.nature.com/articles/s41...

Visual experience exerts an instructive role on cortical feedback inputs to the primary visual cortex: doi.org/10.1016/j.cu... Dual color 2P to measure the tuning properties and retinotopic organization of inputs from the LM visual area in L1 of V1 in mice reared wearing goggles

🔬🧠 Releasing the 1.0 version of #Suite2p and THE PAPER w/ @marius10p.bsky.social! Now with GPU acceleration. Want to use Suite2p but don’t have 100,000 neuron recordings? We show you how to get those with a standard 2p microscope #neuroscience #imaging #neuroAI www.biorxiv.org/content/10.6...

🚨 new work from the lab on how eye movements 👀 versus orofacial movements influence 🐭 visual cortex activity 🧠 #neuroscience #behavior #neuroAI

Muscarinic Acetylcholine Receptor Activators as Transformative Therapeutics for Schizophrenia Review Article www.annualreviews.org/content/jour...

Rising Stars: In vivo monitoring of neurochemical dynamics by genetically encoded neuromodulator sensors www.sciencedirect.com/science/arti...

⚠️ New paper alert and what a way to end 2025! 🎉 Happy to share our story “Sleep-dependent infraslow rhythms are evolutionarily conserved across reptiles and mammals.” published today in Nature Neuroscience. Sleeping dragons 🦎 and functional ultrasound! Read the full paper here: rdcu.be/eWJHb 1/8

Patch-clamp data analysis in Python: dataframes and statistics spikesandbursts.wordpress.com/2025/12/28/p...

Spatially heterogeneous acetylcholine dynamics in the striatum promote behavioral flexibility Rewarded outcomes evoked phasic decreases in acetylcholine, whereas unexpected non-reward following reversal triggered widespread increases that predicted lose-shift behavior www.nature.com/articles/s41...

Modulation of metastable ensemble dynamics explains the inverted-U relationship between tone discriminability and arousal in auditory cortex Tone discriminability exhibited an inverted-U with arousal, which could be reproduced in a clustered spiking network model. www.cell.com/neuron/abstr...

Norepinephrine-mediated arousal fluctuations drive inverted U-shaped functional connectivity dynamics "we found arousal modulated inverted U-shaped global functional connectivity (FC) dynamics, peaking at middle arousal level" www.nature.com/articles/s41...

Intravital observation of neuronal and immune cell dynamics in the developing mammalian brain: www.cell.com/cell/fulltex... "intravital imaging of externally immobilized embryos (IMEE) method for long-term, large-field, and deep-depth imaging of mouse embryos"

You can now find all the patch-clamp Python notebooks on the blog's GitHub: github.com/dav1dcg/spik... And a new Python tutorial for using the motion-correction feature of the CaImAn toolbox: github.com/dav1dcg/neur... Hope you find them useful! github.com/dav1dcg/spik...

Time, space, memory and brain–body rhythms — a Perspective by György Buzsáki #neuroscience #neuroskyence www.nature.com/articles/s41...

REM sleep reduces subthreshold depolarization in cortical pyramidal neurons in a region-specific manner: doi.org/10.1016/j.ce... "NMDA receptors drive subthreshold depolarization specifically during REM sleep."

Continuous cell-type diversification in mouse visual cortex development www.nature.com/articles/s41...

Cracking the complexity of REM sleep www.cell.com/trends/neuro...

More powerful tools for understanding the brain. 🧠🔍 Today, comprehensive, cross-species developing brain cell atlases were released to help advance health and disease research. 🧵 #studyBRAIN #BICAN

First neurons didn’t appear overnight. We trace their roots to ancient secretory cells - showing how lifestyle & behavior shaped the evolution of first synapses.🧠🌊 #Evolution #Neuroscience Our latest in @natrevneuro.nature.com Link: rdcu.be/eMX3E @jeffcolgren.bsky.social @msarscentre.bsky.social

Illuminating calcium and potassium dynamics with red fluorescent sensors journals.plos.org/plosbiology/...

That merely being “under review” by a Nature family journal is offered as a quality proxy for a paper is a tragic illustration of the extent to which academia is addicted to brands and outsources evaluation

TT faculty job opening in #Neuroscience! We are looking for a colleague to join us in our fantastic Biology Department and Neuroscience Program at Brandeis. We are a group of *very* collaborative, supportive, and productive scientists (& humans!) so please apply academicjobsonline.org/ajo/jobs/30961

In case someone finds it more useful, I am starting to upload the code from the blog’s patch-clamp tutorials to GitHub. Check it out! github.com/dav1dcg/spik...

Modulation of speed-dependent acetylcholine release in the hippocampus by spatial task engagement: www.cell.com/cell-reports...

Distinct representations of economic variables across regions and projections of the frontal cortex: www.cell.com/neuron/fullt... Task for expected value and risk associated with reward-predicting stimuli. Stronger expected-value coding in dorsal cortex, risk coding in medial cortex.

Rapid adaptive optics enabling near noninvasive high-resolution brain imaging in awake behaving mice Under 2P excitation, adaptive optics measures the aberrated point spread function in ≈0.1 s/measurement, compensating for aberrations and scattering. www.nature.com/articles/s41...

As ever, beautiful #cryoEM work from the lab of Hong Zhou with field-defining insights using #cryoET: “Kiss-shrink-run” unifies mechanisms for synaptic vesicle exocytosis and hyperfast recycling | Science www.science.org/doi/10.1126/...