Jack Holcombe
@jackholcombe.bsky.social
📤 1115
📥 347
📝 101
Science, data and climbing
http://jackholcombe.com/
pinned post!
Such an amazing experience sharing science with a wonderful community! Thanks so much 🧬🔬@edrc2025.bsky.social
@fly-eds.bsky.social
5 months ago
3
15
3
reposted by
Jack Holcombe
Ben Ewen-Campen
2 days ago
My paper on how the fruit fly foregut uses a modified cell cycle to respond to tissue damage and cell loss is now published :)
www.nature.com/articles/s41...
#proventriculus
#drosophila
add a skeleton here at some point
4
42
12
reposted by
Jack Holcombe
Peter Stefanovic
6 days ago
'I didn't grow up wanting to be a politician, I'm a plumber' The green Party's Hannah Spencer has won the Gorton and Denton, with Reform in second and Labour finished third
loading . . .
72
1699
434
First bike to work without a coat this year! (Also whats that weird colour in the sky???)
6 days ago
1
3
0
reposted by
Jack Holcombe
Toby Andrews
about 1 month ago
Job alert! 📣 I’m looking for a research assistant to join my new team
@idrm.ox.ac.uk
Were using
#zebrafish
to understand gene-environment interactions that shape the heart 🫀generate natural diversity 🐸🐭 and contribute to congenital defects ❤️🩹 Full info below, and please share! 🫶🏻
bit.ly/467TO0M
0
34
23
reposted by
Jack Holcombe
Clelia Amato PhD
about 1 month ago
Have a look at our latest preprint, "Nuclear plasticity regulates macrophage phagocytic capacity in vivo".
#apoptoticbodies
#efferocytosis
#nucleus
#Drosophila
#macrophages
#mechanoresponse
#InVivo
#LiveImaging
doi.org/10.64898/202...
2
4
3
Amazing city, even better lab!
add a skeleton here at some point
about 1 month ago
0
1
0
reposted by
Jack Holcombe
Katy
3 months ago
Aaand... my first cover!! RpS6 phosphorylation (magenta) in a Udd (ribosome biogenesis factor) mutant ovary 🔬
add a skeleton here at some point
5
32
6
reposted by
Jack Holcombe
Rory Cooper
4 months ago
🚨 Come join us
@sheffielduni.bsky.social
for a PhD on the evolution and development of feathers and flight! 🐣🔬 This project is supervised by
@matt-towers.bsky.social
&
@alexgfletcher.bsky.social
, and I'm excited to be involved as a project advisor. Please share!
www.findaphd.com/phds/project...
🧪
3
36
19
reposted by
Jack Holcombe
Scott Waddell
4 months ago
@senapati.bsky.social
latest and greatest! Charly Treiber on board too. Over and out.
www.biorxiv.org/content/10.1...
loading . . .
Visceral signaling of post-ingestive malaise directs memory updating in Drosophila
Consolidation is a time when labile memories transition to a stable form. Malaise learning in Drosophila reveals consolidation to also permit memory updating. Flies taught to associate one of two odor...
https://www.biorxiv.org/content/10.1101/2025.10.21.683769v1
1
42
18
reposted by
Jack Holcombe
The Museum of English Rural Life
5 months ago
AWS is down, post hog
63
4641
1100
reposted by
Jack Holcombe
Taylor Mitchell Brown
5 months ago
Scientists just found several fossil bumblebees covered in pollen that directly matches fossil flowers nearby. The 24-million-year-old discovery reveals the oldest known evidence connecting pollinators to the pollinated.
#Paleontology
#NationalFossilDay
🧪🏺 New at
@sciencenews.bsky.social
loading . . .
These ancient bumblebees were found with their pollen source
Insects have long pollinated plants, but evidence of ancient pairing is rare. Fossils now show bees and linden trees goes back 24 million years.
https://www.sciencenews.org/article/ancient-bumblebees-found-pollen
12
456
122
reposted by
Jack Holcombe
Levayer Lab
5 months ago
Happy to share the last version of our story
@currentbiology.bsky.social
on the role of interfacial tension in mechanical cell competition led by
@leovalon.bsky.social
and Alexis Matamoro Vidal
www.sciencedirect.com/science/arti...
loading . . .
3
71
27
reposted by
Jack Holcombe
MRC Laboratory of Molecular Biology
5 months ago
John Gurdon, former Group Leader and Head of
@cellbiol-mrclmb.bsky.social
has died. Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology. More:
www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
3
99
35
Bloody lovely
www.bbc.co.uk/news/live/cy...
loading . . .
Firm linked to Baroness Michelle Mone must pay £122m after breaching Covid PPE contract, judge rules
The government wins its case against PPE Medpro - part of a consortium led by Baroness Mone's husband - after it supplied non-compliant gowns in 2020.
https://www.bbc.co.uk/news/live/cy08xg226l1t
5 months ago
1
2
0
reposted by
Jack Holcombe
Joachim Goedhart
5 months ago
Identification of optimal fluorophores for use in the Drosophila embryo by Timothy E Saunders and team:
www.biorxiv.org/content/10.1...
1
54
26
reposted by
Jack Holcombe
Bethan Clark
5 months ago
I wrote something on developmental biology and disability and put it up on the node last night:
thenode.biologists.com/developmenta...
I've been nervous to share because some of it veers a bit personal but they are thoughts that won't stay quiet. Would love to know what people think about it!
loading . . .
Developmental Biology and Disability - the Node
Hopeful monsters. Morphospace. Mutation. Natural variation. Mutagenesis screens. Polymorphism. Deformity. Phenotype. Disease. Adaptation. Anomaly.
https://thenode.biologists.com/developmental-biology-and-disability/uncategorized/
6
39
22
reposted by
Jack Holcombe
Delaevanio
5 months ago
Some amazing talks but highlights for me were David Bilder on innate immune-tumour interactions,
@jackholcombe.bsky.social
‘s PhD prize tour de force and exciting and beautiful data and new tools to look at basement membrane and clotting hot out of
@stramerlab.bsky.social
1
1
1
reposted by
Jack Holcombe
(GIRISH)MALI LAB
5 months ago
Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia. Open access link below:
www.nature.com/articles/s41...
Here's a cool animated summary
loading . . .
8
93
30
Such an amazing experience sharing science with a wonderful community! Thanks so much 🧬🔬@edrc2025.bsky.social
@fly-eds.bsky.social
5 months ago
3
15
3
reposted by
Jack Holcombe
EDRC2025
5 months ago
This is the organizing team behind
#EDRC2025
María Dominguez, Javier Morante
@morantelab.bsky.social
, Juan Sanchez-Alcaniz
@sanchezalcaniz.bsky.social
, Pepe Pastor-Pareja
@pastorparejalab.bsky.social
and Ana Carmena
0
24
7
reposted by
Jack Holcombe
Kyra Campbell
5 months ago
We are loving the
@edrc2025.bsky.social
!! Please come find us at the poster sessions and coffee breaks!
0
11
3
reposted by
Jack Holcombe
Dafni Hadjieconomou
5 months ago
If you find yourself at
@edrc2025.bsky.social
please check my wonderful postdoc's talk
@neurogut.bsky.social
at the gut workshop this afternoon. Gut, sex, reproduction, our new story! In combo with
@irenemiguel-aliaga.bsky.social
!
@fly-jedi.bsky.social
#EDRC2025
3
26
6
reposted by
Jack Holcombe
Ben Ewen-Campen
6 months ago
“Trump's Harvard cuts threaten a giant in the biomedical research community: A database about the tiny fruit fly” The FlyBase grant is run through the Perrimon lab at HMS, so when Trump cut off 100% of our NIH $, it causes existential risk to the entire community
www.nbcnews.com/science/scie...
loading . . .
Trump's Harvard cuts threaten a giant in biomedical research: A database about the tiny fruit fly
This spring, the Trump administration rescinded a grant that maintained FlyBase, a pillar of global basic research, as part of its broader $2.2 billion funding cuts at Harvard.
https://www.nbcnews.com/science/science-news/trumps-harvard-cuts-threaten-giant-biomedical-research-community-datab-rcna230610
0
10
5
reposted by
Jack Holcombe
Mark A. Hanson
8 months ago
Specifically on the
#metascience
side, congrats to
@josephlemaitre.bsky.social
and
@brunolemaitre.bsky.social
on this consequential piece. 🎉 By dissecting factors associated with
#reproducibility
within a single field, there are broad lessons for
#ScientificPublishing
and broader
#science
.
add a skeleton here at some point
0
5
5
reposted by
Jack Holcombe
Ben Ewen-Campen
8 months ago
🔬New paper! This has been my personal favorite project I’ve ever done - also, the only one that the President has been relentlessly trying to destroy by 100% defunding our lab & institution. Please enjoy:
www.biorxiv.org/content/10.1...
1
52
15
reposted by
Jack Holcombe
Alex Gould Lab
8 months ago
Calling all meeting organizers…
@biologists.bsky.social
now have a calculator to estimate your event’s carbon footprint and to test various reduction scenarios.
thenode.biologists.com/event-carbon...
loading . . .
Event carbon calculator - the Node
I am excited to announce the release of our event carbon calculator, our latest resource to support the creation of sustainable events. Estimate your
https://thenode.biologists.com/event-carbon-calculator/uncategorized/
4
37
20
reposted by
Jack Holcombe
Helena Cocheme
8 months ago
🎉Excited to share our latest paper, published in Nature Communications!🎉 "Enhancing autophagy by redox regulation extends lifespan in Drosophila"
#redox
#metabolism
#ageing
#Drosophila
@natcomms.nature.com
@mrc-lms.bsky.social
doi.org/10.1038/s414...
loading . . .
Enhancing autophagy by redox regulation extends lifespan in Drosophila - Nature Communications
Redox signalling is emerging as an important regulator of metabolism and physiology, which is dysregulated in ageing and disease. Here, the authors show that redox regulation of a key redox sensitive ...
https://doi.org/10.1038/s41467-025-60603-w
8
80
36
So honoured to receive this prize! Really looking forward to EDRC!
add a skeleton here at some point
9 months ago
1
8
0
reposted by
Jack Holcombe
EDRC2025
9 months ago
Congratulations to
@jackholcombe.bsky.social
for his
#EDS
best PhD thesis award! Jack will give a plenary talk at
#EDRC2025
add a skeleton here at some point
0
13
7
reposted by
Jack Holcombe
Gaynor Ann Smith
9 months ago
✨️ Come join my lab! ✨️ I have an ARUK funded post doc position available for a talented ECR to work with Drosophila and human iPSC derived neurons.
krb-sjobs.brassring.com/TGnewUI/Sear...
loading . . .
Job Search | Cardiff University
Search for Internet job results.
https://krb-sjobs.brassring.com/TGnewUI/Search/Home/HomeWithPreLoad?partnerid=30011&siteid=5460&PageType=searchResults&SearchType=linkquery&LinkID=6#jobDetails=2214379_5460
0
2
4
reposted by
Jack Holcombe
FlyBase
9 months ago
We currently have a call for support that has gone out to European labs, to support FlyBase-UK. We are asking our colleagues from labs in the US and other countries to wait for a similar call to them that will go out in the near future, to support the US sites. We thank you for your patience.
add a skeleton here at some point
0
81
126
reposted by
Jack Holcombe
Levayer Lab
10 months ago
Many cells during development are exposed to caspase activation and yet survive. Why some die and not others ? We found out that the memory of previous caspase activation bias significantly later death comitment and bias death distribution and single cell decision
www.biorxiv.org/content/10.1...
loading . . .
9
102
43
reposted by
Jack Holcombe
Mark A. Hanson
11 months ago
The mechanisms & regulation of insect
#antimicrobialpeptides
&
#HDPs
is of wide interest. We now appreciate their function in vivo is much more complex than what's described in vitro. Our primer on insect AMP regulation, evolution & function. Pub:
doi.org/10.1016/B978...
🟩OA:
bit.ly/MHLH2025
1/n
1
27
11
reposted by
Jack Holcombe
Andreas Prokop
11 months ago
If using Bloomigton
#Drosophila
Stock Center stocks, pls. acknowledge them & their NIH funding (P40 OD018537). Papers listing this no. are being harvested as evidence. We massively depend on the
@bdsc.bsky.social
& they need our support in these dire times!
@flybase.bsky.social
@fly-eds.bsky.social
0
93
107
reposted by
Jack Holcombe
British Society for Developmental Biology
11 months ago
We are delighted to announce that the winner of the 2025 Waddington Medal is Helen Skaer!
bsdb.org/2025/03/25/2...
1
39
16
reposted by
Jack Holcombe
Rory Cooper
12 months ago
Check out these feather buds on the chicken embryo's wing! Our latest study
@plosbiology.org
reveals that temporary inhibition of sonic hedgehog signalling transforms feathers into simple, protofeather-like structures—similar to those of their dinosaur ancestors🔬🦖🧪
journals.plos.org/plosbiology/...
loading . . .
7
119
41
reposted by
Jack Holcombe
Ali Twelvetrees
12 months ago
Do you need some science joy in your life? Do you like neurons? Maybe glia? Molecules? Cell biology? Save the date for
#NeuroBioUK25
- the venue is booked and we are excited to see you and your incredible science there on the 12th of September!
neurobiouk.sites.sheffield.ac.uk
1
29
16
reposted by
Jack Holcombe
Vincent Croset
about 1 year ago
‼️🔬 I am looking for a PhD student to investigate the molecular signatures of memory engrams in Drosophila. 🎓 Fully funded 4-year PhD position (BBSRC NEEDL) 📍 Durham University, UK More details and instructions to apply:
tinyurl.com/durhamPhD
#Drosophila
#Neuroskyence
#Neuroscience
#Memory
0
34
24
reposted by
Jack Holcombe
Austin E. Y. T. Lefebvre
about 1 year ago
Do you LOVE organelles?? Well I am THRILLED to announce that Nellie has been published in
@naturemethods.bsky.social
! Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy 🧵1/N
loading . . .
4
188
84
Beyond belief hearing the government brag about the UKs 'world class universities and lifesciences sector' when half of them are on the verge of collapse
about 1 year ago
0
1
0
reposted by
Jack Holcombe
Anestis Tsakiridis
about 1 year ago
Development folks: the next Northern England Developmental Biology
@bsdb.bsky.social
@biologists.bsky.social
meeting will take place on the 10th of July in Sheffield. Great speaker line-up, cheap registration fee and plenty of slots for ECR talks. Registration deadline=31/5, see poster for details
1
9
13
reposted by
Jack Holcombe
Carlos Ribeiro
about 1 year ago
Question to the
#neurobiology
#evolution
community: Can anyone point me to literature on the divergence in excitatory
#neurotransmitter
use between invertebrates and vertebrates? Specifically how insects got to mainly use acetylcholine and vertebrates glutamate? Thanks!
5
16
13
reposted by
Jack Holcombe
Helen Matthews
about 1 year ago
🚨 PhD position available for Oct 25 🔬Using advanced microscopy to understand how keratin networks control tissue mechanics An interdisciplinary
#cellbiology
#biophysics
collaboration with Ruby Peters &
@alicepyne.bsky.social
👇 Apply by March 14
www.findaphd.com/phds/project...
1
13
12
reposted by
Jack Holcombe
Mark A. Hanson
about 1 year ago
Per their request, we decided to go for it. I changed the title to "The strain on antioxidant publishing" and did a bunch of ctrl find+replace for words like "publisher" with "gut niche" and just sent it back. Find the paper here:
direct.mit.edu/qss/article/...
1/3
add a skeleton here at some point
3
48
16
reposted by
Jack Holcombe
Alicia Hidalgo Lab
about 1 year ago
Looking for an enthusiastic post-doc to investigate how experience shapes the brain. Drosophila neurogenetics, molecular and cellular mechanisms, imaging, optogenetics, neural circuits and behaviour will be used. At University of Birmingham campus, UK. Application deadline 19 March. Pls RT.
0
13
17
reposted by
Jack Holcombe
Neil Shubin
about 1 year ago
Gene editing technology began by people studying salt marshes. Ozempic began by folks studying the venom of Gila Monsters. Support for basic science has empowered us to understand our world. Tethering it to applications health has transformed and saved countless lives.
48
3322
743
I for one, accept and welcome our clam overlords with open arms
add a skeleton here at some point
about 1 year ago
0
1
0
reposted by
Jack Holcombe
Alex Gould Lab
about 1 year ago
Our latest... Congrats to Seb Sorge, Victor Girard & coauthors for devising HolFast, a chemically defined (holidic) diet for
#Drosophila
development that performs almost as well as a yeast diet. If you study developmental
#nutrition
or
#metabolism
please try it out...
www.cell.com/developmenta...
0
42
16
Stem cell or deathy looking skull???
#fluorescencefriday
about 1 year ago
0
18
0
Load more
feeds!
log in