Monoallelic IFT140 Variants Causing Childhood-Onset Autosomal Dominant Polycystic Kidney Disease bit.ly/3J9ZIWT

EDITORIAL: Guidance on Care for Autosomal Dominant Polycystic Kidney Disease: A Patient Perspective bit.ly/4bIyDEt (FREE)

Le #CJN en mode running c'est le #NEPHRORUN 🦵 l'occasion de visiter #STRASBOURG en brûlant des calories🥨 @dguerrot.bsky.social @mickaelbob.bsky.social @lobbedezt.bsky.social

J'ai lu le rapport provisoire de l'inspection générale des finances sur l'Ordre des médecins. Accrochez-vous, c'est du brutal ! 1/13 x.com/FannyRga/sta...

FIND CKD meets primary outcome (GFR slope) in n ~ 1500 with proteinuric non-diabetic CKD Bayer press release: www.bayer.com/media/en-us/... BL data + design paper pubmed.ncbi.nlm.nih.gov/38858818/ in NDT H/T Brendon Neuen on LinkedIn (!)

Urinary dipstick findings and UTI risk with SGLT2 inhibitors: a post hoc analysis of the CANVAS and CREDENCE trials doi.org/10.1093/ndt/...

Saline Doesn’t Ruin Hyponatremia Labs (and it might help) How many times have you been evaluating a patient in the ED and bemoaned the sneaky liter of saline they got before anyone sent some urine for analysis. Turns out it doesn't ruin the labs at all. pbfluids.com/2026/03/sali...

Great to see the fantastic nephrology podcast community highlighted by #NephMadness 👍 French-speaking listeners may also enjoy #NephrOdio, a nephrology education podcast with 630K downloads to date !

#NephMadness 2026: The PodCrawl Featuring these podcasts: - GN in Ten @isgd.bsky.social - Global Kidney Care @theisn.org - @freelyfiltered.bsky.social - @febrilepodcast.com - Kidney Commute @nkf-professionals.bsky.social - @coreimpodcast.bsky.social - Nephron Segment bit.ly/NM26Podcrawl

Finerenone improves kidney and cardiovascular outcomes in patients with chronic kidney disease and type 2 diabetes, but its efficacy in type 1 diabetes is unknown. The FINE-ONE trial involving patients with CKD and type 1 diabetes is summarized in a new Quick Take video. nej.md/3PcIJWt

This prospective study in #ASNJASN of 976 adults measured the association between subclinical primary aldosteronism and kidney outcomes. Read more: kidney.pub/JASN1039 Rémi Goupil#ASNJASN

🙋‍♀️🙋‍♂️ Help shape practice on hypertension in ADPKD! 🔎 An ERKNet survey for adult & pediatric nephrologists, based on a PKD France initiative with support by ERA Kidney & Genes WG and ESPN 🇪🇺 Many thanks for your input ! Dominique Guerrot & Djalila Mekahli

🙋‍♀️🙋‍♂️ Help shape practice on hypertension in ADPKD! 🔎 An ERKNet survey for adult & pediatric nephrologists, based on a PKD France initiative with support by ERA Kidney & Genes WG and ESPN 🇪🇺 Many thanks for your input ! Dominique Guerrot & Djalila Mekahli

www.sciencedirect.com/science/arti... Podocyte targeted therapy: TRPC6 inhibition for the treatment of focal segmental glomerulosclerosis: a randomised, placebo-controlled, phase 2 trial of BI 764198

Protein Intake and Mortality in Older Adults With CKD url: jamanetwork.com/journals/jam... discovered thanks to @cyrilmousseaux.bsky.social

Meta-analysis: #SGLT2 inhibitors slow kidney decline consistently across CKD severity and albuminuria range, supporting their routine use for kidney health. ja.ma/4pNzTve

CKD prevalence in elderly and the eGFR inflation effect, a very important paper in the @ndt-era.bsky.social . Not just for elderly but also for the young CKD population academic.oup.com/ndt/article/... #nephinp #nephrology_in_practice

#NephGR tomorrow at @ottawahospital.on.ca Tristan De Nattes from Rouen on treating ABMR #NephSky

Dans une nouvelle étude des scientifiques de l'Inserm ont analysé comment le système lymphatique se dérègle dans l’insuffisance cardiaque. Ils ont, pour la première fois, identifié les mécanismes responsables de ce dysfonctionnement. Lire le communiqué : presse.inserm.fr/decouverte-d...

For critically ill patients who had both severe metabolic acidemia and moderate to severe acute kidney injury, sodium bicarbonate therapy did not significantly decrease day 90 all-cause mortality. ja.ma/4pFsAWU

Well actually you wrote “renal” instead of “kidney” in a Twitter post in 2022… Access denied, sorry

Hypertension, un danger silencieux : venez participer à une matinée de sensibilisation jeudi 11 décembre à Marseille. www.laprovence.com/article/sant... #santé #hypertension

A long delay between pre print and publication means this paper only got better and better. Congrats @rose-hill.bsky.social and all collaborators, including many in renal physiology. A role for PIEZO2 in sensing pressure in the kidney and regulating the renin pathway. www.cell.com/cell/fulltex...

Stopping Versus Continuing Metformin in Patients With Advanced CKD: A Nationwide Scottish Target Trial Emulation Study bit.ly/3ZdrYxb #OpenAccess #VisualAbstract #CKD

I’ve called GLP-1 agents like Ozempic and Mounjaro "miracle drugs." But a new study forces me to re-evaluate that moniker. The miracle has a problem: It ends when the prescription runs out. Let's look at the data on the "Rebound Effect." 🧵

Among older adults with frailty, evidence on the benefits and risks of discontinuing antihypertensive drugs is limited. Research findings from the RETREAT-FRAIL trial are summarized in a new Quick Take video. nej.md/482WnBv #MedSky #CardioSky

Suivez le conseil du Pr Guerrot, signez et faites tourner cette pétition. On s'en fout que ce ne soit pas un outil parfait, c'est mieux que rien.

Our recording of an excellent and educational rounds by Dominique Bertrand from Rouen is now live www.youtube.com/watch?v=xUx3... #Transplantation in highly sensitized recipients, with the #imlifidase experience in particular!

Medicare for All would save $450B a year. Every dollar spent on food stamps generates $1.50-$1.80 in economic activity. Each dollar going to low-wage workers adds $1.20 to the economy overall. It’s not about what this country can or can’t afford. It’s about priorities.

I met a clever renal fellow at #KidneyWk who named his pets Ace and Arb. I’m inspired. I’ll name my next puppies Muddy and Waxy #UrinarySediment

In the PISCES trial involving participants receiving hemodialysis, fish oil (n−3 fatty acids) was compared with corn-oil placebo. The rate of serious cardiovascular events was lower with daily fish-oil supplementation. Full trial results: nej.md/49zWuqo @asnkidney.bsky.social | #KidneyWk

Highlights from my talk yesterday on Alport syndrome spectrum of disorders. (since no one posted it, I'll have to do it myself) Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵

Machine perfusion is better than just cold storage for kidneys 10 year follow up of the original 2009 trial in the @nejm.org www.nejm.org/doi/full/10.... #NephSky #KidneyWk

Interesting paper in @ckj-era.bsky.social - In my own practice I offer genetic testing to all my ADPKD patients now Genetic Testing in Autosomal Dominant Polycystic Kidney Disease: Why It Matters in 2025 url: academic.oup.com/ckj/article/...

Among participants with advanced pheochromocytoma or paraganglioma, belzutifan showed durable antitumor activity and a reduced need for antihypertensives, although most participants had treatment-related adverse events. Full LITESPARK-015 phase 2 trial results: nej.md/475bfP9 #ESMO25

🫀 #Hypertension in autosomal dominant polycystic kidney disease: unique pathways, common consequences. In #ADPKD, high blood pressure is often the first clinical sign and not just a complication of the kidney disease. Actually its mechanisms differ markedly from other CKD-related hypertension... 🧵

New—Effects of #empagliflozin on conventional and exploratory acute and chronic #kidney outcomes: an individual participant-level meta-analysis thelancet.com/journals/lan... #SGLT2 inhibitor #CKD #OpenAccess #MedSky #EndoSky #RenalSky

SGLT-2 Inhibition in ADPKD? DAPA-PKD & STOP-PKD - Prof. Emilie Cornec Le Gall & Prof. Roman-Ulrich Müller youtu.be/9e-UFBnIyDI?... @ecorneclegall.bsky.social @muellerrom.bsky.social @kronbichlerlab.bsky.social @sarahelena.bsky.social @gunnarheine.bsky.social @marcussaemann.bsky.social

Mono-allelic pathogenic variants in JAG1 cause Autosomal Dominant Tubulo-interstitial Kidney Disease (ADTKD-JAG1) doi.org/10.1016/j.kint.2025.08.033 #ckd #chronickidneydisease #MedSky #NephSky @institutimagine.bsky.social @lafhf.bsky.social @nihrnewcastlebrc.bsky.social @ap-hp.bsky.social

Childhood obesity has quadrupled since the 1960s. Now over 20% of kids meet the definition (>95th percentile of BMI). This is driving type 2 diabetes in children, and increases the risk of other diseases as adults. We need to talk about weight-loss drugs for kids. 🧵

In this video, Professor Dominique Guerrot presents the DAPA-PKD study, a collaborative research effort he co-leads with Professor Emilie Cornec-Le Gall (Brest). This important study will evaluate the potential of SGLT2 inhibitors, such as dapagliflozin, in the treatment of #ADPKD.

Tonight it's all about ADPKD! KDIGO Guidelines / ERA Genes & Kidney Working Group - Prof. Roser Torra, Prof. Roman-Ulrich Müller youtu.be/qjnYDsYbx0Q?... @rosertorra.bsky.social @muellerrom.bsky.social @dguerrot.bsky.social @gunnarheine.bsky.social @kronbichlerlab.bsky.social

I have a feeling sales of home blood pressure cuffs are going to spike because people working in Primary Care like myself are going to be telling patients to confirm what the Apple watch is telling them with an actual blood pressure cuff.

🧵How to write and manage your first research budgets The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.

📚 The 2025 #KDIGO Guidelines recommend ambitious BP targets to manage hypertension in ADPKD: 🎯 ≤110/75 mmHg (HBPM) for adults <50 y with preserved renal function (G1–G2), 🎯 <120 mmHg systolic (office BP) in older adults, if tolerated.

#NephrOdio podcasts 🎧 🚀 Half a million downloads !

New 2025 AHA/ACC Hypertension Guideline dropped! www.jacc.org/doi/10.1016/... #hypertension #medsky #nephsky

CONFIDENCE trial: For patients with both chronic kidney disease and type 2 diabetes, whether combination therapy with finerenone and empagliflozin would improve outcomes over single-drug therapy is unclear. Research findings are summarized in a new Quick Take video. nej.md/40Szhuy

In the introduction, @johngreensbluesky.bsky.social drops some TB facts Annually more than a million people die of TB Overall, more than a *billion* people have died of TB in last 2 centuries That’s also something like 1 in 7 people who have ever lived 🤯 #NephJCBookClub

🫀 #Hypertension in autosomal dominant polycystic kidney disease: unique pathways, common consequences. In #ADPKD, high blood pressure is often the first clinical sign and not just a complication of the kidney disease. Actually its mechanisms differ markedly from other CKD-related hypertension... 🧵