CKD prevalence in elderly and the eGFR inflation effect, a very important paper in the @ndt-era.bsky.social . Not just for elderly but also for the young CKD population academic.oup.com/ndt/article/... #nephinp #nephrology_in_practice

#NephGR tomorrow at @ottawahospital.on.ca Tristan De Nattes from Rouen on treating ABMR #NephSky

Dans une nouvelle étude des scientifiques de l'Inserm ont analysé comment le système lymphatique se dérègle dans l’insuffisance cardiaque. Ils ont, pour la première fois, identifié les mécanismes responsables de ce dysfonctionnement. Lire le communiqué : presse.inserm.fr/decouverte-d...

For critically ill patients who had both severe metabolic acidemia and moderate to severe acute kidney injury, sodium bicarbonate therapy did not significantly decrease day 90 all-cause mortality. ja.ma/4pFsAWU

Well actually you wrote “renal” instead of “kidney” in a Twitter post in 2022… Access denied, sorry

Hypertension, un danger silencieux : venez participer à une matinée de sensibilisation jeudi 11 décembre à Marseille. www.laprovence.com/article/sant... #santé #hypertension

A long delay between pre print and publication means this paper only got better and better. Congrats @rose-hill.bsky.social and all collaborators, including many in renal physiology. A role for PIEZO2 in sensing pressure in the kidney and regulating the renin pathway. www.cell.com/cell/fulltex...

Stopping Versus Continuing Metformin in Patients With Advanced CKD: A Nationwide Scottish Target Trial Emulation Study bit.ly/3ZdrYxb #OpenAccess #VisualAbstract #CKD

I’ve called GLP-1 agents like Ozempic and Mounjaro "miracle drugs." But a new study forces me to re-evaluate that moniker. The miracle has a problem: It ends when the prescription runs out. Let's look at the data on the "Rebound Effect." 🧵

Among older adults with frailty, evidence on the benefits and risks of discontinuing antihypertensive drugs is limited. Research findings from the RETREAT-FRAIL trial are summarized in a new Quick Take video. nej.md/482WnBv #MedSky #CardioSky

Suivez le conseil du Pr Guerrot, signez et faites tourner cette pétition. On s'en fout que ce ne soit pas un outil parfait, c'est mieux que rien.

Our recording of an excellent and educational rounds by Dominique Bertrand from Rouen is now live www.youtube.com/watch?v=xUx3... #Transplantation in highly sensitized recipients, with the #imlifidase experience in particular!

Medicare for All would save $450B a year. Every dollar spent on food stamps generates $1.50-$1.80 in economic activity. Each dollar going to low-wage workers adds $1.20 to the economy overall. It’s not about what this country can or can’t afford. It’s about priorities.

I met a clever renal fellow at #KidneyWk who named his pets Ace and Arb. I’m inspired. I’ll name my next puppies Muddy and Waxy #UrinarySediment

In the PISCES trial involving participants receiving hemodialysis, fish oil (n−3 fatty acids) was compared with corn-oil placebo. The rate of serious cardiovascular events was lower with daily fish-oil supplementation. Full trial results: nej.md/49zWuqo @asnkidney.bsky.social | #KidneyWk

Highlights from my talk yesterday on Alport syndrome spectrum of disorders. (since no one posted it, I'll have to do it myself) Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵

Machine perfusion is better than just cold storage for kidneys 10 year follow up of the original 2009 trial in the @nejm.org www.nejm.org/doi/full/10.... #NephSky #KidneyWk

Interesting paper in @ckj-era.bsky.social - In my own practice I offer genetic testing to all my ADPKD patients now Genetic Testing in Autosomal Dominant Polycystic Kidney Disease: Why It Matters in 2025 url: academic.oup.com/ckj/article/...

Among participants with advanced pheochromocytoma or paraganglioma, belzutifan showed durable antitumor activity and a reduced need for antihypertensives, although most participants had treatment-related adverse events. Full LITESPARK-015 phase 2 trial results: nej.md/475bfP9 #ESMO25

🫀 #Hypertension in autosomal dominant polycystic kidney disease: unique pathways, common consequences. In #ADPKD, high blood pressure is often the first clinical sign and not just a complication of the kidney disease. Actually its mechanisms differ markedly from other CKD-related hypertension... 🧵

New—Effects of #empagliflozin on conventional and exploratory acute and chronic #kidney outcomes: an individual participant-level meta-analysis thelancet.com/journals/lan... #SGLT2 inhibitor #CKD #OpenAccess #MedSky #EndoSky #RenalSky

SGLT-2 Inhibition in ADPKD? DAPA-PKD & STOP-PKD - Prof. Emilie Cornec Le Gall & Prof. Roman-Ulrich Müller youtu.be/9e-UFBnIyDI?... @ecorneclegall.bsky.social @muellerrom.bsky.social @kronbichlerlab.bsky.social @sarahelena.bsky.social @gunnarheine.bsky.social @marcussaemann.bsky.social

Mono-allelic pathogenic variants in JAG1 cause Autosomal Dominant Tubulo-interstitial Kidney Disease (ADTKD-JAG1) doi.org/10.1016/j.kint.2025.08.033 #ckd #chronickidneydisease #MedSky #NephSky @institutimagine.bsky.social @lafhf.bsky.social @nihrnewcastlebrc.bsky.social @ap-hp.bsky.social

Childhood obesity has quadrupled since the 1960s. Now over 20% of kids meet the definition (>95th percentile of BMI). This is driving type 2 diabetes in children, and increases the risk of other diseases as adults. We need to talk about weight-loss drugs for kids. 🧵

In this video, Professor Dominique Guerrot presents the DAPA-PKD study, a collaborative research effort he co-leads with Professor Emilie Cornec-Le Gall (Brest). This important study will evaluate the potential of SGLT2 inhibitors, such as dapagliflozin, in the treatment of #ADPKD.

Tonight it's all about ADPKD! KDIGO Guidelines / ERA Genes & Kidney Working Group - Prof. Roser Torra, Prof. Roman-Ulrich Müller youtu.be/qjnYDsYbx0Q?... @rosertorra.bsky.social @muellerrom.bsky.social @dguerrot.bsky.social @gunnarheine.bsky.social @kronbichlerlab.bsky.social

I have a feeling sales of home blood pressure cuffs are going to spike because people working in Primary Care like myself are going to be telling patients to confirm what the Apple watch is telling them with an actual blood pressure cuff.

🧵How to write and manage your first research budgets The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.

📚 The 2025 #KDIGO Guidelines recommend ambitious BP targets to manage hypertension in ADPKD: 🎯 ≤110/75 mmHg (HBPM) for adults <50 y with preserved renal function (G1–G2), 🎯 <120 mmHg systolic (office BP) in older adults, if tolerated.

#NephrOdio podcasts 🎧 🚀 Half a million downloads !

New 2025 AHA/ACC Hypertension Guideline dropped! www.jacc.org/doi/10.1016/... #hypertension #medsky #nephsky

CONFIDENCE trial: For patients with both chronic kidney disease and type 2 diabetes, whether combination therapy with finerenone and empagliflozin would improve outcomes over single-drug therapy is unclear. Research findings are summarized in a new Quick Take video. nej.md/40Szhuy

In the introduction, @johngreensbluesky.bsky.social drops some TB facts Annually more than a million people die of TB Overall, more than a *billion* people have died of TB in last 2 centuries That’s also something like 1 in 7 people who have ever lived 🤯 #NephJCBookClub

🫀 #Hypertension in autosomal dominant polycystic kidney disease: unique pathways, common consequences. In #ADPKD, high blood pressure is often the first clinical sign and not just a complication of the kidney disease. Actually its mechanisms differ markedly from other CKD-related hypertension... 🧵

should we screen for CKD in the general population? Finally, flozins, finerenone and GLP1s allow a good cost-effectiveness case www.nephjc.com/news/2025/7/... for #NephJC shorts Time to stop just being dialysis-ologists and flozinate, glipinate! #NephSky

Awesome infographic on genetic testing in ADPKD by Neera Dahl, @pranavgarimella.bsky.social and Fouad Chebib www.kidneynews.org/view/journal...

"The suburbia of Rouen" @dguerrot.bsky.social

Watch our next stop on YouTube: Diagnosis of Allograft Rejection Today & Tomorrow - Dr. Olivier Aubert, Dr. Aylin Akifova @olivieraubert.bsky.social @aylinink.bsky.social youtu.be/cqe3R3Q9B4Y?...

❓ Can we measure #bloodpressure in the arm with a closed AV #fistula after kidney transplant? ✅ YES! Here is our our latest study published in Hypertension @ahajournals.bsky.social showing no significant BP difference between arms post-AVF closure 👉🏼 www.ahajournals.org/doi/10.1161/...

Our second stop (Tour Academique): Update PD: Focus Assisted PD & Anticoagulation - Prof. T. Lobbedez & Dr. C. Béchade (Caen, France) @lobbedezt.bsky.social @clemencebechade.bsky.social youtu.be/rLO1X7sBILc?...

It's Tour Académique time again! Our first stop: Imlifidase in Highly Sensitized Allograft Recipients - Dr. Dominique Bertrand (Rouen, France) youtu.be/4xWzaXn0o8w?...

On est parti ! #TourAcadémique2025 @dgfn.bsky.social @oegn.bsky.social @sfndt.bsky.social @dguerrot.bsky.social youtube.com/watch?v=4xWz...

📅Tour Académique 2025 from 4th-25th July: French, German & Austrian nephrologists will present current research & practical topics relating to renal medicine.Topics: AKI after Glyoxylic Acid for Hair-Straightening | Update PD /Imlifidase in Highly Sensitized Allograft Recipients etc.

Join us for our Grand Départ on Friday Evening! 🙏 to @dguerrot.bsky.social for co-chairing notre #TourAcadémique 2025 @markusathome.bsky.social

#TourAcadémique2025 Proud to announce this year's line-up together with @dguerrot.bsky.social @dgfn.bsky.social @oegn.bsky.social @sfndt.bsky.social youtu.be/dK4NO5TTKl4?...

And live at NEJM www.nejm.org/doi/full/10.... Trial from Ottawa at #CCR25 Really, who still cares about balanced versus normal saline arguments! (Beyond some nerdy nephrons and Josh)

In the CONFIDENCE trial in persons with chronic kidney disease and type 2 diabetes, combination therapy with finerenone and empagliflozin led to a greater reduction in the urinary albumin-to-creatinine ratio than either drug alone. Full trial results: nej.md/4jEVbbk #ERA25 #MedSky #Nephrology

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This is such a great resource: www.kidney-international.org/article/S008... #nephrology #eGFR

Promising! flozination in ADPKD (mostly older adults with DM or CVD) - presumably those with another valid indication - associated with slower GFR slope journals.lww.com/cjasn/pages/... in @asnpublications.bsky.social #CJASN With no obvious harm signal