ICYMI: Why are damaged muscles more likely to generate fatty tissue as we age? doi.org/10.1172/JCI1... Pei Wang & team find gasdermin E signaling unexpectedly promotes skeletal muscle repair by sustaining tissue-resident macrophage function and restraining maladaptive adipose tissue remodeling.

Wetterwald, Köck et al. @petrovalab.bsky.social report the existence of an endothelial metabolic checkpoint where MYCT1 restricts activity of IFITM2/3 to prevent energy waste at the vascular barrier and enable fat storage. rupress.org/jem/article/... 🎥 See video summary: youtu.be/SGZ-5GiZvrI

Iruela-Arispe highlights new work by @petrovalab.bsky.social (rupress.org/jem/article/...) showing that endothelial cells actively regulate energy storage in white adipose tissue through MYCT1–IFITM2/3-dependent control of endolysosomal trafficking & mTORC1 signaling. rupress.org/jem/article/...

Proteinase 3 Drives Murine Diabetic Kidney Disease by Mediating Caspase-3-dependent Apoptosis of Podocytes doi.org/10.1016/j.kint.2026.02.020 #MedSky #NephSky #OpenAccess #diabetes #diabeticnephropathy

Patients with recurrent kidney stone disease stand to benefit from personalized diagnostics. Here, Ruxandra Bachmann-Gagescu & team perform deep biochemical phenotyping, revealing prognostic value of rare genetic variants in adult kidney stone disease: doi.org/10.1172/JCI1...

ercsg2026.com A stimulating scientific event to present and discuss #kidneydisease #science4health #pathomechanisms #translationalresearch #emergingtherapies and more! The European kidney community will convene in Paris from April 9-12

Don’t overlook the kidney in SARS-CoV-2 pneumonia—even in the absence of overt acute kidney injury @olilen.bsky.social, Pierre-Louis Tharaux & team report on a strong association between kidney-derived proteins and IL-10 levels and mortality: doi.org/10.1172/jci....

www.sciencedirect.com/science/arti... Podocyte targeted therapy: TRPC6 inhibition for the treatment of focal segmental glomerulosclerosis: a randomised, placebo-controlled, phase 2 trial of BI 764198

Des scientifiques de l'Inserm ont identifié des indicateurs biologiques permettant de prédire la mortalité à 3 mois des patients hospitalisés pour une pneumonie Covid-19 peu sévère. Lire le communiqué : presse.inserm.fr/covid-19-dec...

@insight.jci.org the CORIMUNO-19 collaborative group releases a predictive score for COVID-19 and unravels the overlooked impact of subclinical acute kidney injury. @inserm.fr @ap-hp.bsky.social @inserm.fr @frm-officiel.bsky.social @anrs-mie.bsky.social 10.1172/jci.insight.198244

Mineralocorticoid receptor inhibition in parietal epithelial cells prevents focal segmental glomerulosclerosis and crescentic glomerulonephritis. doi.org/10.1016/j.kint.2025.07.037 #OpenAccess #NephSky #MedSky #CKD #FSGS #chronickidneydisease @parcc-inserm.bsky.social @rwth.bsky.social

Executive summary of the #KDIGO 2025 Clinical Practice Guideline for the Management of Immunoglobulin A Nephropathy (#IgAN) and Immunoglobulin A Vasculitis (#IgAV) doi.org/10.1016/j.kint.2025.04.003 #OpenAccess #MedSky #NephSky @kdigo.org

Among hypertensive adults with ambulatory AKI, this #ASNCJASN study found plasma biomarkers reflecting impaired kidney tubule health measured at the time of ambulatory AKI are associated with subsequent non-recovery in kidney function. Read more: kidney.pub/CJASN0910

📚 Déjà 97 articles sur le blog 'Le #diabète dans tous ses états' ! Un contenu rigoureux et accessible. Physiopathologie, traitements, complications, innovations… Une ressource unique pour comprendre toutes les facettes de cette maladie complexe www.le-diabete-dans-tous-ses-etats.precidiab.org

Syndrome d’auto-brasserie : être ivre sans boire une goutte d’alcool Ce trouble diffère du syndrome d'auto-brasserie urinaire dans lequel on trouve de l’alcool dans l’urine mais pas dans le sang. www.lemonde.fr/blog/realite... [Rediff]

Video Abstract: Capillary loss and fibrosis in experimental kidney disease is prevented with TIE2 activation: youtu.be/oSB3CP5UDPE

Cancer : la France doit savoir pourquoi elle est surexposée

Mineralocorticoid Receptor #MR inhibition in parietal epithelial cells #PEC prevents #FSGS and #crescenticGN. Furthermore, we didn’t find 11βHSD in PECs, suggesting that standard of care could stimulate MR, which is not optimal. @isgd.bsky.social doi.org/10.1016/j.ki...

Perturbation of the circadian clock in chronic diseases involving organ fibrosis This review by Mukherji et al. highlights circadian mechanisms, their perturbations predisposing toward chronic disease and fibrosis, and the promise of chronotherapy: www.jci.org/articles/vie...

Enthusiastic about this emerging field. Perhaps a key to understanding and treating the multiorgan complications of #diabetes and #metabolic syndrome?

Inspiring and fun meeting with outstanding @rkramann.bsky.social at the @parcc-inserm.bsky.social #Masterclass @olilen.bsky.social with the community, #our KVIM team and young early career researchers ! Thank you Rafael!

Inhibiting MR protects against glomerular damage by preventing the activation of parietal epithelial cells. A novel mechanism that should impact medical practice. www.sciencedirect.com/science/arti... @parcc-inserm.bsky.social @olilen.bsky.social @upcite.bsky.social @inserm.fr

Nature research paper: Ribonucleotide incorporation into mitochondrial DNA drives inflammation go.nature.com/3KBRg2W

Take a peek: This issue’s cover features 3D imaging and single-cell genomics by David A. Long @daniyaljafree.bsky.social & team, revealing lymphatic rewiring in kidney tissue with chronic transplant rejection: buff.ly/BZEw4az

Hoover, Hacohen, Davidson @northwellhealth.bsky.social et al. analyze the intrarenal myeloid compartment in four #lupus #nephritis mouse models and 155 humans using single-cell profiling, spatial transcriptomics, and functional studies. rupress.org/jem/article/...

Arase, Murakami, Takeda et al. identify RUNX2 and BHLHE40 as key factors driving tissue-resident memory T cells (TRM) characteristic of #Crohns disease. Blocking these transcription factors mitigated the cytotoxic TRM phenotype in human disease samples. rupress.org/jem/article/...

Is #preeclampsia ever “mild?” Lessons on long-term consequences for offspring from a Danish registry–based study Commentary by S Jesudason & G Piccoli doi.org/10.1016/j.kint.2025.05.011 Original article: doi.org/10.1016/j.kint.2025.04.017 #MedSky #NephSky #CKD #diabeticnephropathy #PedsNeph

Super-resolved optical imaging, reconstruction, and spatial analysis of whole mouse glomeruli via the Glomerulus Mapping and Analysis Pipeline doi.org/10.1016/j.kint.2025.07.024 #NephSky #MedSky #glomerulus @uwchemistry.bsky.social @uwcse.bsky.social @uwnephrology.bsky.social

Kidney-resident macrophages limit toxin-induced inflammation through their hallmark functions doi.org/10.1016/j.kint.2025.07.022 #NephSky #MedSky #AKI #acutekidneyinjury

ICYMI: Chemotaxis as a driver in immune privilege. O. Thaunat & team dissect the mechanisms of endothelial preservation during cellular rejection and identify mechanisms underlying graft vasculature immune privilege. buff.ly/Mwn8t1c

ICYMI:

‼️EXTRAORDINARY WORLD RECORD Brutal 48.5C Chillas,PAKISTAN 🇵🇰 1250m ! WORLD RECORD OF HIGHEST TEMPERATURE ABOVE 1000M asl BUT...Yesterday 49.3C Bafq IRAN 🇮🇷 altitude 999m (they should have moved the station a bit) Also crazy 46.1C Bunji 🇵🇰1469m asl History is rewritten again

New organ clock data support the anti-aging benefits of estrogen for postmenopausal women. Reviewed here in context with previous and other recent reports. erictopol.substack.com/p/new-anti-a...

Hot day on the French Riviera: With 37.4C Sete broke its record of July highest temperature on record.

East Asia: The hell is coming. Eastern China,The Koreas,Japan and parts of Far East Russia are gonna live hazardous conditions with temperatures up to 40C,up to 30C at night,extreme humidity and locally heat indexes >50C. Records will be hundreds (at best)

A highly transmissible new COVID-19 variant is spreading in the U.S. “Those in high-risk groups should consider getting the vaccine now if they haven’t been vaccinated in the last six months," Prof. Albert Ko told TODAY. www.today.com/health...

A proof-of-concept study for determining the functional impact of variants of uncertain significance (VUS)! Muthiah Bose et al. used CRISPR-Select as a tool in the classification of rare VUS in the PALB2-binding domain of BRCA2: buff.ly/oFc574N

ICYMI: A smooth operator for blood pressure! Katherine Gallagher & team show the histone demethylase JMJD3 in vascular smooth muscle cells regulates endothelin receptor expression and blood pressure: buff.ly/K8b0CnB

EXTRAORDINARY- MOST EXTREME HEAT WAVE IN WORLD CLIMATIC HISTORY 52.6 in Kuwait,widespread 49/50C in a dozen countries. 44C at 45 latitude in Kazakhstan with night minimums up to 29C Next days Dozens of thousands of records from Morocco to Japan broken locally with 5/6C margins

🚨 LATE-BREAKING SESSION ALERT 🚨 #PodocyteConference 🐙 Pathology-oriented multiplex integrative mapping - Victor Puelles introduces the PathoPlex! 🔥 Can we relate outcomes with disease-specific tissue mapping? 🧐 tobias-b-huber.bsky.social

🌟 EMERGING CAREER HIGHLIGHTS 🌟 #PodocyteConference 🐙 Fantastic talk by Charlotte Boys on the molecular heterogeneity of PEC proliferation in IgAN and FSGS - future secrets for crescents? 🌙 tobias-b-huber.bsky.social

Prof. dannygale.bsky.social‬ enlightens how studying large cohorts, such as the RaDaR Registry, allows for deeper understanding and gap closing in rare diseases 🔑 #PodocyteConference 🐙 ukkidney.org‬ tobias-b-huber.bsky.social

A look into the future by Prof. Moin Saleem 🧐 at the #PodocyteConference 🐙 Walking towards gene therapy in Glomerular Diseases 🧬🤯 kidneyresearchuk.org‬ tobias-b-huber.bsky.social

Brilliant talk by Prof. Ulf Panzer at the #PodocyteConference 🐙 From immune-profiling to precise treatment 🎯 and a new hypothesis involving Granzyme K in ANCA-GN 🌟 tobias-b-huber.bsky.social

Excellent lecture and work on the central role of PECs in crescent formation 🌙 by Prof. Pierre-Louis Tharaux at the #PodocyteConference 🐙 tobias-b-huber.bsky.social

Exciting news! 🌟 The ISGD Centers of Excellence in Glomerular Disease (COE-GD) criteria have been finalized after 2+ years of meticulous work. Read our full press release here and learn about our commitment to advance GD care, research, and advocacy! 👉 bit.ly/COE-GD #ISGD #GlomerularDisease #COEGD

p-Tau217 is a breakthrough blood test that can predict and may help prevent Alzheimer's disease. erictopol.substack.com/p/the-breakt... Here's the rundown on it. Free, open-access.

The real problem about science isn't about loss of trust. It's about not having a voice, a counter. @nature.com www.nature.com/articles/d41... Whai if the 300,000 scientists supported by NIH stood up? Or even half of them. Instead of <1%