@tharaux-lenoir-lab.bsky.social
đ€ 22
đ„ 49
đ 10
reposted by
Kidney International
3 months ago
Mineralocorticoid receptor inhibition in parietal epithelial cells prevents focal segmental glomerulosclerosis and crescentic glomerulonephritis.
doi.org/10.1016/j.kint.2025.07.037
#OpenAccess
#NephSky
#MedSky
#CKD
#FSGS
#chronickidneydisease
@parcc-inserm.bsky.social
@rwth.bsky.social
0
9
3
reposted by
Kidney International
2 months ago
Executive summary of the
#KDIGO
2025 Clinical Practice Guideline for the Management of Immunoglobulin A Nephropathy (#IgAN) and Immunoglobulin A Vasculitis (#IgAV)
doi.org/10.1016/j.kint.2025.04.003
#OpenAccess
#MedSky
#NephSky
@kdigo.org
0
5
3
reposted by
ASN Publications
about 1 month ago
Among hypertensive adults with ambulatory AKI, this #ASNCJASN study found plasma biomarkers reflecting impaired kidney tubule health measured at the time of ambulatory AKI are associated with subsequent non-recovery in kidney function. Read more:
kidney.pub/CJASN0910
0
3
1
reposted by
Marc Gozlan
about 1 month ago
đ DĂ©jĂ 97 articles sur le blog 'Le
#diabĂšte
dans tous ses états' ! Un contenu rigoureux et accessible. Physiopathologie, traitements, complications, innovations⊠Une ressource unique pour comprendre toutes les facettes de cette maladie complexe
www.le-diabete-dans-tous-ses-etats.precidiab.org
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Le DiabÚte dans tous ses états
Un blog, comme aucun autre, pour dĂ©couvrir et tout comprendre des mille et une facettes du diabĂšte et de lâobĂ©sitĂ©.
https://www.le-diabete-dans-tous-ses-etats.precidiab.org/
0
8
5
reposted by
Marc Gozlan
about 1 month ago
Syndrome dâauto-brasserie : ĂȘtre ivre sans boire une goutte dâalcool Ce trouble diffĂšre du syndrome d'auto-brasserie urinaire dans lequel on trouve de lâalcool dans lâurine mais pas dans le sang.
www.lemonde.fr/blog/realite...
[Rediff]
0
7
4
reposted by
Journal of Clinical Investigation
about 2 months ago
Video Abstract: Capillary loss and fibrosis in experimental kidney disease is prevented with TIE2 activation:
youtu.be/oSB3CP5UDPE
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Capillary loss and fibrosis in experimental kidney disease is prevented with TIE2 activation
In this episode, Marie Jeansson explains how the paper's findings suggest that TIE2 activation via angiopoietin-2âbinding and TIE2-activating antibody warrants investigation as a therapy in humanâŠ
https://youtu.be/oSB3CP5UDPE
0
1
1
reposted by
Le Monde
3 months ago
Cancer : la France doit savoir pourquoi elle est surexposée
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Cancer : la France doit savoir pourquoi elle est surexposée
LâĂ©tude du « Lancet », qui a placĂ© la France en tĂȘte des pays les plus touchĂ©s, doit servir de signal dâalarme. Quâun pays dĂ©veloppĂ© ignore lâensemble des causes dâune incidence singuliĂšre du cancer nâest pas acceptable.
https://www.lemonde.fr/idees/article/2025/10/11/cancer-la-france-doit-savoir-pourquoi-elle-est-surexposee_6645750_3232.html
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Mineralocorticoid Receptor
#MR
inhibition in parietal epithelial cells
#PEC
prevents
#FSGS
and
#crescenticGN
. Furthermore, we didnât find 11ÎČHSD in PECs, suggesting that standard of care could stimulate MR, which is not optimal.
@isgd.bsky.social
doi.org/10.1016/j.ki...
3 months ago
0
0
0
reposted by
Journal of Clinical Investigation
3 months ago
Perturbation of the circadian clock in chronic diseases involving organ fibrosis This review by Mukherji et al. highlights circadian mechanisms, their perturbations predisposing toward chronic disease and fibrosis, and the promise of chronotherapy:
www.jci.org/articles/vie...
0
5
4
Enthusiastic about this emerging field. Perhaps a key to understanding and treating the multiorgan complications of
#diabetes
and
#metabolic
syndrome?
add a skeleton here at some point
3 months ago
0
1
1
Inspiring and fun meeting with outstanding
@rkramann.bsky.social
at the
@parcc-inserm.bsky.social
#Masterclass
@olilen.bsky.social
with the community,
#our
KVIM team and young early career researchers ! Thank you Rafael!
3 months ago
1
5
1
Inhibiting MR protects against glomerular damage by preventing the activation of parietal epithelial cells. A novel mechanism that should impact medical practice.
www.sciencedirect.com/science/arti...
@parcc-inserm.bsky.social
@olilen.bsky.social
@upcite.bsky.social
@inserm.fr
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Mineralocorticoid receptor inhibition in parietal epithelial cells prevents focal segmental glomerulosclerosis and crescentic glomerulonephritis.
Focal segmental glomerulosclerosis (FSGS) is a common histological lesion in adults worldwide. It results from initial podocyte injury, followed by a âŠ
https://www.sciencedirect.com/science/article/pii/S0085253825007483
3 months ago
1
2
0
reposted by
Nature
3 months ago
Nature research paper: Ribonucleotide incorporation into mitochondrial DNA drives inflammation
go.nature.com/3KBRg2W
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Ribonucleotide incorporation into mitochondrial DNA drives inflammation - Nature
Imbalanced nucleotide metabolism leads to age- and mtDNA-dependent inflammatory responses and senescence-associated secretory phenotype in senescence.
https://go.nature.com/3KBRg2W
1
17
6
reposted by
Journal of Clinical Investigation
3 months ago
Take a peek: This issueâs cover features 3D imaging and single-cell genomics by David A. Long
@daniyaljafree.bsky.social
& team, revealing lymphatic rewiring in kidney tissue with chronic transplant rejection:
buff.ly/BZEw4az
0
5
2
reposted by
Journal of Experimental Medicine
4 months ago
Hoover, Hacohen, Davidson
@northwellhealth.bsky.social
et al. analyze the intrarenal myeloid compartment in four
#lupus
#nephritis
mouse models and 155 humans using single-cell profiling, spatial transcriptomics, and functional studies.
rupress.org/jem/article/...
0
3
1
reposted by
Journal of Experimental Medicine
4 months ago
Arase, Murakami, Takeda et al. identify RUNX2 and BHLHE40 as key factors driving tissue-resident memory T cells (TRM) characteristic of
#Crohns
disease. Blocking these transcription factors mitigated the cytotoxic TRM phenotype in human disease samples.
rupress.org/jem/article/...
0
2
1
reposted by
Kidney International
4 months ago
Is
#preeclampsia
ever âmild?â Lessons on long-term consequences for offspring from a Danish registryâbased study Commentary by S Jesudason & G Piccoli
doi.org/10.1016/j.kint.2025.05.011
Original article:
doi.org/10.1016/j.kint.2025.04.017
#MedSky
#NephSky
#CKD
#diabeticnephropathy
#PedsNeph
0
4
5
reposted by
Kidney International
4 months ago
Super-resolved optical imaging, reconstruction, and spatial analysis of whole mouse glomeruli via the Glomerulus Mapping and Analysis Pipeline
doi.org/10.1016/j.kint.2025.07.024
#NephSky
#MedSky
#glomerulus
@uwchemistry.bsky.social
@uwcse.bsky.social
@uwnephrology.bsky.social
0
4
4
reposted by
Kidney International
4 months ago
Kidney-resident macrophages limit toxin-induced inflammation through their hallmark functions
doi.org/10.1016/j.kint.2025.07.022
#NephSky
#MedSky
#AKI
#acutekidneyinjury
0
2
2
reposted by
Journal of Clinical Investigation
5 months ago
ICYMI: Chemotaxis as a driver in immune privilege. O. Thaunat & team dissect the mechanisms of endothelial preservation during cellular rejection and identify mechanisms underlying graft vasculature immune privilege.
buff.ly/Mwn8t1c
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0
1
1
reposted by
Nature Reviews Nephrology
5 months ago
ICYMI:
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The link between dementia and kidney disease demands changes in patient care
Nature Reviews Nephrology, Published online: 21 July 2025; doi:10.1038/s41581-025-00984-9The risk of cognitive impairment and dementia in people with chronic kidney disease is under-recognized. Better awareness and early intervention are crucial to improving patient outcomes.
https://www.nature.com/articles/s41581-025-00984-9?utm_source=bluesky&utm_medium=social&utm_campaign=nrneph
0
1
1
reposted by
Extreme Temperatures Around the World
6 months ago
âŒïžEXTRAORDINARY WORLD RECORD Brutal 48.5C Chillas,PAKISTAN đ”đ° 1250m ! WORLD RECORD OF HIGHEST TEMPERATURE ABOVE 1000M asl BUT...Yesterday 49.3C Bafq IRAN đźđ· altitude 999m (they should have moved the station a bit) Also crazy 46.1C Bunji đ”đ°1469m asl History is rewritten again
0
97
66
reposted by
Eric Topol
6 months ago
New organ clock data support the anti-aging benefits of estrogen for postmenopausal women. Reviewed here in context with previous and other recent reports.
erictopol.substack.com/p/new-anti-a...
17
285
61
reposted by
Extreme Temperatures Around the World
6 months ago
Hot day on the French Riviera: With 37.4C Sete broke its record of July highest temperature on record.
1
62
23
reposted by
Extreme Temperatures Around the World
6 months ago
East Asia: The hell is coming. Eastern China,The Koreas,Japan and parts of Far East Russia are gonna live hazardous conditions with temperatures up to 40C,up to 30C at night,extreme humidity and locally heat indexes >50C. Records will be hundreds (at best)
2
128
58
reposted by
Yale School of Public Health
6 months ago
A highly transmissible new COVID-19 variant is spreading in the U.S. âThose in high-risk groups should consider getting the vaccine now if they havenât been vaccinated in the last six months," Prof. Albert Ko told TODAY.
www.today.com/health...
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New COVID Variant NB.1.8.1 'Nimbus' Now Driving 37% of Cases in US: Know These Symptoms
A highly transmissible new COVID-19 variant called NB.1.8.1, aka "Nimbus," is spreading in the United States, CDC data show. What to know about symptoms and vaccines.
https://www.today.com/health/coronavirus/new-covid-variant-nb181-nimbus-symptoms-rcna212304
0
24
18
reposted by
Journal of Clinical Investigation
6 months ago
A proof-of-concept study for determining the functional impact of variants of uncertain significance (VUS)! Muthiah Bose et al. used CRISPR-Select as a tool in the classification of rare VUS in the PALB2-binding domain of BRCA2:
buff.ly/oFc574N
0
5
1
reposted by
Journal of Clinical Investigation
7 months ago
ICYMI: A smooth operator for blood pressure! Katherine Gallagher & team show the histone demethylase JMJD3 in vascular smooth muscle cells regulates endothelin receptor expression and blood pressure:
buff.ly/K8b0CnB
0
2
1
reposted by
Extreme Temperatures Around the World
7 months ago
EXTRAORDINARY- MOST EXTREME HEAT WAVE IN WORLD CLIMATIC HISTORY 52.6 in Kuwait,widespread 49/50C in a dozen countries. 44C at 45 latitude in Kazakhstan with night minimums up to 29C Next days Dozens of thousands of records from Morocco to Japan broken locally with 5/6C margins
2
85
65
reposted by
International Society of Glomerular Disease
7 months ago
đš LATE-BREAKING SESSION ALERT đš #PodocyteConference đ Pathology-oriented multiplex integrative mapping - Victor Puelles introduces the PathoPlex! đ„ Can we relate outcomes with disease-specific tissue mapping? đ§ tobias-b-huber.bsky.social
1
3
1
reposted by
International Society of Glomerular Disease
7 months ago
đ EMERGING CAREER HIGHLIGHTS đ #PodocyteConference đ Fantastic talk by Charlotte Boys on the molecular heterogeneity of PEC proliferation in IgAN and FSGS - future secrets for crescents? đ tobias-b-huber.bsky.social
0
4
1
reposted by
International Society of Glomerular Disease
7 months ago
Prof. dannygale.bsky.social⏠enlightens how studying large cohorts, such as the RaDaR Registry, allows for deeper understanding and gap closing in rare diseases đ #PodocyteConference đ ukkidney.org⏠tobias-b-huber.bsky.social
0
3
1
reposted by
International Society of Glomerular Disease
7 months ago
A look into the future by Prof. Moin Saleem đ§ at the #PodocyteConference đ Walking towards gene therapy in Glomerular Diseases đ§Źđ€Ż kidneyresearchuk.org⏠tobias-b-huber.bsky.social
0
6
3
reposted by
International Society of Glomerular Disease
7 months ago
Brilliant talk by Prof. Ulf Panzer at the #PodocyteConference đ From immune-profiling to precise treatment đŻ and a new hypothesis involving Granzyme K in ANCA-GN đ tobias-b-huber.bsky.social
0
4
1
reposted by
International Society of Glomerular Disease
7 months ago
Excellent lecture and work on the central role of PECs in crescent formation đ by Prof. Pierre-Louis Tharaux at the #PodocyteConference đ tobias-b-huber.bsky.social
0
3
1
reposted by
International Society of Glomerular Disease
7 months ago
Exciting news! đ The ISGD Centers of Excellence in Glomerular Disease (COE-GD) criteria have been finalized after 2+ years of meticulous work. Read our full press release here and learn about our commitment to advance GD care, research, and advocacy! đ
bit.ly/COE-GD
#ISGD
#GlomerularDisease
#COEGD
0
5
2
reposted by
Eric Topol
9 months ago
p-Tau217 is a breakthrough blood test that can predict and may help prevent Alzheimer's disease.
erictopol.substack.com/p/the-breakt...
Here's the rundown on it. Free, open-access.
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The Breakthrough Blood Test for Alzheimer's Disease
The p-Tau217 Biomarker for Prediction and Prevention
https://erictopol.substack.com/p/the-breakthrough-blood-test-for-alzheimers
20
515
178
reposted by
Eric Topol
9 months ago
The real problem about science isn't about loss of trust. It's about not having a voice, a counter.
@nature.com
www.nature.com/articles/d41...
Whai if the 300,000 scientists supported by NIH stood up? Or even half of them. Instead of <1%
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Scienceâs big problem is a loss of influence, not a loss of trust
Evidence shows that science and scientists remain highly trusted. But genuine scientific voices are not shouting loud enough over the noise to hold sway.
https://www.nature.com/articles/d41586-025-01068-1
7
306
72
reposted by
Melissa & Chris Bruntlett
9 months ago
The first of its kind in Germany, a 300 metre stretch of cycle path in Freiburg has been covered with a roof made of 912 photovoltaic solar panels. Not only does it protect cyclists from wind, sun, and rain, but it makes use of valuable real estate to generate 280 MWh of renewable energy each year.
7
208
58
reposted by
Eric Topol
9 months ago
The vaccine against Shingles helps protect against dementia, results of a natural experiment, adding to prior evidence "implications are profound" New
@nature.com
www.nature.com/articles/d41...
nature.com/articles/s41...
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A natural experiment on the effect of herpes zoster vaccination on dementia - Nature
Using a natural experiment that avoids common bias concerns, this study finds that the live-attenuated shingles vaccine reduced the probability of a new dementia diagnosis within a follow-up period of...
https://nature.com/articles/s41586-025-08800-x
164
5953
2026
reposted by
ASN Publications
10 months ago
The findings of this study highlight the substantial and growing Cardiovascular-Kidney-Metabolic (CKM) syndrome -related burden, emphasizing the urgent need for comprehensive and targeted interventions.
https://bit.ly/JASN0658
#ASNJASN
#diabetes
0
5
2
reposted by
ASN Publications
10 months ago
Broad collection of family history in context of CKD improved clinical risk stratification. Family history of diabetes associated with higher risk of CKD progression independent of diabetes status or polygenic risk score for diabetes in cohorts.
https://bit.ly/JASN0653
@madmarasa.bsky.social
0
6
6
reposted by
Nature Portfolio
10 months ago
A systematic review and meta-analysis in Nature Human Behaviour shows that people discern true from false news with ease. When making mistakes, people err on the side of skepticism and rate true news as false, instead of being fooled by false news.
https://go.nature.com/4h6TQZC
đ§Ș
2
65
30
reposted by
The Wall Street Journal
10 months ago
Emulsifiers, used to improve the texture of food, are in all sorts of products. But there is growing concern about the potential health risks from eating them.
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Emulsifiers Make Food More Appealing. Do They Also Make You Sick?
Emerging research suggests there might be a link between the texture-tweaking agents and all sorts of health risks.
https://www.wsj.com/health/wellness/emulsifiers-make-food-more-appealing-do-they-also-make-you-sick-be0850ae
6
28
16
reposted by
Eric Topol
10 months ago
We've known social disadvantage was linked to adverse health outcomes. A @NatureMedicine study used high- throughput proteomics to show there is accelerated aging, increased risk of 66 age-related diseases, and unfavorable changes in the immune system, âŹïž inflammation
www.nature.com/articles/s41...
3
177
57
www.bbc.com/reel/video/p...
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Japan's solution to the solar panel waste problem
As billions of solar panels near the end of their lifespan, Japan looks at innovative solutions to recycle them.
https://www.bbc.com/reel/video/p0ky4ql8/japan-s-solution-to-the-solar-panel-waste-problem
10 months ago
0
0
0
#journéemondialedurein
#WorldKidneyDay
@FondationduRein lance les appels à candidature pour 3 prix. -Prix de la Fondation du Rein -Prix Gabriel Richet pour les jeunes chercheurs -Prix Michel Olmer de recherche sur la maladie rénale chronique Merci aux donateurs de la Fondation !
10 months ago
0
0
0
reposted by
Kidney International
10 months ago
Repression of peroxisome proliferation-activated receptor γ coactivator-1α by p53 after
#kidneyinjury
promotes mitochondrial damage and maladaptive
#kidney
repair
doi.org/10.1016/j.kint.2025.02.009
#MedSky
#NephSky
#renalfibrosis
#kidneyfibrosis
#cisplatin
#aki
#acutekidneyinjury
0
3
1
reposted by
Eric Topol
10 months ago
Multiple sclerosis requires Epstein-Barr virus infection as an underpinning, exhibits self-directed antibodies to EBNA1, the virus's nuclear antigen, representing molecular mimicry. This combines with/ genetic risk factors (Figure, compared w/healthy controls)
@pnas.org
www.pnas.org/doi/epub/10....
13
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120
www.perplexity.ai/page/student...
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Student Cracks Century-Old Math Problem
Divya Tyagi, a graduate student at Penn State University, has refined a century-old mathematical problem in wind turbine aerodynamics, originally developed by...
https://www.perplexity.ai/page/student-cracks-century-old-mat-wN0I7t44Q8qaalwydsOpEw
10 months ago
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0
0
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