"Belém offers a chance to place health at the centre of climate governance and confront the increasingly ominous consequences of delay." Ahead of #COP30, a new World Report: spkl.io/63326AbDDC

When asked to draw a scientist, school-age kids in the United States are increasingly sketching women, according to a study from 2018. Read more on #STEMSTEAMDay: https://scim.ag/4qFrPON

JP Empana and X Jouven Team @PARCC reveal that sex differences in out-of-hospital cardiac arrest characteristics and outcomes were observed across all age groups and became more pronounced with increasing age, consistently indicating a better prognosis for males. heart.bmj.com/content/earl...

New online! Gene–environment interactions in the pathogenesis of cardiovascular disease #CardioSky

À l’occasion des 10 ans des attentats du 13 novembre, l’Inserm vous propose un magazine exceptionnel sur le trouble de stress post-traumatique (TSPT) et ses effets sur la mémoire. 🗓️ RDV le 13/11 à 13h00 en direct sur la chaîne YouTube de l'Inserm pour ce nouveau n° de 30’ santé.

A Eichmann, K Boye and colleagues @PARCC and @Yale University of Medicine establish Netrin-1 as a promising therapeutic target for preventing blood-retina barrier breakdown in retinal vascular diseases. link.springer.com/article/10.1...

Interested in working with us? @upcite.bsky.social @parcc-inserm.bsky.social @esendocrinology.bsky.social @sfendocrino.bsky.social @jedi-sfe.bsky.social @ese-eyes.bsky.social @a5-adrenal.bsky.social www.linkedin.com/feed/update/...

Great discoveries often arise from work that was looking for something completely different. www.nature.com/articles/d41...

Funders must recognise that great discoveries often come from studies that seeks to advance knowledge for its own sake go.nature.com/3X5lbUg

[Préannonce] Fin novembre, l’ANR participera au nouvel appel à projets transnational du partenariat européen pour la médecine personnalisée, EP PerMed "Médecine Personnalisée pour les maladies #cardiovasculaires, #métaboliques et #rénales" (#CARMEN2026) ➡ anr.fr/fr/detail/ca...

A Loupy @PARCC and colleagues of the international consortium of digital twins in healthcare and medicine reveal distinct biological clock patterns across different life stages. www.nature.com/articles/s41...

P Breillat and B Terrier from PL Tharaux team @PARCC showed that NK-cell dysfunction in VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome contributes to increased susceptibility to severe infections. doi.org/10.1182/bloo...

Pr MC Zennaro @PARCC and colleagues from the European EndoCompass project initiative established a research roadmap for adrenal and cardiovascular endocrinology. doi.org/10.1093/ejen...

A gene that causes obesity is paradoxically linked to a reduced risk of having heart disease and high cholesterol, according to an analysis of thousands of people with obesity. go.nature.com/4o2YDzC

In this Communications Biology article, authors modeled cardiomyocyte geometry revealing that mitochondrial–sarcoplasmic architecture enhances respiration by facilitating ion and lipid transfer for efficient cardiac metabolism🫀 @parcc-inserm.bsky.social doi.org/10.1038/s420...

C Jouve and colleagues from Team Hulot @PARCC demonstrate that mitochondrial-sarcoplasmic architecture and geometry are critical spatial features that ensure bioenergetic efficiency of cardiomyocytes rdcu.be/eKD1n

Hopes of securing a United Nations treaty on plastic pollution are fading after the final round of negotiations ended without an agreement. go.nature.com/3J74xjN

New online! The global cardiovascular–liver–metabolic syndemic: epidemiology, trends and challenges #CardioSky

Book review 📚 The cutting-edge medical approaches that could transform ageing go.nature.com/46Fu2Sp

Pr JS Hulot team @PARCC revealed that CD51 contributes to the immune-fibrotic axis driving heart failure progression under pressure overload. www.sciencedirect.com/science/arti...

Mineralocorticoid receptor inhibition in parietal epithelial cells prevents focal segmental glomerulosclerosis and crescentic glomerulonephritis. doi.org/10.1016/j.kint.2025.07.037 #OpenAccess #NephSky #MedSky #CKD #FSGS #chronickidneydisease @parcc-inserm.bsky.social @rwth.bsky.social

Team Loupy@PARCC characterizes the Immune Response in Pig-to-human Heart Xenografts Using a Multimodal Diagnostic System | Circulation www.ahajournals.org/doi/10.1161/...

🚨 New paper from the lab in ATVB Dexamethasone protects against COVID-19 endothelium-induced coagulopathy 🦠🔥🫁🩸 @davidmsmadja.bsky.social @hopitalpompidou.bsky.social @upcite.bsky.social @parcc-inserm.bsky.social @ahajournals.bsky.social @inserm.fr www.ahajournals.org/doi/10.1161/...

Inspiring and fun meeting with outstanding @rkramann.bsky.social at the @parcc-inserm.bsky.social #Masterclass @olilen.bsky.social with the community, #our KVIM team and young early career researchers ! Thank you Rafael!

D Smadja team @PARCC shows that Dexamethasone Suppresses Endotheliopathy and Endothelial-Induced Coagulopathy in COVID-19 | Arteriosclerosis, Thrombosis, and Vascular Biology www.ahajournals.org/doi/10.1161/...

PL Tharaux team and MC Zennaro team @PARCC show that mineralocorticoid receptor inhibition in parietal epithelial cells prevents focal segmental glomerulosclerosis and crescentic glomerulonephritis. - Kidney International www.kidney-international.org/article/S008...

N Bouatia-Naji and T Berrandou @PARCC participate to a study showing that KLK15 alters connective tissues in hypermobile Ehlers-Danlos syndrome: iScience www.cell.com/iscience/ful...

This week on the Nature Podcast 🔊 This AI tool predicts your risk of 1,000 diseases — by looking at your medical records go.nature.com/46rd492

And LLMs are more likely than a human intermediary to comply with prompts that promote cheating go.nature.com/3VnGUpG

"Treating careful scholarship as somehow less important than the acquisition of data can adversely affect the reliability of the scientific record and consequently, the course of science," writes H. Holden Thorp in a new #ScienceEditorial. https://scim.ag/4mqrKet

From 24 to 26 September 2025, Pr RM Bruno and Pr N Bouatia -Naji from PARCC will participate to the third edition of the Women’s Health Conference. This event will gather global leaders in women’s health to drive progress and foster international dialogue. iwish.u-pariscite.fr/events/event...

Please join us for our Interdisciplinary Conference on Women's Health at Université Paris Cité on 24-26 September! @upcite.bsky.social @echelles-umr8264.bsky.social @institutcochin.bsky.social @ludivinedoridot.bsky.social @OPPaLE-inserm @parcc-inserm.bsky.social @Ceped IRD

Pr. JS Hulot @PARCC and colleagues provide expert consensus document which delineates Heart Failure (HF) trajectories, examines factors reflecting HF improvement beyond recovery of LVEF, and explores the prognostic implications of these phenotypic transitions. doi.org/10.1002/ejhf...

In a medical first, researchers report that they have implanted CRISPR-edited pancreas cells into a person with type 1 diabetes go.nature.com/46paWQ0

Maladie thromboembolique veineuse : prédire le risque de récidive grâce à la génétique Lire le communiqué : presse.inserm.fr/maladie-thro...

New online! Transcriptional regulation in heart development, disease and regeneration: reassessing the fetal gene hypothesis #CardioSky

Pr. A Eichmann and colleagues @PARCC and @Yale University School of medicine unravel that PIEZO1 blockade reduces arteriovenous malformations formation and alleviates cellular and molecular hallmarks of ALK1-deficient cells. doi.org/10.1161/CIRC...

Collaborative work from E Camerer @PARCC highlights S1PR1 as a new regulator of both lymphatic valves and tertiary lymphoid organs (TLOs), and suggests that TLOs could be a marker for underlying lymphatic disorders. doi.org/10.1084/jem....

C Cochain and coworkers @PARCC reveal that platelets interact with macrophages in the ischemic heart, and this interaction causes macrophages to become proinflammatory. academic.oup.com/jleukbio/art...

A lung from a genetically modified pig has been transplanted into a person for the first time. Lungs are complex organs to transplant, but the surgery is a step towards clinical trials. go.nature.com/3JXSDbS

Only 1 in 4 adults in the WHO African Region has ideal cardiovascular health (CVH). A recent study by Dr.JP Empana and coworkers @PARCC reveals crucial insights from 22 countries. jamanetwork.com/journals/jam...

A multinational study by Professors M. Antignac, X. Jouven, @PARCC and other colleagues revealed a disturbing trend in sub-Saharan Africa: a significant number of antidiabetic drugs are of poor quality. www.thelancet.com/journals/ecl...

Posts about research on Bluesky receive substantially more attention than similar posts on X, formerly called Twitter go.nature.com/45Ftiw4

A Bois, P Menasché and colleagues @PARCC explore strategies for heart regeneration, offer insights into cardiomyocyte proliferation, evaluate in vivo models, and discusse integrating in vitro human cardiac models to advance cardiac regeneration research. rdcu.be/eC3Gc

Dr. MC Zennaro and colleagues @PARCC aim to develop updated guidelines for the diagnosis and management of Primary Aldosteronism. They provide a practical, clinical approach to identify and treat this often-underdiagnosed cause of hypertension. Check here: academic.oup.com/jcem/article...

O. Lenoir, P.L. Tharaux and co-workers @PARCC have developed PathoPlex, a powerful new framework for multiplexed tissue imaging. This scalable tool maps over 140 proteins at subcellular resolution, helping to uncover key disease mechanisms in kidney health and disease. rdcu.be/eCs2P

David Smadja and co-workers @PARCC found that the biomarker sST2 independently predict clinical outcomes in hospitalized COVID-19 patients. www.nature.com/articles/s41...

B Tavitian team and coworkers @PARCC used MRI to evaluate myocardial strain and T1 mapping in mice. This methodological approach not only refines imaging sequences but also offers insights into cardiac function and tissue characteristics. www.nature.com/articles/s41...

PARCC Highlight: New research from Pr Rosa Maria Bruno @PARCC INSERM and Université Paris Cité, published in the European Heart Journal, reveals that COVID-19 can accelerate vascular aging, especially in women. doi.org/10.1093/eurh...