B. Gaye and E. Marijon @PARCC, in collaboration with colleagues from the ERADICATE Consortium (Ending Rheumatic Heart Disease through Advanced Diagnosis, Intervention, Care, Access, Treatment, and Equity), are leading a strategy aimed at eradicating rheumatic heart disease. doi.org/10.1093/eurh...

A Eichmann and Colleagues @PARCC showed that endothelial ROCK1 and 2 maintain junctional integrity and ensure proper angiogenesis and lumen formation. These data also indicate the need for careful consideration when using ROCK inhibitors in disease settings. doi.org/10.1093/cvr/...

Pr D Smadja @PARCC calls to action for Health desinformation. the next battle for public health will be waged not only in hospitals and laboratories but also in the information spaces where truth competes with virality. It is time for science to go viral—for the right reason!

Dans une nouvelle étude des scientifiques de l'Inserm ont analysé comment le système lymphatique se dérègle dans l’insuffisance cardiaque. Ils ont, pour la première fois, identifié les mécanismes responsables de ce dysfonctionnement. Lire le communiqué : presse.inserm.fr/decouverte-d...

Pr D Smadja @PARCC and colleagues confirmed the absence of vascular benefit of Hydroxychloroquine (HCQ) treatment, reinforcing evidence against HCQ’s clinical utility in COVID-19 and underscoring the need for alternative endothelial-targeted approaches. link.springer.com/article/10.1...

L’ANR participe au nouvel appel à projets transnational du partenariat européen pour la médecine personnalisée, EP PerMed : "Médecine Personnalisée pour les maladies #cardiovasculaires, #métaboliques et #rénales" #CARMEN2026 📆 10/02/2026 (pré-propositions) ➡ anr.fr/CARMEN2026

Susan Monarez was fired after less than a month as Director of the CDC for holding the line on scientific integrity She is part of Nature's 10 - our list of people who shaped science in 2025 go.nature.com/48FnHpx

Academia is unprepared for the rise in chatbot use among students go.nature.com/4iPtlKz

Pr A Loupy team @PARCC has developed a novel FFPE-based molecular diagnostic system which accurately identified cardiac allograft rejection. academic.oup.com/eurheartj/ad...

H Ait-Oufella @PARCC and colleagues review the role of trained immunity in cardiovascular disease.

Artificial intelligence promises rapid and polite feedback on papers — but we must first review the reviewer, says Giorgio F. Gilestro go.nature.com/3McjUsw

🗞️ À découvrir aujourd’hui dans @lexpress.fr : "Le financement de nouveaux projets de recherche est menacé : l'alerte de Claire Giry (ANR)".

‘Emerald’ or ‘Paris’ green was once a highly popular pigment among painters, but the chemistry behind its slow decay over time has been unclear go.nature.com/4paYhqU

JP Empana and colleagues @PARCC assess the prevalence, awareness, and treatment of hypertension in 37 african countries from 2003 to 2022 | JACC www.jacc.org/doi/10.1016/...

"Encouragingly, 89% of the public viewed scientists as intelligent, 65% thought they were honest, and 65% believed they were working to solve real-world problems." Richard Horton's latest Offline: Is there really a trust crisis in science? tinyurl.com/2x59cw6b

La cérémonie des Prix Inserm 2025 a récompensé 5 lauréates et lauréats !

Still two more #ParisPostdocsSeminars before the end of the month! 🧪Dr. Arianna Giannetti 📆 Nov 25th 📍 @parcc-inserm.bsky.social | #Stress #Thrombosis 🧪Dr. Camila Valenzuela-Montenegro 📆Nov 27th 📍 @institutcurie.bsky.social | #Salmonella #EpithelialCells Don't miss them! #Science #Postdoc

In a small study, gene editing slashed blood levels of two fats that contribute to clogged arteries and ramp up risks of heart disease, potentially for life. https://scim.ag/486nL1o

Peripartum cardiomyopathy is now the leading cause of maternal death in many parts of the world. A Seminar summarises current knowledge of peripartum cardiomyopathy genetics, pathophysiology, diagnostic approaches, medical management, and outcome: spkl.io/63320AdQNn

Canal Détox, c'est l'initiative de l'Inserm qui lutte contre les fausses informations en santé. Découvrir la série : presse.inserm.fr/le-canal-det...

A new study finds that women’s names filled just 23% of author slots in a sample of nearly 900 retracted articles published in medical journals between 2008 and 2017 go.nature.com/49pgmN7

A Loupy @PARCC and colleagues provide the first long-term physiologic, immunologic, and infectious disease monitoring of a pig-to-human kidney xenotransplant. Please read more: doi.org/10.1038/s415...

C'est aujourd'hui ! ⬇️

New online! Integration of cardiovascular and mental health: from concepts to the clinic #CardioSky

Are geopolitical tensions affecting research output? go.nature.com/4o229JK

The 2025 @lancetcountdown.bsky.social report reveals climate change inaction is costing lives and livelihoods, and harming the economy. During #COP30, explore recommendations for action: spkl.io/63324AbjGM#COP30#LancetClimate25

"Belém offers a chance to place health at the centre of climate governance and confront the increasingly ominous consequences of delay." Ahead of #COP30, a new World Report: spkl.io/63326AbDDC

When asked to draw a scientist, school-age kids in the United States are increasingly sketching women, according to a study from 2018. Read more on #STEMSTEAMDay: https://scim.ag/4qFrPON

JP Empana and X Jouven Team @PARCC reveal that sex differences in out-of-hospital cardiac arrest characteristics and outcomes were observed across all age groups and became more pronounced with increasing age, consistently indicating a better prognosis for males. heart.bmj.com/content/earl...

New online! Gene–environment interactions in the pathogenesis of cardiovascular disease #CardioSky

À l’occasion des 10 ans des attentats du 13 novembre, l’Inserm vous propose un magazine exceptionnel sur le trouble de stress post-traumatique (TSPT) et ses effets sur la mémoire. 🗓️ RDV le 13/11 à 13h00 en direct sur la chaîne YouTube de l'Inserm pour ce nouveau n° de 30’ santé.

A Eichmann, K Boye and colleagues @PARCC and @Yale University of Medicine establish Netrin-1 as a promising therapeutic target for preventing blood-retina barrier breakdown in retinal vascular diseases. link.springer.com/article/10.1...

Interested in working with us? @upcite.bsky.social @parcc-inserm.bsky.social @esendocrinology.bsky.social @sfendocrino.bsky.social @jedi-sfe.bsky.social @ese-eyes.bsky.social @a5-adrenal.bsky.social www.linkedin.com/feed/update/...

Great discoveries often arise from work that was looking for something completely different. www.nature.com/articles/d41...

Funders must recognise that great discoveries often come from studies that seeks to advance knowledge for its own sake go.nature.com/3X5lbUg

[Préannonce] Fin novembre, l’ANR participera au nouvel appel à projets transnational du partenariat européen pour la médecine personnalisée, EP PerMed "Médecine Personnalisée pour les maladies #cardiovasculaires, #métaboliques et #rénales" (#CARMEN2026) ➡ anr.fr/fr/detail/ca...

A Loupy @PARCC and colleagues of the international consortium of digital twins in healthcare and medicine reveal distinct biological clock patterns across different life stages. www.nature.com/articles/s41...

P Breillat and B Terrier from PL Tharaux team @PARCC showed that NK-cell dysfunction in VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome contributes to increased susceptibility to severe infections. doi.org/10.1182/bloo...

Pr MC Zennaro @PARCC and colleagues from the European EndoCompass project initiative established a research roadmap for adrenal and cardiovascular endocrinology. doi.org/10.1093/ejen...

A gene that causes obesity is paradoxically linked to a reduced risk of having heart disease and high cholesterol, according to an analysis of thousands of people with obesity. go.nature.com/4o2YDzC

In this Communications Biology article, authors modeled cardiomyocyte geometry revealing that mitochondrial–sarcoplasmic architecture enhances respiration by facilitating ion and lipid transfer for efficient cardiac metabolism🫀 @parcc-inserm.bsky.social doi.org/10.1038/s420...

C Jouve and colleagues from Team Hulot @PARCC demonstrate that mitochondrial-sarcoplasmic architecture and geometry are critical spatial features that ensure bioenergetic efficiency of cardiomyocytes rdcu.be/eKD1n

Hopes of securing a United Nations treaty on plastic pollution are fading after the final round of negotiations ended without an agreement. go.nature.com/3J74xjN

New online! The global cardiovascular–liver–metabolic syndemic: epidemiology, trends and challenges #CardioSky

Book review 📚 The cutting-edge medical approaches that could transform ageing go.nature.com/46Fu2Sp

Pr JS Hulot team @PARCC revealed that CD51 contributes to the immune-fibrotic axis driving heart failure progression under pressure overload. www.sciencedirect.com/science/arti...

Mineralocorticoid receptor inhibition in parietal epithelial cells prevents focal segmental glomerulosclerosis and crescentic glomerulonephritis. doi.org/10.1016/j.kint.2025.07.037 #OpenAccess #NephSky #MedSky #CKD #FSGS #chronickidneydisease @parcc-inserm.bsky.social @rwth.bsky.social

Team Loupy@PARCC characterizes the Immune Response in Pig-to-human Heart Xenografts Using a Multimodal Diagnostic System | Circulation www.ahajournals.org/doi/10.1161/...

🚨 New paper from the lab in ATVB Dexamethasone protects against COVID-19 endothelium-induced coagulopathy 🦠🔥🫁🩸 @davidmsmadja.bsky.social @hopitalpompidou.bsky.social @upcite.bsky.social @parcc-inserm.bsky.social @ahajournals.bsky.social @inserm.fr www.ahajournals.org/doi/10.1161/...

Inspiring and fun meeting with outstanding @rkramann.bsky.social at the @parcc-inserm.bsky.social #Masterclass @olilen.bsky.social with the community, #our KVIM team and young early career researchers ! Thank you Rafael!