It's Congress-Update time! Check out our new webinar "Post ESC 2025"! youtu.be/6C6lJWUHlc8?...

Last days of summer...

Tonight it's all about ADPKD! KDIGO Guidelines / ERA Genes & Kidney Working Group - Prof. Roser Torra, Prof. Roman-Ulrich Müller youtu.be/qjnYDsYbx0Q?... @rosertorra.bsky.social @muellerrom.bsky.social @dguerrot.bsky.social @gunnarheine.bsky.social @kronbichlerlab.bsky.social

Effects of empagliflozin on conventional and exploratory acute and chronic kidney outcomes by Drs. Herrington, Staplin et al. www.sciencedirect.com/science/arti... SGLT2 I reduces the risk of acute and chronic kidney outcomes irrespective of the size of the acute dip in eGFR.

Fractional flow reserve-guided renal artery stenting in atherosclerotic renovascular hypertension: the FAIR randomized trial by Drs. Li, Li et al. academic.oup.com/eurheartj/ar... BP and antihypertensive medication usage decreased significantly after stenting in patients with FFR < 0.80

Novel developments in the treatment of HFrEF - Prof. Dr. John McMurray (Glasgow, UK) youtu.be/kK8N-5RkEfc?... Prof. McMurray discusses new developments in the treatment of HFrEF, focusing on new outcome data for vericiguat and digitoxin from the VICTOR and DIGIT-HF studies.

A Phase 3 Trial of Telitacicept for Systemic Lupus Erythematosus by Drs. van Vollenhoven, Zhang et al. www.nejm.org/doi/full/10.... The incidence of a clinical response was higher with telitacicept (a new dual inhibitor of the cytokines B-lymphocyte stimulator and APRIL) than with placebo.

Our experts explain: CKD of unexplained cause: ERA G & K Consensus - Prof. @ecorneclegall.bsky.social, Prof. Halbritter, Prof. Müller youtu.be/RzupTGtHs8g?... They present the CKDx consensus statement of the ERA Genes & Kidney Working Group, published in NDT.

Urinary tract infection and continuation of SGLT-I in diabetic patients by Drs. Wu, Yiu et al. academic.oup.com/eurheartj/ar... Discontinuing SGLT2 inhibitors after a UTI was linked to a higher risk of cardiovascular and renal outcomes but was not associated with fewer recurrent UTI.

Stream it now! Our webinar in cooperation with NDT: IgA-NP: Treatment Standard & Future Perspective - Prof. Jonathan Barratt, Prof. Jai Radhakrishnan @ndt-era.bsky.social @kronbichlerlab.bsky.social @gunnarheine.bsky.social @hjanders.bsky.social youtu.be/l0g9_lkW5_w?...

Sodium Bicarbonate for Severe Metabolic Acidemia and Acute Kidney Injury The BICARICU-2 Randomized Clinical Trial by Drs. Jung, Jaber et al. jamanetwork.com/journals/jam... In this randomized trial infusion of sodium bicarbonate did not improve 90-day mortality.

New DGfN Board elected! Prof. Julia Weinmann-Menke joins the board of the German Society of Nephrology. Prof. Martin K. Kuhlmann (President), Prof. Elke Schäffner and PD Dr. Georg Schlieper were re-elected. More info 👉 www.dgfn.eu/vorstand.html #Nephrology #DGfN #CKD

How to diagnose and treat superficial vein thrombosis (SuVT) by Drs. Piazza, Bikdeli et al. jamanetwork.com/journals/jam...

KDIGO publishes its new guidelines on IgA Nephropathy (IgAN) / IgA Vasculitis (IgAV) kdigo.org/guidelines/i...

Primäre Hyperoxalurie - Prof. Dr. Bernd Hoppe (Bonn) Prof. Dr. Bernd Hoppe explains the pathophysiology, diagnostics, current and possible future therapies of primary hyperoxaluria. youtu.be/T18mxSSlG7g?...

Anti-glomerular Basement Membrane Disease - Treatment Standard by Drs. McAdoo, Pusey et al. academic.oup.com/ndt/article/...

Atypical Hemotytic Uremic Syndrome (aHUS) - Prof. Fadi Fakhouri (Lausanne, Switzerland) youtu.be/k0UlfUh_PZU?... Prof. Fakhouri discusses pathophysiology, diagnosis, treatment and prognosis of atypical Hemolytic Uremic Syndrome (aHUS).

Abnormal electrocardiogram findings in athletes by Drs. Finocchiaro, D’Ascenzi et al. A consensus statement of the European Association of Preventive Cardiology of the European Society of Cardiology! academic.oup.com/eurheartj/ar...

Impfungen 25 / 26: Influenza, SARS-CoV-2, RSV, Pneumokokken - Prof. Dr. Klaus Stöhr, Prof. Dr. Barbara Gärtner youtu.be/V5P-eDvf9jI?...

Transthyretin amyloid cardiomyopathy: from cause to novel treatments by Drs. Fontana, Gillmore et al. academic.oup.com/eurheartj/ar...

The relationship between obesity and chronic kidney disease: Conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference by Drs. Furth, Rossing et al. www.kidney-international.org/article/S008...

SGLT-2 Inhibition in ADPKD? DAPA-PKD & STOP-PKD - Prof. Emilie Cornec Le Gall & Prof. Roman-Ulrich Müller youtu.be/9e-UFBnIyDI?... @ecorneclegall.bsky.social @muellerrom.bsky.social @kronbichlerlab.bsky.social @sarahelena.bsky.social @gunnarheine.bsky.social @marcussaemann.bsky.social

Where the sea meets the sky, peace begins

Extended reduced-dose DOAC: APICAT / RENOVE - Prof. Isabelle Mahé / Prof. Francis Couturaud youtu.be/RXttWKQ-sM4?... Prof Mahé and Prof. Couturaud discuss the use of reduced-dose NOAC treatment for extended treatment of VT, based upon their APICAT and RENOVE trials.

A Crossover Trial of Hospital-Wide Lactated Ringer’s Solution versus Normal Saline by Drs. McIntyre, Taljaard et al. www.nejm.org/doi/full/10.... Lactated Ringer’s solution rather than normal saline did not result in a lower incidence of death or readmission to the hospital.

Our new webinar is now available! Schlaganfall: Update für Internisten 2025 - Prof. Dr. Christoph Kleinschnitz (Essen) youtu.be/vGdg_YIf7uc?...

And the wheel keeps turning...

Kidney function trajectories before and after hospitalization for HFrEF by Drs. Kobayashi, Girerd et al. academic.oup.com/eurheartj/ar... In HFrEF, kidney function decline may precede a HF events by up to one year. Monitoring eGFR slopes may allow early detection of patients at risk.

2025 Concise Clinical Guidance: An ACC Expert Consensus Statementon the Diagnosis and Management of Pericarditis A Report of the American College of Cardiology Solution Set Oversight Committee www.jacc.org/doi/epdf/10....

It's Friday again! Posttransplantations-Lymphome - Priv.-Doz. Dr. Florian Kocher, Prof. Dr. Dominik Wolf (Innsbruck) youtu.be/t3mWguKpq7E?...

Every sunset is an opportunity to reset.

2025 Concise Clinical Guidance: An ACC Expert Consensus Statement on Medical Weight Management for Optimization of Cardiovascular Health by Drs. Gilbert, @drmarthagulati.bsky.social, Gluckman, @mkittlesonmd.bsky.social, Rikhi, Saseen, Tchang

The third study in a row which failed to show beneficial outcomes with potassium binders!

Leadless pacing: a comprehensive review by Drs. Saleem-Talib, Ramanna et al. academic.oup.com/eurheartj/ar... In this review, the past, present, and future of leadless pacing are discussed with a focus on cutting-edge implantation techniques, clinical outcomes, and modern advancements.

Antibody-mediated Rejection - Treatment Standard by Drs. Böhmig, Budde et al. academic.oup.com/ndt/article/... An expert opinion paper about Treatment Standard by ABMR.

Osteoporose - DVO Leitlinien - Dr. Friederike Thomasius (Frankfurt am Main, Germany) youtu.be/lnkZPucWO-g?... Interesting facts about the diagnosis and treatment of osteoporosis (in german language)!

We wish you a pleasant end to the Whitsun weekend!

Dietary Patterns, Sodium Reduction, and Blood Pressure in Type 2 Diabetes - The DASH4D Randomized Clinical Trial by Drs. Pilla, Appel et al. jamanetwork.com/journals/jam... DASH4D diet and sodium reduction achieved a significant reduction in BP, primarily from sodium reduction.

Watch our recent video in german language about Osteoporosis! youtu.be/lnkZPucWO-g?...

Osteoporosis: A Review by Drs. Morin, Schousboe et al. jamanetwork.com/journals/jam... Antiresorptive agents are recom. for pat. at high fracture risk. Anabolic treatment with parathyroid hormone analogs / sclerostin inhibitors can be considered for very high-risk pat.

The Launch - HTN Randomized Clinical Trial by Drs. Saxena, Rodman et al.: jamanetwork.com/journals/jam... Lorundrostat, an ASI, has been shown to be safe and effective in lowering blood pressure in adults with uncontrolled hypertension and treatment-resistant hypertension.

Do you already know our Tour Académique 2025? youtu.be/dK4NO5TTKl4?...

Cannabidiol and Liver Enzyme Level Elevations in Healthy Adults by Drs. Florian, Rouse et al. jamanetwork.com/journals/jam... The incidence of elevated ALT or AST coupled with increased eosinophilia, underscores the need for further investigation on the long-term effects of CBD use.

Semaglutide in Adults with Type 1 Diabetes and Obesity by Drs. Shah, Snell-Bergeon et al. evidence.nejm.org/doi/full/10.... In adults with T1D and obesity, treatment with semaglutide significantly improved the achievement of the composite primary outcome.

Hello to all new followers! We'll update you twice a week on current studies in internal medicine, and there's a new episode on YouTube every Friday! Which MARKUS@HOMe episode is your favorite? What topic would you like to see an episode on? We look forward to your feedback!

Coffee and cardiovascular disease by Drs. Dewland, Marcus et al. academic.oup.com/eurheartj/ar... The available data suggest that moderate coffee consumption is associated with a reduced risk of hypertension, T2D, myocardial infarction, arrhythmias, HF, and overall mortality.

First-Line Treatment of Pulmonary Sarcoidosis with Prednisone or Methotrexate by Drs. Kahlmann, Wijsenbeek et al. www.nejm.org/doi/full/10.... Treatment with MTX was noninferior to prednisone with regard to the change from baseline to week 24 in the percentage of the predicted FVC.

A preview of our next webinar!

Life Support in Hemodialysis Emergencies - Treatment standard by Drs. Aoun, Combe, Jadoul academic.oup.com/ndt/article-... This review is a guide for the initial management of patients undergoing HD and experiencing a medical emergency.

Daily steps and health outcomes in adults: a systematic review and dose-response meta-analysis by Drs. Ding, Clare, Owen et al. thelancet.com/journals/lan... 7000 steps per day are associated with clinically meaningful improvements in health outcomes.