What an exciting weekend... So many new studies to discuss!

ESC Dyslipidemia Guidelines - 2025 Update - Prof. Dr. François Mach, Geneva, Switzerland youtu.be/-y_ma-kW61o?... Prof. Mach presents the 2025 Focused Update of the European Guidelines for the management of dyslipidaemias, which have been published by @escardio.bsky.social @eassociety.bsky.social.

Rituximab for Relapsing Nephrotic Syndrome in Adults by Drs. Isaka, Hiromura et al. jamanetwork.com/journals/jam... The relapse-free rate at week 49 was 87.4%(95% CI, 69.8%-95.1%) in the rituximab group and 38.0%(95% CI, 22.1%-53.8%) in the placebo group.

Short-Term Anticoagulation versus DAPT for Preventing Device Thrombosis Following LAAC: The ANDES RCT by Drs. Rodés-Cabau, Salaun et al. www.ahajournals.org/doi/10.1161/... The use of DOAC after LAAC failed to reduce DRT compared to DAPT but it was associated with an improved safety profile.

Stream it now! Our webinar in cooperation with NDT: IgA-NP: Treatment Standard & Future Perspective - Prof. Jonathan Barratt, Prof. Jai Radhakrishnan @ndt-era.bsky.social @kronbichlerlab.bsky.social @gunnarheine.bsky.social @hjanders.bsky.social youtu.be/l0g9_lkW5_w?...

Sodium Bicarbonate for Severe Metabolic Acidemia and Acute Kidney Injury The BICARICU-2 Randomized Clinical Trial by Drs. Jung, Jaber et al. jamanetwork.com/journals/jam... In this randomized trial infusion of sodium bicarbonate did not improve 90-day mortality.

Urinary tract infection and continuation of SGLT-I in diabetic patients by Drs. Wu, Yiu et al. academic.oup.com/eurheartj/ar... Discontinuing SGLT2 inhibitors after a UTI was linked to a higher risk of cardiovascular and renal outcomes but was not associated with fewer recurrent UTI.

Our experts explain: CKD of unexplained cause: ERA G & K Consensus - Prof. @ecorneclegall.bsky.social, Prof. Halbritter, Prof. Müller youtu.be/RzupTGtHs8g?... They present the CKDx consensus statement of the ERA Genes & Kidney Working Group, published in NDT.

A Phase 3 Trial of Telitacicept for Systemic Lupus Erythematosus by Drs. van Vollenhoven, Zhang et al. www.nejm.org/doi/full/10.... The incidence of a clinical response was higher with telitacicept (a new dual inhibitor of the cytokines B-lymphocyte stimulator and APRIL) than with placebo.

Novel developments in the treatment of HFrEF - Prof. Dr. John McMurray (Glasgow, UK) youtu.be/kK8N-5RkEfc?... Prof. McMurray discusses new developments in the treatment of HFrEF, focusing on new outcome data for vericiguat and digitoxin from the VICTOR and DIGIT-HF studies.

Fractional flow reserve-guided renal artery stenting in atherosclerotic renovascular hypertension: the FAIR randomized trial by Drs. Li, Li et al. academic.oup.com/eurheartj/ar... BP and antihypertensive medication usage decreased significantly after stenting in patients with FFR < 0.80

Effects of empagliflozin on conventional and exploratory acute and chronic kidney outcomes by Drs. Herrington, Staplin et al. www.sciencedirect.com/science/arti... SGLT2 I reduces the risk of acute and chronic kidney outcomes irrespective of the size of the acute dip in eGFR.

SGLT-2 Inhibition in ADPKD? DAPA-PKD & STOP-PKD - Prof. Emilie Cornec Le Gall & Prof. Roman-Ulrich Müller youtu.be/9e-UFBnIyDI?... @ecorneclegall.bsky.social @muellerrom.bsky.social @kronbichlerlab.bsky.social @sarahelena.bsky.social @gunnarheine.bsky.social @marcussaemann.bsky.social

The relationship between obesity and chronic kidney disease: Conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference by Drs. Furth, Rossing et al. www.kidney-international.org/article/S008...

Transthyretin amyloid cardiomyopathy: from cause to novel treatments by Drs. Fontana, Gillmore et al. academic.oup.com/eurheartj/ar...

Impfungen 25 / 26: Influenza, SARS-CoV-2, RSV, Pneumokokken - Prof. Dr. Klaus Stöhr, Prof. Dr. Barbara Gärtner youtu.be/V5P-eDvf9jI?...

Abnormal electrocardiogram findings in athletes by Drs. Finocchiaro, D’Ascenzi et al. A consensus statement of the European Association of Preventive Cardiology of the European Society of Cardiology! academic.oup.com/eurheartj/ar...

Atypical Hemotytic Uremic Syndrome (aHUS) - Prof. Fadi Fakhouri (Lausanne, Switzerland) youtu.be/k0UlfUh_PZU?... Prof. Fakhouri discusses pathophysiology, diagnosis, treatment and prognosis of atypical Hemolytic Uremic Syndrome (aHUS).

Anti-glomerular Basement Membrane Disease - Treatment Standard by Drs. McAdoo, Pusey et al. academic.oup.com/ndt/article/...

Primäre Hyperoxalurie - Prof. Dr. Bernd Hoppe (Bonn) Prof. Dr. Bernd Hoppe explains the pathophysiology, diagnostics, current and possible future therapies of primary hyperoxaluria. youtu.be/T18mxSSlG7g?...

KDIGO publishes its new guidelines on IgA Nephropathy (IgAN) / IgA Vasculitis (IgAV) kdigo.org/guidelines/i...

How to diagnose and treat superficial vein thrombosis (SuVT) by Drs. Piazza, Bikdeli et al. jamanetwork.com/journals/jam...

Tonight it's all about ADPKD! KDIGO Guidelines / ERA Genes & Kidney Working Group - Prof. Roser Torra, Prof. Roman-Ulrich Müller youtu.be/qjnYDsYbx0Q?... @rosertorra.bsky.social @muellerrom.bsky.social @dguerrot.bsky.social @gunnarheine.bsky.social @kronbichlerlab.bsky.social

"After all this time": More than five decades of Dr. Braunwald's research on Hypertrophic Cardiomyopathy summarized in a review paper by Dr. Braunwald www.nejm.org/doi/full/10....

Last days of summer...

It's Congress-Update time! Check out our new webinar "Post ESC 2025"! youtu.be/6C6lJWUHlc8?...

Efficacy and Safety of Baxdrostat in Uncontrolled and Resistant Hypertension by Drs. Flack, Williams, et al. www.nejm.org/doi/full/10.... The addition of baxdrostat to background therapy resulted in a significantly lower seated systolic blood pressure at 12 weeks than placebo.

The ALONE-AF Randomized Clinical Trial by Drs. Kim, Joung, et al. jamanetwork.com/journals/jam... After AF ablation discontinuing OAC therapy resulted in a lower risk for the composite outcome of stroke, systemic embolism, and major bleeding vs continuing direct OAC therapy.

An exciting weekend in Madrid for all cardiologists – ESC Congress 2025! What was your highlight?

Dialysate K+, GI K+ Binders & A Fib in HD - ADAPT - Prof. David Charytan (New York City, NY, USA) Prof. Dr. Charytan discusses how interventions into potassium homeostasis may affect the risk of atrial and ventricular arrhythmia, focussing upon his ADAPT study. youtu.be/IRIdrp1dk14?...

Effect of Intensive Blood Pressure Control on Stroke by Drs. Li & Li et al. www.jacc.org/doi/10.1016/... Compared with targeting <140 mmHg, targeting <120 mmHg halved the risk of hemorrhagic stroke and did not increase that of ischemic stroke.

Dalbavancin for Treatment of Staphylococcus aureus Bacteremia: The DOTS Randomized Clinical Trial by Drs. Turner, Holland et al. jamanetwork.com/journals/jam... In adult participants with complicated S aureus bacteremia, dalbavancin was not superior to standard therapy.

Friday is always our favorite day - a new MARKUS@HOMe Webinar! Anti-Nephrin-Antikörper bei Podozytopathien - Prof. Huber, Prof. Tomas, Dr. Hengel, Dr. Mühlig youtu.be/nq3VQbb-WwE?...

2025 Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines www.ahajournals.org/doi/10.1161/...

KDIGO 2025 ADPKD Guideline: A commentary on diagnosis and management of hepatopancreatic manifestations by the ERA Working Group Genes & Kidney by Drs. @muellerrom.bsky.social , @joostphdrenth.bsky.social, et al. academic.oup.com/ndt/article/...

Where the sea meets the sky, peace begins

Extended reduced-dose DOAC: APICAT / RENOVE - Prof. Isabelle Mahé / Prof. Francis Couturaud youtu.be/RXttWKQ-sM4?... Prof Mahé and Prof. Couturaud discuss the use of reduced-dose NOAC treatment for extended treatment of VT, based upon their APICAT and RENOVE trials.

A Crossover Trial of Hospital-Wide Lactated Ringer’s Solution versus Normal Saline by Drs. McIntyre, Taljaard et al. www.nejm.org/doi/full/10.... Lactated Ringer’s solution rather than normal saline did not result in a lower incidence of death or readmission to the hospital.

2025 Concise Clinical Guidance: An ACC Expert Consensus Statement on Medical Weight Management for Optimization of Cardiovascular Health by Drs. Gilbert, @drmarthagulati.bsky.social, Gluckman, @mkittlesonmd.bsky.social, Rikhi, Saseen, Tchang

Every sunset is an opportunity to reset.

It's Friday again! Posttransplantations-Lymphome - Priv.-Doz. Dr. Florian Kocher, Prof. Dr. Dominik Wolf (Innsbruck) youtu.be/t3mWguKpq7E?...

2025 Concise Clinical Guidance: An ACC Expert Consensus Statementon the Diagnosis and Management of Pericarditis A Report of the American College of Cardiology Solution Set Oversight Committee www.jacc.org/doi/epdf/10....

Kidney function trajectories before and after hospitalization for HFrEF by Drs. Kobayashi, Girerd et al. academic.oup.com/eurheartj/ar... In HFrEF, kidney function decline may precede a HF events by up to one year. Monitoring eGFR slopes may allow early detection of patients at risk.

And the wheel keeps turning...

Our new webinar is now available! Schlaganfall: Update für Internisten 2025 - Prof. Dr. Christoph Kleinschnitz (Essen) youtu.be/vGdg_YIf7uc?...

Aldosterone and Aldosterone Modulation in Cardio-Kidney Diseases by Drs. Fioretti, Butler et al. www.jacc.org/doi/10.1016/... This review describe the role of aldosterone, steroidal and nonsteroidal MRA and aldosterone synthase inhibitors in cardio-kidney diseases.

Patent Foramen Ovale and Stroke: A Review by Drs. Kent, Wang et al. jamanetwork.com/journals/jam... Percutaneous PFO closure substantially reduces the risk of stroke recurrence in well-selected patients younger than 60 years after cryptogenic stroke.

Sunday is beach day!

The finale of our Tour Academique! AKI after Glyoxylic Acid for Hair-Straightening - Prof Emmanuel Letavernier & Prof Linda Shavit youtu.be/428kB8L9Kgw?...

Daily steps and health outcomes in adults: a systematic review and dose-response meta-analysis by Drs. Ding, Clare, Owen et al. thelancet.com/journals/lan... 7000 steps per day are associated with clinically meaningful improvements in health outcomes.