Neuroscientists around the world use Brain Map to accelerate their research. 🧠📈 Explore the massive, free library of datasets, protocols, computational tools, and more at portal.brain-map.org #OpenScienceWeek

An in-depth perspective piece discussing the transformative impact of AI coding tools in neuroscience research, featuring my work on SpikeAgent and AI interfaces for neural data analysis. @zuwan-lin.bsky.social www.thetransmitter.org/craft-and-ca...

Dear bluesky neuroscientists: You should pay attention to the field of LLM mechanistic interpretability. Not because LLMs are like real brains (they are absolutely nothing alike), but because mech interp analysis methods would be useful in neuroscience. Start learning here: tinyurl.com/48pum4pb

𝗕𝗿𝗮𝗶𝗻-𝘄𝗶𝗱𝗲 𝗰𝗼𝗺𝗽𝘂𝘁𝗮𝘁𝗶𝗼𝗻𝘀 Spatially distributed and regionally unbound cellular resolution brain-wide processing loops in mice 𝗕𝗿𝗮𝗶𝗻 𝗿𝗲𝗴𝗶𝗼𝗻𝘀 𝗼𝗿 𝗱𝘆𝗻𝗮𝗺𝗶𝗰 𝘁𝗵𝗿𝗲𝗮𝗱𝘀? Dynamical processing winding through most brain regions. Looks like a must read. www.biorxiv.org/content/10.1... #neuroskyence

Science is a team effort, and the @alleninstitute.org has put in a lot of effort! They screened thousands of AAV enhancers to find the best and brightest, culminating in the AAV Enhancer Collection at Addgene. Learn more about all of the details in our newest blog post!

You're in research because you want to advance science, share your results with others, grow in your career & connect with the community. Here are 7 reasons why posting preprints on bioRxiv & medRxiv can help you meet those goals. 💚 #OpenScience #Preprints #ScienceCommunication #bioRxiv #medRxiv

I wrote a Comment on neurotheory, and now you can read it! Some thoughts on where neurotheory has and has not taken root within the neuroscience community, how it has shaped those subfields, and where we theorists might look next for fresh adventures. www.nature.com/articles/s41...

Thrilled to share our new study showing microglia prune astrocyte processes in adult brain, to regulate synaptic transmission, hypothalamic neuron activity, and salt-induced hypertension in🐀. Huge team effort - congratulations to all🥂🍾🎉

This is an airyscan confocal movie of mitochondria (white) moving around in a mouse astrocyte. Actin filaments are in orange and microtubules are in blue.

FlyBase needs your help! We ask that European labs continue to contribute to Cambridge, UK FlyBase, whereas US and other non-European labs can contribute to US FlyBase. For more information and how to donate: wiki.flybase.org/wiki/FlyBase...

VIVIT: Resolving trans-scale volumetric biological architectures via ionic glassy tissue @cellcellpress.bsky.social www.cell.com/cell/fulltex...

Let’s do this www.universityofcalifornia.edu/get-involved...

New electron microscopy study in @nature.com Neuroscience finds that layer 5 ET neurons mostly connect to inhibitory cells locally, esp. those suppressing other excitatory cells, suggesting a "winner-take-all" system. 🧠📈 www.nature.com/articles/s41...

A big day for preventing mitochondrial diseases from transmitting to the next generation www.nature.com/articles/d41... www.nejm.org/doi/full/10.... www.nejm.org/doi/full/10.... www.nejm.org/doi/full/10....

Your sleep pressure is powered by your mitochondria! Sleep, energy, and ageing are all connected through mitochondrial bioenergetics in neurons. Brilliant work from Gero Miesenböck’s lab, just out in Nature @nature.com www.nature.com/articles/s41...

The complete Cosmos series by Carl Sagan is now available at the Internet Archive. archive.org/details/Cosm... h/t @[email protected] for spotting this. @archive.org #cosmology #astronomy #science

A few weeks ago, I talked to @neildegrassetyson.com on his StarTalk Radio about our efforts to understand human brain disorders with stem cell models including #assembloids. We touched on the promise of these technologies, the challenges & the mission behind the work www.youtube.com/watch?v=HEBj...

Today I learned the @amnh.org is pay-what-you-wish for NY residents, making it easy to dip in for a quick visit with my new pal Apex Stegosaurus 😍

The dynamics and geometry of choice in the premotor cortex 🧠 Nature 2025 #neuroskyence www.nature.com/articles/s41...

CryoRhodopsins: A comprehensive characterization of a group of microbial rhodopsins from cold environments www.science.org/doi/10.1126/...

Your brain learns for you even when you're not actively learning. Maybe. (in mice).

Our new paper out now in Science explores how neural activity in the lateral entorhinal cortex (LEC) *drifts* over time - and *jumps* at key boundaries - to help organize events in memory. 🔗 www.science.org/doi/10.1126/... Here's a quick summary of what we found 🧵👇

Nature research paper: Nerve-to-cancer transfer of mitochondria during cancer metastasis https://go.nature.com/46c474I

Your brain doesn’t just passively track time ⏳ - it structures it. In @Science.org we show that activity in 🧠 memory circuits (LEC) drifts constantly, but makes sharp jumps at key moments, segmenting life into meaningful events. (1/2) 👉 www.science.org/doi/10.1126/...

Holyyyyyy....I am a tired exhausted puddle on the floor. What a day for @vrubinobs.bsky.social! This observatory is incredible. Highly, HIGHLY recommend joyscolling around Rubin's Skyviewer. I quite like this galaxy - which is your favorite? 🔭🧪 skyviewer.app

Our groundbreaking Dark Sectioning technique is now published in Nature Methods! 🎉 It supercharges existing imaging systems: 🔬 Widefield → Confocal 🔬 Single-photon → Multiphoton 🔬 2D-SIM → 3D-SIM Now integrated in Airy PolarSIM and #FlexSIM! doi.org/10.1038/s415... #Microscopy #Fluorescence

Grid cells have a geometry in time. Thanks to @azvollan.bsky.social l & @rjgardner.bsky.social for this heroic discovery. @ercresearch.bsky.social #KiloNeurons @m-bmoser.bsky.social @kavlintnu.bsky.social @nature.com @kavlifoundation.bsky.social www.nature.com/articles/s41...

1/6 Why does the brain maintain such precise excitatory-inhibitory balance? Our new preprint explores a provocative idea: Small, targeted deviations from this balance may serve a purpose: to encode local error signals for learning. www.biorxiv.org/content/10.1... led by @jrbch.bsky.social

My med school textbook says stimulants like Ritalin treat hyperactivity by “stimulating” the brain’s attention and cognitive control systems. We studied children taking stimulants in the ABCD Study, and the largest differences were actually in arousal and reward networks! Check out our preprint!

Happy 99th birthday to the man who gave voice to the wild. 🎉 Sir David Attenborough, thank you for a lifetime dedicated to the natural world, and for sharing its story with wisdom, wonder, and grace. You've inspired generations to fall in love with nature.

Taiwan Yellow Tit (Machlolophus holsti) endemic to taiwan by Joinus12345 #birds #nature #photography

ACTION ITEM-----ACTION ITEM Implementation of Schedule F This is what a lot of us have been worried about. This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs. BUT THERE IS A COMMENT PERIOD... 1/n

Another image from this incredible foggy morning at the iconic Mont Saint Michel last week… #photography #art #landscape #history #myregion

Really looking forward to discussing these ideas at the Neuroscience & Philosophy Salon tomorrow! 😊 You can register here: umd.zoom.us/meeting/regi...

The brain as it's never been seen before. Scientists have created the largest wiring diagram and functional map of a mammal brain to date. 🧠📈 @princetonneuro.bsky.social @jhuapl.bsky.social @uwgradschool.bsky.social @bcmfromthelabs.bsky.social @unigoettingen.bsky.social

The most comprehensive map to date of cell structure and function in the mouse cortex reveals a previously unappreciated level of coordination among inhibitory interneurons. By Katie Moisse #neuroskyence www.thetransmitter.org/connectome/i...

A tour de force study from Taipale&Yin labs. It expands the vocabulary of the Regulatory Code by adding 1131 TF:TF composite motifs that are different from the individual TF motifs. The new composite motifs are enriched in cell-type specific elements and active in vivo www.nature.com/articles/s41...

Researchers have created the largest and most detailed wiring diagram of a mammalian brain to date, by mapping cells in a cubic millimetre of a mouse’s brain tissue https://go.nature.com/4cu68dN

The MICrONS Project www.nature.com/immersive/d4... "An unprecedented dataset of high resolution anatomical images of individual cells in mouse visual cortex, mapped on to their responses", "integrated view of function and structure"

Scientists map the half-billion connections that allow mice to see www.princeton.edu/news/2025/04... #MICrONS project

How do we associate the flavors we experience during a meal 🍽️😋 with postingestive effects like food poisoning 🤢🤮 that arise much later? Our answer in @nature.com this week: Illness signals from the gut reactivate and strengthen flavor representations in the amygdala. 📄: nature.com/articles/s41...

Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety: @cellpress.bsky.social www.cell.com/cell/fulltex...

🥼 Janelia researchers led by @boazmohar.bsky.social @nspruston.bsky.social @rhodamine110.bsky.social & @svoboda314.bsky.social @alleninstitute.bsky.social have developed a new imaging tool that maps brain-wide changes in neuronal connections. 🧠 🔗 www.janelia.org/news/new-ima...

✨ Announcing a new glutamate indicator - iGluSnFR4! ✨ Launched as a pair, iGLuSnFR4s and iGluSnFR4f have high-sensitivity and fast activation/deactivation for recording synapses. More on the indicators and what they are already revealing: www.biorxiv.org/content/10.1... 🧠📈

This is the way.

If you do multi-plane 2p imaging, you may see the same cells across planes. We built Suite3D exactly for this purpose! It removes duplicates, corrects axial movement, finds more cells with less noise, much faster than alternatives. github.com/alihaydarogl... Try on your data, and reach out!

Many of us use 2p scopes to image 3D volumes of brain. But then we analyze the data plane by plane, resulting in duplicated neurons, missed neurons, and low s/n. Let's go 3D! Suite3D: Volumetric cell detection for two-photon microscopy by @haydari.bsky.social & team. www.biorxiv.org/content/10.1...

Here at Princeton, we’re amplifying our university president’s leadership. It’s time for everyone - faculty, students, staff - to speak out. tl;dr: rights can’t be blackmailed. From me and science colleagues: www.dailyprincetonian.com/article/2025...

Nature research paper: GluA2-containing AMPA receptors form a continuum of Ca2+-permeable channels https://go.nature.com/4bOLhBx