@mnprioleau.bsky.social
📤 33
📥 34
📝 1
Group leader@ijmonod. Studying DNA replication and genomic instability
reposted by
Institut Jacques Monod
20 days ago
#JobOffer
💼 Ingénieur d'étude H/F en biologie moléculaire 📆 1e décembre 2025 📍 Institut Jacques Monod /
@mnprioleau.bsky.social
Candidatez sur le portail emploi CNRS avant le 3 octobre 🔗
emploi.cnrs.fr/Offres/CDD/U...
0
0
2
reposted by
The EMBO Journal
2 months ago
Eliminating both
#separase
inhibition mechanisms –via securin and via cyclin B1-Cdk1– reveals absence of robust cohesin protection in metaphase II
#oocytes
Katja Wassmann
@meiosis-mom.bsky.social
and colleagues
www.embopress.org/doi/full/10....
0
5
4
reposted by
James Gahan
about 1 month ago
Just a few more days left to apply!
add a skeleton here at some point
0
2
6
reposted by
Axel Delamarre
3 months ago
Our paper is now out in Molecular Cell! Check the thread in this former post:
www.cell.com/molecular-ce...
add a skeleton here at some point
5
54
29
reposted by
Aurele Piazza
about 1 month ago
Transcription and recombination are two universal DNA-dependent processes, but how they are coordinated remains largely unknown. Here we characterized transcription-recombination priority rules in yeast. 🧵
www.embopress.org/doi/full/10....
1
28
14
reposted by
Maxim Greenberg
about 2 months ago
I believe that over the past ~ two decades, since the breakthrough papers on UHRF1, this is the first reported DNA methylation phenotype of its close paralog, UHRF2 (and not for lack of trying). Congrats to Ambre Bender and Michael Weber on this fantastic study!
www.nature.com/articles/s41...
loading . . .
UHRF2 mediates resistance to DNA methylation reprogramming in primordial germ cells - Nature Communications
DNA methylation in mouse primordial germ cells (PGCs) is restricted to transposable elements, but how this unique DNA methylome is established is poorly understood. Here, the authors identify UHRF2 as...
https://www.nature.com/articles/s41467-025-61954-0
1
33
11
reposted by
Axel Delamarre
4 months ago
Hi everyone! The latest method from the Whitehouse lab: PCP PCP uses a novel proximity barcoding strategy to simultaneously map 3D genome organization at various resolutions at the single molecule level: Out soon, check the updated BioRxiv – little thread: 1/11
www.biorxiv.org/content/10.1...
1
41
20
reposted by
Nezar Abdennur
3 months ago
I'm proud to announce the latest release of 🧬
#Oxbow
🏹, with new features to make NGS data analysis more powerful, efficient, and "composable". Learn more at:
oxbow.readthedocs.io
loading . . .
2
23
14
reposted by
Di Antonio Research Group
3 months ago
Ready for super-G4s? We have identified clusters of G4s in intergenic regions that act as super-enhancers in ovarian cancer cells, hence the name super-G4! These are de novo super-enhancers that are not underpinned by canonical epigenetic marks, supporting the epigenetic role of G4s
rdcu.be/evXtf
0
6
3
reposted by
Aga Gambus
3 months ago
It is finally out 👍😀. Great job of the team (mostly absent from Bsky) and
@m-saponaro.bsky.social
CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS url:
academic.oup.com/nar/article/...
loading . . .
CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS
Abstract. Disassembly of the replication machinery (replisome) from chromatin is an active process driven by two ubiquitin ligases Cul2LRR1 and TRAIP, whic
https://academic.oup.com/nar/article/53/13/gkaf530/8196077
1
36
13
reposted by
Björn Schumacher
4 months ago
Register now for the 7th German-French DNA Repair Meeting, which will take place at the Campus Pierre et Marie Curie of Sorbonne University in Paris, France, from 5–7 November 2025.
premc.org/dnarepair202...
0
16
11
reposted by
Aga Gambus
3 months ago
Genome Biology conference in Birmingham UK in September. Check out our great invited speakers! Lots of slots for talks selected from abstracts too! Please repost 😀
add a skeleton here at some point
0
7
5
reposted by
Rougeulle lab
4 months ago
If you are interested by epigenetics, early human development in excellent scientific environment in middle of Paris, we are recruiting a postdoc.
app.beetween.com/WeaselWeb/p/...
Don't hesitate to apply or share the post !
loading . . .
Beetween
https://app.beetween.com/WeaselWeb/p/#/apply/job/z21lk5qfur9g/postdoctoral-position-epigenetics-on-human-x-chromosome-inactivation-m-f
0
12
21
reposted by
Alessandra Brambati
5 months ago
Excited to share our latest from my postdoc at
@mskcancercenter.bsky.social
in the Sfeir Lab, in collaboration with the Simon Powell Lab! We uncovered a novel genome repair mechanism in human cells: RNA-templated DNA double-strand break repair (RT-DSBR). (1/5)
3
52
21
reposted by
Institut Jacques Monod
5 months ago
#JobOffer
💼 Ingénieur d’étude H/F en biologie moléculaire 📍 Equipe Prioleau 📅 1e septembre 2025 🔗
emploi.cnrs.fr/Offres/CDD/U...
Candidatez avant le 19 mai 2025
0
1
3
reposted by
Institut Jacques Monod
6 months ago
✍️ The
@vdoye.bsky.social
Lab contributed to the publication of a new article 📖
@naturecomms.bsky.social
📃 Nuclear pores safeguard the integrity of the nuclear envelope 🔗
www.nature.com/articles/s41...
add a skeleton here at some point
0
1
2
reposted by
Anton Goloborodko
6 months ago
Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!!
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...
loading . . .
Rules of Engagement
YouTube video by Johan Gibcus
https://www.youtube.com/watch?v=pmvOrmErhhc
7
98
59
reposted by
Deegan Lab
6 months ago
3rd edition of the fantastic UK DNA replication meeting is happening next September in Edinburgh. Don't miss out 🧬🏴
www.biochemistry.org/events-and-t...
loading . . .
UK DNA Replication Meeting 2026
Research in the DNA replication field is progressing at a remarkable rate. Technological innovations in biochemical reconstitution, structural biology, proteomics and DNA sequencing are helping to rap...
https://www.biochemistry.org/events-and-training/events-calendar/uk-dna-replication-meeting-2026/
0
22
16
reposted by
Institut Jacques Monod
6 months ago
📣 The
@ijmonod.bsky.social
is hosting this year the Paris-Munich Epigenetics - Workshop and Symposium, an exciting exchange between the Paris and Munich epigenetic research communities!
1
7
6
reposted by
Palancade lab
6 months ago
🥚🔄🐓 - Another narrative of our last paper:
communities.springernature.com/posts/r-loop...
loading . . .
R-loops and Genetic Instability: a Chicken and Egg Problem
Investigating the relationships between R-loops and genetic instability led to the discovery that some DNA:RNA hybrids actually arise as a consequence of DNA lesions.
https://communities.springernature.com/posts/r-loops-and-genetic-instability-a-chicken-and-egg-problem
0
1
2
reposted by
Stem Cells, Regeneration & Evolution
7 months ago
Paper alert! We are a little late but very proud of the team's latest study on the neurogenic functions of the Notch signalling pathway during
#regeneration
and posterior elongation in
#platynereis
.
@ijmonod.bsky.social
@cnrsbiologie.bsky.social
@upcite.bsky.social
www.biorxiv.org/content/10.1...
loading . . .
Multifaceted conserved functions of Notch during post-embryonic neurogenesis in the annelid Platynereis
Notch signaling is an evolutionarily conserved pathway known to orchestrate neurogenesis by regulating the transition of progenitor cells to differentiated neurons and glia, as well as by directing ne...
https://www.biorxiv.org/content/10.1101/2025.03.09.642222v1
1
9
5
reposted by
Valérie Borde
7 months ago
!! Postdoc position available to study homologous recombination in live cells through advanced microscopy analyses in a collaboration between our lab and Angela Taddei's lab, both at
@institutcurie.bsky.social
in Paris. Apply to :
[email protected]
0
7
11
reposted by
bioRxiv Developmental Biology
7 months ago
Dual PAX3/7 transcriptional activities spatially encode spinal cell fates through distinct gene networks
https://www.biorxiv.org/content/10.1101/2025.03.11.642668v1
0
5
4
reposted by
Centro de Investigaciones Biológicas Margarita Salas (CSIC)
7 months ago
#CIBseminars Destroying the eukaryotic replisome Karim Labib, MRC Protein Phosphorylation and Ubiquitylation Unit, U. Dundee 📅March 13 🕙12pm The seminar will take place at
@cib-csic.bsky.social
and streamed online ➡️
https://m.mtrbio.com/etxkvhixds
0
3
5
reposted by
Dirk Remus
7 months ago
How do replisomes walk on DNA? And what happens when they run into a G-quadruplex?
@sahilbatra.bsky.social
and
@benallwein.bsky.social
provide unexpected insight in our latest paper with Richard Hite
@mskcancercenter.bsky.social
@science.org
www.science.org/doi/10.1126/...
. Congrats to all authors!
loading . . .
G-quadruplex–stalled eukaryotic replisome structure reveals helical inchworm DNA translocation
DNA G-quadruplexes (G4s) are non–B-form DNA secondary structures that threaten genome stability by impeding DNA replication. To elucidate how G4s induce replication fork arrest, we characterized fork ...
https://www.science.org/doi/10.1126/science.adt1978
8
107
50
reposted by
Richard Sever
7 months ago
Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers]
openrxiv.org
1/n
loading . . .
Homepage - openRxiv
openRxiv is an independent non-profit, the new organizational home for bioRxiv and medRxiv, enabling researchers to instantly share groundbreaking findings with the global scientific community.
https://openrxiv.org/
55
2574
893
reposted by
Institut Jacques Monod
7 months ago
✍️The
@palancadelab.bsky.social
published a new article 📖
@naturecomms.bsky.social
📃 DNA lesions can frequently precede DNA:RNA hybrid accumulation 🔗
www.nature.com/articles/s41...
add a skeleton here at some point
0
7
1
reposted by
Stem Cells, Regeneration & Evolution
7 months ago
You are interested in a Master 2 internship in a dynamic and supportive team working on animal
#regeneration
in Paris at
@ijmonod.bsky.social
? Take a look at our project proposal and contact us!
@stemdevevo.bsky.social
stemdevevo.wordpress.com/wp-content/u...
1
5
8
reposted by
Ana Pombo
7 months ago
Join us for the 2025 GRC Genome Architecture
www.grc.org/genome-archi...
@spp2202.bsky.social
@jobdekker.bsky.social
@metorrespadilla.bsky.social
@jopkind.bsky.social
@dimplenotani.bsky.social
@stanleyqilab.bsky.social
@andybelmont.bsky.social
@fondufemittendorf.bsky.social
@boyanbonev.bsky.social
0
31
12
reposted by
Institut Jacques Monod
7 months ago
💼
#Internship
offer The Gazave Lab is recruiting a Master 2 student for the project "Unravelling animal regeneration success, insights from the annelid Platynereis" More informations ⬇️
add a skeleton here at some point
0
3
5
reposted by
Valérie Borde
7 months ago
📣 Last days to register to the "Physics meet Genome" summer school in beautiful Cargèse, Corsica, June 2nd to 6th 2025. Discover the full program and register by March 8th here:
iesc-inscriptions.fr
0
3
2
reposted by
Maxim Greenberg
7 months ago
See you at Jussieu in Paris tomorrow at 1:30 PM! We will march by the Statue of Liberty at Luxembourg Garden, a great symbol of our treasured alliance and shared values! 🧪🗽
@standupforscifr.bsky.social
@sufs-paris-rp.bsky.social
@standupforscience.bsky.social
add a skeleton here at some point
1
27
12
reposted by
CNRS Biologie
7 months ago
#RésultatScientifique
| Un équilibre subtil dans la duplication des chromosomes 🧬🔬
@kathrinmarheineke.bsky.social
et ses collaborateurs révèlent que la réplication de l'ADN repose sur deux stratégies opposées et que Plk1 joue un rôle de coordination !
buff.ly/SNH5hl6
loading . . .
Yin-Yang dans la duplication des chromosomes
La duplication du matériel génétique est une étape fondamentale de la multiplication des cellules. Dans une étude parue dans Nucleic Acids Re
https://www.insb.cnrs.fr/fr/cnrsinfo/yin-yang-dans-la-duplication-des-chromosomes
1
7
7
reposted by
Romain Koszul
8 months ago
Our latest work: how can compartmentalization emerge in a eukaryotic genome lacking canonical heterochromatin? By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient!
#chromatin
#3Dgenome
#generegulation
www.science.org/doi/10.1126/...
👇
loading . . .
Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus
In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and a...
https://www.science.org/doi/10.1126/science.adm9466
3
185
86
reposted by
Aga Gambus
8 months ago
To all postdocs on the path to independece: the next round of postdoctoral bbsrc fellowships is open. It provides a chance of independent research with a support of a host lab.
www.ukri.org/opportunity/...
.
loading . . .
2025 BBSRC Fellowships scheme
Apply for funding to carry out independent research within a host laboratory and gain leadership skills.
https://www.ukri.org/opportunity/2025-bbsrc-fellowships-scheme/
0
7
2
genesdev.cshlp.org/content/earl...
Must read review: lambda-SNS-seq and OK-seq results finally reconciled. Great relief for those who have been using l-SNS for a long time!
loading . . .
The double life of mammalian DNA replication origins
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
https://genesdev.cshlp.org/content/early/2025/02/04/gad.352227.124.short?rss=1
8 months ago
0
1
0
reposted by
Deniz Gökbuget
8 months ago
🚨 New Paper Alert! 🚨 Our latest study on KMT2C/KMT2D (mutated in 20% of cancers) reveals a new function for H3K4me1 in regulating DNA replication timing (RT) and origin activity during cell state transitions. Check it out:
www.cell.com/cell-reports...
. More info ⬇️
loading . . .
KMT2C/KMT2D-dependent H3K4me1 mediates changes in DNA replication timing and origin activity during a cell fate transition
Gökbuget et al. use machine learning to quantify chromatin state changes that predict DNA replication timing changes during cell differentiation. By following up on top predictors through functional v...
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00043-9
2
24
15
reposted by
Kathrin Marheineke, CNRS research director
8 months ago
We are happy to share our latest study, published today in Nucleic Acids Research (
doi.org/10.1093/nar/...
)
@ijmonod.bsky.social
,
@i2bcparissaclay.bsky.social
. Many thanks to our collaborators !
loading . . .
Dual DNA replication modes: varying fork speeds and initiation rates within the spatial replication program in Xenopus
Abstract. Large vertebrate genomes duplicate by activating tens of thousands of DNA replication origins, irregularly spaced along the genome. The spatial a
https://doi.org/10.1093/nar/gkaf007
0
3
3
you reached the end!!
feeds!
log in