Omar Kamileen
@omarkamileen.bsky.social
📤 92
📥 283
📝 22
An impatient optimist. 🇩🇪🇱🇰
reposted by
Omar Kamileen
Maite Colinas
5 days ago
Our funky R-stereoselective Epi-STR is now available online and open access at its permanent home
@angewandtechemie.bsky.social
. 🥳 This is Clara's first first-author paper, makes me extra happy!
@mpi-ce.bsky.social
#PlantScience
#natprod
doi.org/10.1002/anie...
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reposted by
Omar Kamileen
Chris Simms
3 days ago
And here's one for
@sciam.bsky.social
on the amazing biology of the European blister beetle (Meloe proscarabaeus). The larvae, which clump together in an orange mass, are the first animals known to mimic flower scent - they do it to attract bees. 🧪 🪲 🐝 🌼
www.scientificamerican.com/article/beet...
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These baby beetles work together to look—and smell—like flowers
Parasitic beetles are the first animals known to imitate floral scents
https://www.scientificamerican.com/article/beetle-larvae-mimic-flower-scents-to-attract-bee-hosts/
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reposted by
Omar Kamileen
SEBiology
2 days ago
We are deeply saddened by the passing of Professor Philippa Borrill, SEB Plant President Medallist (2022). Her work and mentorship had a lasting impact on the plant science community. Read our tribute:
www.sebiology.org/resource/rem...
⬇️ Her Scientists with Impact interview is in this thread
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Remembering Professor Philippa Borrill: A leading voice in plant science
The SEB mourns the loss of Professor Philippa Borrill, an outstanding plant scientist, inspiring leader, and 2022 SEB Plant President Medallist.
https://www.sebiology.org/resource/remembering-professor-philippa-borrill-a-leading-voice-in-plant-science.html
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reposted by
Omar Kamileen
Scientific American
4 days ago
Parasitic beetles are the first animals known to imitate floral scents
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These baby beetles work together to look—and smell—like flowers
Parasitic beetles are the first animals known to imitate floral scents
https://www.scientificamerican.com/article/beetle-larvae-mimic-flower-scents-to-attract-bee-hosts/
0
81
28
reposted by
Omar Kamileen
Oded Rechavi
13 days ago
Every PI
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reposted by
Omar Kamileen
Molecular Plant & Plant Communications
21 days ago
AI-driven protein engineering: A new paradigm for plant trait design
#review
#MolecularPlant
cell.com/molecular-pl...
0
2
1
reposted by
Omar Kamileen
Molecular Plant & Plant Communications
about 2 months ago
Conserved and Divergent: Salicylic Acid Biosynthesis and Signaling Pathways across the Plant Kingdom
#review
#MolecularPlant
cell.com/molecular-pl...
0
1
1
How nature borrows ideas from nature. Ahh... beautiful work from Ryan Alam, a colleague and a dear friend of mine :) Bee-hunting beetles are the first animals known to fake the smell of flowers | Science | AAAS
www.science.org/content/arti...
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Bee-hunting beetles are the first animals known to fake the smell of flowers
Study of parasitic blister beetles reveals a new form of chemical deception
https://www.science.org/content/article/bee-hunting-beetles-are-first-animals-known-fake-smell-flowers
about 2 months ago
0
0
1
reposted by
Omar Kamileen
Nature Biotechnology
about 2 months ago
Democratizing CRISPR? Legal complexity, access and the right to science -
@zlsr-unibas.bsky.social
go.nature.com/4rZjTYt
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Democratizing CRISPR? Legal complexity, access and the right to science - Nature Biotechnology
How do intellectual property rights and licensing structures influence access to CRISPR technologies? Could the right to science act as a complementary legal instrument to promote socially beneficial ...
https://go.nature.com/4rZjTYt
0
9
3
reposted by
Omar Kamileen
Ryo Yokoyama
about 2 months ago
A Stable Isotope Tracing Primer for the Mass Spectrometrist - Annual Review of Analytical Chemistry
www.annualreviews.org/content/jour...
@annualreviews.bsky.social
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A Stable Isotope Tracing Primer for the Mass Spectrometrist
Metabolic function plays a key role in our understanding of both biological and pathophysiological processes. Metabolism is a complex combination of intrinsic processes and environmental cues across a...
https://www.annualreviews.org/content/journals/10.1146/annurev-anchem-080524-014717
0
1
1
reposted by
Omar Kamileen
Chenxin Li, PhD
about 2 months ago
Interesting paper: Metabolic enzyme PAL can go into the nucleus in response to high product build up and sequester an activating TF of the pathway, thus acting as a feedback inhibition loop. From:
www.science.org/doi/full/10....
#PlantScience
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A dual role of Arabidopsis PAL nuclear localization in fine tuning flavonoid biosynthesis
PAL’s dual localization links metabolism with transcription, revealing feedback that fine-tunes phenylpropanoid regulation.
https://www.science.org/doi/full/10.1126/sciadv.adz6970
0
17
13
reposted by
Omar Kamileen
Conor McClune
about 2 months ago
Lovely C&EN
@cenmag.bsky.social
story on the history and personal impact of the cancer drug Taxol. After spending recent years deciphering how yew trees, our source for Taxol, synthesize this lifesaving drug, it’s so nice to see it in the larger context
#secmet
#medsky
Plants are amazing chemists.
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Paclitaxel saved my life. New discoveries could boost supply
After decades, scientists have finally pieced together the 23-step biosynthetic pathway to produce this cancer drug
https://cen.acs.org/pharmaceuticals/drug-development/Paclitaxel-saved-life-New-discoveries/104/web/2026/02
0
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www.nature.com/articles/s41...
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A geometric foundation model for enzyme retrieval with evolutionary insights - Nature Catalysis
Predicting the function of enzymes remains difficult and current computational methods require improvement. Now EnzymeCAGE, a geometric deep learning model, has been developed to more accurately predi...
https://www.nature.com/articles/s41929-026-01478-y
2 months ago
0
0
0
reposted by
Omar Kamileen
Ryo Yokoyama
2 months ago
Synthetic Biology of Plants and Microbes for Agriculture, Environment, and Future Applications | Chemical Reviews
pubs.acs.org/doi/10.1021/...
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Synthetic Biology of Plants and Microbes for Agriculture, Environment, and Future Applications
Agriculture is under pressure to provide food for a growing population and the feedstock required to drive the bioeconomy. Methods to breed and genetically modify plants are inadequate to keep pace. W...
https://pubs.acs.org/doi/10.1021/acs.chemrev.4c00687
0
3
1
reposted by
Omar Kamileen
Ryo Yokoyama
2 months ago
Expanding enzyme functionality through site-specific incorporation of noncanonical amino acids: Trends in Biochemical Sciences
www.cell.com/trends/bioch...
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Expanding enzyme functionality through site-specific incorporation of noncanonical amino acids
Enzymes are nature’s catalysts, capable of performing complex chemical transformations with remarkable precision and efficiency, yet their potential is confined by the chemistry of 20 canonical amino ...
https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004%2825%2900300-7
0
1
1
reposted by
Omar Kamileen
Jeremy Baskin
4 months ago
Proximity labeling users: check out this study by
@zhixingchen2.bsky.social
and Peng Zou, which establishes how much contact-dependence vs. diffusion is responsible for biotinylation — tl;dr TurboID has a much smaller effective radius!
www.nature.com/articles/s41...
1/2
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Spatial barcoding reveals reaction radii and contact-dependent mechanism of proximity labeling - Nature Chemical Biology
A DNA nanoruler platform enables precise measurement of the labeling radii of TurboID and APEX2, uncovering their contact-dependent mechanisms. These findings redefine the enzymology of proximity labe...
https://www.nature.com/articles/s41589-025-02086-w
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reposted by
Omar Kamileen
Ryo Yokoyama
4 months ago
Mass spectrometry imaging: principles and applications in plant research
nph.onlinelibrary.wiley.com/doi/10.1111/...
@newphyt.bsky.social
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Mass spectrometry imaging: principles and applications in plant research
Mass spectrometry imaging (MSI) is an advanced analytical technique that combines mass spectrometry with spatial mapping, enabling the direct, label-free detection and visualization of molecular dist...
https://nph.onlinelibrary.wiley.com/doi/10.1111/nph.70834
0
5
1
reposted by
Omar Kamileen
bioRxiv Plant Bio
4 months ago
Dopamine biosynthesis in plants
https://www.biorxiv.org/content/10.64898/2025.12.10.693491v1
0
5
1
www.nature.com/articles/s41...
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Scikit-bio: a fundamental Python library for biological omic data analysis - Nature Methods
Nature Methods - Scikit-bio: a fundamental Python library for biological omic data analysis
https://www.nature.com/articles/s41592-025-02981-z
4 months ago
0
1
0
reposted by
Omar Kamileen
bioRxivpreprint
4 months ago
Nicotine biosynthesis completed by cryptic activating glucosylation
https://www.biorxiv.org/content/10.64898/2025.12.04.692101v1
0
11
6
reposted by
Omar Kamileen
Natural Product Reports
4 months ago
🔓Don't miss in our latest issue this
#OpenAccess
review by
@maximilianfrey.bsky.social
& co.
@ipbhalle.bsky.social
,
@unihalle.bsky.social
&
@mpi-ce.bsky.social
looking at the biosynthesis of biologically active terpenoids in the mint family
#naturalproducts
#secmet
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Biosynthesis of biologically active terpenoids in the mint family (Lamiaceae)
Covering: 2000 to 2025 The Lamiaceae family, the sixth largest among angiosperms, is renowned for its rich diversity of terpenoids, many of which exhibit remarkable bioactivities, including…
https://pubs.rsc.org/en/content/articlelanding/2025/np/d5np00026b
0
6
4
www.nature.com/articles/s41...
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Next-generation method for preparing plant cells for single-cell RNA sequencing - Nature Methods
The plant cell wall makes the preparation of high-quality cells for single-cell RNA sequencing challenging. To tackle this issue, we developed FX-Cell, a method that enables the enzymatic digestion of...
https://www.nature.com/articles/s41592-025-02940-8
4 months ago
0
0
0
reposted by
Omar Kamileen
Manuel Lera-Ramirez
5 months ago
#OpenCloning
is a an Open Source alternative to SnapGene/Benchling that supports automation and integration with other software ✅ Free 🔓 Open Source 🧬 More cloning methods than SnapGene 🤖 Can be automated with python 👨🔬 Built by a researcher — for researchers! 👉 Check it out at
opencloning.org
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reposted by
Omar Kamileen
ETH Zurich
5 months ago
Researchers have manufactured organic light-emitting diodes (OLED) on a nanoscale – that’s around a hundred times smaller than a human cell. This not only enables ultra-sharp screens and microscopes, but also opens up entirely novel possibilities for wave optics applications.
ethz.ch/en/news-and-...
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Manufacturing the world's tiniest light-emitting diodes
Researchers from ETH Zurich have manufactured organic light-emitting diodes (OLEDs) on a nanoscale – that’s around a hundred times smaller than a human cell. This not only enables ultra-sharp screens ...
https://ethz.ch/en/news-and-events/eth-news/news/2025/11/manufacturing-the-worlds-tiniest-light-emitting-diodes.html
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17
5
reposted by
Omar Kamileen
Plaschka lab
5 months ago
How does messenger RNA (mRNA) get out of the nucleus to become a protein? Eukaryotic mRNA is packaged, exported, and then translated in the cytoplasm. But how do these steps work? And what are open questions? Check out our new review for our take:
www.annualreviews.org/content/jour...
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reposted by
Omar Kamileen
Maddy Seale
5 months ago
And now we have Arabidopsis plants with 8 chromosomes instead of 10 and no obvious phenotypic differences, this week in
@science.org
#PlantScience
Paper here:
www.science.org/doi/10.1126/...
Perspective here:
www.science.org/doi/10.1126/...
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CRISPR-Cas–mediated heritable chromosome fusions in Arabidopsis
The genome of Arabidopsis thaliana consists of 10 chromosomes. By inducing CRISPR-Cas–mediated breaks at subcentromeric and subtelomeric sequences, we fused entire chromosome arms, obtaining two eight...
https://www.science.org/doi/10.1126/science.adz8505
0
97
38
reposted by
Omar Kamileen
Nature Biotechnology
5 months ago
Multimodal learning enables chat-based exploration of single-cell data -
@bocklab.bsky.social
@cemm.oeaw.ac.at
@meduniwien.ac.at
go.nature.com/3WPGJnW
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Multimodal learning enables chat-based exploration of single-cell data - Nature Biotechnology
CellWhisperer uses multimodal learning of transcriptomes and text to answer questions about single-cell RNA-sequencing data.
https://go.nature.com/3WPGJnW
1
17
8
reposted by
Omar Kamileen
Femke de Jong
5 months ago
Tension, suspense, or narrative arc in a story is the stuff that keeps the reader going. But how do you introduce suspense in a scientific article? That is what my latest post is all about.
aboutacademicwritingandzo.substack.com/p/how-to-wri...
#AcademicWriting
#WritingTips
#NarrativeArc
#Suspense
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How to write your paper like a page turner
Working my way through scientific articles I often lose my focus.
https://aboutacademicwritingandzo.substack.com/p/how-to-write-your-paper-like-a-page
0
2
2
www.nature.com/articles/s41...
Really fabulous work! Animal pigments engineered in bacteria.
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Growth-coupled microbial biosynthesis of the animal pigment xanthommatin - Nature Biotechnology
A growth-coupled biosynthetic pathway enables xathommatin synthesis in the soil bacterium Pseudomonas putida.
https://www.nature.com/articles/s41587-025-02867-7
5 months ago
0
2
0
reposted by
Omar Kamileen
Nature Biotechnology
6 months ago
Agrobacterium-mediated transformation of plants and fungi is enhanced by plasmid copy number variants
go.nature.com/3CdewQS
rdcu.be/eNaje
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Binary vector copy number engineering improves Agrobacterium-mediated transformation - Nature Biotechnology
Agrobacterium-mediated transformation of plants and fungi is enhanced by plasmid copy number variants.
https://go.nature.com/3CdewQS
0
12
2
reposted by
Omar Kamileen
Moonyoung Kang
6 months ago
Excited to see our paper online! We combined scMS and scRNA-seq from the same plant cells 🌱 — a step toward true single-cell multi-omics in plants. Overview 👇
add a skeleton here at some point
0
15
5
reposted by
Omar Kamileen
Ryo Yokoyama
6 months ago
Discovery and engineering of the biosynthesis of rotenoids
www.nature.com/articles/s44...
@natsynth.nature.com
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Discovery and engineering of the biosynthesis of rotenoids - Nature Synthesis
Rotenoids are natural insecticides from Fabaceae plants. Here the complete biosynthetic pathway to make rotenoids is elucidated in Amorpha fruticosa and Tephrosia vogelii, revealing a unique Fe(II)-de...
https://www.nature.com/articles/s44160-025-00907-3
0
2
3
reposted by
Omar Kamileen
Maite Colinas
7 months ago
Very exciting to finally see our iridoid cyclase ICYC online
@natplants.nature.com
! A joined effort with Robin Buell’s lab with Josh Wood generating snRNA-seq, and my student Chloée Tymen performing the initial experiment.
#natprod
#PlantScience
@mpi-ce.bsky.social
www.nature.com/articles/s41...
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Discovery of iridoid cyclase completes the iridoid pathway in asterids - Nature Plants
Iridoids are terpenoid metabolites found in thousands of plants. Using single-cell transcriptomics, the authors discovered an unexpected enzyme that has been neofunctionalized to catalyse the cyclization required to form the iridoid scaffold.
https://www.nature.com/articles/s41477-025-02122-6
2
20
14
reposted by
Omar Kamileen
Maeda Plant Metabolism Lab
7 months ago
Our new study in Nature Plants maps how "multi-tasking" enzymes in plants transfer nitrogen, a key step toward improving crop N use efficiency. 🌱 Big thanks to our collaborators from Max Planck, Hokkaido Univ, & MSU, and for support from @NSF and @DOE. Learn more:
rdcu.be/eFOFN
#PlantMetabolism
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Mapping multi-substrate specificity of Arabidopsis aminotransferases
Nature Plants - Systematic characterization of Arabidopsis aminotransferase family enzymes uncovered many previously unrecognized activities and revealed their multi-substrate specificity, aspects...
https://rdcu.be/eFOFN
0
17
8
reposted by
Omar Kamileen
SattelyLab
8 months ago
Beautiful work by Yaereen and former lab member Kevin! Learn more about the anti-cancer compound homoharringtonine and its'biosynthesis in plants here 🌿https://www.biorxiv.org/content/10.1101/2025.08.26.672243v1
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Discovery of homoharringtonine pathway enzymes reveals a whole plant model for coordinated biosynthesis
Plants have evolved to produce diverse molecules that inhibit protein translation. A lead example is homoharringtonine (HHT), both a key tool for ribosomal profiling and an FDA-approved treatment for ...
https://www.biorxiv.org/content/10.1101/2025.08.26.672243v1
1
8
3
reposted by
Omar Kamileen
Ryo Yokoyama
8 months ago
The multilayered regulation of aromatic amino acid biosynthesis in plants: Trends in Biochemical Sciences
www.cell.com/trends/bioch...
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The multilayered regulation of aromatic amino acid biosynthesis in plants
The shikimate and aromatic amino acid (AAA) biosynthetic pathways are crucial for the production of L-phenylalanine (Phe), L-tyrosine (Tyr), and L-tryptophan (Trp), as well as vitamins, hormones, and ...
https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004%2825%2900185-9
0
2
1
reposted by
Omar Kamileen
Itai Yanai
8 months ago
Discovery happens less when you're trying to be the expert and more when you're trying to be the learner.
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reposted by
Omar Kamileen
Ryo Yokoyama
8 months ago
Protein Structural Phylogenetics
academic.oup.com/gbe/article/...
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Protein Structural Phylogenetics
Abstract. Protein structural phylogenetics is an interdisciplinary branch of molecular evolution that (i) uses 3D structural data to trace evolutionary his
https://academic.oup.com/gbe/article/17/8/evaf139/8239332
0
5
1
reposted by
Omar Kamileen
Mitja M. Zdouc
8 months ago
Into natural product biosynthesis & tailoring enzymes? Frustrated by the lack of a dedicated resource to explore their functions? Tired of endless literature searches for reaction info? Meet the MITE database, freely available at
mite.bioinformatics.nl
. Preprint:
doi.org/10.26434/che...
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reposted by
Omar Kamileen
Nature Biotechnology
8 months ago
Inspired by natural molecular glues, drug hunters are chasing protein–protein interactions with next-gen small molecules tuned for enhanced tissue specificity and reduced toxicity
www.nature.com/articles/s41...
rdcu.be/eAC91
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Natural molecular glues spur next-gen small molecules for ‘undruggable’ targets - Nature Biotechnology
Inspired by natural molecular glues, drug hunters are chasing protein–protein interactions with next-gen small molecules tuned for enhanced tissue specificity and reduced toxicity.
https://www.nature.com/articles/s41587-025-02779-6
0
17
1
reposted by
Omar Kamileen
SattelyLab
8 months ago
Couldn't have said it better! Great job
@taralowensohn.bsky.social
, Will, and Chun! Special thanks to the Gao lab at
@stanford.edu
#singlecell
#plantbiology
add a skeleton here at some point
0
7
4
reposted by
Omar Kamileen
Conor McClune
8 months ago
A truly enabling new approach by
@taralowensohn.bsky.social
Will Cody and
@sattelylab.bsky.social
to probe plant genetics at scale. Single-gene-per-cell delivery coupled to an effective transcriptional selection system
www.biorxiv.org/content/10.1...
1
20
14
reposted by
Omar Kamileen
Maite Colinas
9 months ago
Ingenane biosynthesis enzymes in
@newphyt.bsky.social
by
@matildeflorean.bsky.social
,
@carstenschotte.bsky.social
from
@oconnorlab.bsky.social
@mpi-ce.bsky.social
in collaboration with Ian Graham lab members.
#natprod
#PlantScience
doi.org/10.1111/nph....
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Identification of BAHD‐acyltransferase enzymes involved in ingenane diterpenoid biosynthesis
The plant family Euphorbiaceae is an abundant source of structurally complex diterpenoids, many of which have reported anticancer, anti-HIV, and anti-inflammatory activities. Among these, ingenol-3-...
https://doi.org/10.1111/nph.70388
0
8
3
reposted by
Omar Kamileen
Nature Chemical Biology
9 months ago
Here, the authors
@oconnorlab.bsky.social
@mpi-ce.bsky.social
uncover the mechanism of epimerization behind uncommon 3R-containing alkaloids in Mitragyna speciosa (Kratom) and study their inclusion in downstream biosynthesis
#PlantScience
#natprod
www.nature.com/articles/s41...
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Enzymatic epimerization of monoterpene indole alkaloids in kratom - Nature Chemical Biology
Monoterpene indole alkaloids are formed via a 3S stereoselective condensation between secologanin and tryptamine. Here the authors uncover the mechanism of epimerization behind uncommon 3R-containing ...
https://www.nature.com/articles/s41589-025-01970-9?utm_source=bluesky&utm_medium=social&utm_campaign=nchembio
0
11
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reposted by
Omar Kamileen
Laura Gunn
10 months ago
SynBio: it’s what plants crave
doi.org/10.1093/jxb/...
J Exp Bot Insights article from *Dan Hong Loh* - she discusses the impacts of Rubisco SynBio tool expansions from Archer et al. 2025 (
doi.org/10.1093/jxb/...
).
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A SynBio explosion: a whole new world for Rubisco engineering
This article comments on:Archer J, Kathpalia M, Lee B, Li S, Wang T. 2025. Effects of chaperone selectivity on the assembly of plant Rubisco orthologs in E
https://doi.org/10.1093/jxb/eraf189
0
8
5
reposted by
Omar Kamileen
eLife
9 months ago
Heron is a new intuitive software tool that helps researchers design complex experiments even if they don’t have in-depth technical expertise. 🔗
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Streamlining experimental setups
A new software tool called Heron helps researchers to design and run complex experimental systems without needing in-depth technical expertise.
https://buff.ly/AdAhzaW
0
11
5
reposted by
Omar Kamileen
Trends in Plant Science
9 months ago
July Issue. Read FREE: Sequencing historical RNA: unrealized potential to increase understanding of the plant tree of life (see cover); Decoding the evolution of C4 photosynthesis; Transcellular regulation of ETI-induced cell death; & much more
www.cell.com/trends/plant...
#plantscience
0
10
3
reposted by
Omar Kamileen
Dr. Todd Ewing PhD.
9 months ago
Researchers
@emoryuniversity.bsky.social
observe
#longevity
benefit of
#psilocybin
#psychedelic
mushroom
news.emory.edu/stories/2025...
— extended human skin & lung cell lifespan by 50% — increase aged mice survival by 30% — reduces oxidative stress — improves DNA repair 🧪
#health
#science
#aging
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Psilocybin delays aging, extends lifespan, new Emory study suggests | Emory University | Atlanta GA
Emory University researchers identified that psilocin, a byproduct of consuming psilocybin, the active ingredient in psychedelic mushrooms, actively delays aging in cells and organisms.
https://news.emory.edu/stories/2025/07/hs_psilocybin_aging_study_10-07-2025/story.html
3
11
2
reposted by
Omar Kamileen
Addgene
9 months ago
Want to become a cloning wizard? 🪄 Our latest blog post is packed with hands-on tips for mastering Modular Cloning — advice on how to prepare for the process, handle reagents, high-throughput methods, and more. Start your MoClo quest here:
https://twp.ai/4io9Rn
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blog.addgene.org
Tips and Tricks for Using Golden Gate Modular Cloning (MoClo)
https://twp.ai/4io9Rn
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11
5
reposted by
Omar Kamileen
Pam Marrone, PhD
9 months ago
Yes when I was on the board of
@cornelluniversity.bsky.social
the women profs told us exactly this..and even moreso for the minority profs: minority students flocked to them as role models to ask for mentoring and advice, taking time away from the Prof's own research
#womeninscience
#womeninstem
add a skeleton here at some point
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