Sam Carr
@carrsc.bsky.social
📤 29
📥 52
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Plant molecular biology and biochemistry
www.nature.com/articles/s41...
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Cellular water-potential sensing through biomolecular condensation - Nature
Plants sense water deficiency through SAM8 protein condensation, which responds to reduced hydration and triggers stress adaptation by altering RNA export and gene translation.
https://www.nature.com/articles/s41586-026-10591-8
5 days ago
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reposted by
Sam Carr
Lichman Lab
19 days ago
Pleased to share our full publication of our manuscript describing completion of nicotine biosynthesis in
@natcomms.nature.com
following our pre-print from December last year. In this work we solve the 200-year-old puzzle of how tobacco plants make nicotine.
www.nature.com/articles/s41...
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Nicotine biosynthesis is completed by cryptic activating glucosylation - Nature Communications
Despite the significance of nicotine, a neuroactive alkaloid produced by tobacco, its biosynthesis has remained elusive. Here, the authors report the in vitro and in planta reconstruction of a fo...
https://www.nature.com/articles/s41467-026-72705-0
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reposted by
Sam Carr
Keri Backus
about 1 month ago
Super excited to launch POCAxOMAP with
@dschweppe.bsky.social
and
@oligopain.bsky.social
and led by Eli Biletch, Conor Herlihy and Lidan Li. If you’ve ever wanted to do proximity labeling on DNA, RNA, or protein without genetic engineering, look no further.
www.biorxiv.org/content/10.6...
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The preprint for some recent work of mine is live. We show that the activity and product stereochemistry of a biosynthetic enzyme can be influenced through protein-protein interactions.
add a skeleton here at some point
about 1 month ago
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reposted by
Sam Carr
Scientific American
about 2 months ago
Parasitic beetles are the first animals known to imitate floral scents
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These baby beetles work together to look—and smell—like flowers
Parasitic beetles are the first animals known to imitate floral scents
https://www.scientificamerican.com/article/beetle-larvae-mimic-flower-scents-to-attract-bee-hosts/
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reposted by
Sam Carr
Maite Colinas
about 2 months ago
Our funky R-stereoselective Epi-STR is now available online and open access at its permanent home
@angewandtechemie.bsky.social
. 🥳 This is Clara's first first-author paper, makes me extra happy!
@mpi-ce.bsky.social
#PlantScience
#natprod
doi.org/10.1002/anie...
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reposted by
Sam Carr
Max Planck Institute for Chemical Ecology
3 months ago
The process by which the cinchona tree produces quinine has been elucidated. In a new study published in
@nature.com
, researchers from the
@oconnorlab.bsky.social
and the
@universityofga.bsky.social
unveil the biosynthetic pathway behind this 400-year-old secret.
www.ice.mpg.de/548102/PR_Ki...
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Mystery of quinine biosynthesis solved
For centuries, the process by which the cinchona tree produces its valuable alkaloids, including the life-saving quinine used to treat malaria, was shrouded in mystery. Now, a research team from the M...
https://www.ice.mpg.de/548102/PR_Kimbadi-Lombe_Zhou
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reposted by
Sam Carr
Maite Colinas
4 months ago
In our latest preprint we report the unexpected discovery of Epi-STR, an R-stereoselective ortholog of the S-selective canonical Strictosidine synthases (STRs). Found in the rather obscure plant Pogonopus specious. This work was led by my stellar student Clara Morweiser!
#natprod
#PlantScience
add a skeleton here at some point
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reposted by
Sam Carr
Nature
4 months ago
Nature research paper: Single-molecule dynamics of the TRiC chaperonin system in vivo
go.nature.com/4qZM3Cn
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Single-molecule dynamics of the TRiC chaperonin system in vivo - Nature
Single-particle tracking experiments in intact cells reveal dynamic co- and post-translational interactions of the TRiC–PFD chaperonin complex with client proteins during in vivo protein folding.
https://go.nature.com/4qZM3Cn
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Here, we explore the protein-protein interactions between monoterpene indole alkaloid biosynthetic enzymes. This work was the result of strong effort by Chloe Langley, who Allwin McDonald and I had the privilege to work with. Congrats to the team! ACS Chemical Biology
pubs.acs.org/doi/full/10....
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Protein–Protein Interactions Modulate a Key Branch Point in Monoterpene Indole Alkaloid Biosynthesis
Biosynthetic pathways of specialized metabolites utilize protein–protein interactions (PPIs) to facilitate metabolic flux and sequester reactive intermediates. The monoterpene indole alkaloid pathway of Catharanthus roseus contains several metabolic branch points that may be mediated via transient PPIs. We investigated one branch point of this pathway that is responsible for the conversion of the intermediate dehydrosecodine into three possible cyclized alkaloid scaffolds, which act as intermediates en route to medicinally important alkaloids, such as vinblastine. We verified previously observed PPIs between reductase-cyclase pairs and additionally uncovered PPIs between evolutionarily related protein homologues. Through structural analysis of dehydrosecodine cyclases, we identified surface residues that appear to mediate interaction with the upstream reductase. We then demonstrated, via in vitro competition assays, that these residues impact the distribution of downstream products. These results highlight the significance of transient PPIs in the control and regulation of specialized metabolite pathways.
https://pubs.acs.org/doi/full/10.1021/acschembio.5c00485
4 months ago
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