Hallo guys! I have a question for the #proteomics community. Do you guys guys have any suggestions for an instrument calibration solution that is not as expensive as the FlexMix from Thermo?

Hello! We are currently hiring for two post-doc positions on projects related to plant natural products, enzymes, and developing new systems to make useful small molecules. More details on our website: lichmanlab.weebly.com/post-docs.html

The Secondary Metabolism feed is really seeing a significant uptick. More views/day, and climbing, + a lot more useful posts with moderation. Nice to see others are finding the new server useful, too! If you do research in this area, follow and keep an eye on it! 🧪🖥️🦠🧬 bsky.app/profile/danu...

Call for a tenure-track position at our Department of Plant Molecular Biology in Lausanne! We are searching for promising early-career researchers in the broad field of plant-organismal interactions. Deadline: November 30, 2025 - Please re-post! career5.successfactors.eu/career?caree...

Most importantly, the effort still continues and we hope to reach 200,000 analyzed compounds in a few months, with all the data publicly available with no restrictions. This open resource is super valuable for the whole metabolomics community and especially for ML applications.

The @pluskal-lab.org is helping colleagues around the world identify unknown compounds. A #research article about their vast #massspec library has been published in @natmethods.nature.com with Corinna Brungs & @robinschmidt.bsky.social as the first two authors. See more ► www.uochb.cz/en/news/732

New Article: "Mapping multi-substrate specificity of Arabidopsis aminotransferases" rdcu.be/eGD9j Systematic characterization of aminotransferases: novel activities and multi-substrate specificity, probably contributing to the robustness of the N metabolic network.

I'm looking for PhD students to join the lab starting August 2026. We study the evolution of insect chemical signals so if you're interested in evolutionary biology, chemical ecology, molecular biology, behavior, or genetics, this could be a good fit for you! More info here: tinyurl.com/mrxchwfm

A lovely joint writing effort with Robin Buell! PAPER from @alaingoossenspsb.bsky.social in @plantphys.bsky.social academic.oup.com/plphys/advan...

Want to know what natural products are in clinical trials? Read this review! Great job from Mark Butler, Rob Capon, Mark Blaskovich! pubs.rsc.org/en/content/a... #naturalproducts #antibiotic #amr #drugdiscovery #drug

pubs.rsc.org/en/content/a... We just published the paper Biosynthesis of biologically active terpenoids in the mint family (Lamiaceae) in Natural Products Reports. Thanks to everyone involved! :)

A chromosome-level Mitragyna parvifolia genome unveils spirooxindole alkaloid diversification and mitraphylline biosynthesis (Larissa C Laforest , Tuan-Anh M Nguyen , Gabriel Oliveira Matsumoto , et al) doi.org/10.1093/plce... #PlantScience

I was shocked when I first saw these results from standard climate models used in IPCC reports: for high emissions, the Atlantic overturning circulation #AMOC shuts down in all 9 models that ran past 2100, and is well on the way to shutdown by 2100. Our paper on that is out today.🧵

PLANT HYBRIDIZATION AND METABOLIC DIVERSITY: 🌱 Zafra-Delgado et al. analyzed >400 naturally occurring hybrids in the field using metabolomics + NMR to get a comprehensive view of their chemistry. @mpi-ce.bsky.social 👉 doi.org/10.1111/tpj.70444

3️⃣ Vacuum and sonication treatment (VAST) enables efficient transient gene expression in various monocot and eudicot plant seedlings: A transient expression method that dramatically improves gene expression efficiency and uniformity across several monocot and eudicot seedlings. tinyurl.com/38p2ud6w

2️⃣ Optimized R2 Retroelement Complexes Enable Precise and Efficient DNA Insertion into Plant Genomes: We engineered R2 protein to insert multi-kb DNA precisely into a safe harbor site in plants achieving 24% efficiency and 1 copy insertion per genome. Compact, precise, powerful! tinyurl.com/5n73za6h

#PlantScience #secmet

💯 agree. No reason to provide sugar to Arabidopsis, many reasons against.

Coming out in @NaturePlants today (rdcu.be/eBScJ): The mechanism for essential amino acid transport across the chloroplast envelope. We identified RETICULATA1 (RE1) as a new type of transport protein. #PlantScience #AminoAcidTransport #Chloroplasts. @franzikuhnert.bsky.social @weberlab.bsky.social

Heute trendet #Wahlfreiheit wegen einer Petition, in der es um #Gentechnik geht. Sie richtet gegen ein laufendes Verfahren auf EU-Ebene zur Regulierung von Neuen Genomischen Techniken in der Pflanzenzüchtung. Der Petitionstext enthält zahlreiche Fehler. Die Wahlfreiheit ist nicht in Gefahr:

Passiflora is cyanogenic, but the Feigl-Anger test detects only those with both cyanogenic glycoside + enzyme. Passiflora suberosa (R) has both (so the test paper turns blue). Passiflora incarnata (L) has the glycoside but lacks the enzyme (paper stays white). ☠️ #HCN #Botany 🌾🧪🌱 1/2

Hey, calling all Natural Products and Secondary Metabolism people! @jgi.doe.gov is looking for feedback prior to reorganizing data structures and portals. #secmet is underrepresented right now. Hit the link if you want to share your ideas or complaints! Even (especially) if you don't use our stuff!

Introducing the 1,000 Flower Collection 🧬🌹 I’m creating 1,000 genetically designed flowers each crafted with new colors, patterns, and shapes. Here’s how I’m making it happen… and how you can join me on this journey 🧵(1/7)

A new study, based on an analysis of thousands of publications and their authors and editors, shows paper mills are just part of a complex, interconnected system that includes publishers, journals, and brokers. scim.ag/3H9kwwQ

#terpnet2025 is starting today My first time at terpnet and first time in Australia! So glad to have been invited to this.

Director at Max Planck - a unique position! The Open Call for Expressions of Interest in Max Planck Directorships is open now and can be submitted by the 31st of October 2025. ➡️ mpg.de/directors - Please share the Open Call among potential candidates.

Meet our director Sarah O'Connor, @oconnorlab.bsky.social, a presence to be reckoned with in the plant science community! Read the latest interview with @newphyt.bsky.social ‬to learn about her passion for plant science and the scientists who inspired her: nph.onlinelibrary.wiley.com/doi/10.1111/...

Our story on the biosynthesis of anti-inflammatory triterpenes from pot marigold is published ☺️ We had a lot of fun working on this beautiful & interesting species. Well done team marigold! 🌼 www.nature.com/articles/s41...

The first in a coming array of papers looking at the co-transcriptome of 72 Botrytis genotype in 10 different host plants is out. Summary is the pathogen uses a combination of general virulence and host specific plasticity (not new genes) to infect dicots. www.biorxiv.org/content/10.1...

Three back-to-back Salicylic Acid biosynthesis papers 1/3 www.nature.com/articles/s41...

Three-step biosynthesis of salicylic acid from benzoyl-CoA in plants www.nature.com/articles/s41...

New Pre-print! A long-standing question for transcription factor biology is how their chromatin context dependency works in plants. In this collaboration with Fred Berger lab, we present some new ideas not only in Arabidopsis but also in Marchantia. www.biorxiv.org/content/10.1...

Many transcription factor families have evolutionarily conserved binding motifs in plants (Sanja Zenker , Donat Wulf , Anja Meierhenrich , Prisca Viehöver , Sarah Becker , Marion Eisenhut , Ralf Stracke , Bernd Weisshaar , Andrea Bräutigam) doi.org/10.1093/plph... #PlantScience

The new issue of @newphyt.bsky.social features a profile of Sarah E. O'Connor ( @oconnorlab.bsky.social ): nph.onlinelibrary.wiley.com/doi/10.1111/... #PlantScience #PlantMetabolites #PlantChemistry

Ingenane biosynthesis enzymes in @newphyt.bsky.social by @matildeflorean.bsky.social, @carstenschotte.bsky.social from @oconnorlab.bsky.social @mpi-ce.bsky.social in collaboration with Ian Graham lab members. #natprod #PlantScience doi.org/10.1111/nph....

Here, the authors @oconnorlab.bsky.social @mpi-ce.bsky.social uncover the mechanism of epimerization behind uncommon 3R-containing alkaloids in Mitragyna speciosa (Kratom) and study their inclusion in downstream biosynthesis #PlantScience #natprod www.nature.com/articles/s41...

Here's a fun perspective piece on Cyanobacteria as prolific natural product producers with great potential for drug discovery. Thanks especially to @philmuslab.bsky.social for ringleading and letting us contribute! pubs.rsc.org/en/content/a...

Next one out from @oconnorlab.bsky.social department in @natchembio.nature.com. Work led by my office mate Allwin McDonald on the epimerisation of monoterpenoid indole alkaloids in Kratom! #PlantSci #NatProd rdcu.be/ewvtP

The first person to sequence a whale at single cell resolution is guaranteed a CNS paper. Then you'd need to sequence a family of whales.

Check out the Ziemert Lab’s new YouTube channel m.youtube.com/@ZiemertLab We’ve uploaded short tutorial videos on how to use our tools for genome mining and natural product discovery. Thanks Semih, @martinaadamek.bsky.social @turgutmesut.bsky.social ! #GenomeMining #SecMet #naturalproducts

How do plants decide the fate of a wound and what to regenerate? Water availability! Abdul Kareem and colleagues show that regeneration outcomes after tissue cutting are controlled by water. A 🧵/n 👇 www.nature.com/articles/s41...

A million shades of green: understanding and harnessing plant metabolic diversity Rocky Payet, Anne Osbourn et al presents a step-by-step guide to starting a project that characterises plant secondary metabolites www.embopress.org/doi/full/10....

How plants sense injury in their barrier tissue, periderm? Painstakingly detailed and amazing work by post doc Hiroyuki Iida shows that wounding is sensed by the diffusion of two gases: ethylene and oxygen. @treebiocoe.bsky.social‬ @erc.europa.eu‬ 1/x 🧵 www.nature.com/articles/s41...

🚨 Vacancy PhD student 🚨 Passionate about #CRISPR, plant biotechnology, & breeding? Join our project on meiotic recombination in #maize 🌽 A collaboration of our lab @fbwugent.bsky.social, ILVO & @kuleuvenplantinst.bsky.social 🔗https://www.ugent.be/en/work/scientific/doctoral-fellow-41

Thanks Kew! The paper itself can be found here: www.science.org/doi/10.1126/...

🚨 New preprint alert! 🚨 We used single-cell RNA-seq + GRN analysis to uncover novel morphogenic genes that boost #maize transformation frequency 🌽 www.biorxiv.org/content/10.1... Thanks to @vandepoelelab.bsky.social @bertderybel.bsky.social and all other co-authors! #PlantScience

We have been tracking sequenced plant genomes for many years now not least for our @denbi.bsky.social activities at www.plabipd.de/pubplant_mai.... We have now with about 2000 species finally published this resource doi.org/10.3389/fpls...

📣📣We are #hiring! 📣Please RT! @mpipz.bsky.social has a group leader position available in the broad area of Plant Development and Diversity 🌿. Apply now!🌿 👉http://bit.ly/4nkUvLa #plantsci

Lead author @matildeflorean.bsky.social‬ et al. from the @oconnorlab.bsky.social discover a "fake" enzyme in plants that enables the formation of free indole, a key molecule for defense & attracting pollinators. www.ice.mpg.de/496511/PR_Fl...

Next preprint out from my work @oconnorlab.bsky.social @mpi-ce.bsky.social : the discovery or iridoid cyclase in asterids! Thread below. #PlantScience #natprod www.biorxiv.org/content/10.1...