Ahmed Arafa NP
@ahmedarafaphd.bsky.social
📤 19
📥 35
📝 3
pinned post!
Excited to share our work now out in
@jacs.acspublications.org
Combining fungal metabolic engineering and plant oxidases to enable access to rare gibberellins.
doi.org/10.1021/jacs...
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Chemoenzymatic Synthesis with Plant Oxidases and Metabolic Engineering Enable Rapid Access to Rare Gibberellins
Gibberellins are structurally complex diterpenoid plant hormones with widespread agricultural applications. However, of the 136 known congeners found in nature, very few are easily accessible, prevent...
https://doi.org/10.1021/jacs.6c06067
about 1 month ago
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reposted by
Ahmed Arafa NP
Lichman Lab
19 days ago
Pleased to share our full publication of our manuscript describing completion of nicotine biosynthesis in
@natcomms.nature.com
following our pre-print from December last year. In this work we solve the 200-year-old puzzle of how tobacco plants make nicotine.
www.nature.com/articles/s41...
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Nicotine biosynthesis is completed by cryptic activating glucosylation - Nature Communications
Despite the significance of nicotine, a neuroactive alkaloid produced by tobacco, its biosynthesis has remained elusive. Here, the authors report the in vitro and in planta reconstruction of a fo...
https://www.nature.com/articles/s41467-026-72705-0
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reposted by
Ahmed Arafa NP
Russell Cox Chem
28 days ago
Congratulations Henrike Heinemann and Nick Gerlach who built on the work of Eric Kuhnert for this super 1-step synthesis of cinatrins, funded by
@dfg.de
as part of the Taxonomics SPP Published today in
@chemicalscience.rsc.org
pubs.rsc.org/en/content/a...
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Total and Engineered Biosynthesis of Cinatrins: Inhibitors of Phospholipase A2 and Squalene Synthase
An alkyl citrate biosynthetic gene cluster (ctr) was identified from 47 members of the fungal family of Hypoxylaceae by genome mining. The Hypomontagnella monticulosa MUCL 54604 ctr cluster was deploy...
https://pubs.rsc.org/en/content/articlelanding/2026/sc/d6sc00660d
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reposted by
Ahmed Arafa NP
Russell Cox Chem
about 1 month ago
Congratulations Ahmed Arafa
@ahmedarafaphd.bsky.social
on the publication of Chemoenzymatic Synthesis with Plant Oxidases and Metabolic Engineering Enable Rapid Access to Rare Gibberellins | Journal of the American Chemical Society
pubs.acs.org/doi/10.1021/...
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Chemoenzymatic Synthesis with Plant Oxidases and Metabolic Engineering Enable Rapid Access to Rare Gibberellins
Gibberellins are structurally complex diterpenoid plant hormones with widespread agricultural applications. However, of the 136 known congeners found in nature, very few are easily accessible, prevent...
https://pubs.acs.org/doi/10.1021/jacs.6c06067
1
8
5
Excited to share our work now out in
@jacs.acspublications.org
Combining fungal metabolic engineering and plant oxidases to enable access to rare gibberellins.
doi.org/10.1021/jacs...
loading . . .
Chemoenzymatic Synthesis with Plant Oxidases and Metabolic Engineering Enable Rapid Access to Rare Gibberellins
Gibberellins are structurally complex diterpenoid plant hormones with widespread agricultural applications. However, of the 136 known congeners found in nature, very few are easily accessible, prevent...
https://doi.org/10.1021/jacs.6c06067
about 1 month ago
0
6
2
reposted by
Ahmed Arafa NP
Nature Synthesis
about 1 month ago
Now online: Article by Anan Zhang, Yunfeng Luo, Qi Ding & Benke Hong Enzymatic control of enantioselective dimeric cyclotryptamine alkaloid biosynthesis in Calycanthaceae plants
www.nature.com/articles/s44...
($)
#Chemsky
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Enzymatic control of enantioselective dimeric cyclotryptamine alkaloid biosynthesis in Calycanthaceae plants - Nature Synthesis
The biosynthetic pathway for dimeric cyclotryptamine alkaloids—(−)-chimonanthine, meso-chimonanthine, (−)-folicanthine and (+)-sinodamine B—has been reported in Calycanthaceae plants. The pathway feat...
https://www.nature.com/articles/s44160-026-01058-9?utm_source=bluesky&utm_medium=social&utm_campaign=natsynth
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5
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reposted by
Ahmed Arafa NP
Henryk Straube
6 months ago
Exciting preprint on unlocking accessibility of rare gibberellines by
@russellcoxchem.bsky.social
and
@frankelab.bsky.social
labs. Special congrats to Ahmed! 🥳
doi.org/10.26434/che...
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Chemoenzymatic Synthesis with Plant Oxidases and Metabolic Engineering Enable the Total Biosynthesis of Rare Gibberellins
Gibberellins are structurally complex diterpenoid plant hormones with widespread agricultural applications. However, of the 136 known congeners found in nature, very few are easily accessible, prevent...
https://doi.org/10.26434/chemrxiv-2025-r0q41
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Pleased to announce that our preprint is now available. I am grateful for the excellent supervision and support from Russell, Jakob, and Jenny throughout the project.
doi.org/10.26434/che...
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Chemoenzymatic Synthesis with Plant Oxidases and Metabolic Engineering Enable the Total Biosynthesis of Rare Gibberellins
Gibberellins are structurally complex diterpenoid plant hormones with widespread agricultural applications. However, of the 136 known congeners found in nature, very few are easily accessible, prevent...
https://doi.org/10.26434/chemrxiv-2025-r0q41?utm_campaign=shareaholic&utm_medium=bluesky&utm_source=socialnetwork
6 months ago
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2
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reposted by
Ahmed Arafa NP
SattelyLab
10 months ago
Couldn't have said it better! Great job
@taralowensohn.bsky.social
, Will, and Chun! Special thanks to the Gao lab at
@stanford.edu
#singlecell
#plantbiology
add a skeleton here at some point
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reposted by
Ahmed Arafa NP
Leibniz Universität Hannover (LUH)
11 months ago
Nachschattengewächse als Basis für Arzneimittel: Forschungsteams der
#LUH
und der
@unibonn.bsky.social
entschlüsseln Gensequenz zur Bildung von Steroiden.
@dfg.de
fördert das Projekt mit rund 511.00 Euro.
http://go.lu-h.de/aNhrb
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reposted by
Ahmed Arafa NP
FrankeLab
11 months ago
Extremely happy to see our withanolide biosynthesis paper out in
@natcomms.nature.com
rdcu.be/evHOF
Fantastic team effort with the Pucker group
@bpucker.bsky.social
@puckerlab.bsky.social
at
@unibonn.bsky.social
and Heretsch, Herde and Witte groups at
@unihannover.bsky.social
. Funded by
@dfg.de
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Phylogenomics and metabolic engineering reveal a conserved gene cluster in Solanaceae plants for withanolide biosynthesis
Nature Communications - Withanolides are plant steroids with potent bioactivities found in many medicinal plants including Withania somnifera, but their biosynthetic pathway is largely unknown....
https://rdcu.be/evHOF
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reposted by
Ahmed Arafa NP
FrankeLab
about 1 year ago
Started as a very successful master thesis, now published in JACS. Screening sequence similarity networks turned out to be a great way to discover oxidosqualene cyclases with unusual activity from more than thousand plant transcriptome sequence datasets.
pubs.acs.org/doi/10.1021/...
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Expansion of the Stereochemical Space of Triterpenes by Mining Noncanonical Oxidosqualene Cyclases Across the Diversity of Green Plants
Triterpenoids and steroids are structurally complex polycyclic natural products with potent biological functions, for example, as hormones. In all eukaryotes, the carbon skeletons of these compounds a...
https://pubs.acs.org/doi/10.1021/jacs.4c16956
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