beautiful review article covering many key aspects for studying brain aging -- CD8T cell infiltration, DNA methylation, and killifish as a model system. Thanks to the @brunetlab.bsky.social ! www.cell.com/neuron/fullt...

Reminder starting in October NIH NOFOs won’t be posted in the Guide for grants and contracts. Tips on how to search for opportunities & set up a subscription for custom searches here: grants.nih.gov/news-events/...

Preprint: Maintenance of chronic neuroinflammation in multiple sclerosis via interferon signaling and CD8 T-cell-mediated cytotoxicity www.researchsquare.com/article/rs-7...

A distinct population of CD8+ T cells expressing CD39 and CD73 accumulates with age and supports cancer progression @nataging.nature.com www.nature.com/articles/s43...

Effector fates of ILC are epigenetically imprinted early in ontogeny through the selective loss of DNA methylation at signature genes encoding fate-determining regulators @natimmunol.nature.com www.nature.com/articles/s41... www.nature.com/articles/s41...

Genetic and epigenetic screens in primary human T cells link candidate causal autoimmune variants to T cell networks @natgenet.nature.com www.nature.com/articles/s41...

Now out in @natmachintell.nature.com TCRT5 is a rapid generator of target-conditioned CDR3b, leads SoTA, and yields the first AI-designed self-tolerant binder to an OOD non-viral epitope (w val) 📑: www.nature.com/articles/s42... 🤗: huggingface.co/dkarthikeyan1 👨‍💻: github.com/pirl-unc/tcr_translate

tl;dr T5 style translation model to generate T cell receptors from targets actually kinda works Caveats: not full TCR (CDR3b), strong signal that public data biased towards “polyspecific” TCRs — lo and behold, generated TCR-T is polyspecific in vitro. Open weights, go wild.

Reorganization and progressive depletion of NK/ILC compartment in amyotrophic lateral sclerosis (ALS), with inverse correlation between NK and Th responses in fast progressors @biorxivpreprint.bsky.social @natstann.bsky.social www.biorxiv.org/content/10.1...

CXCR6 promotes dermal CD8+ T cell survival and transition to long-term tissue residence @jimmunol.bsky.social @thelundlab.bsky.social academic.oup.com/jimmunol/adv...

@cp-trendspharma.bsky.social Multitargeting neuroimmune pathways: novel candidates for chronic pain relief www.cell.com/trends/pharm...

Reproducible single-cell annotation of programs underlying T cell subsets, activation states and functions @natmethods.nature.com @soumya-boston.bsky.social @dkotliar.bsky.social www.nature.com/articles/s41...

Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer’s disease: @cp-immunity.bsky.social www.cell.com/immunity/ful...

Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling in male mice www.nature.com/articles/s41... @staceykigar.bsky.social @natcomms.nature.com

Follicular regulatory T cells promote B cell–mediated experimental neuroinflammation and are associated with multiple sclerosis activity www.science.org/doi/10.1126/...

Perspective @nataging.nature.com @miriammerad.bsky.social Restoring resident tissue macrophages to combat aging and cancer www.nature.com/articles/s43...

This study, led by the talented grad student Boyang Li, identifies microglia undergoing cellular senescence in AD, and targeting cholesterol metabolism in senescent microglia is a therapeutic approach to slow AD progression. onlinelibrary.wiley.com/doi/10.1111/...

Durable B-Cell Impairment While Sparing IgA B Cells After Ocrelizumab Therapy in Multiple Sclerosis onlinelibrary.wiley.com/doi/10.1002/...

Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age @natimmunol.nature.com @teichlab.bsky.social @donnafarber.bsky.social www.nature.com/articles/s41...

When it comes to aging, the health of even the smallest vessels is critical to maintaining cognitive function. New study in @nature.com finds that deterioration of the brain's drainage system contributes to reduced blood supply in deep white matter: www.nature.com/articles/s41...

TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells @natimmunol.nature.com @idoyagalab.bsky.social www.nature.com/articles/s41...

Thrilled to share this amazing work from Marie Blanchette & team in the Daneman Lab!!! We found that differences in the BBB across brain regions help regulate local brain function 🧠 Honored to have contributed to the study & to have had Marie as a mentor during my PhD💕 www.nature.com/articles/s41...

Did you ever wonder what insights hide in the multiplets that are usually discarded in flow cytometry? 🫧 Find out in the first publication of my PhD, now out in Nature Methods! www.nature.com/articles/s41... (1/4)

Alzheimer’s disease transcriptional landscape in ex vivo human microglia www.nature.com/articles/s41...

The brain activates front-line immune cells in response to the mere sight of a sick person, mimicking the body’s response to an actual infection. www.nature.com/articles/d41...

Review of the possible role of Matzinger's "danger theory" of damage-associated molecular patterns in CNS as drivers of increased incidence of major depressive disorder www.science.org/doi/10.1126/...

Spatial proteomics of Alzheimer’s disease-specific human microglial states @natimmunol.nature.com www.nature.com/articles/s41... @bendall-lab.bsky.social

Once you have developed a new method you are no longer encouraged to propose using it in your grant application because it is not novel 😂.

Modulating immune cell fate and inflammation through CRISPR-mediated DNA methylation editing www.science.org/doi/10.1126/...

APOE ε4 carriers share immune-related proteomic changes across neurodegenerative diseases www.nature.com/articles/s41...

Immune cell profiling reveals diverse niches of immune residents of the enteric nervous system and potential neuroimmune interactions www.pnas.org/doi/10.1073/...

Mutations in the human CSF1R gene impact microglia’s maintenance of brain white matter integrity @natimmunol.nature.com www.nature.com/articles/s41... www.nature.com/articles/s41...

Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia www.nature.com/articles/s41...

Physiological microbial exposure normalizes memory T cell surveillance of the brain and modifies host seizure outcomes www.nature.com/articles/s41...

Astrocyte-derived CCL5 mediates brain infiltration of CCR5+ neutrophils that drives depression progression www.science.org/doi/10.1126/...

Pleased to share our latest work on neural-immune interactions in aging white matter. It was a long journey, made possible by incredible support and persistent efforts of many colleagues across various locations. Many thanks to everyone involved. www.nature.com/articles/s41...

genomebiology.biomedcentral.com/articles/10.... Quite an indictment of some of the current single cell "virtual cell" foundation models. Even for the relatively mundane applications, cell labeling, batch correction etc, they are poor compared to much simpler & cheaper methods.

Epigenetic regulation of innate immune dynamics during inflammation doi.org/10.1093/jleu...

ZEB2 is a master switch controlling the tumor-associated macrophage program www.cell.com/cancer-cell/... @cp-cancercell.bsky.social @idoamitlab.bsky.social

Brand new review by the @mancusorenzo.bsky.social lab on microglial heterogeneity: Laura Fumagalli et al. dive into transcriptional states across development, disease, sex & CNS regions—plus annotation tools. Out now in Nature Neuroscience: 📄 https://www.nature.com/articles/s41593-025-01931-4

Nice to see this finally published! Congratulations @jack-humphrey.bsky.social www.nature.com/articles/s41... (Collaborative work with Panos Roussos and his team! ) Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing

Updated from the preprint, our paper, "Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation" is now published. www.cell.com/cell-reports...

DNA methylation differences between cord and adult white blood cells reflect postnatal immune cell maturation www.nature.com/articles/s42...

Our new method CytoCoSet computes sample-level feature representations from single-cell data, while taking into account per-cell molecular features and additional clinical covariates. Congratulations to Chi-Jane for leading this work! bmcbioinformatics.biomedcentral.com/articles/10....

HypoMap is out!

Dynamic trajectories of human peripheral immune cells from birth to old age @natimmunol.bsky.social www.nature.com/articles/s41... www.nature.com/articles/s41...

1/ New in #ScienceImmunologyResearch! We explored how the brain maintains equilibrium with the immune system. Our focus? The key player in immune tolerance and tissue function regulation: regulatory T cells (Tregs). Let’s dive in! www.science.org/doi/10.1126/... @immunoeditor.bsky.social

Review Tissue-resident immune cells: from defining characteristics to roles in diseases www.nature.com/articles/s41...

Chronological versus immunological aging: Immune rejuvenation to arrest cognitive decline www.cell.com/neuron/abstr...

Deep profiling deconstructs features associated with memory CD8+ T cell tissue residence www.cell.com/immunity/ful... @cp-immunity.bsky.social