My new use for Gemini: I give it a bunch of information and ask it to write me code to make a nice infographic figure to plot in python and it is amazing !

My PhD student Chi-Jane is graduating soon and looking for her next position. She is an expert in CyTOF and IMC analysis, especially :) she can help you to derive predictive immune signatures from your data 💻🧫 check out her awesome website !! chencookie.github.io/index.html

Microglia protein profiles in CSF across Alzheimer’s disease clinical stages @nataging.nature.com www.nature.com/articles/s43...

Persistent microglial activation following neonatal CMV infection mediates neurodegeneration www.science.org/doi/10.1126/...

@cp-immunity.bsky.social spotlight Defined molecular and anatomical pathway through which inflammatory signals are sensed by the brain and translated into active social withdrawal www.cell.com/immunity/ful... on @cellcellpress.bsky.social www.cell.com/cell/fulltex...

Multi-organ transcriptomic aging atlas in killifish, with both males and females! 🐟🐟🐟 Huge congratulations to Emma, Jing, Tony and the entire team!! ✨⭐ @emkcosta.bsky.social @jingxunchen.bsky.social Wyss-Coray lab! www.nature.com/articles/s43...

@biorxivpreprint.bsky.social Optimal transport fate mapping resolves T cell differentiation dynamics across tissues www.biorxiv.org/content/10.6... @natstann.bsky.social

when it's your turn to give lab meeting and you don't have new results to show

"Cross-Organ Neuroimmunology of Behavior". Xuanming Guo and I discuss a new framework that reconceptualizes behavior as an emergent property of a distributed, brain-body neuroimmune network. lnkd.in/eihqZ_ay. @sinaiimmuno.bsky.social @sinaibrain.bsky.social

Online now: Immunity in Alzheimer’s disease: From mechanisms to therapies

New study—and exciting collaboration with Wei Wang, Cong Liu (UCSD), and Kay Chung (new lab at UNC)—that provides a platform for designing T cells into specific states. We identified state-selective TFs for CD8 T cell states that enable “recipes” for cell engineering! www.nature.com/articles/s41...

Overjoyed to share our new work exploring the antigen specificity of CSF-expanded CD8+ T cells in #multiplesclerosis #EBV in @natimmunol.nature.com #immunology 🧪🧵1/ www.nature.com/articles/s41...

Online now: Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition

@biorxivpreprint.bsky.social The innate cytokine IL-18 inhibits CNS autoimmunity through preferential activation of protective CD8 T-cells @cannalab.bsky.social www.biorxiv.org/content/10.6...

Review @moltherapy.bsky.social Redefining Multiple Sclerosis with CAR-T Cell Therapy www.cell.com/molecular-th...

Review @natrevneuro.nature.com Immune dysfunction in Alzheimer disease www.nature.com/articles/s41...

Resolving the mysteries of brain clearance and immune surveillance: @cp-neuron.bsky.social www.cell.com/neuron/fullt...

@natimmunol.nature.com News & Views Quiet custodians of CD8+ T cell fate www.nature.com/articles/s41... on www.nature.com/articles/s41... www.nature.com/articles/s41...

Meeting report @natimmunol.nature.com Neuroimmune interactions in health and disease www.nature.com/articles/s41...

NEW STUDY! Building on pioneering work by Dr. Alison Goate, an international team of researchers, led by #IcahnMountSinai's Anne Schaefer, ID'd distinct population of neuroprotective #Microglia that may point to new therapeutic approach for #Alzheimers. @nature.com 👉 www.nature.com/articles/s41...

trying to fit a project timeline and a power calculation into a proposal when it is stuffed to the brim 😂

beautiful review article covering many key aspects for studying brain aging -- CD8T cell infiltration, DNA methylation, and killifish as a model system. Thanks to the @brunetlab.bsky.social ! www.cell.com/neuron/fullt...

Reminder starting in October NIH NOFOs won’t be posted in the Guide for grants and contracts. Tips on how to search for opportunities & set up a subscription for custom searches here: grants.nih.gov/news-events/...

Preprint: Maintenance of chronic neuroinflammation in multiple sclerosis via interferon signaling and CD8 T-cell-mediated cytotoxicity www.researchsquare.com/article/rs-7...

A distinct population of CD8+ T cells expressing CD39 and CD73 accumulates with age and supports cancer progression @nataging.nature.com www.nature.com/articles/s43...

Effector fates of ILC are epigenetically imprinted early in ontogeny through the selective loss of DNA methylation at signature genes encoding fate-determining regulators @natimmunol.nature.com www.nature.com/articles/s41... www.nature.com/articles/s41...

Genetic and epigenetic screens in primary human T cells link candidate causal autoimmune variants to T cell networks @natgenet.nature.com www.nature.com/articles/s41...

Now out in @natmachintell.nature.com TCRT5 is a rapid generator of target-conditioned CDR3b, leads SoTA, and yields the first AI-designed self-tolerant binder to an OOD non-viral epitope (w val) 📑: www.nature.com/articles/s42... 🤗: huggingface.co/dkarthikeyan1 👨‍💻: github.com/pirl-unc/tcr_translate

tl;dr T5 style translation model to generate T cell receptors from targets actually kinda works Caveats: not full TCR (CDR3b), strong signal that public data biased towards “polyspecific” TCRs — lo and behold, generated TCR-T is polyspecific in vitro. Open weights, go wild.

Reorganization and progressive depletion of NK/ILC compartment in amyotrophic lateral sclerosis (ALS), with inverse correlation between NK and Th responses in fast progressors @biorxivpreprint.bsky.social @natstann.bsky.social www.biorxiv.org/content/10.1...

CXCR6 promotes dermal CD8+ T cell survival and transition to long-term tissue residence @jimmunol.bsky.social @thelundlab.bsky.social academic.oup.com/jimmunol/adv...

@cp-trendspharma.bsky.social Multitargeting neuroimmune pathways: novel candidates for chronic pain relief www.cell.com/trends/pharm...

Reproducible single-cell annotation of programs underlying T cell subsets, activation states and functions @natmethods.nature.com @soumya-boston.bsky.social @dkotliar.bsky.social www.nature.com/articles/s41...

Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer’s disease: @cp-immunity.bsky.social www.cell.com/immunity/ful...

Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling in male mice www.nature.com/articles/s41... @staceykigar.bsky.social @natcomms.nature.com

Follicular regulatory T cells promote B cell–mediated experimental neuroinflammation and are associated with multiple sclerosis activity www.science.org/doi/10.1126/...

Perspective @nataging.nature.com @miriammerad.bsky.social Restoring resident tissue macrophages to combat aging and cancer www.nature.com/articles/s43...

This study, led by the talented grad student Boyang Li, identifies microglia undergoing cellular senescence in AD, and targeting cholesterol metabolism in senescent microglia is a therapeutic approach to slow AD progression. onlinelibrary.wiley.com/doi/10.1111/...

Durable B-Cell Impairment While Sparing IgA B Cells After Ocrelizumab Therapy in Multiple Sclerosis onlinelibrary.wiley.com/doi/10.1002/...

Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age @natimmunol.nature.com @teichlab.bsky.social @donnafarber.bsky.social www.nature.com/articles/s41...

When it comes to aging, the health of even the smallest vessels is critical to maintaining cognitive function. New study in @nature.com finds that deterioration of the brain's drainage system contributes to reduced blood supply in deep white matter: www.nature.com/articles/s41...

TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells @natimmunol.nature.com @idoyagalab.bsky.social www.nature.com/articles/s41...

Thrilled to share this amazing work from Marie Blanchette & team in the Daneman Lab!!! We found that differences in the BBB across brain regions help regulate local brain function 🧠 Honored to have contributed to the study & to have had Marie as a mentor during my PhD💕 www.nature.com/articles/s41...

Did you ever wonder what insights hide in the multiplets that are usually discarded in flow cytometry? 🫧 Find out in the first publication of my PhD, now out in Nature Methods! www.nature.com/articles/s41... (1/4)

Alzheimer’s disease transcriptional landscape in ex vivo human microglia www.nature.com/articles/s41...

The brain activates front-line immune cells in response to the mere sight of a sick person, mimicking the body’s response to an actual infection. www.nature.com/articles/d41...

Review of the possible role of Matzinger's "danger theory" of damage-associated molecular patterns in CNS as drivers of increased incidence of major depressive disorder www.science.org/doi/10.1126/...

Spatial proteomics of Alzheimer’s disease-specific human microglial states @natimmunol.nature.com www.nature.com/articles/s41... @bendall-lab.bsky.social