How do GWAS and rare variant burden tests rank gene signals? In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck! 🧬🧪🧵 www.nature.com/articles/s41...

Very proud of you @tszfung.bsky.social for so many achievements!! 🎊

Why do complex traits differ in their genetic architecture? In our new PLOS Biology paper, we will try to convince you that two simple scaling laws drive differences in the number, effect sizes and frequencies of causal variants affecting complex traits. Thread: journals.plos.org/plosbiology/...

5 YEARS of HGG Advances! Mike, Jessica, Sara, and so many others have done such a fantastic job in shaping and expanding the journal. Please consider submitting your work in genetics/genomics with us!

I'm hiring a computational biologist interested in complex trait genetics using deep learning approaches. Reach out to me, if interested.

We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics. www.biorxiv.org/content/10.1... (1/n)

SINGER, our ARG inference method, is finally published and freely available online: doi.org/10.1038/s415... It was a long journey – 16 months from initial submission to acceptance. Is it just me, or has peer review gotten more arduous lately? 4+ rounds of review isn't so unusual these days...

Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1... I am attempting an explainer thread for the first time here: (I am usually too exhausted to post one)

Please consider applying to be HGG new EiC! HGG is a fantastic avenue for publishing work in genetics and genomics, striving for fast turnaround and is committed to open access.

📣Online NOW! 📄Estimation of demography and mutation rates from one million haploid genomes 🧑‍🤝‍🧑 @jgschraiber.bsky.social @jeffspence.github.io @docedge.bsky.social

Huge congrats Roshni! Couldn’t wait to see what comes next in the new role!!

I'm thrilled that my lab at NYU is now supported by an NIH MIRA grant! I'm looking to hire 1-2 senior lab members (outstanding postdoc candidates or experienced staff scientists) with expertise in computational or statistical methods in human genetics or genomics. Please share!

Super proud of my first student, @jingyour.bsky.social! Well done! Looking forward to the amazing work you will do in the future 🥲 bsky.app/profile/jing...

Super excited to see this out. What started as some math in a grant in 2020, to a student deciding to take this on in 2022, to published in 2025. These things can take time and patience is key!

My talk from this year's probgen is finally out. Where do linear mixed models and random effects come from? They emerge from *mutations* on Ancestral Recombination Graphs.

Congrats on the first PhD work!! Very nicely done! @alnahid.bsky.social

New paper by Luke O'Connor @lukeoconnor.bsky.social and Guy Sella @gs2747.bsky.social

An insightful @cp-trendsgenetics.bsky.social perspective on our recent article about the early evolution of genome regulation in animals. www.cell.com/trends/genet... Thank you Omar and @ferdix.bsky.social!

🧪🖥️🧬 It's here!! Our second MPRA, which is totally different from the first. For starters, there's no human sequences anywhere! Instead there's marsupials, wolves, pandas and a lot of hard work from lab members past & present, chief amongst them @navya-shukla.bsky.social (looking for a postdoc btw)

Very excited to see this out and delighted to have played a small part -- @courtsmithrun.bsky.social did a deep dive into the pleiotropy of the HLA locus and found tons of cool stuff, including lots of associations at the SNP, HLA allele, and haplotype levels.

Staff scientist position (computational): I am looking for a computational scientist to join my genomics lab at Stanford. They should have an outstanding skillset in ML/statistical methods for genomic applications, postdoc experience and a strong publication record. #sciencejobs

Delighted to share the first preprint of my postdoc in the @carlanderson.bsky.social lab www.medrxiv.org/content/10.1...! 🚨 A super exciting study I co-led with the very talented @tobioinformatics.bsky.social . Stay tuned to see what we learned about genetic susceptibility to complex disease. 🧬🧵 1/

I probably won't have time to make a video out of this. But the materials are available online, and should be pretty self-explanatory. Hope this is useful to some people. privefl.github.io/statgen-cour...

Check out our new preprint on Lilace, a statistical tool for scoring FACS-based deep mutational scanning experiments! Lilace directly models the shift between variant fluorescence distributions and provides score uncertainty estimates to better assess reliability and reproducibility. (1/3)

Textbooks: “Enhancers are just a bunch of TFBSs” But how do they REALLY work? New paper with many contributors here @berkeleylab.lbl.gov, @anshulkundaje.bsky.social, @anusri.bsky.social A 🧵 (1/n) Free access link: rdcu.be/erD22

It was fun writing this short piece on the omnigenic model. Sharing it here, though it's a painful time as my family, along with millions of others, is at risk in Iran and the region.

Ferrari @jazlynmooney.bsky.social et al. find that while parameter scaling improves efficiency, strong scaling distorts diversity, intensifies background selection, and alters linkage patterns. 🔗 doi.org/10.1093/gbe/evaf097 #genome #evolution #bioinformatics

Our new work is now out in AJHG "Natural selection acting on complex traits hampers the predictive accuracy of polygenic scores in ancient samples." Great collaboration with @delvecchyo.bsky.social and Emilia Huerta-Sanchez, led by Valeria Añorve-Garibay.

🚨 Applications are open for the UCLA Postdoct Training Program in Neurobehavioral Genetics 🧠🧬 Deadline: 6/30 👉 neurogen.semel.ucla.edu/curriculum/ Contact me if you're interested to write a proposal together combining genetics + functional genomics + digital phenotypes from wearables/smartphones!

📣New from @mathiesoniain.bsky.social & co! 📄Meta-analysis of uveal #melanoma #GWAS identifies novel risk loci and population effect size heterogeneity 👉https://bit.ly/4kGlIX8

Such a blessing to have had this journey with the most supportive advisors @nmancuso.bsky.social and Steven Gazal, as well as my amazing lab mates! I couldn’t have asked for better

Why do so many disease risk variants show no regulatory effects in GTEx and/or other standard eQTL studies? What do we mean when we say a regulatory effect is "context-specific" and how do we define the context? We explored these questions using brain organoids and oxygen stress.

My HPC team at UC Davis is hiring! Looking for an experienced sysadmin to help build and maintain clusters (hardware and software). HPC experience great, but if you’re an experienced sysadmin and willing to learn, please apply! careerspub.universityofcalifornia.edu/psc/ucdavis/...

🧵 It's raining outside, perfect for some vibe coding... ☔ So I built something cool with @anthropic.com's Claude Desktop! Introducing Claude Text Editor - edit ANY text, ANYWHERE on macOS with Claude's help. No more copy-paste gymnastics! 🚀

I’ve been studying gene regulation in primates for over 20 years, and using RNA-seq since 2008 to compare expression across species. We thought we were being careful. We used curated orthologous exons to minimize alignment bias and focused on biologically meaningful comparisons. We were wrong.

Out today in @pnas.org! www.pnas.org/doi/10.1073/...

Excited to share that my PhD defense is coming up! I’ll be presenting on "statistical and computational approaches to characterize functional architectures for human diseases and complex traits". 📅 June 9 (Monday) at 2-4pm PST zoom link: usc.zoom.us/j/93369681715

I'm excited to announce that I'll be starting a lab at UCSF in the @ihgatucsf.bsky.social and @ucsf-epibiostat.bsky.social in July. We'll work at the intersection of statistical genetics, population genetics, and machine learning.

We have 2-3 group leader positions opening @fimm-uh.bsky.social !! We are looking for outstanding candidates in human genetics and precision medicine. This time we have a focus on population health data science. E.g. AI for EHR/health data        Generous starting package 💰 shorturl.at/FAk6n

I have an opportunity to hire a staff scientist for my lab. Looking for someone with outstanding skillset in ML/statistics, genomics applications; interest in mentoring, strong publication record, PD experience required. Email CV to me+cc my assistant (see 'contact' on my website). Ad to follow.

I have been amazed that my advisors can spot the tiniest extra space between two words in the doc. Now I can see it too, like right there lol.

Reminder to folks in genetics/genomics, HGG Advances is a wonderful open-access journal to publish your work in. Consider submitting your latest and greatest with us! :D

📣 🥳 🧑‍💻 Our department is hiring: Tenure-Track Assistant Professor / Associate Professor in Bioinformatics at Aarhus University, Denmark Deadline June 1st Thanks for sharing! mbg.au.dk/en/news-and-...

It's that time of the year again: ASHG Abstracts! ASHG has always provided an excellent avenue to present novel methods in StatGen and GenEpi, get early feedback, and meet your colleagues! Deadline is June 9th, so still plenty of time :D Link below 👇 www.ashg.org/meetings/202...

Congratulations to Malone Center affiliate member @stephaniehicks.bsky.social on this distinction from @amstatnews.bsky.social!

Super excited to share my latest preprint with @klohmueller.bsky.social! Here we leverage the unique signature that recessive deleterious variants can lead to an increase in archaic ancestry to tackle a classic question - the dominance distribution on the human genome www.biorxiv.org/content/10.1...

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I hope to see you at ProbGen 2026 on March 25th-28th! I expect a wonderful meeting as always!

1/n 🚨Very excited to share our recent work!🚨 To understand gene regulation across diverse environmental conditions and cellular contexts, we treated a broad array of human cell types with three environmental exposures in vitro. www.biorxiv.org/content/10.1...

Multitasking is a disaster