The F1 region of ATP synthase interacts with TCA cycle enzymes. www.nature.com/articles/s41...

1/ Mitochondrial Na⁺ links metabolism, Ca2+ signaling and disease. We know how it gets in, how it gets out, and proteins that use it. But: we've never actually seen Na⁺ in single mitochondria in live cells. We started with an unusual observation, went down a rabbit hole & found some cool biology .

Endosomal mRNA transport coordinates local mitochondrial bioenergetics during polar fungal growth https://www.biorxiv.org/content/10.64898/2026.06.12.731371v1

Retrograde mitochondrial transport is required for mitochondrial biogenesis in zebrafish neurons www.nature.com/articles/s41...

New paper! How do RNAs "know" where to go inside a cell? We dug into the sequence elements that route RNAs to the right place. It turns out that, in mammals, they're surprisingly massive (>200 nt), multipartite, and wonderfully complicated. 🧵

Mitochondria directly interact with the nuclear pore complex! www.nature.com/articles/s41...

Functional specialization within the mitochondrial network: Are all mitochondria created equal? www.cell.com/cell-metabol...

Two Genomes, One Metabolome: Mitonuclear Incompatibility Remodels Developmental Metabolism and Fitness in Drosophila https://www.biorxiv.org/content/10.64898/2026.05.29.728848v1

🚨Excited to announce a new preprint from our lab, where we describe an ancient metabolic axis that controls mitochondrial genome copy number; a mechanism we uncovered in human cells that stretches through evolution to control mtDNA in flies, yeast and even plants!

#Mitochondria serve as a holdout compartment for aggregation-prone proteins hindering efficient degradation www.nature.com/articles/s41...

Microtubule dynamics control the direction of cardiomyocyte growth | Science www.science.org/doi/10.1126/...

Alternative organelle targeting of OPA1 mediates fatty acid release from lipid droplets https://www.biorxiv.org/content/10.64898/2026.05.07.723579v1

Loss of mitochondrial co-chaperone GRPEL2 protects mice from age- and diet-induced obesity https://www.biorxiv.org/content/10.64898/2026.05.07.723644v1

TCA cycle rewiring underpins histone acetylation sourcing and cell-fate transitions during exit from naive pluripotency

Loss of MTPAP disrupts mitochondrial RNA processing causing upregulation of type I interferon signalling https://www.biorxiv.org/content/10.64898/2026.05.04.722669v1

How to design effective scientific figures

Protein import-driven mitochondrial hyperactivation dictates angiogenesis independently of HIF-1α https://www.biorxiv.org/content/10.64898/2026.04.11.717880v1

Structural Basis of Mitochondrial Transcription Regulation via Interactions of PolRMT and TFAM with Upstream Promoter DNA https://www.biorxiv.org/content/10.64898/2026.04.09.717523v1

SLC6A6 mediates taurin import to sustain mitochondrial tRNA modifications. www.nature.com/articles/s42...

MitoAtlas: a Domain-Resolved Spatial Map of the Human Mitochondrial Proteome www.biorxiv.org/content/10.6...

Mechanisms of human mitochondrial leaderless mRNA translation initiation. www.nature.com/articles/s41...

U2AF regulates the translation and localization of nuclear-encoded mitochondrial mRNAs. www.cell.com/molecular-ce...

Pearling drives mitochondrial DNA nucleoid distribution | Science www.science.org/doi/10.1126/...

Excited to share our @natprot.nature.com paper on using RNA proximity labeling to map subcellular RNA transcriptomes. We’ve been working in this area for a while and wanted to create a resource paper to guide the uninitiated reader. rdcu.be/fblvI

Rab12 is a regulator of mitophagy and mitochondrial homeostasis https://www.biorxiv.org/content/10.64898/2026.03.29.715103v1

Mitochondrial ATP production promotes T cell differentiation and function by regulating chromatin accessibility https://www.biorxiv.org/content/10.64898/2026.03.27.714789v1

A molecular switch in NAC prevents mitochondrial protein mistargeting by SRP www.nature.com/articles/s41...

Online now: Mitochondrial lactate venting limits oxidative stress

Proximity labelling of the BAK macropore uncovers a new role for SLC35A4-MP in mitochondrial dynamics www.biorxiv.org/content/10.6...

Mitochondrial inner membrane interactors of Aurora kinase A/AURKA and PHB2 shape organelle metabolic heterogeneity. https://www.biorxiv.org/content/10.64898/2026.03.17.712317v1

Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress. www.science.org/doi/10.1126/...

Mitochondria contact lipid droplets through the mitochondrial import complex binding to lipid metabolism enzyme Ayr1 www.nature.com/articles/s41...

Metabolic stress reveals widespread accumulation of cap-unmethylated RNAs https://www.biorxiv.org/content/10.64898/2026.02.23.707474v1

Mammalian cells form hibernating disomes akin to those in bacterial cells - but connected via ribosomal RNA www.science.org/doi/10.1126/... co-first with: @andschwarz.bsky.social with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more 🧵 0/6 #MolBio 🧪

Our work is published today: ‘Oxygen metabolism in descendants of the archaeal-eukaryotic ancestor’. This was a huge effort lead by @katyappler.bsky.social. Extremely grateful to have been a part of this amazing project! 😊🦠🧬 Links: www.nature.com/articles/s41... www.nature.com/articles/s41...

Cytoplasmic mRNA granules regulate cell fate decisions during PINK1/Parkin mitophagy https://www.biorxiv.org/content/10.64898/2026.02.13.705862v1

New Online! Mechanisms and disease relevance of mitochondrial translation in humans

Organelle communication networks rewire to support lipid metabolism during neuronal differentiation https://www.biorxiv.org/content/10.64898/2026.02.10.704675v1

Researchers identify brain neurons responsible for building endurance after exercise #inmice. spkl.io/63322AtDPj#inmice J. Nicholas Betley & colleagues @cp-neuron.bsky.social

Long in the making, but happy to present the Chlamydomonas chlororibosome! Cryo-ET🔬reveals a large new domain on the small subunit, built from multiple extensions in conserved ribosomal proteins. bioRxiv 📖: shorturl.at/q44tG This suggests greater chlororibosome diversity than expected! 1/n 🧵

🧬🔬🎥 @science.org Live-cell single-molecule dynamics of eukaryotic RNA polymerase machineries | Science www.science.org/doi/10.1126/...

Integrative modelling reveals the structure of the human Mic60-Mic19 subcomplex and its role as a diffusion barrier in mitochondria. www.biorxiv.org/content/10.6...

ALKB-1-dependent tRNA methylation is required for efficient paternal mitochondrial elimination www.nature.com/articles/s41...

Schwarz lab @bostonchildrens.bsky.social identify a mechanism coupling mitochondrial movement to energy demand. When energy levels are low, the energy-sensing kinase AMPK phosphorylates the motor/adaptor protein TRAK1, arresting #mitochondria via the #actin #cytoskeleton. rupress.org/jcb/article/...

5' UTR length regulates alternative N-terminal protein isoform production in health and disease https://www.biorxiv.org/content/10.64898/2026.01.20.700518v1

We then used qExM to measure the abundance of mitochondrial respiratory chain complexes in situ! We measured the abundances for Complex I, III, and IV. How they differ in absolute abundances in metabolically distinct subpopulations And even how T-cell activation changes supercomplex density

For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵