Gut mucin fucosylation dictates the entry of botulinum toxin complexes www.nature.com/articles/s41...

Elucidating lipid nanoparticle properties and structure through biophysical analyses - @guptapenn.bsky.social @pennengineering.bsky.social @pennmedicine.bsky.social go.nature.com/4oTt639

Another piece of the #glycoRNA puzzle revealed by @raflynn5.bsky.social and @vijayrathinam.bsky.social!! RNAs with modified base acp3U activate TLR3/7, but not when acp3U is N-glycosylated. This is how cell surface/secreted glycoRNAs avoid stimulating autoimmunity. www.nature.com/articles/s41...

Using #Caenorhabditis genes to reengineer insect cells to better mimic nematode glycosylation academic.oup.com/glycob/advan...

Scientists have mapped individual sugar molecules on the surface of cells at a resolution once thought to be impossible for light microscopes go.nature.com/40I9Ewv

Expression of a human Gb3/CD77 synthase in insect and human cells: comparison of activity and glycosylation https://www.biorxiv.org/content/10.1101/2025.06.09.658241v1

More insights into #glycoRNA, this time found within exosomes! www.nature.com/articles/s41...

A case study on the challenges of evaluating AI predictions in biology and the implications for published results. 1/2 rachel.fast.ai/posts/2025-0...

Marcin Czerwinski Interesting review about glycoRNAs as immune regulators. tinyurl.com/mvutz9ye #glycotime

An interesting study on archaeal extracellular vesicles (AEVs) in the human gastrointestinal tract: opening new avenues for microbiome-host interaction research. shorturl.at/dpn4v

Yeyyyy!! The preprint for Glycam-Web is out! ⬇️ Super congrats @olivercgrant.bsky.social and all! Glycam-Web is a 🔝 complex carbohydrate builder, very accurate and intuitive while fast. We use it *ALL the time*, so I am delighted that now I can cite it properly 👍🤩 doi.org/10.1101/2025...

MALDI imaging of lipids, metabolites and glycans all on the same section! From Ramon Sun and colleagues. www.nature.com/articles/s41...

Fantastic new study from Raphael Rodriguez' lab shows that induced proximity concepts can be used to induce Ferroptosis! Inducing proximity of lysosomal iron and lipids induces lipid peroxidation! What a cool concept! Have a look at our News/Views with @olzmannlab.bsky.social shorturl.at/cbc8D

Check it out - amazing new work by @raflynn5.bsky.social and Kostas Tzelepis labs, discovery of a cell surface RNA/glycoRNA binding protein that is also a cancer antigen, new target for antibody therapy! www.nature.com/articles/s41...

"Our LPD-3 complex structural data reveal protein–lipid interactions that suggest a model for how the native LPD-3 complex mediates bulk lipid transport and provides a foundation for mechanistic studies of bridge-like lipid transport proteins (BLTPs)." 🤯🤯😍 www.nature.com/articles/s41...

Biallelic loss of SEC24C proteins (elements of COP IIcoat protein complex II which participate in intracellular trafficking) causes i.a. primary microcephaly, brain anomalies, epilepsy and hearing loss, but also deregulation of N-glycosylation. New type of CDG? tinyurl.com/3cyfyhua #glycotime

Great review about gene therapy for hemophilia – from basic science to first approvals of “One-and-Done” therapies. Must-read! tinyurl.com/52jnjzcp

Shi et al show ⬇️ that mucin-domain glycoproteins in the brain endothelial glycocalyx are highly dysregulated during ageing and neurodegenerative disease, leading to severe perturbations of the BBB function #glycotime at its best! 💥🧠🍬🎉 doi.org/10.1038/s415...

Check out our web tool for searching for interactors of your favorite cell surface protein, developed by undergrad Pinyu Liao and postdoc postdoc Brendan Floyd @stanford-chemh.bsky.social cellsurfacemap.org

Our Lectin-PAINT work is out! A super-resolution approach to study membrane-exposed glycans with nm resolution and in live cells. Multiplexed 8-colors imaging mapping heterogeneity in "glycotype" with single molecule resolution. Fantastic work of our Marrit! #Glycotime www.nature.com/articles/s42...

Our new paper in print describes a new approach: release and analysis of N-glycans in less than 24 hours. A perfect approach for those that are glycan-curious as it does not require changing any of your proteomics buffers! 1/5 #glycotime #teammassspec pubs.acs.org/doi/10.1021/...

The self-driving multiscale microscope from @daetwylerstephan.bsky.social is out. It can image an entire zebrafish embryo longitudinally and follow a volume of interest over time with high resolution. We used it to study cancer-immune cell interactions. www.nature.com/articles/s41...

ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🍬🍭🔬 For the first time, we’re able to study the molecular architecture of the glycocalyx at single-sugar resolution—a longstanding challenge in glycobiology! #glycotime Preprint and #bluetorial below!!

This is an amazing achievement - angstrom scale imagine of glycan molecules, what a great time for #glycotime. Congrats Leonhard Möckl! www.biorxiv.org/content/10.1...

🧬🧪Protein codes promote selective subcellular compartmentalization | Science www.science.org/doi/10.1126/... Henry Kilgore @itamarchinn.bsky.social @pgmikhael.bsky.social Ilan Mitnikov, et al. @aihealthmit.bsky.social @whiteheadinstitute.bsky.social @mitofficial.bsky.social

We are very happy to present our work on N-glycoproteomics!🍬 Our method enables the selective enrichment and precise quantification of intact N-glycopeptides to explore the dynamics of glycosylation microheterogeneity. www.nature.com/articles/s41...

2′-Fucosyllactose inhibits human norovirus replication in human intestinal enteroids but not in infant jejunal enteroids that have significantly lower expression of α1–2-fucosylated glycans @sashi-ramani.bsky.social bit.ly/4h45vsG #glycotime

Our latest work on Siglec binding to sulfated glycans. Great help: @khookh.bsky.social, @pengwu.bsky.social ,@raflynn5.bsky.social. Fom 1st PhD graduate of the lab (Jaesoo Jung) and help from Edward, Zeinab, Jhon, Kelli, @tayloregray.bsky.social, and Chris from my lab. pubs.acs.org/doi/10.1021/...

New year, new paper from my group! Ribosomes translocation into the spore of Bacillus subtilis is highly organised and requires peptidoglycan rearrangements Funded by @FNP_org_pl @EMBO_YIP performed at @IBBPAS #subtiwiki www.nature.com/articles/s41...

Synthesis of the hard-to-obtain 0-series of ganglioside glycans: introduction of sialic acid overcomes the limitation of substrate specificity of Campylobacter jejuni β1–4-N acetylgalactosaminyltransferase. tinyurl.com/yvc8w93b #glycotime

Glycosylation on extracellular vesicles and its detection strategy: Paving the way for clinical use. tinyurl.com/58yvsj6z #glycotime

I recommend! New paper @kmikolajczyk.bsky.social shows that exosomes containing Galα1→4Gal epitope can effectively neutralize Shiga toxin 1 tinyurl.com/53knbhmt #glycotime

GOLPH3 and GOLPH3L maintain Golgi localization of LYSET and a functional mannose 6-phosphate transport pathway tinyurl.com/7p7pf754 #glycotime

Excellent review on coagulation factor VIII and its role in hemophilia. Synthesis, posttranslational modifications, secretion, variants, circulation, clearance, role of vWF, acitvation, immunogenicity. Must-read! @bloodjournal.bsky.social tinyurl.com/2abt6w5c

Interesting article about the role of N- and O-glycans in dynamic behaviour and function of filaments in Archaea (model species Sulfolobus acidocaldarius) tinyurl.com/myhvvasv #glycotime

Human Gb3/CD77 synthase (α1,4-galactosyltransferase), encoded by A4GALT gene, forms Galα1 → 4Gal structures on glycosphingolipids and glycoproteins. Its products play important role in cancer metastasis and chemoresistance. More in our review tinyurl.com/3ht9t6ed #glycotime

Glycoconjugate Vaccines: Platforms and Adjuvants for Directed Immunity #glycotime #glycobiology

Interesting piece about glycosylated RNAs (glycoRNAs): sialylated glycoRNAs are present in human cell lines, and sialylation of glycoRNAs depends on the catalytic isoforms of the oligosaccharyltransferase (OST) complex. tinyurl.com/vhz2rj8a

Interesting! CD320, receptor that mediates vitamin B12 uptake in most tissues (bound to transcobalamine), requires presence of O-glycans but not N-glycans for cell surface expression. New paper at JBC. tinyurl.com/59demayr

CRISPR screens and lectin microarrays demonstrate that two high mannose regulators (TM9SF3 and the CCC complex) control complex N-glycosylation via regulating Golgi morphology and function. #glycotime tinyurl.com/mtw7h9bm

What was the reason for GPI-anchored proteins to evolve? It takes 30 genes to form a GPI anchor, and many important proteins like alkaline phosphatase or acetylcholinesterase use it. More about it tinyurl.com/mundnmu7 #glycotime

O-GlcNAcylation modulates expression and abundance of N-glycosylation machinery, with UDP-GlcNAc acts as a sensor between two spatially distinct glycosylation pathways. Role in PMM2-CDG explained. tinyurl.com/bdhmfvam #glycotime #CDG

Everyone lecturing about bioenergetics must update the notes: mitochondrial membrane potential is controlled not by a H+ gradient only (as was known until yesterday), but by a H+ AND a Na+ gradient. The Na+-specific Na+/H+ exchanger resides in the P-module of Complex I. tinyurl.com/yd4tr96w