Karim Almahayni 🍉
@karimalmahayni.bsky.social
📤 45
📥 35
📝 7
Microscopy🔬| Glycans🍭| Pharmacology 💊@MPI_Light |@uniofoxford ‘20, @sheffielduni ‘19
pinned post!
ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🍬🍭🔬 For the first time, we’re able to study the molecular architecture of the glycocalyx at single-sugar resolution—a longstanding challenge in glycobiology!
#glycotime
Preprint and
#bluetorial
below!!
add a skeleton here at some point
11 months ago
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Karim Almahayni 🍉
Luciano A. Masullo
3 months ago
Our article "Ångström-resolution imaging of cell-surface glycans" made it to the cover of Nature Nanotechnology! 🤩
@natnano.nature.com
www.nature.com/nnano/volume...
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Karim Almahayni 🍉
Nature Nanotechnology
3 months ago
Now online: October 2025 Issue. - Focus Issue on
#biosensing
, - DNA moiré superlattices, - Sugars at Ångström-resolution, - Solid-state
#nanopores
, - Non-aqueous Li
#batteries
, - - Neuromorphic vision, - Peptide
#hydrogels
, - Deep learning for
#LNPs
and more...
www.nature.com/nnano/volume...
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Karim Almahayni 🍉
Max Planck Institute for the Science of Light (MPL)
3 months ago
With deep sadness, we share that Prof. Jochen Guck, Director at the Max Planck Institute for the Science of Light passed away on October 3. His visionary work bridged physics and medicine. We have lost a brilliant scientist and dear friend.
mpl.mpg.de/news/article...
@fau.de
📸 Stephan Spangenberg
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Karim Almahayni 🍉
Ryan Flynn
3 months ago
We’re excited to report work led by postdoc Jennifer Porat in the lab, finding that DNA accumulates on the surface of living cells and that the secreted extracellular protein DNASE1L3 can modulate its levels on B and T cells. With a new twist for ATAC-seq as well
www.biorxiv.org/content/10.1...
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DNASE1L3 surveils mitochondrial DNA on the surface of distinct mammalian cells
The extracellular space is a critical environment for discriminating self versus non-self nucleic acids and initiating the appropriate immune responses through signaling cascades to relay information ...
https://www.biorxiv.org/content/10.1101/2025.10.05.680464v1
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Karim Almahayni 🍉
Leonhard Möckl
4 months ago
Excited to see this one out in JACS! We analyzed how molecular interactions lead to self-organization of glycolipids down to microseconds and nanometer spatiotemporal scales. Amazing collaboration with the Sandoghdar lab,
@biomemphys.bsky.social
, and Thisbe Lindhorst!
pubs.acs.org/doi/abs/10.1...
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Bottom-up Investigation of Spatiotemporal Glycocalyx Dynamics with Interferometric Scattering Microscopy
Over recent decades, the glycocalyx, an extracellular organelle composed of a multitude of glycolipids, glycoproteins, proteoglycans, and glycoRNA, has gained considerable interest in cellular biology...
https://pubs.acs.org/doi/abs/10.1021/jacs.5c08659
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Karim Almahayni 🍉
Nature Nanotechnology
5 months ago
Research Briefing: "Visualizing the nanostructure of the cell’s sugar coat." Here, the author's views, expert opinion, and insights behind the recently published paper "Ångström-resolution imaging of cell-surface glycans" are presented.
#Glycotime
www.nature.com/articles/s41...
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Karim Almahayni 🍉
Nature
5 months ago
Scientists have mapped individual sugar molecules on the surface of cells at a resolution once thought to be impossible for light microscopes
go.nature.com/40I9Ewv
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Cell's sugar coating mapped at below-nanometre resolution
Nature - Super-resolution technique works with off-the-shelf optical microscopes.
https://go.nature.com/40I9Ewv
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reposted by
Karim Almahayni 🍉
Luciano A. Masullo
5 months ago
Ångström-resolution imaging of cell-surface glycans Now published in Nature Nanotechnology! 🤩
@natnano.nature.com
www.nature.com/articles/s41...
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Karim Almahayni 🍉
Nature
5 months ago
Scientists have mapped individual sugar molecules on the surface of cells at a resolution once thought to be impossible for light microscopes
go.nature.com/4l2wVjS
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Cell's sugar coating mapped at below-nanometre resolution
Super-resolution technique works with off-the-shelf optical microscopes.
https://go.nature.com/4l2wVjS
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reposted by
Karim Almahayni 🍉
Nature Nanotechnology
5 months ago
News article
@nature.com
covering a recent study published
@natnano.nature.com
Cell's sugar coating mapped at below-nanometre resolution. "Super-resolution technique works with off-the-shelf optical microscopes."
#Glycotime
www.nature.com/articles/d41...
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Cell's sugar coating mapped at below-nanometre resolution
Super-resolution technique works with off-the-shelf optical microscopes.
https://www.nature.com/articles/d41586-025-02376-2
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reposted by
Karim Almahayni 🍉
Dr. Fiona
5 months ago
Excuse me while i geek out over this so hard
#GlycoTime
(
@elisafadda.bsky.social
👀 👀 👀)
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Karim Almahayni 🍉
Nature Nanotechnology
5 months ago
New paper online: Ångström-resolution imaging of cell-surface glycans. The molecular organization of sugars in the native
#glycocalyx
has been resolved at 9 ångström using bioorthogonal metabolic labeling and
#superresolution
imaging of DNA barcodes.
#Glycotime
www.nature.com/articles/s41...
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Ångström-resolution imaging of cell-surface glycans - Nature Nanotechnology
By combining bioorthogonal metabolic labelling and resolution enhancement through sequential imaging of DNA barcodes, the molecular organization of individual sugars in the native glycocalyx has been ...
https://www.nature.com/articles/s41565-025-01966-5?utm_source=bluesky&utm_medium=social&utm_campaign=nnano
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reposted by
Karim Almahayni 🍉
Leonhard Möckl
5 months ago
Very happy to see this one out - the first molecular-resolution imaging of glycocalyx components in their native environment! Great collaboration with
@jungmannlab.bsky.social
- congrats to first authors
@karimalmahayni.bsky.social
and
@lumasullo.bsky.social
and to the whole team!
add a skeleton here at some point
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reposted by
Karim Almahayni 🍉
Leonhard Möckl
8 months ago
GLYCAN ATLASSING: NANOSCALE ANALYSIS OF GLYCOCALYX ARCHITECTURE ENABLES FUNCTIONAL TRACING OF CELL STATE 🍭🔬🧬 Don’t judge a book by its cover - judge a cell by its cover! We can now trace how cell state is encoded in glycocalyx state.
#glycotime
#microscopy
www.biorxiv.org/content/10.1...
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Karim Almahayni 🍉
Janis Gonzales MD MPH FAAP
9 months ago
My daughter died from AML and I don’t want any other parent to go through what we did. This type of vital research must be funded.
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Karim Almahayni 🍉
Nature Biotechnology
9 months ago
A new druggable cancer target: RNA-binding proteins on the cell surface
#NBTintheNews
answers.childrenshospital.org/aml-cancer-t...
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A druggable target for AML: cell-surface RNA-binding proteins - Boston Children's Answers
Researchers have found a readily druggable target on the surface of acute myeloid leukemia (AML) cells — but not normal blood cells.
https://answers.childrenshospital.org/aml-cancer-target-npm1/
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Karim Almahayni 🍉
Carolyn Bertozzi
9 months ago
Check it out - amazing new work by
@raflynn5.bsky.social
and Kostas Tzelepis labs, discovery of a cell surface RNA/glycoRNA binding protein that is also a cancer antigen, new target for antibody therapy!
www.nature.com/articles/s41...
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Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein - Nature Biotechnology
An RNA-binding protein on leukemia cells provides an effective target in mouse models.
https://www.nature.com/articles/s41587-025-02648-2
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Karim Almahayni 🍉
Leonhard Möckl
9 months ago
A wonderful study, published today in Nature Biotech.: NPM1 is a marker of AML and can be targeted for efficient therapy!
@karimalmahayni.bsky.social
created the first SR reconstructions of NPM1 on the cell surface. Great collaborative work, spearheaded by
@raflynn5.bsky.social
and Kostas Tzelepis!
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Karim Almahayni 🍉
Nature Biotechnology
9 months ago
Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein -
@raflynn5.bsky.social
go.nature.com/3YbT1In
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Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein - Nature Biotechnology
An RNA-binding protein on leukemia cells provides an effective target in mouse models.
https://go.nature.com/3YbT1In
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Happy to have contributed to this amazing story identifying cell surface NPM1 as a promising therapeutic strategy in acute myeloid leukaemia, check it out!
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9 months ago
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Thrilled to be part of this masterpiece published today in CELL 🚀🔬!! Check it out!
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10 months ago
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Karim Almahayni 🍉
Carolyn Bertozzi
11 months ago
This is an amazing achievement - angstrom scale imagine of glycan molecules, what a great time for
#glycotime
. Congrats Leonhard Möckl!
www.biorxiv.org/content/10.1...
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Angstrom-resolution imaging of cell-surface glycans
Glycobiology is rooted in the study of monosaccharides, Angstrom-sized molecules that are the building blocks of intricate glycosylation patterns. Glycosylated biomolecules form the glycocalyx, a dens...
https://www.biorxiv.org/content/10.1101/2025.02.07.637003v1
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reposted by
Karim Almahayni 🍉
Leonhard Möckl
11 months ago
ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS🍬🍬🍬 For the first time, we are able to image the molecular architecture of the glycocalyx at Ångström resolution. A dream come true! Read the preprint:
biorxiv.org/content/10.110…
And find our tweetorial below
#glycotime
me
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ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🍬🍭🔬 For the first time, we’re able to study the molecular architecture of the glycocalyx at single-sugar resolution—a longstanding challenge in glycobiology!
#glycotime
Preprint and
#bluetorial
below!!
add a skeleton here at some point
11 months ago
2
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reposted by
Karim Almahayni 🍉
Wehner lab | Neuroregeneration
11 months ago
Excited to share the latest work from our lab:
www.biorxiv.org/content/10.1...
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Biphasic inflammation control by dedifferentiated fibroblasts enables axon regeneration after spinal cord injury in zebrafish
Fibrosis and persistent inflammation are interconnected processes that inhibit axon regeneration in the mammalian central nervous system (CNS). In zebrafish, by contrast, fibroblast-derived extracellu...
https://www.biorxiv.org/content/10.1101/2025.01.27.635043v1
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Karim Almahayni 🍉
Max Planck Institute for the Science of Light (MPL)
12 months ago
LIGHTs on for our Bluesky channel! 💡 Stay up to date with all the latest news from our research on the
#science
of
#light
and the institute!
#sciencebluesky
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Our latest paper made the cover! 🎉 We developed a library of light-activated molecules designed for precise, localized induction of cell death in biological systems, characterized both in vitro and in vivo. Great collaboration with
@wehnerlab.bsky.social
Read more:
pubs.acs.org/doi/full/10....
12 months ago
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