Silvia's simulations showed that while all epitopes expose Sia for binding, Siglec-6 recognises and binds only GM1 because of a key interaction with the membrane through W127 and K126, which orientates the V-set domain to bind the Sia through Arg122 and the terminal Gal to the C-C' loop 😎

Wee thread 🧵⬇️ on our new #glycotime with @siglecdude.bsky.social John Klassen and @glycocode.bsky.social 🥳 where we show Siglecs as molecular precision tools, able to recognise sialylated glycans with surgical precision in their natural environment, not bad for a lectin! 😎 doi.org/10.1038/s420...

"FIFA Peace Prize – Football Unites the World" 👍🏼

To be clear: I believe everyone in this video should be held on trial for Treason and violating the Constitution. I suggest Minneapolis MN as the ideal site for said trial.

I just wish Virginia Giuffre was here to see Andrew Mountbatton-whateverthehell in handcuffs

Sucks to live in the era of a lot of people learning that it takes a lot less time and effort to destroy stuff than to build (or re-build) it.

UK: Prince Andrew arrested. South Korea: Former President Yoon sentenced for life. Brazil: Former President Bolsonaro serving a 27-year sentence. USA: President Trump demands $10 billion payout from taxpayers.

I miss having an articulate president.

My heights have officially been wuthered. Absolutely phenomenal and beautiful rendition of the classic novel, in my opinion, I think the tone of classism was exceptionally clear, the racism was missing (if not inverted) but overall the tortured love plot was powerful.

My family still keeps a "Help Wanted. No Irish Need Apply" sign hung in our house so M*sk can take this racist dog whistle and shove it right up where the sun dont shine.

Our paper on [Bentopy](doi.org/10.1002/pro....) is out in Protein Science! We developed Bentopy to make assembling large-scale MD models more accessible, building on what we learned from trying to simulate whole-cell models. Here's our updated Martini JCVI-syn3A cell model👇

Continually absolutely disgusted with the many ways in which this administration is actively and directly harming children. Party of "family values" my ass.

SAVE Act: Asks for naturalization papers which US birth citizens do not have. Or REAL ID which requires your last name match that of your birth certificate, which disqualifies married women who are US citizens. Or passport which poor rural Americans usually don’t have. SAVE Act is anti American

what will i do with all the random 4 letter codes i have stuck in my head?!

Do you love building AI/ML models across a wide range of research topics? TU Wien is hiring two senior scientists/postdocs for a university-wide AI/ML service center (www.tuwien.at/datatudiscovery). Computer science: jobs.tuwien.ac.at/Job/263874 Science/engineering: jobs.tuwien.ac.at/Job/263875

On my way to Aachen for the 5th German workshop on structural predictions of membrane proteins: from ion channels to G protein-coupled receptors. I will talk about drug transporters and Toll-like receptors tomorrow. #compchem

This made me cry! What a powerful show! youtu.be/G6FuWd4wNd8?...

This is America the beautiful, home of the brave.

Every American needs to watch this:

dont mind me just crying in my office

This work started as a bachelor project and @1nussi1.bsky.social and @felixgrunberger.bsky.social showed that CsmR is a very interesting regulator important for controlling motiliy and cellshape in Haloferax volcanii. The preprint is out now: www.biorxiv.org/content/10.6...

Americans are already working DURING high school, Americans are already delaying retirement, most have NO retirement savings. Most ALREADY work SEVERAL jobs. This is absolute nonsense. Taxing a handful of billionaires would more than remove debt. This is pointless blame-gaming. Don't fall for it.

No one is illegal on stolen land built by stolen hands.

As an American, opening up my first bill from a doctors appointment was an absolute ROLLER COASTER ride.

The research of Dr. Gladys West, who died Jan. 17 at 95, laid the groundwork for the GPS. Thanks in part to her, anyone with a smartphone can navigate easily from one place to the next, without having to stop to ask for directions.

when will this horror end...

Two Democratic members of Congress attacked in three days. Maxwell Frost was assaulted on Saturday, Ilan Omar tonight.

Just submitted my first manuscript as an independent PI

No words, just tears and a broken heart.

Yes this is a Science account, but its also a political account because we can't do science if ICE shoots us in the street for protecting our fellow humans.

Wife and I in tears reading this…

While attempting to sleep last night I remembered the scene in Jojo Rabbit where jojo finds his mom's feet hanging above his head in the street. i thought to myself "well at least we aren't there" and then one word came to mind "YET". Here leads to there. Now will become then. Unless we act.

Different uniforms. Same kneeling man. Same rifles. Same state telling the world this is order. History does not repeat politely. It reuses its favorite methods. If you think this is exaggerated, you are standing in the second photo.

DHS has shot 12 people during immigration enforcement operations since September:

"guns dont kill people, federal agents kill people"

"What we’re … seeing is the toll of the uncertainty." My latest story for @science.org—part of a package that explores how the U.S. scientific community has changed under Trump—includes new numbers on graduate enrollment and faculty hiring. www.science.org/content/arti...

not me asking ChatGPT if anyone is mad at me

And when all the dust settles and we (the US) are on the path to rebuilding our (US) reputation, some will say "We really just didnt know what was happening" I want EVERYONE to be ready to say "BULL-F*CKING-SHIT" because all of this is playing out in 1080p (please *do not* excuse my language)

There is going to come a time in your life when you are chatting with a guy, at a barbecue or something, a new coworker maybe, a dad at school drop off, and he tells you he used to be in ICE. You’re going to need to spit on that guy

soooo Minnesota leading the revolution orrrrr?

Hallo 👋 ich bin's!!

Im rooting for Bad Bunny this super bowl season

The only thing the US can recycle is fascism

trying to learn German by watching Love is Blind Germany

Me: *logging in to my email*

was it called Ocean's 8 because women do the same job for 70% of the pay?

Worth noting: Citizens United was 2010 and the NRA spent $46 mill on lobbying in 2013 alone

I love that Rick Scott is on CNN talking about all the waste and deception in the health care/insurance business. He really is an expert since his company paid a record $1.7 billion in fines for Medicare fraud.

In his deposition for his Medicare fraud case, where he committed (at the time) the greatest amount of Medicare fraud ever, Rick Scott invoked the 5th Amendment 85 times. This is who the GOP has as their "Healthcare Expert".