Cortical folding patterns are encoded in the geometry of the unfolded neocortex. https://www.biorxiv.org/content/10.64898/2026.06.05.730475v1

📣 new preprint multimodal atlas. Imaging + scRNA, 57M cells. 🧬🔬 Cells are complex dynamical systems — but most ways we measure them destroy them. We asked: how does live imaging compare to scRNA-seq, the field’s gold std? The answer surprised us 🧵 www.biorxiv.org/content/10.6...

Hello #world, meet 1,000× Expansion Microscopy. A small gel would grow to the size of an Olympic swimming pool, while amino-acid-scale distances become visible with ordinary light microscopy. Led by Helena Hu from @eboyden3.bsky.social's lab, in collab with us. Story: www.biorxiv.org/content/10.6...

As someone interested in both genetics & neural activity, I appreciate the common challenge of linking causal function to system-level understanding. This excellent review by @jamesbriscoe.bsky.social & Maizels shows a way forward for gene networks in development pubmed.ncbi.nlm.nih.gov/41803457/

“Using an optical backfilling method relying on photoactivable GFP, we generate a whole-brain map of all neurons sending axons towards the spinal cord. This approach reveals far more SPNs than previously described through conventional strategies.” Bonkers work from @wyartlab.bsky.social 🐟🧠

A fossil nervous system meets modern neurobiology. We found that a living comb jelly preserves neural architecture remarkably similar to those inferred from Cambrian fossils over 500 million years old 🤩. www.biorxiv.org/content/10.6...

Overall very cool stuff. A reconfigurable instrument that repurposes equipment investment in adaptive optics, SLM, lasers, to do a lot of different things 🧪

Today in Nature, we report MouseMapper: foundation-model AI to map disease perturbations across the entire mouse body cell-by-cell. In obesity, it revealed body-wide inflammation & unexpected facial nerve damage. www.nature.com/articles/s41... More at: x.com/erturklab/st...

Where, exactly, does learning happen in the brain? Out today in @nature.com, we identify a synaptic locus of birdsong learning and show that the circuit can be tuned to make birds learn faster - but at a cost. Read on👇 #neuroskyence 🧪 #prattle 💬 #bioacoustics Shareable link: rdcu.be/fiyrS

RegVelo introduces an end-to-end generative framework that jointly infers gene regulatory networks and developmental dynamic @cellcellpress.bsky.social @saukaspengler.bsky.social @fabiantheis.bsky.social www.cell.com/cell/fulltex...

This is the way.

New preprint: Whole-body 3D kinematics of freely behaving 𝐷𝑟𝑜𝑠𝑜𝑝ℎ𝑖𝑙𝑎 New tech from @blobology.bsky.social & others at @hhmijanelia.bsky.social, which @ispizua.bsky.social and @elliottabe.bsky.social used to gain insight into 3D structure of locomotion & courtship www.biorxiv.org/content/10.6...

Notre discipline mise en avant dans Le Monde :) Interview de l'un des pionniers de l'évo-dévo, Denis Duboule, qui parle de l'histoire de l'évo-dévo, de ses découvertes mais aussi des questions qui restent à explorer ! www.lemonde.fr/sciences/art...

A clear/significant finding derived from the single cell (sc) analysis of biological systems has been the realization that phenotypically homogeneous populations are heterogeneous at the level of gene expression (GE). www.cell.com/fulltext/S00... 🧵

arxiv.org/abs/2604.23903 (Thanks to @memming.bsky.social for leading the writing of this opinion piece!)

“For 30 years, we’ve taught students that the mouse olfactory epithelium is divided into a handful of broad zones, within which receptor choice is essentially random,” @odorjohan.bsky.social told me. Now we know it's not random. My latest for @nature.com 🧪 www.nature.com/articles/d41...

Beautiful work led by Yansong (Kevin) Lu on skeletal muscle growth in zebrafish, giant danio, Danionella cerebrum, and killifish. HCR, new image analysis tool, scRNA-seq, and CRISPR. New international collaborations between Uni Melbourne, NCVC/Osaka, Stanford & ARMI www.biorxiv.org/content/10.6...

The Developmental Origins of Behavioral Individuality - great review by Benjamin de Bivort www.annualreviews.org/content/jour...

"Cybernetics. A word invented by Professor Wiener to describe the field of control and communication theory, whether in the machine or in the animal. None of the authors quite understands what the word means, so it has not been used in this book."

Félix Simon's paper is out in its final form 😍 When we got into (extreme) detail in the temporal and spatial patterning of neuroblasts, Félix asked a simple question "sure, but how does this translate into neuronal cell fate?". www.nature.com/articles/s41...

A new preprint shows that deep learning can make a fly walk realistically using a worm’s brain — exposing a fundamental problem with how connectome models are being built and sold to investors. By @natmesanash.bsky.social #neuroskyence www.thetransmitter.org/systems-neur...

FYI: New online! Gene regulatory networks: from correlative models to causal explanations

First atlas of brain organization shows development over a lifetime - from birth to 100 years! The tour-de-force paper is here www.nature.com/articles/s41... 🧪 @nature.com www.nature.com/articles/d41...

🧵 New preprint led by @bingbrunton.bsky.social, @elliottabe.bsky.social, @lawrencehu.bsky.social We gave a worm brain control of a fly body and it walked What did we learn? Nothing, other than deep reinforcement learning is effective We call it the digital sphinx www.biorxiv.org/content/10.6...

Foundational work in #zebrafish can be credited to "fruitful" discussions between #Drosophila researchers such as José Campos-Ortega & Christiane Nüsslein-Volhard. By the late 1980s, multidisciplinary approaches honed in flies were finally applied to a vertebrate. #ZebrafishFunFacts 🧪

Cosyne invited me to give a long tutorial (4 hours!) on methods to quantify differences high-d neural recordings across animals, brain regions, deep neural nets, etc. The recording is up on youtube. I hope it inspires more research on this fundamental topic! www.youtube.com/watch?v=n44x...

Youthful antics predict lifespan? Using machine learning & continuous recordings of #killifish behavior from adolescence until death, @brunetlab.bsky.social & @deisseroth.bsky.social find early-life behavior predicted future lifespan! Now published @science.org: www.science.org/doi/10.1126/... 🧪 1/2

Very happy to see this out. 👏 @yinanwan.bsky.social Bogdan Bintu and team. Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...

1/7 🧠 My journey into development begins with this work and question: how does the brain's spatial navigation system develop? We found that the neural networks for spatial navigation (tori and rings) are preconfigured and only later anchor gradually to the world with experience! 🧵

I tracked every keyword in 22 years of Cosyne abstracts to map how computational neuroscience evolved — from Bayesian brains to neural manifolds to LLMs — and where it's heading next.

New paper hot off the (pre-)press! We dig into the evolutionary origins of neural computations for behavioral control across mice, monkeys, and humans: www.biorxiv.org/content/10.6.... As our lab's first foray into comparative analysis of neural dynamics, I’m super excited about this work! 1/18

First whole-brain recording of social sound processing in a vertebrate. Surprises start in the hindbrain; thalamus gates conspecific calls; male and female brains diverge downstream. Work by @joerghenninger.bsky.social, @mh123.bsky.social sky.social and team. www.biorxiv.org/content/10.6...

An exciting study with Roberto Garza and Armin Bahl biorxiv.org/content/10.6... We combine high-throughput behavioral assays in larval zebrafish with drift-diffusion modeling studying integration dynamics across development and a variety of mutants . Give it a read :D

🛠️ February’s most-read Tools and Resources paper introduces idtracker.ai to rethink multi-animal tracking: buff.ly/Ho0b3xz Learn more about publishing your tools or resources with us: buff.ly/pivLQX0

The ratstronaut dataset is available on DANDI! (and analyzed with @pynapple.bsky.social 😍)

🔬🧠 Releasing the 1.0 version of #Suite2p and THE PAPER w/ @marius10p.bsky.social! Now with GPU acceleration. Want to use Suite2p but don’t have 100,000 neuron recordings? We show you how to get those with a standard 2p microscope #neuroscience #imaging #neuroAI www.biorxiv.org/content/10.6...

New paper alert! 🚨 We found that the brain's compass is remarkably stable at two scales 1️⃣ the system maintains its internal organization for weeks 2️⃣ It "remembers" its orientation for weeks, even after a single visit This may be key to how the brain aligns its other maps. Paper: rdcu.be/e3waP

A perfect chance juxtaposition of posts emphasizing that variation is at the center of life, and we need approaches that highlight rather than average out that variation

This is who runs this account

A new community-driven lab handbook for reducing conflict and creating more positive and equitable work environments gets strong support from a survey of 200 researchers. buff.ly/K7CGFLV

I am very happy (and a bit scared) to present to you what we have been working on over the last 4 years. This manuscript is exactly what I dreamt of when I started the lab and I could not be happier and prouder of the outcome!

Sequences are everywhere! In every brain region. And are written in stone. Invariant Activity Sequences Across the Mouse Brain. Out today, by Célian Bimbard, with @kenneth-harris.bsky.social. Based on data by Célian and by @intlbrainlab.bsky.social. www.biorxiv.org/content/10.6...

“A process which led from the amoeba to man appeared to the philosophers to be obviously a progress - though whether the amoeba would agree with this opinion is not known" - Bertrand Russell, 1976. Time-lapse video of Vampyrella lateritia eating Spirogyra algae from Science Source/Oliver Skibbe. 🦠

And here is the PDF of the 4th course @college-de-france.fr. You will find the justification and presentation of geometric representation of cell decisions, a parsimonious mathematical model for signalling and cell state transitions tinyurl.com/yc7u296j

My first paper just got published last week! *Longitudinal tracking of neuronal activity from the same cells in the developing brain using Track2p* elifesciences.org/articles/107...

Intravital observation of neuronal and immune cell dynamics in the developing mammalian brain: @cellpress.bsky.social www.cell.com/cell/fulltex...

How do neural circuits generate the walking rhythm? Using connectome simulations, @sarahpugly.bsky.social found a minimal central pattern generator (CPG) that produces oscillations in leg motor neurons. Same circuit motif for each 🪰 leg. w @bingbrunton.bsky.social www.biorxiv.org/content/10.1...

Our Method of the Year 2025 is...drumroll please...EM-based connectomics!! Our Editorial introduces our choice and highlights six Comments and other related content in this special issue. Please join us in celebrating EM-based connectomics! 🎉🧠🔬 www.nature.com/articles/s41...