James Watson has died www.nytimes.com/2025/11/07/s...

1/10 Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from? Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria. www.biorxiv.org/content/10.1...

Thrilled to announce our paper identifying and characterizing DPEP1 as the receptor of the porcine coronavirus PHEV is now out in Nature Microbiology @natureportfolio.nature.com ! 🥳 Huge thanks to everyone involved! 🙏 www.nature.com/articles/s41...

✨Excited that the main project of my PhD is now available as a pre-print on #bioRxiv Here, we used #CryoET to visualise mitochondrial proteostatic stress and together with SPA #CryoEM shed light into the functional cycle of the Hsp60:10 chaperone system. #TeamTomo 🔗 www.biorxiv.org/content/10.1...

A new Nature Medicine study analyzing health records from >100 million people in the US offers compelling evidence that reactivation of varicella-zoster virus (VZV) ,the same virus that causes chickenpox and shingles may contribute to dementia risk. www.nature.com/articles/s41...

Out in Science Advances: Our #cryoEM structure of HFTV1, a virus infecting the halophile #archaea. *First full atomic structure (containing all structural proteins) of any tailed virus!* Congrats and thanks to all co-authors and our fantastic collaborators! www.science.org/doi/10.1126/...

This year’s Nobel Prize in Physiology or Medicine has been awarded to three scientists for discovering a class of immune cells that help to prevent the body from attacking its own tissues go.nature.com/3VNrH1s

Are viruses capable of regulating protein synthesis in the nuanced way of cellular organisms? Kinda! I’m excited to share some of my postdoc work that leveraged giant DNA viruses to address this question.

New preprint alert! 🦟 <-> 🦠 <-> 🧑 I am thrilled to share our latest study on alphavirus host adaptation. More specifically, on how a single codon helps blunt alphavirus-induced host innate immune responses in mosquito and human cells. Continue reading for more! www.biorxiv.org/content/10.1...

Viro3D paper is out! We predicted 85,000 protein structures from human & animal viruses. 1/5 🧵 📑 Paper doi.org/10.1038/s443... 🔭 Explore virosphere viro3d.cvr.gla.ac.uk

You’ve heard of ubiquitination, meet deazaguanylation: Doug Wassarman in our lab discovered phage defense pathways have co-opted Q nucleobase biosynthetic enzymes to catalyze a new form of protein conjugation chemistry @science.org www.science.org/doi/10.1126/...

How can we understand the earliest events in evolution of eukaryotic immunity? @yao-li.bsky.social reports incredible molecular fossils of complete bacterial-like operons in eukaryotes that illuminate how animal immunity was first acquired from anti-phage defense www.biorxiv.org/content/10.1...

New preprint! If some merbecoviruses use DPP4 and others use ACE2, what do those hedgehog merbecoviruses use?! As it turns out, neither! In our latest study, we uncover the "missing" receptor for the MERS-related viruses in hedgehogs. [These findings were first shared at ASV this year] (1/6)

📢 New preprint alert! We designed synthetic proteins that can block bacterial immune systems, allowing phages + plasmids to overcome natural defenses. This could transform phage therapy + genetic engineering. Here’s what we found 🧵 Preprint🔗: www.biorxiv.org/content/10.1...

Our preprint, in collaboration with Rino Rappuoli & Emanuele Andreano, is out! Co-led by colleagues at TLS, my grad student Ling Zhou @lingzhou.bsky.social, and postdoc Emily Rundlet @cryoemily.bsky.social, we identified OPG153 as a poxvirus bnAb target via B cell isolation & AlphaFold3 prediction.

🚨 Fungi + viruses + mammalian lungs? Buckle up! Our new paper in @natmicrobiol.nature.com uncovers the story of a deadly fungus and its gnarly viral hitchhiker — and how this duo may change how we diagnose & treat fungal disease 🍄🫁🚨 doi.org/10.1038/s415... ⬇️

Excited to share our new @natmicrobiol.nature.com paper revealing the most complete arenavirus glycoprotein complex (GPC) structures to date 🤩 www.nature.com/articles/s41...

🧬 Our new preprint showing gasdermin E is dispensable for inflammatory responses and pathogenesis in H1N1 influenza. Unlike our prior work on GSDMD. 🫁🦠🐁 www.biorxiv.org/content/10.1...

First preprint from the Nemudryi Lab! 🍾 In this work, we link antiviral immunity in bacteria and humans by showing that homologs of human Schlafen nucleases protect bacteria from phages. www.biorxiv.org/content/10.1...

🦠🧍‍♀️From bacterial to human immunity. We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity. Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social www.science.org/doi/10.1126/...

💥 Couldn’t be more stoked our study identifying a completely new CMV virion surface complex involved in cell entry is now published at Nature Micro 🦠 H/T @paramyxologist.bsky.social + Lauren Henderson, Erica Ollmann Saphire Chris Benedict @natmicrobiol.nature.com www.nature.com/articles/s41...

Excited to see this collaborative work with Olivia Rissland's lab finally out. We found lots of 2A peptides and an entirely new 2A class. www.cell.com/cell-reports...

🚨PRE-PRINT ALERT🚨 We mapped yellow fever virus-host protein interactions and did cool stuff with the data! 🧵 1/n www.biorxiv.org/content/10.1...

Latest preprint from the lab, many years in the making! By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase. This could have big implications for our understanding of viral replication & assembly (🧵) www.biorxiv.org/content/10.1...

Excited to share our new paper led by recent PhD, Dr. Hannah Schmidt! We found that UFMylation unexpectedly promotes flavivirus particle production by specifically regulating viral assembly. Check it out! #virology #UFMylation #flaviviruses journals.asm.org/doi/10.1128/...

First time working on dolphin/whale viruses 🐬🦠🐳. Check out our new preprint with @danielhurdiss.bsky.social et al. describing the structure and glycan shield of two cetacean coronavirus spikes. Some neat glycoproteomics work by @tshamorkina.bsky.social in this one. www.biorxiv.org/content/10.1...

⚠️ Discovery of a new mode of viral transmission: Deltaviruses spread through a viral Trojan Horse ! These viral satellites that do not encode their own glycoproteins, are in fact physically encapsulated within their helper virus particles! www.biorxiv.org/content/10.1... A thread 1/14

Outbreaks of Marburg virus (MARV) disease have been increasingly more frequent recently. Here we describe a prefusion-stabilized MARV GP and a best-in-class MARV neutralizing antibody! Led by @aminaddetia.bsky.social with @virbiotechnology.bsky.social @hhmi.org www.biorxiv.org/content/10.1...

www.microbe.tv/twiv/categor... my work was featured on twiv again 🥹

Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals. www.science.org/doi/10.1126/...

Very interesting new study from authors including Nobel Prize winner David Baker. I'm glad that it cites one of my related papers 😀 I've faced plenty of skepticism from editors & others about the importance of this line of research, perhaps this will shift ... www.biorxiv.org/content/10.1...

Out now! A fresh perspective on interferon-mediated antiviral activity -- How many ISGs does it take to inhibit a virus? Perhaps far fewer than we think. dx.plos.org/10.1371/jour...

Happy to be able to contribute to this very cool preprint Characterization of the glycoproteins of novel fish influenza B-like viruses #glycotime #lovevirology @uu-cbdd.bsky.social www.biorxiv.org/content/10.1...

Now online! The structure of human sweetness

Simultaneous polyclonal antibody sequencing and epitope mapping by cryoEM and mass spec: how far can we go? Check out the final version of our paper in eLife: elifesciences.org/articles/101...

Our study exploring the evolutionary mechanism of alphavirus opal codon retention is now online! www.science.org/doi/10.1126/...

Latest findings on cryptic infection of giant viruses published in @ScienceMagazine. We discovered a large virus hiding within a green algal genome producing virions. www.science.org/doi/10.1126/...

Recombination between positive-sense and negative-sense RNA viruses: journals.plos.org/plospathogen...

Our study on the molecular basis of shifts in receptor recognition by western equine encephalitis virus (WEEV) in the past century, led by Xiaoyi Fan and @wanyuviridae.bsky.social , is online! 👏🎉 www.cell.com/cell/fulltex...

Pretty much everything is fucked, but here is some beautiful and exciting science from @archaeon-alex.bsky.social and colleagues. www.science.org/doi/10.1126/...

CBASS, CRISPR, and mCpol- oh my! What a satisfying collaboration with @aaronwhiteley.bsky.social 's lab- we uncovered a new cyclic dinucleotide signaling pathway, but it doesn't work how you'd expect! Check out the thread from @aesully98.bsky.social for an overview of the most important findings!

The maternal antibody paradox: how are these antibodies both good and bad? Excited to share our new insights for rotavirus vaccines www.biorxiv.org/content/10.1...

🚨 New study in @pnas.org ! 🚨 We identified MITD1, a brain-specific interferon-inducible factor that 𝗶𝗻𝗵𝗶𝗯𝗶𝘁𝘀 𝗳𝗹𝗮𝘃𝗶𝘃𝗶𝗿𝘂𝘀 𝗿𝗲𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻, including WNV, USUV, ZIKV & DENV. 🔗 Read the paper: www.pnas.org/doi/10.1073/... 👇 Thread with take-home messages below! #Virology #Flavivirus #Interferon

Ann Palmenberg was a trailblazer in virology and infectious disease research — but that was just for starters. A great scientist, mentor and friend, she lived every day to its fullest. news.wisc.edu/remembering-...

Happy to share our manuscript on the in situ visualization of the copia retrotransposon in its final form today published in @cellcellpress.bsky.social www.cell.com/cell/fulltex.... What’s new?

I am very happy to announce that we solved the in-virus #cryoEM structure of the #HIV matrix protein. The structure helped us to resolve a long mystery in HIV biology. A🧵1/5 Read more in Nature: www.nature.com/articles/s41... 🧪

Nature research paper: The conserved HIV-1 spacer peptide 2 triggers matrix lattice maturation https://go.nature.com/4kfnsXr

The world may be horrible at the moment, but I am thrilled to share a preprint on our work to develop novel diagnostics and tools to study #Oropouche virus, (probably) the most important virus that you’ve never heard of: doi.org/10.1101/2025... Bluetorial follows 🟦🧵

Excited to share the work of Jonathan Perr where he uncovered a surprisingly common feature of cell surfaces - the presentation and clustering of RNA binding proteins with #glycoRNA. Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...