Trying to get on 405N from 6th Ave always makes me miss bike commuting.

An underrated 21st century skill is knowing what level of digital friendship you should have with somebody. Getting that Instagram request and being able to say, "no, LinkedIn mutuals is right for us." Tough when you realize belatedly that you don't actually want to know what your gym trainer thinks

Like most drug discovery researchers, I’ve been watching the “peptides for everything” craze with a mixture of amusement and alarm:

All smartglasses should look like a cybertruck. We need to be able to identify them from afar!

The lab diamond industry wants you to believe if you choose a lab diamond your conscience is free and clear. That isn’t true, unless you want to do the legwork behind researching the cutting facility, their practices and conditions.

Look at the gorgeous pieces & go read the post about their creation. 🫶 “But we cannot afford to be limited by fear, we must gain sustenance from the present. Taking inspiration from our friends, our neighbors, our scientists, to make room for something different.” amyraehill.com/leaving-room...

Trying to get an ester hydrolysis to go to completion in the presence of an acrylic amide is an annoyingly fine line to walk.

If you want to know what it's like to work in the history of the Middle Ages and Antiquity, try to reconstruct what happened to some poor kid in a local after-school program based solely on this email.

walkable cities strongly encourage a feeling of imagined community that helps make you a good citizen. if you experience the city only in slices it's easier to see large swathes of it as fundamentally alien or hostile.

Extremely local post! If you're on the east side of #PDX and interested in farm fresh eggs delivered to your door every two weeks, DM me. Our farm has a couple slots open for egg delivery. They are, wihtout a doubt, the best eggs you can get anywhere, from the happiest chickens.

The Taste Buds Instagram account is like a perfect advertisement for urbanism. New York is an incredibly unique city obviously, but the value of great cities is that they let you encounter a wide array of different cultures and experiences without needing a car. It rules!

The possibility of an opioid pain-relief compound with fewer side effects and lower addiction potential. Let’s hope it pans out:

Can only describe this as D&D/theater kids deciding to play late-70s Black Sabbath. youtu.be/rQixE9aPd0w

I used to do an "album club" with my friends where we'd gather and do exactly this. It was like book club, but without the homework. Whomever proposed the album could give a little intro, then we talked about it after. If you want an idea to structure a regular gathering of people, try it sometime

The infinite growth model is one of the worst things to happen to journalism/media. At some point you reach the ceiling of people who want to read your magazine! You can just make enough money to pay people well and publish things and not grow forever!

Good for him but I am tired of learning about all the ways a 41-year-old candidate for U.S. Senate supposedly has a lot more growing and learning to do. Maybe do that before the Senate? And maybe try out a lower office before then? Or maybe we just watch him blossom into another Sinema/Fetterman.

After big dams on the upper Klamath River in far northern CA were removed in 2024, Chinook (king) salmon migrated upstream for the first time in 100+ years--and now they have hatched.

Yes, and then adults wonder why 20 somethings today are so damn depressed. Of course, it's the crap economy, but they've also been policed, helicoptered and/or both their entire lives. They're not free to breathe and find out who they truly are.

"I'm making those choices to appeal to men, and these dudes are too, but they got there from incel philosophy trickling into the culture. They removed women from their aesthetic calculus because they hate them."

THE POWER FANTASY is the first comic I've read in a long time that genuinely takes my breath away. It feels the way comics felt when I was eighteen and anything was possible, when they were written by wizards and drawn by magicians, when my favorite story could be past the next page. It's real good.

Criminals are not very bright, Episode 34892: - When deciding to mix something with the victim's water maybe don't choose a substance literally designed to separate things out from water - Also a poor idea to search for how precisely to cause injury to your coworker on a work device 0/10 enjoy jail

At its core, the political economy of scholarship was never supposed to rely on ~$50k from a smelting fortune. Institutions have hollowed out their support, the feds have done the same, and all that's left is inadequate private funding.

Not having to take quantum was in fact part of why I was a biochemistry instead of a chemistry major. www.smbc-comics.com/comic/easier

I hope to see you all tomorrow, folks! Let’s support this measure that encourages the city to act like this is an emergency - we need more housing, and we can’t wait another 2 years to implement IE4A!!

Adding to this good thread: train yourself to be happy for other people. Even if it means eating a little shit (I said a *little*.) This is something we train women for specifically & it's one of the reasons men suck. If you can do this it eases all the tasks GLHM lists here.

Publication – Nicola Di Cosmo, Lorenzo Pubblici, « Venice and the Mongols. The Eurasian Exchange That Transformed the Medieval World » rmblf.be/2026/04/14/p...

Years ago, a writer friend was passing through on tour. I didn't know him that well, but I liked what I knew of him - and when he suggested that I join him (and the other writer touring with them) to hang and sign stock, I said "Sure, let's do it." So the three of us spent a day doing that. (1)

people just don't like to be reminded that much of what makes up the internet is funny black teenagers, and that a lot of the language they use comes directly from them (it's giving, that part, clocked it, the tea, etc etc)

I think a lot of things about our conversations and broader culture would improve if we were slower to pass judgement on things. especially if and where what passes for developing an opinion about something is picking a side of an ongoing dispute - and thus implicitly accepting its terms

Some folks think that for rights to be valuable, they have to be exclusive, but what makes rights valuable is that they are *defended.* And the kind of country you can be most sure will defend your rights is the country which would defend anyone's rights.

Want to help us take a big hammer to that half century of downzoning? See you on Wednesday at 5PM outside City Hall!

“All that he has, Like smoke, Into the sky will evaporate.” - Sumerian proverb One side of the tablet has the neat teacher’s handwriting, while the other seems to show the less perfect, but still lovely, student’s copy. It was made in a Babylonian school around 1900-1600 BCE

The car that hit me was from 2010 and was around 3,000 lbs. The average weight of new cars in the US in 2024 was around 4,400 lbs. Car bloat is making our streets deadlier - feels wild that I’m saying this but I’m lucky the person who hit me had an older car.

Happy 8th anniversary to the tweet that changed us forever. Look at this absolute unit.

#Cat friends in Portland/Vancouver area (or beyond, if interested) my friend Lynn is moving overseas and can't take this lovely 9-yr-old calico with her. If you, or someone you know, can take her in, she needs a new home in the next 10 days!! 😬 bsky.app/profile/lynn...

i will vote for any candidate who offers up this slogan

ok now we just have to find a guy named Joe American to run for president and we’re back in business

i know this is my very specific industry hobbyhorse, but this is true, it's been true for longer than people realize, and many of the systemic solutions for it are pretty hard to implement, both technically and politically

Donating to online scammers posing as legitimate people in need is not morally neutral: You potentially are giving money to brutal slavery and human trafficking networks: www.ohchr.org/en/stories/2...

if we want to continue with home ownership being the dominant form of housing for the median american, we need to do more to make that achievable, and if we want to decouple ownership from overall economic health, we need to make renting more attractive, but we're not doing enough of either

you can safely write off every single politician who talks about retraining as a solution to industry disruption, this will not happen, this has never really happened, it's fiction. maybe there are ways this *could* work, but in my more than two decades of working *in training*, no one's ever tried

“Weiss said the Federal Analogue Act was “effectively dead,” citing U.S. Supreme Court Justice Neil Gorsuch’s past critiques of the law as too vague. And Weiss noted federal drug enforcement agents are preoccupied with combating more deadly drugs like fentanyl — not psychedelics.”

And what he's doing is IMPORTANT work. He's keeping the legacy of some long-gone masters alive. Smithsonian Magazine recently did a story on him and his mission, and you can read it here: And if you happen to be in Tucson, definitely drop in to see them in person. Amazing stuff. 11/end

We really need to talk about the role of Fire Marshalls in holding cities back from safe streets and better housing. Believe me, my grandpa was a fireman - I am obsessed with fire safety. But a lot of this seems like aversion to change more than anything!

In fact, cases of paralytic polio were small. But that number adds up. For example, in 1952, the US experienced its worst polio epidemic in history, with @ 60k reported cases. Of those cases, over 3,000 people died and around 21k people experienced varying degrees of paralysis.

The affect of a well-intoned "dude, what the fuck did you say?" Is truly remarkable. People all the time say "I want to be an ally, how can I help?" And most of the time the answer is just to call out gross behavior.

I'll be at @powells.bsky.social in Portland on May 18th to talk about my new book Lost Worlds: How Humans Tried, Failed, Succeeded, and Built Our World with the fantastic @rkambury.bsky.social! This is an absolute dream come true. www.powells.com/events/patri...

i spend a certain amount of my professional life trying to help ppl come forward and break necessary stories about white nationalist groups & political violence and i tell you what. a lot of things are “open secrets” because speaking out is terrifying and there might not be a clear upside.