Franziska Faber and I are recruiting shared postdocs, PhD students to work on Fusobacterium & new BGCs. www.helmholtz-hiri.de/fileadmin/HI...

The epitranscriptome formed by the growing number of modifications occurring within mRNA transcripts. We have been mapping mRNA modifications for over a decade. => Characterizing their functions -- especially on translation -- is a research frontier.

When people celebrate the individual genius of folks in science, they should also mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)

Regulation by RNAs might be even more extensive than we thought. Many enzymes and other proteins not previously considered as RNA-binding proteins do seem to fall into this class & might have their activity regulated by RNA. www.cell.com/cell/fulltex...

🎉 We’re excited to share our very first preprint!! 🎉 "Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells" 👉 doi.org/10.1101/2025... #FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience

My PhD student @leonielorenz.bsky.social (with Eva Geissen) has made this nice (free) online course to introduce mathematical modelling for biology: www.ebi.ac.uk/training/onl... Including both molecular and epidemiological examples

My colleagues Baptise Rafanel et al. investigated how a newly invading transposon can be silenced. They found that not only antisense insertions in piRNA clusters such as flamenco, but also insertions in the 3‘UTR of genes can drive potent silencing.

EMBL Cell Biology and Biophysics department is searching for a new director. A major position to lead this field in Europe and beyond. embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @cp-cell.bsky.social, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. www.sciencedirect.com/science/arti...

Not sure who came up with "Manhattan Plot", but in 2014 I coined the alternative term "Nijmegen Plot" (inspired by the Dutch town where I live) to describe underwhelming results from our earliest genome-wide association scans of language/reading traits.

How do chromatin remodelers use #IDRs to find TF binding partners? In our new Molecular Cell paper, we show that β-catenin is an adaptor that links SWI/SNF (cBAF) subunit ARID1A with binding partners via IDR-domain interactions. www.cell.com/molecular-ce...

Finally out! I’m thrilled to share our new paper (Wolin et al., Cell 2025). This paper describes SPIDR, a high-throughput method for mapping RBP binding sites. By combining #SPIDR with #cryoEM, we identified the exact binding site of LARP1 within the #mRNA channel of the 40S ribosomal subunit.

Recently I learnt that EMBL-EBI has a free online course about AlphaFold — how it works, strengths and limitations, how to use it — and it's very good! There are also little quizzes and interactives. www.ebi.ac.uk/training/onl...

Opportunity alert!

Hello! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @cp-cellreports.bsky.social, @mardakheh.bsky.social and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit! tinyurl.com/ydn6e3ac

Structure of the microtubule anchoring factor NEDD1 bound to the γ-tubulin ring complex. new study from Hugo Muñoz-Hernández, Yixin Xu, Michal Wieczorek @mike-wieczorek.bsky.socia @ethz.ch and colleagues: rupress.org/jcb/article/... #Cytoskeleton #StructuralBiology #CryoEM

Out now in @natchem.nature.com! Lots to unpack here, but in short - we show that SMM enabled fragment based design is useful on RNAs to improve chemical properties like affinity and brightness of fluorophore ligands. www.nature.com/articles/s41...

Have a look at this short Journal Club I had the great pleasure to write for @natrevmcb.nature.com about a 2012 landmark study by Castello et al. Read only link: rdcu.be/elEYW

An amazing new enabling technology. Measurements of molecular size and shape on a chip. Couldn't be prouder of our friend Madhavi Krishnan of @ox.ac.uk this was and is one among the must fun collaborations I ever had. www.science.org/doi/10.1126/...

Barbara McClintock proposed – over 40 years ago – that transposable element activity could be a response to stress, and I think that we are still only beginning to understand how right she was.

#EMBOClimateResilience “The way in which our universities have divided up the sciences does not reflect the ways in which nature has divided up its problems” @embo.org @monicabettencourt.bsky.social

We are organizing a conference for young researchers at the intersection between physics & biology: www.embl.org/about/info/c... @embl.org @events.embl.org @intcha.bsky.social Please consider applying/registering -- the deadline is already in one week!

Today all 27 EU countries endorsed the Warsaw Declaration. Thank you for your solid support in calling for the independence of the European Research Council to be preserved and for the role of the ERC to be expanded. polish-presidency.consilium.europa.eu/media/r5fa13... 🇪🇺

Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n

Our study on the #riboregulation of key mitotic factors is now published in Nature Communications www.nature.com/articles/s41... Additional findings include: - RNA stimulates AURKA kinase activity - RNA stabilises AURKA conformation #RNA #RNAsky #mitosis #spindle

🧪 Open position: Scientific Grant Writer

#Communiqué 🗞️ Le CNRS exprime sa solidarité avec les scientifiques exerçant aux États-Unis, où la liberté académique est aujourd'hui mise à l’épreuve. 👉 www.cnrs.fr/fr/presse/le...

Interested in RNA biology, especially mRNA processing and export from nucleus to cytoplasm? We are looking for an enthusiastic PhD student to investigate the RNA-binding proteins Sub2 and Tho1 🧪🧫🔬 More details and instructions on how to apply: www.uni-giessen.de/de/ueber-uns...

Do you LOVE organelles?? Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social! Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy 🧵1/N

Thank you very much, Bowel Cancer UK, for funding our work! This is a joint project with Ralf Zwacka, Andrea Mohr and Greg Brooke, devoted to nucleosomics of cfDNA in colorectal cancer. Please forward this to relevant candidates for a postdoc on this project! generegulation.org/job-opening/

Within the @hlsalliance.bsky.social Interinstitutional Postdoctoral Call #PostDocCalls in Heidelberg, Ulrike Engel and myself are looking for a posdoc interested in the RNA dependence of microtubule regulators. See project #55 of the call (option A) www.health-life-sciences.de/opportunitie...

This week we had International Day of Women and Girls in Science 👩‍🔬 🥼 🔬 There are many women working to provided the resources at PDBe, AlphaFoldDB, EMDB and EMPIAR. Lets met a few of them! #IDWGS #WomeninSTEM #WomenInScience #WhatAScientistLooksLike

Check out one of our latest "Pictures of the Month" in #CYTOSKELETON #microscopymonday onlinelibrary.wiley.com/doi/full/10....

The German Research Council (DFG) has just announced drastic funding cuts—a deeply concerning development in times of growing hostility toward science and global crises. The DFG is not to blame; rather, it is the result of Germany’s self-destructive austerity policies. www.dfg.de/de/aktuelles...

🔬 Happy International Day of Women and Girls in Science! 🔬 The GBM celebrates the brilliant women shaping biochemistry & molecular biology. #WomenInScience #IDWGIS #STEM #GBM gbm-online.de/de/die-gbm.h...

Here is an exciting opportunity from the IMSEAM - Selhuber-Unkel Group for a Masters Program at Universität Heidelberg. Next info sessions are February 11 and 19. More information on the website: lnkd.in/esbENqeJ Hashtag#IMSEAM Hashtag#UniHeidelbergIMSEAM Hashtag#UniHeidelberg Hashtag#MasterMSSE

📢 Es ist 5 vor 12❗ "Aufstehen für Demokratie" setzt sich für faktenbasierte politische Entscheidungen und Demokratie ein: www.aufstehenfuerdemokratie.de www.openpetition.de/!ychtb 📅 Sei dabei am 12.02 um 11:55 Uhr an Hochschulen und Forschungseinrichtungen 🔬 Wissenschaft braucht Demokratie 🤝

Check it out! Another novel RNA modification - ADP-ribosylation - that was previously only known on proteins. A cousin to #glycoRNA 👏 www.nature.com/articles/s41...

Our paper is out! We delevoped a method to follow individual translating ribosomes for hours in living cells, and discovered that ribosomes are great friends and help each other in problematic situations: www.cell.com/cell/fulltex...

New paper alert! ‼️‼️ Super happy to share that my postdoc paper is finally out! 1/3 We looked at scaling of chromosome separation during anaphase in zebrafish embryos.

Looking for activities that are both fun and educational for K-12 students? BioNook curates free, online ways for kids (and parents) to learn about science and the world of biology research. wi.mit.edu/bionook

‘Stamp out paper mills’ — science sleuths on how to fight fake research By Anna Abalkina, René Aquarius, Elisabeth Bik, David Bimler, Dorothy Bishop, Jennifer Byrne, Guillaume Cabanac, Adam Day, Cyril Labbé & Nick Wise @nature.com www.nature.com/articles/d41...

Small RNAs - history. Now its small proteins, dark matter all around us! www.nature.com/articles/d41...

so cool!

Are you interested in exploring RNA with cutting-edge techniques in a dynamic, collaborative and international environment? Just click below to learn more or send me a message. We will be happy to connect and discuss this further! Dear Colleagues in the RNA field, please RT and spread the word :)

We are very happy to see that so many scientists moved to Bluesky! Let us help to connect the DKFZ community here 💙 go.bsky.app/V64sJYM

Is there anyone doing experiments on Sunday? Then this Positive Potato is for you too! All the best everyone.

A colleague and myself had the chance yesterday to test a STELLARIS STED, a great opportunity to have a look at a beautiful dividing cell 😍 #mitosis #celldivision #STED

Announcing the next EMBO Chromosome Segregation and Aneuploidy Meeting! Italy 2025. Please register and join us for another exciting and friendly meeting in a beautiful location meetings.embo.org/event/25-ane...