H. Courtney Hodges
@hodgeshc.bsky.social
📤 350
📥 220
📝 12
Baylor College of Medicine
pinned post!
How do chromatin remodelers use
#IDRs
to find TF binding partners? In our new Molecular Cell paper, we show that β-catenin is an adaptor that links SWI/SNF (cBAF) subunit ARID1A with binding partners via IDR-domain interactions.
www.cell.com/molecular-ce...
4 months ago
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reposted by
H. Courtney Hodges
From the Labs at Baylor College of Medicine
4 months ago
Drs. HC Hodges
@hodgeshc.bsky.social
,
#chanyuensan
, K Cermakova
@cermakova.bsky.social
et al discovered a molecular bridge that facilitates interactions among disordered proteins involved in regulating
#geneExpression
.
#BetaCatenin
@bcmhouston.bsky.social
#MolecularCell
blogs.bcm.edu/2025/07/24/f...
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A molecular bridge helps disordered proteins work properly
The findings reveal that despite their disordered nature, the protein interactions that drive gene expression are surprisingly modular and even have an underlying organization.
https://blogs.bcm.edu/2025/07/24/from-the-labs-a-molecular-bridge-helps-disordered-proteins-work-properly/
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How do chromatin remodelers use
#IDRs
to find TF binding partners? In our new Molecular Cell paper, we show that β-catenin is an adaptor that links SWI/SNF (cBAF) subunit ARID1A with binding partners via IDR-domain interactions.
www.cell.com/molecular-ce...
4 months ago
11
89
38
What do SWI/SNF-addicted cancers have in common? And when are they most sensitive to SWI/SNF inhibition? Check out Katka’s thread highlighting our most recent paper
add a skeleton here at some point
almost 2 years ago
0
11
5
reposted by
H. Courtney Hodges
Alex Holehouse
about 2 years ago
A labor of love - our review on why IDRs matter for cellular function is live in Nat. Rev. Mol. Cell. Biol:
www.nature.com/articles/s41...
Working with Birthe Kraglund on this was such a pleasure, and we hope this review will be helpful to a broad audience!
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