Amazing work from the team at Oxford to pull apart how chromatin structure is organised at enhancers.

This is a super resource - looking forward to having a good poke around

Awesome work looking inside #RNA structural ensembles during folding- congrats!

I’m a fair-weather poster on here to say the least. However, I'm pleased to present our latest paper. A great effort from all authors and an interesting insight into transcriptional regulation (we think!). www.cell.com/molecular-ce...

This is super cool!

What is a promoter? And how does it work? We very happy to share our latest work trying to understand enhancer-promoter compatibility. I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters www.biorxiv.org/content/10.1...

Great review of the super #NeuroBioUK2025 meeting in September. Well done to everyone who organised it @exdrososcientia.bsky.social @alexfellows1.bsky.social and @dozenoaks.bsky.social for putting together such a great meeting for the community! 👏🧠🔬 tinyurl.com/4jn7yrmt roll on next year!

Collective challenges need collective solutions. Happy to share the insights we've gained from the way our cells handle this: www.nature.com/articles/s41... and its summary www.crick.ac.uk/news/2025-09....

We have space for two postdoctoral fellows in the Taipale Lab at the @sangerinstitute.bsky.social. This is a core-funded open position! Come with your ideas and interests and we can develop a project together. sanger.wd103.myworkdayjobs.com/en-US/Wellco...

Our study on the role of LTR5HS and SVAs in regulation of human neural crest migration is now published as peer-reviewed paper on @molsystbiol.org! Congrats to first author brilliant postdoc Laura Deelen, and all the authors involved! @imperialsci.bsky.social www.embopress.org/doi/full/10....

Come and hear about our latest story! It's a really nice series as well- sign up for the mailing list for updates #condensates #UKcondensates

This looks super useful!

Such a cool story- great to see it finally out in the wild #enhancers #geneRegulation

✨Exciting news: the main story of my PhD is out in Science! Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation. 📖 Read the full story here: www.science.org/doi/10.1126/...

New review on computational design of intrinsically disordered proteins 🖥️🍝 by @giuliotesei.bsky.social @fpesce.bsky.social & 👴 doi.org/10.48550/arX...

We (and many!) have been thinking a lot about how to quantifiably measure the material properties of biomolecular condensates inside cells. Chris (my final year PhD student) wrote this great review article about microscopy-based techniques link.springer.com/article/10.1... @phar.cam.ac.uk

Looking forward to catching up with everyone at the @biochemsoc.bsky.social #transcription and #chromatin UK #TCUK meeting today in sunny Manchester! #BiochemEvent 🧬🔬☔️ www.eventsforce.net/biochemsoc/f...

New online! Is enhancer-driven gene regulation all wrapped up?

Nice use of #smFRET to study #idr #dynamics

👀 Multiple human enhancer RNAs contain long translated open reading frames genesdev.cshlp.org/content/earl...

Really excited to get our seminars back up and running. @gracebower.bsky.social is going 1st and if you haven't read her range extender story, you're in for a treat! + @creminslab.bsky.social has the 2nd talk and will tell us about the amazing work happening in her lab!

www.nature.com/articles/s41...?

Great news, no more grant deadlines 😀 MRC applicant-led funding – UKRI share.google/lP742F01GmuK...

The emerging roles of long non-coding RNAs in the nervous system www.nature.com/articles/s41...

Cracking lineup of @fnucleosome.bsky.social seminars over the next few months!

Last day to register for the awesome #NeuroBioUK25! Everything #molecular #neurobiology to kick off you autumn!

Just dropped: Super exciting lineup this year for NeuroBio UK! There's still time to register if you haven't done so yet!

Ooh, look. When we covered the climate impacts of machine learning (“AI”) on Rare Earth in June we found it really frustrating that none of the tech companies would tell anyone the water and energy costs. Now Google has made at least some of it public. More of this! (and preferably raw data too).

Are you a @biophysicalsoc.bsky.social member? Vote in the 2025 election by 01/08! @timcraggs.bsky.social is nominated as Industry Rep. We encourage everyone to vote for this important cause, regardless of who you're voting for 🙂 www.biophysics.org/elections/bp... #biophysics #lifescience

Had a super day at the inaugural Nucleic Acids Institute 🧬🧬🧬summer symposium at The University of Sheffield. Loads of fantastic talks and posters and discussion from across all of our faculties and research themes, and two inspiring keynotes Congratulations also to all our prize winners!🥇🎖️🥈

Super new work from Chris and the team, including some cool #smFRET showing changes to n #RNAstructure- have a read!

New preprint alert! 🚨👇 I'm delighted to share the latest research from @jemmabetts.bsky.social in our group: ‘A new protein-dependent riboswitch activates ribosomal frameshifting’. Huge congratulations to Jemma for the first manuscript of her PhD! ✨ www.biorxiv.org/content/10.1...

Do viruses control protein translation using riboswitches? Via protein-mediated regulation of -1 programmed ribosomal frameshifting? We think the do. Very happy to have played a (small) part in this epic paper by @jemmabetts.bsky.social, @chillzaa.bsky.social and colleagues. See 👇for bluetorial.

New preprint. ATF4 activation is thought to lead to longer lifespans. However, our study shows that suppression rather than activation extends lifespan in the fly. New Qs: how we can target ATF4 or its downstream targets to gain targeted longevity benefits. www.biorxiv.org/content/10.1...

This is incredible, and going to be amazingly useful for so many things. I'm already thinking of experiments 🤔 www.science.org/doi/10.1126/... #IDRs #IDPs #ensembles

The Baker lab @uwproteindesign.bsky.social did it again 😱 Protein design of IDPs binders www.ipd.uw.edu/2025/07/hitt...

Two fantastic talks from the #nucleicAcids world at today's @biochemsoc.bsky.social SM@SH seminar! Great to welcome Askash Basu from Durham to hear about bendability in #DNA sequences and beautiful cryoEM from Anamika Kumari Lahiri Lab in the ECR talk slot! 🧬🧬🧬👏@sheffielduni.bsky.social

Interested in developmental epigenetics? So are we! Apply now to join us for your postdoc! Multiple positions across multiple groups @mrc-lms.bsky.social Projects spanning germline demethylation, gene regulation, genome architecture in development & disease 👇👇 lms.mrc.ac.uk/work/vacanci...

This is a proper tour de force of integrative structural biology and biochem! (Including from our own @eecutts.bsky.social @mcb-sheffield.bsky.social) so many crucial roles for SLiMs in fundamental cellular processes.

Thinking about who's hanging out with you RNA in cells? Here's a super overview of the (many!) things you can do to find out. Many thanks @mardakheh.bsky.social @shechnerlab.bsky.social #RNA #RNAinteractome

Question: Does tea taste better out of a custom built @ei-science.bsky.social mug? I'm pretty sure I can taste the #singlemolecules..

Forget what you think you know about single-molecule fluorescence spectrometry instruments! Introducing the EI-FLEX... Find out more and request a tech spec > bit.ly/45AqRLv #singlemolecules #biophysics #smfret #fcs #innovation

Excited to share our new paper in @cp-molcell.bsky.social Molecular Cell: "Catalytic-dependent and independent functions of the histone acetyltransferase CBP promote pioneer-factor-mediated zygotic genome activation" — the big part of my PhD! www.cell.com/molecular-ce...

Curious about epigenetics, gene regulation, and developmental biology? Apply for the PhD position in Mannervik lab at Stockholm University! We use single-cell genomics and genetic approaches to uncover how cells acquire their identities during development. Explore the chromatin landscape with us!

Postdoc positions open in my lab (Francis Crick Institute) to study 1. initiation of DNA replication. 2. chromatin replication/epigenetic inheritance. Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists. Deadline 3 August 2025. crick.wd3.myworkdayjobs.com/External/job...

Ooh, this looks like fun! (And really useful) #acetylation

Congratulations on your fabulous @thelisterinstitute.bsky.social prize @chillzaa.bsky.social !! Super well deserved! Hopefully we'll catchup soon to say well done in person 🥳🍾

Textbooks: “Enhancers are just a bunch of TFBSs” But how do they REALLY work? New paper with many contributors here @berkeleylab.lbl.gov, @anshulkundaje.bsky.social, @anusri.bsky.social A 🧵 (1/n) Free access link: rdcu.be/erD22

Very smart way to distinguish between eu/heterochromatin for single nucleosome tracking. "Replication-dependent histone labeling dissects the physical properties of euchromatin/heterochromatin in living human cells" From @kazu-maeshima.bsky.social lab www.science.org/doi/10.1126/...

In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput approach to measure nuclear condensate formation, and applied it to ~14,000 IDPs to find out! rdcu.be/eq975