Meeting Alert! Santa Cruz Developmental Biology Meeting! 👇 @socdevbio.bsky.social @insdb.bsky.social @bscb-official.bsky.social @isdb.bsky.social @bsdb.bsky.social @ascbiology.bsky.social

A new paper out in @natmethods.nature.com introduces NimbusImage, a cloud-computing platform for image analysis ft. William Niu (SAS), Jingxin Li (@cambupenn.bsky.social), @aofarrell.bsky.social (Bioengineering) & @arjunraj.bsky.social (@penngenetics.bsky.social) www.nature.com/articles/s41...

🚨Preprint 2/2: Several studies implicate condensates in RTK fusion onco-signaling. So we were surprised to find that condensates are entirely dispensable😮(!). A study from proteins to mice, by dynamic duo @davidgonzmar.bsky.social and @trmumford.bsky.social. www.biorxiv.org/content/10.6... 👇

🚨New preprint(1/2)! We show that RTK fusion oncoproteins broadly suppress EGFR signaling. How? Sequestration of adapters as the shared principle. Led by superb PhD student Carol Gao. www.biorxiv.org/content/10.1... Implications for drug tolerance/resistance, and includes one big surprise🫧.👇

🚨Publication update🚨 DEC1 regulates human β cell functional maturation and circadian rhythm: Cell Reports www.cell.com/cell-reports...

*New preprint alert* uncovering a mechanical pacemaker that synchronizes nephron formation with branching of the kidney's epithelial tubule tree. Read below to learn about this twisty journey lead by Sam Grindel and Sachin Davis in the lab. [Movie by Nils Lindstrom] www.biorxiv.org/content/10.1...

Very excited to see our paper, led by @amilangscience.bsky.social, out today in @pnas.org! This one was a true adventure, filled with surprises at every turn. “Erythroid precursors regulate local oxygen tension and repair outcomes in the bone marrow niche.” www.pnas.org/eprint/NJ8XC...

Stop by to see our posters at #CellBio2025, including plenty of unpublished new directions!

if you are attending #CellBio2025 please check out the posters from our lab @hugheslabpenn.bsky.social. The lab will have a great showing this year featuring my talented colleagues @lsprahl.bsky.social @danielalber.bsky.social and many others!

Our story on mechanosensation in baroreceptor cells of the kidney is finally out! Well worth the wait on this project we began in 2020 that turned into a massive collaborative effort within the kidney field. 🫘 www.sciencedirect.com:5037/science/arti...

SAVE THE DATE! Stoked to organize the 2026 Santa Cruz Developmental Biology Meeting with @rashmi-priya.bsky.social, @lowelab.bsky.social, and Shelbi Russell. Come learn about Biomedicine, Biomechanics, and the Biosphere, August 24-28, 2026. Registration dates, etc., coming soon! Please RT

So: can a cell hold hands with itself…and do we care? YES and YES! Read on to learn WHY, HOW, and what this has to do with…PARIS (and tree-hugging)? Swansong of Dr. Anamika; Hannah Kim on drums; and fantastic undergrads (Margaret/Lauren) ! 1/n advanced.onlinelibrary.wiley.com/doi/10.1002/...

Fantastic mechanics in fertility / development story from @katecavanaugh.bsky.social. Hiring committees take note 👀

Now #published @pnas.org: "A model for boundary-driven tissue morphogenesis", a great #biophysics #devbio collaboration led by @danielalber.bsky.social @zhaoshh.bsky.social: doi.org/10.1073/pnas.2505160122 @mpipks.bsky.social @mpi-cbg.de @csbdresden.bsky.social @flatironinstitute.org

Cool paper by new Hughes lab postdoc @danielalber.bsky.social

Apply to join our Penn Bioengineering department, featuring friendly, supportive faculty and staff, rigorous science, and top students! apply.interfolio.com/173716

Great opportunity to work with a very creative PI

Aria Huang's @azyhuang.bsky.social paper is out on beautiful embryonic kidney 3D cultures that branch properly and enable live defect analysis. She also finds intriguing effects of adhesion and stiffness on explant size, shape, and nephron formation - boundary conditions matter! rdcu.be/eBSUK

Pathologists have used nuclear & tissue shapes to diagnose #cancer for decades, but what is the molecular basis for this? In our latest work, we develop a computational pipeline to figure this out in #colorectalcancer! Check out 🧵& preprint #mechanobiology #stemcells www.biorxiv.org/content/10.1...

Do you like neuronal #plasticity? #genetics? #Celegans? Check out 1st installment of work by Kristi Zoga in the lab. Kristi screened 20 conserved #autism genes for roles in experience-dependent #neuron remodeling and a related behavior. doi.org/10.1093/genetics/iyaf156

pYtags - our in vivo biosensors for receptor tyrosine kinases - in all their beauty on the cover of Cell Reports! Read more here: www.cell.com/cell-reports...

Super cool project #2

Super cool project @vayyappan.bsky.social

Birth defects kill twice as many children as cancer. Animal model are crucial; no stem-cell or computer models can yet recapitulate the embryo's complexity. If you support birth defects research tell NIH that animal models are important! Click & scroll below to comment. tinyurl.com/mr3he6bx

New preprint out! We show how cellular nematic order can be harnessed to program tissue-wide force fields and guide 3D shape transformations. The tissue morphogenesis logic, now engineered into living, programmable materials. www.biorxiv.org/content/10.1... #ActiveMatter #TissueEngineering

Start of 2025 @mblscience.bsky.social Physiology course! This is the second year of Amy @gladfelterlab.bsky.social and I co-Directing this absolutely amazing and life-changing course: www.mbl.edu/education/ad...

Our own @azyhuang.bsky.social is a student this year representing the kidney fanatics

fantastic series of work by @bugajlab.bsky.social and @dennishuang.bsky.social

I'm a big fan of this paper on the shape of rose petals. www.science.org/doi/10.1126/...

Whoa, fantastic stuff! This may be just the beginning of the somites <--> kidneys connection

I remember that @sshekhr.bsky.social was thinking about this way back at MBL @mblscience.bsky.social Woods Hole Physiology course 2014. Congrats & way cool Shashank!

Early-career researchers can apply for a funded place at our Workshop 'New Technologies for Studying and Reprogramming Development' organised by Alex Dunn, @zevgartner.bsky.social , @adrianjacobo.bsky.social and Matthew Kutys. 📆Apply by 23 May biologists.com/workshops/no... #BiologistsWorkshops

How can an individual protein show adaptation? The light- and temp-sensitive BcLOV4 gives a pulse of translocation during a step input of light. Answer in our preprint: *intra-molecular* feed-forward regulation. bit.ly/3Rg9veD A @bugajlab.bsky.social collab with @nmrkaygee.bsky.social 🧵

Thrilled to be featured in The New York Times! @nytimes.com Fantastic piece by @jack-tamisiea.bsky.social on our discovery of the role of physical forces in evolution! With insightful comments from @wcratcliff.bsky.social!

1. Struggling to integrate single-cell datasets? Finding it hard to resolve clear differentiation trajectories? Reveal the underlying structure in your data with CONCORD.

Super excited to be launching NimbusImage.com! Cloud-based image analysis to democratize machine learning! Documentation here! docs.nimbusimage.com

Our paper on 96-well control of temperature is now out @cp-cellsystems.bsky.social. Exceedingly proud of this work led by Will Benman, plus Pavan Iyengar, @trmumford.bsky.social, and much of our lab. Come for DIY hardware, stay for the stress granule dynamics and memory🧵 📝 tinyurl.com/thermoPlate

How do embryos ensure precise tissue patterning? It’s all about timing cell divisions! Our new preprint reveals how cell proliferation syncs with signaling oscillations to regulate precision of somite formation and growth. Check the full story: www.biorxiv.org/content/10.1...

Very cool preprint by my colleague Kate McDole and her postdoc Katie Goodwin @cellbiol-mrclmb.bsky.social using beautiful imaging and quantitative methods to understand the wondrous migrations of primordial germ cells in mouse embryos doi.org/10.1101/2025...

Congrats to @llobrienlab.bsky.social on winning an Innovative Science Accelerator Award from @isackuh.bsky.social! She pioneered whole tissue 3D imaging of #kidney nerves. Now she will map changes in these nerves from acute injury to chronic disease for the first time! med.unc.edu/cellbiophysi...

thanks for the highlight @stemcellpodcast.com!

Thank you for the highlight Rita! We also think these types of tools will open many new avenues, both fundamental and applied. And kudos for the very thoughtful and fair process @naturemethods.bsky.social

Congrats @parahsaramore.bsky.social !

Happy holidays from the Hughes lab ✨ #fluorescencefriday

Aria Huang's @azyhuang.bsky.social pre-print just came out on effects of adhesion and stiffness on global kidney explant size, shape and nephron forming efficiency. Along the way, she achieves beautiful 3D cultures that retain proper branching geometry, check it out! biorxiv.org/cgi/content/...

Those at @ascbiology.bsky.social #CellBio2024 conference tomorrow, check out @azyhuang.bsky.social Aria Huang's work on 'truly' 3D, live explant cultures of mouse embryonic kidneys for studying cell dynamics and congenital disease!

Those at @ascbiology.bsky.social #CellBio2024 conference tomorrow, check out @lsprahl.bsky.social Louis Prahl's work on optogenetic control of the RET RTK toward engineered branching morphogenesis!

These dancing cells and I are in San Diego for #CellBio2024 this week! Come check out my talk during the "Building Biological Tubes" subgroup on Sunday, December 15 at 9am to hear me present some progress towards controlling epithelial organization in kidney tissues and organoids.

Super excited to announce my new lab at the University of Michigan opening Jan 2025! 🎉We’ll study how cells work together to shape the GI tract, with ties to regeneration & disease. Hiring at all levels—esp. a research tech to help launch the lab! Info: huyckelab.org #DevBio #CellBio #Hiring