Vinay Ayyappan
@vayyappan.bsky.social
📤 22
📥 39
📝 10
Penn MD/PhD student. Runner when bones work
pinned post!
[0/8] Stoked to share our work with
@arjunraj.bsky.social
on tissue organization in the gastruloid. We use lineage tracing and spatial transcriptomics to show that diversity among stem cell clones promotes, rather than hinders, gastruloid development:
www.biorxiv.org/content/10.1...
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Gastruloid patterning reflects division of labor among biased stem cell clones
Embryonic development typically requires precise coordination among cells to achieve reproducible outcomes, leading to the assumption that cellular heterogeneity must be minimized or buffered against....
https://www.biorxiv.org/content/10.1101/2025.07.12.664536v1
2 months ago
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reposted by
Vinay Ayyappan
Alex Hughes Lab
about 1 month ago
Aria Huang's
@azyhuang.bsky.social
paper is out on beautiful embryonic kidney 3D cultures that branch properly and enable live defect analysis. She also finds intriguing effects of adhesion and stiffness on explant size, shape, and nephron formation - boundary conditions matter!
rdcu.be/eBSUK
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[0/8] Stoked to share our work with
@arjunraj.bsky.social
on tissue organization in the gastruloid. We use lineage tracing and spatial transcriptomics to show that diversity among stem cell clones promotes, rather than hinders, gastruloid development:
www.biorxiv.org/content/10.1...
loading . . .
Gastruloid patterning reflects division of labor among biased stem cell clones
Embryonic development typically requires precise coordination among cells to achieve reproducible outcomes, leading to the assumption that cellular heterogeneity must be minimized or buffered against....
https://www.biorxiv.org/content/10.1101/2025.07.12.664536v1
2 months ago
1
26
12
reposted by
Vinay Ayyappan
Jesse Veenvliet
2 months ago
Excellent work indeed, but I feel in this context
@adrianobolondi.bsky.social
fantastic work should also be mentioned
www.cell.com/developmenta...
add a skeleton here at some point
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reposted by
Vinay Ayyappan
Alfonso Martinez Arias
2 months ago
Two new preprints from the
@arjunraj.bsky.social
on
#gastruloids
. Both excellent. Exploring the relationship between macroscopic reproducibility v microscopic heterogeneity. Stunning experiments and much to think about
biorxiv.org/content/earl...
biorxiv.org/content/earl...
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