Thalamic NRXN1-Mediated Input to Human Cortical Progenitors Drives Upper Layer Neurogenesis https://www.biorxiv.org/content/10.1101/2025.04.25.650717v1

I begrudgingly admit that actin is pretty cool 🤩 🎥 Primary mouse myotubes labeled with Lifeact-mScarlet-I3 (cyan) and H2B-mStayGreen (red). #FluorescenceFriday

Congratulations to winners of The Brain Prize 2025! Professors @michellemonje.bsky.social, @stanfordmedicine.bsky.social and @hhmi.org Investigator, and Frank Winkler, Heidelberg University Hospital, have pioneered the field of Cancer Neuroscience. Learn more: brainprize.org/winners/canc...

Happy to share our new study on the functional reprogramming of neutrophils in the brain tumor microenvironment by hypoxia-driven lactylation @theaacr.bsky.social @wistar.org @moffittnews.bsky.social

Online now: Online now: The kinase RIPK3 promotes neuronal survival by suppressing excitatory neurotransmission during central nervous system viral infection

Automatic cell analysis using #AI Researchers retrained existing AI-based software on over 17,000 microscopy images with over 2 million structures to develop this new model - Segment Anything for Microscopy: www.uni-goettingen.de/en/3240.html... #NatureMethods research: doi.org/10.1038/s415...

White matter (WM) #astrocytes differ significantly from grey matter (GM) astrocytes, with WM astrocytes in the forebrain exhibiting unique proliferation capacity 🧪🧠 www.nature.com/articles/s41...

Excited to share our review on astrocyte aging, out today! Hopefully the only Friday surprises this week are Liddelow lab publications! 🧪 #neuroskyence @liddelowsa.bsky.social

Just in case you thought that removing DEI criteria would mean that everyone is competing equally: NIH is removing grad students from underrepresented backgrounds from the applicant pool altogether. Their applications will not be considered. Other students, not from these backgrounds, will be.

Really interesting paper 🧪 🤩 Immune evasion through mitochondrial transfer 😮 Ikeda et al find that #mitochondria from cancer cells can #transfer over to T cells - altering their #metabolism & reducing antitumour immunity www.nature.com/articles/s41... www.nature.com/articles/d41... @nature.com

Are you using 5xFAD mice to study Alzheimer’s disease? Our work out today @cp-neuron.bsky.social may be relevant to you 🐁🧠 Age and sex are known to influence Aβ plaque burden in these mice. Here, we found that the transgene parentage is another strong determinant. Thread below: (1/11)

Out now in @cp-neuron.bsky.social: We found that the parental source of the transgene influences amyloid plaque load in 5xFAD mice, highlighting the need to clearly report breeding schemes to support the consistency and reproducibility of AD research using this model. www.cell.com/neuron/fullt...

new out in Nature: lovely paper www.nature.com/articles/s41...

For #FluorescenceFriday, tau (blue) and long loops of neurofilament proteins are shown in a primary hippocampal neuron 🔬 #Neuroscience #Microscopy

Cool work on the effects of OPC specific deletion of glucocorticoid receptors! Glucocorticoids target postnatal oligodendrocyte precursor cells to modulate adult hippocampal network plasticity and stress-induced behavior www.biorxiv.org/content/10.1...

I am super excited to share our article addressing a longstanding question in neurobiology: how Ca²⁺ signaling cascades initiated at dendritic spines operate at a distance. Check it out here: authors.elsevier.com/sd/article/S... @cp-cell.bsky.social.

Excited to share our latest article! We find that the brain tumor Glioblastoma has a circadian clock that syncs with its host’s environment. These tumors also hijack the circadian clock and use daily signals, like glucocorticoids, to grow 🧠⏱️ @erikherzog.bsky.social More: www.cell.com/cancer-cell/...

The birth of fruit fly's central nervous system imaged with multicolor #adaptive #lightsheet microscopy. The microscope self-aligns to a signal that appears during imaging. www.nature.com/articles/nbt...

#flourescent(almost)friday (make sure to full screen this!) Some hippocampal neurons and dendritic arbors visualized from mCherry with a 3.6x objective in a SmartSPIM using iDisco.

Programming tissue-sensing T cells that deliver therapies to the brain www.science.org/doi/10.1126/...

What a great initiative! 👉 Highlighting an outstanding paper by another researcher. 👉 Below is a must-read by @jgrutzendler.bsky.social and team 👇 www.science.org/doi/full/10....

Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer’s Disease This further adds to the mounting evidence that microglia are perhaps much better at Aβ plaque formation than plaque clearance. What a fantastic study 🤩

Important article that challenges the classic view of axons as simple tubes. To what extent they fluctuate in diameter is up for debate - see some thoughts in this commentary piece in @science.org. Exciting time for axon scientists!

Which one are you? Among scientists are collectors, classifiers, and compulsive tidiers-up; many are detectives by temperament and many are explorers; some are artists and others artisans. There are poet-scientists and philosopher-scientists and even a few mystics. –Peter Medawar

🚀 It's #FluorescenceFriday, and commissural axons are coming at you! 🧪🔬 15-hour time-lapse of chick commissural axons navigating and crossing the CNS midline (and reverse). One stack taken every 10 minutes. Pixels were color-coded in the z-axis. #LiveImaging #Neuroscience #Science #Microscopy 🧠✨

SAVE THE DATE Discuss the interactions between the nervous system and cancer in our first @helloeacr.bsky.social conference on #CancerNeuroscience next year! 🗓️ Oct. 14-16, 2025 📍Bilbao, Spain 📥 Abstracts due June 30, 2025 📥 Register by Sept. 15, 2025 For more info, visit eacr.org/conference/c...

Tlr7 drives sex differences in age- and Alzheimer’s disease–related demyelination www.science.org/doi/10.1126/...

Starting the week strong! Cheering myself up for the next challenges with 15 min of axonal growth cone dynamic madness. F-actin (cyan) and membrane (magenta) show their dance. One image taken every 10 s.🧠🔬 #MicroscopyMonday #LiveImaging #Neuroscience #Microscopy

Playing catchup :) 2 bioRxiv preprints related to our goal of imaging neural activity across entire brains: In Vivo Optical Clearing of Mammalian Brain, synthneuro.org/publications... Imaging the voltage of neurons distributed across entire brains of larval zebrafish, synthneuro.org/publications...

Now that more people are migrating here, my intro post needs an update: I recently joined the @winklerlab.bsky.social as a PhD student, tackling the communication networks that underlie treatment resistance in glioblastoma 🧠🧫 as part of our larger focus on #Cancer #Neuroscience Happy to connect! ✨

👋 Hello Bluesky! Great to be here. We are the Winkler Lab, at the UKHD and @dkfz.bsky.social Heidelberg 🇩🇪. We work on the #cancerneuroscience of #braintumors, hoping to better understand these diseases and search for new treatments. Looking forward to interact with many of you in the future!

Hi! Obligatory intro tweet - I'm Erinne, a Filipino 🇵🇭 master's student in #Neuroscience currently at the Max Planck Institute for Multidisciplinary Sciences 🇩🇪 Interested in neural circuits, brain tumors, AD, memory. I've worked as a science writer & am passionate about sci communication & outreach.