3 papers in Cell @cellpress.bsky.social today exploring the mechanistic connection between Epstein-Barr virus and multiple sclerosis #MultipleSclerosis cell.com/cell/fulltex... cell.com/cell/fulltex... www.cell.com/cell/fulltex...

Endless

WE ARE HIRING! The Smyth Lab at Monash University is looking for a postdoc to join our team! Come join us if you are excited about neuroimmunology and the meninges. 📍 Melbourne, Australia 🇦🇺 Apply now: careers.pageuppeople.com/513/cw/en/jo... #Neuroimmunology #Meninges #PostdocJobs

Agency declines to reappoint Walter Koroshetz, who has led NINDS since 2015

Our latest collaboration with @jkpritch.bsky.social – led by joint post-doc Mineto Ota – is in @nature.com today: www.nature.com/articles/s41...

Looking forward to reading this one!

I am very grateful for Steve's leadership and excited to step into this new role! www.neuro.duke.edu/news/lisberg...

NIH grant applicants: October and November grant application submission *deadlines* will be rescheduled (🤯). Specific dates TBD. grants.nih.gov/grants/guide...

Bluetorial-Jim Watson I met Jim Watson a few times but did not know him well. However, I was greatly influenced by his book “The Double Helix”. He was a complicated human being with some very, very bad features, but some good contributions. What follows is my personal perspective. 1/41

Applications are open for the 2026 Zara Weinberg cohort of Leading Edge, named in honor of the incredible, brilliant, fearless @weinberz.witchlab.org. The LE community has been truly transformative for my scientific journey and my happiness. Please apply!! www.leadingedgesymposium.org/apply/

Zara Weinberg passed away earlier this week. She joined my lab earlier this year when her postdoc lab formally closed. She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.

Excited to share some research highlights today during the neuroimmune sessions at KAI2025, beautiful day in Incheon, Korea

Very pleased to publish this new review with Farah Wahbeh on the role of #EBV in #Multiplesclerosis. I learned a lot writing this, I hope others find it useful too www.neurology.org/doi/10.1212/...

A show of bipartisan support for NIH. Basically flat except for ARPA-H. The President’s budget proposal basically ignored (as it should have been).

Honored to receive an @alzassociation.bsky.social Research Grant for my project “Role of APOE4-driven microglial mitochondrial dysfunction”. Excited to advance our research on APOE4, neurovascular inflammation, and microglial metabolism in Alzheimer’s disease. Grateful to be #ALZFunded !!

#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...

This is so frustrating. In 2018 I remember thinking how this paper would transform my work since we were already looking at mitophagy. I have cited this paper in 3 of my papers between 2018-2020 and probably every grant application. This guy won a 2021 breakthrough prize in part because of this work

I have NIGMS R35, impact score 12 NIHGRI R21, 4th percentile NHGRI R01, 7th percentile (co-I) and it seems like none will be funded. 0/3. PO (who has been very helpful) said "Unfortunately, I do not expect this application will be selected for funding in FY25." 😭

one of the best!

Delighted to share this perspective piece by Lewis Yu on microbial regulation of serotonin and neuroimmune interactions. Looking forward to sharing more on this topic soon 🤞 www.sciencedirect.com/science/arti...

Managed to track down some texas-style bbq in san diego. Gathered the lab to celebrate their accomplishments and keep building our amazing community!

The numbers of women in science falls substantially at the transition from postdoc to independent investigator/ PI So what can we do to prevent this? One initiative we now organise annually at #EACR is the highly successful 'Women in Leadership' workshop ⏬ #WomenInScience 🧪 @helloeacr.bsky.social

200 days in, checking in on HHMI funding opportunities: Freeman Hrabowski Scholars Program - not accepting applications Gilliam Fellows Program - not accepting applications Hanna H. Gray Fellows Program - not accepting applications Investigator Program - not accepting applications

Just to give the TL;DR on this one: *The* main purpose of the EO is to move funding priorities and decisions away from experts and career professionals over to political appointees. With the ultimate power held by Vought / OMB.

Thrilled to share that I received the NoA for my first R01 “Mechanisms of pathogenic microglial populations in CNS inflammation”. Major milestone for the Lab. Extremely grateful for SS/SRO, PO and everyone else at NINDS for their continued support. Photo of my lab, wife and son, celebrating!

RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...

We need a new microscope objective. A $1.6k tariff for something that you can hold in your hand and that is only manufactured in Germany

www.sciencedirect.com/science/arti... Great review on "Alzheimer’s disease and vascular biology – A focus on the procoagulant state"

Surreal…

🔥New preprint from the lab! Led by @rileyirmen.bsky.social Tau pathology reprograms glucose metabolism to support glutamatergic activity and excitatory imbalance 📍 biorxiv.org/content/10.1101/2025.07.25.666872v1 🧵 on how tau disrupts the metabolism–excitability balance in Alzheimer’s disease

Happening Now! Mark-up of Labor, Health, and Human Services www.appropriations.senate.gov/hearings/ful...

The NIH budget will INCREASE by $400 million — not slashed by 40%, as Trump proposed — according to a proposal by Senate appropriators, says Sen Murray. "Some have asked if there will even be an NIH by [2029]. The commmittee's resounding message is yes—Congress has your back", she says.

I hope this true!

UPDATE: The pause was scrapped Tuesday evening after intervention by top White House officials. www.wsj.com/politics/pol...

Dr. Uri Manor feels like much of his early life was blessed by fate.

The NIH was healthiest when pay lines were in the 20th percentile range. We are headed into an environment where pay lines are in the 5% range. In my entire career, I’ve only had 3 grants that scored better than 5%. And my lab is considered a successful one. This is going to destroy science.

@manorlaboratory.bsky.social !

Academic chairs waiting for endowments #academia

PO just confirmed that our 5th percentile R01 is not getting funded. Past NCI Payline at 4 percent. Cant believe it.

so.... NIH issued a news item clarifying the new use of animals policy. It seems that the bottom line is that NIH will not issue NoFOs specifically about creation or use of animal models of disease. 1/2 grants.nih.gov/news-events/...

NIH will only accept six new, renewal, resubmission, or revision applications from an individual Principal Investigator/Program Director or Multiple Principal Investigator for all council rounds in a calendar year. grants.nih.gov/grants/guide....

Excellent paper -- adding to journal club lineup!

Update on funding curves and late non-competitive renewals. First, funding curves for new and competitive renewals. 1/n

ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox | Science www.science.org/doi/10.1126/...

🎉 Over the moon to share the first paper from my lab!! We discovered an unexpected role for the cytokine OSM in lung epithelial homeostasis and repair. 🧵 1/n www.science.org/doi/10.1126/...

The Trump Admin slashed over 1000 fellowships from the NSF's Graduate Research Fellowship Program, which has produced Nobel Prize winners, tech entrepreneurs, & national security experts. While countries like China are doubling down on scientific investment, Trump is hurting our pipeline of talent.

New York Times article on the end (at least for the moment) of NIH grant terminations... [Gift link] www.nytimes.com/2025/06/25/s...

As per the NIH POs in our session just now: Columbia University is having funding freeze lifted. Nice to hear some good news for a change!

An NIH staffer reacts to today's ruling: "I'm looking forward to the day that we are so slammed with work trying to reinstate everything that we had to terminate illegally — I'll work 24/7 to make that happen if I can."