I have an opportunity to hire a staff scientist for my lab. Looking for someone with outstanding skillset in ML/statistics, genomics applications; interest in mentoring, strong publication record, PD experience required. Email CV to me+cc my assistant (see 'contact' on my website). Ad to follow.

Our paper on the theoretical properties of SNP heritability in admixed populations is out in Genetics: academic.oup.com/genetics/adv... with @jinguohuang.bsky.social, @nicole-kleman.bsky.social , Saonli Basu, and Mark Shriver

Excited to share our work on using pathway-specific polygenic scores to discover gene-environment interactions www.medrxiv.org/content/10.1...

When should adaptation arise from a polygenic response versus few large effect changes? https://www.biorxiv.org/content/10.1101/2025.05.15.654234v1

J-PEP is a new method that clusters disease-associated loci by combining pleiotropic SNP effects with tissue-specific epigenomic data. It improves biological resolution across complex traits. doi.org/10.1101/2025...

Integrative multi-omics QTL colocalization maps regulatory architecture in aging human brain https://www.medrxiv.org/content/10.1101/2025.04.17.25326042v1

Very excited to share our preprint led by M. Levin @skoyama.bsky.social J. Woerner & with S. Damrauer assessing genome-wide pleiotropy of >1,000 clinical traits across ~1.7M individuals with nearly 30K locus-trait associations! www.medrxiv.org/content/10.1... @medrxivpreprint.bsky.social

What is epistasis? New preprint Blue-torial! (Work by the wonderful postdocs Maryn Carlson and Bryan Andrews) www.biorxiv.org/content/10.1...

If we take regional averages, genes associated with education predict height better than genes associated with height. Why? On a regional level, education-associated genes pick up environmental differences between richer and poorer neighborhoods 🧬💰 From www.nature.com/articles/s41...

A flu lineage has likely gone extinct since 2020 🧵

The New York Times recently had an article on IVF and embryo selection which I think buries a few important ledes about these products ...

Did you get a chance to read the thread on our new @naturehumbehav.bsky.social paper on SES yet? If not, don't worry, I have something better for you! Check out this comic by the amazing @lizahaart.bsky.social Complete comic: communities.springernature.com/posts/are-we... Or in this thread 👇🏾

In every civilization, people end up sorted into levels of socio-economic status (SES). We explore the history, present, and future of scientific research on the complicated relationship between SES and DNA in @naturehumbehav.bsky.social💰🧬🎓 Link: rdcu.be/efacK Thread below 👇🏽

New preprint! We worked with @msftresearch.bsky.social and @broadinstitute.org to see whether large language models (LLMs) can be useful to variant scientists in deciding whether genetic variants seen in a patient are responsible for their disease. tl;dr yes they can: www.biorxiv.org/content/10.1...

How selection can incorporate evolutionary history into the genetic architecture of a single cell, giving rise to a hypermutable locus that appears to anticipate environmental change, thereby accelerating adaptive evolution. www.science.org/doi/10.1126/...

I can't believe we're still allowing completely inadequate and uninterpretable Epigenome-Wide Association Studies (EWAS) to be published. I don't care that this study is probably well-intentioned, and probably trying to draw attention to awful events in Syria. www.nature.com/articles/s41...

Insufficient evidence for natural selection associated with the Black Death These claims are unsupported for four reasons... Finally, we find no evidence of significant change in frequency of the ERAP2 variant rs2549794... www.nature.com/articles/s41...

Insufficient evidence for a severe bottleneck in humans during the Early to Middle Pleistocene transition academic.oup.com/mbe/advance-...

Distinct explanations underlie gene-environment interactions in the UK Biobank. www.cell.com/ajhg/abstrac...

Multiple-testing corrections in selection scans using identity-by-descent segments https://www.biorxiv.org/content/10.1101/2025.01.29.635528v1

Our review on the genomics of rare disease in the Greater Middle East is out this week in @naturegenet.bsky.social www.nature.com/articles/s41...

Our papers, out today in @nature.com, show how ancient DNA from the Eneolithic and Bronze Age steppe points to a North Pontic origin of the Indo-European language family and a Caucasus-Lower Volga (CLV) origin of Indo-Anatolian (inclusive of the now extinct Anatolian languages). 1/

“The distribution of highly deleterious variants across human ancestry groups”. Preprint with Anastasia Stolyarova and @gcbias.bsky.social: www.biorxiv.org/content/10.1...

Think of a polygenic score you care about. Are direct genetic effects driving variation among people in this predictor? Or perhaps other, confounding factors? We at the @arbelharpak.bsky.social & @docedge.bsky.social Labs developed a method to tackle this question. [1/n]

A homozygous SVA retrotransposon insertion is discovered to be likely the most common mutation in ASPA (encodes aspartoacylase) underlying Canavan disease. 1/ Gonzalez, Bell, et al. medRxiv www.medrxiv.org/content/10.1...

www.biorxiv.org/content/10.1... Smart study to test whether lower prediction accuracy in non-Europeans is due to between-population differences in population structure, genetic nurture, or assortative mating.

I've always wondered about the pigmentation GWAS signals like TYR, OCA2 etc. in the GWAS of OCT-derived phenotypes. A new preprint elegantly investigates the phenotypic and genetic correlation between retinal pigment epithelium (RPE) thickness (which is measured using OCT) 1/

Nice visualization of the extensive pleiotropy of multiple sclerosis (MS)-associated GWAS signals with a wide range of autoimmune diseases. 1/ Zeng, Atlas, et al. medRxiv www.medrxiv.org/content/10.1...

Do mutations that drive evolution improve many traits or few? Does this change over the course of evolution? Excited to share our work in PLOS Biology exploring these questions in the first 2 adaptive steps w/ Yuping Li, @gsherloc.bsky.social, @petrovadmitri.bsky.social 🧵 doi.org/10.1371/jour...

Million Veteran Program & FinnGen teams are pleased to release v1 meta-analysis of MVP, FinnGen and UKBB GWAS data. This first version includes ~300 binary disease definitions across >1.5 M individuals. Browse scans at: mvp-ukbb.finngen.fi

Check out the presentation I gave in Estonia on the relationship between genetics and playing videogames 🎮🧬 I look forward to sharing more exciting results from this project in 2025! youtu.be/q6NrDP1_T8s?...