New article to read! Myasthenia gravis following the initiation of statin therapy. ➡️ Statin initiation may be associated with increased risk of new-onset MG during the first 6–12 months. 🔗 doi.org/10.1111/joim.70072 #MyastheniaGravis #MG #statins

The immune systems paradox Some widespread prokaryotic immune systems are absent in eukaryotes, whereas relatively rare ones became central to eukaryotic innate immunity @audeber.bsky.social & E. Koonin hypothesize the answer is #HGT shareable link: rdcu.be/e2EmD www.nature.com/articles/s41...

Expansion microscopy may be the hi-res hero that many biologists have been craving.

"There are several possible reasons for this unsettling state of affairs" www.nature.com/articles/s41...

A very nice review on type I IFN autoantibodies: www.sciencedirect.com/science/arti...

The IL17REL gene encodes a decoy receptor of IL-17 family cytokines to control gut inflammation Qi Li et al. 🧪 www.nature.com/articles/s41...

Pancreatic cancer is the third deadliest cancer. Treatment often fail due to resistance. A new study in PNAS led by Mariano Barbacid tackles this with a triple combination therapy that induces robust tumor regression and prevents the onset of tumor resistance in mice. #SciSky #MedSky #Oncology

Alex Pretti was a colleague at the VA. We hired him to recruit for our trial. He became an ICU nurse- I lover working with him. He was a good kind person who lived to help and these fuckers executed him. White. Hot. Rage.

Increased prevalence of #autoantibodies neutralizing IFNλ2/3 in young individuals with #CysticFibrosis. New report from Kevin Groen, Emanuela Bruscia, Marc Emmenegger, Benjamin Hale @benhale.bsky.social and colleagues: rupress.org/jhi/article/... #Autoimmunity #Infections

Not sure this counts as a timeline cleanse but check out the weird little cars I made

It's AI colonialism

Human genetics guides the discovery of CARD9 inhibitors with anti-inflammatory activity @cellcellpress.bsky.social @thexavierlab.bsky.social @broadinstitute.org www.cell.com/cell/fulltex...

The main bank account holding revenue from the Venezuelan oil sales is located in Qatar. “There is no basis in law for a president to set up an offshore account that he controls so that he can sell assets seized by the American military,” Sen. Elizabeth Warren. www.semafor.com/article/01/1...

www.nature.com/articles/s41... 📖 CD19 CAR-T cells for treatment-refractory autoimmune diseases: the phase 1/2 CASTLE basket trial “CASTLE suggests the feasibility, safety and efficacy of Zorpo-cel in three different autoimmune diseases and paves the way for conducting a pivotal study.” #SLE #CART

🧬 New in @cellpress.bsky.social 🧵 1/ With @casanovalab.bsky.social , we propose a rethinking of monogenic disorders of immunity: 👉 common variants can matter — a lot.

www.science.org/doi/10.1126/... Very interesting paper

DHS Warns Any Action By Americans Will Be Treated As Domestic Terrorism https://theonion.com/dhs-warns-any-action-by-americans-will-be-treated-as-domestic-terrorism/

Students get it: > She also argues that the use of AI can mean that “people aren’t critically thinking” any more. She feels that students who use GenAI consistently “can’t see another viewpoint”. www.irishtimes.com/life-style/p...

Big breakthrough for living drugs. UBC researchers have discovered how to grow “helper” immune cells from stem cells—paving the way for more effective and accessible off-the-shelf immune therapies. Learn more: news.ubc.ca/2026/01/stem...

i feel like i see a lot of "mysterious new account makes big bet on insider information" news stories and not enough people-being-arrested-for-that news stories

OMG 😭 Huntington's is an inherited disease that's like Alzheimers + Parkinson's all in one. NOW: "once the gene therapy has been delivered into the brain... [it] injects a piece of DNA to reprogram the neuron to become a factory for its own cure." LIFE SAVING! www.youtube.com/watch?v=bhEx...

This collab started when I met Fredi at the 2023 #EMDS meeting. Since then it’s been wonderful working with her, @selmatuzlak.bsky.social & Burkhard to explore these GM-CSF dependent #macrophages in #glands. Delighted to see this published in @natimmunol.nature.com 🥳 www.nature.com/articles/s41...

#disastrosanità Medici introvabili, disertati i concorsi per il Pronto soccorso Il 17% dei posti resta vacante, ma la percentuale sale al 47% per i reparti di medicina d’urgenza e al 60% per anatomia patologica. In aumento anche chi va via dall’Italia: dal 2020 oltre 5 mila professionisti

Mariano Tomatis analizza in chiave neo-marxista la nascita del mito della Torino magica, per lui comparso pienamente nel 1978. La prima di due parti, sul sito del gruppo Wu Ming Foundation : www.wumingfoundation.com/giap/2025/12... #Ufo #paranormale #magia #politica #Torino #conflittosociale

We know — from first principles — that LLMs can only create AI slop. Why do people keep needing empirical tests?

The one validated intervention to slow aging and extend healthspan is not for sale. It's exercise. sciencedirect.com/science/arti...

Qian Zhang et al. @casanovalab.bsky.social report a fatal case of avian influenza #H5N1 infection and describe that the presence of AAN-I-IFN may facilitate infection, replication, and adaptation of zoonotic IAVs to humans and, therefore, human-to-human transmission. rupress.org/jem/article/...

"This promise of an AI future, is really just a collective anxiety that wealthy people have about how well they're gonna be able to control us in the future." - @tressiemcphd.bsky.social with an absolute mic drop moment about AI bullshit. Incredible words. Listen to all of it!

My latest feature for @sciam.bsky.social explores the research connecting problems with interoception to a wide variety of mental illnesses, including anxiety disorders, eating disorders, & PTSD. This work is ultimately circling in on a central message: the body & mind are inextricably intertwined.

Patient admitted for respiratory failure, mucus plug on right main bronchus. Found unconscious while waiting for bronchoscopy, no SpO2 variation. Scanning right lung this is what I see. #POCUS #MedEd #FOAMED

The 2025 𝘉𝘦𝘴𝘵 𝘰𝘧 𝘑𝘌𝘔 highlights research in basic #immunology, #immunotherapy & #TumorImmunology, #InbornErrorsOfImmunity, #neurodegeneration, & #inflammation. We remain grounded in our commitment to publishing studies that push the boundaries of our knowledge forward 👉 rupress.org/jem/collecti...

A new series in @jhumimmunity.org: How I Treat: Infections and inborn errors of immunity—Prevention, diagnosis, and treatment url: rupress.org/jhi/article/...

20 years ago, Aaron Osgood-Zimmerman and I would entertain ourselves asking questions like, "How many crickets are in field?" or "How many cells are in the body?" Aaron became a statistician, and I become a biologist. We have now collaborated on an interesting exploration: doi.org/10.64898/202...

I have read, blurbed, reviewed quite a lot of science books this year. Here are some I have particularly enjoyed, in no particular order. @matthewcobb.bsky.social's long awaited biography of Francis Crick did not disappoint. Authoritative and highly readable. 🧵 www.nature.com/articles/d41...

Salk researchers are using a little flowering plant to answer the question: How do cells generate new epigenetic change? The answer marks a major shift in plant biology and may inform future epigenetic engineering strategies with medical and agricultural applications. www.salk.edu/news-release...

I learned that Makary & his top vaccine regulator Vinay Prasad forced FDA scientists to withdraw a paper from Vaccine. I am co-Editor-in-Chief of Vaccine. The data had been presented publicly. It showed the benefits outweigh the risks of COVID vaccines for all ages. bsky.app/profile/save...

'Tn-MUC1, a truncated form of MUC1 decorated with Tn antigen, is frequently overexpressed in pancreatic cancer. Here, we incorporate a non-signaling glyco-bridge binder recognizing Tn-MUC1 into mesothelin-directed CAR-T cells.' #Immunology #Immunotherapy

Hello, here is a review I wrote about how cells sometimes try to synchronise with surrounding cells so that they can do a good job of building tissues during development. It is called "Keeping up with the neighbours" link.springer.com/article/10.1... #DevBio 🧪

Mitochondria form dynamic networks that can be represented as graphs. But the space of graphs is complex. In poster 376 at CellBio2025 Monday Dec 8, Raphie Mostov presents a mathematical approach to represent mitochondria far more simply.

TIL about a memorial ceremony in Iceland in 2019 to mark the end of a glacier, changing the place name from Okjökull to Ok (jökull = glacier). Uncompromising wording on the bronze plaque: "This is to acknowledge that we know what is happening and what needs to be done. Only you know if we did it".

I really do unironically feel like this all the time

Gli Ziziani sono una setta razionalista Usa tipica dei nostri giorni: hanno gravi accuse, e sono un misto di anarchismo, culto della scienza, complottismo e adorazione dell'inferenza bayesiana. www.rollingstone.com/culture/cult... #antropologia #Nuovereligioni #NRM #NMR

Three new manuscripts from Faryabi and Vahedi labs on chromatin folding, ORCA, oncogene regulation and T1D immunology. Individually great, collectively unstoppable. @faryabi.bsky.social @vahedilab.bsky.social @atishayjay.bsky.social tinyurl.com/4nwfbeu2 tinyurl.com/4zaw5cn7 tinyurl.com/25snbf4j

The fall of a prolific science journal exposes the billion-dollar profits of scientific publishing One of the 15 publications that put out the most studies globally has been expelled from the indexing system for irregularities. english.elpais.com/s... 1/3

This latest review synthesizes evidence on the complex relationship between metabolic dysregulation and innate #Immune memory and proposes that targeting #TrainedImmunity may offer novel strategies for diabetes intervention. #medsky #OpenAccess: www.sciencedirect.com/science/arti...

Hey @nature.com, have you got an explanation for how the hell THIS happened? & especially why you accepted a paper with such a bizarre piece of genAI slop in it?! & more to the point, why we should take you seriously at all going forward? www.nature.com/articles/s41...

#Medsky🧪#Neurosky @jama.com #Peripheralneuropathy (PN) , defined as damage to PN , affects ~ 1% of adults worldwide. More than 200 causes of PN exist, with symptoms ranging in severity from mild toe numbness to debilitating symptoms that can require a wheelchair… jamanetwork.com/journals/jam...

@natrevimmunol.nature.com Guidelines for T cell nomenclature www.nature.com/articles/s41...