Our lab is proud to present our latest work harnessing Bridge Recombinase for genome-scale editing in diverse bacteria, microbiome editing, and programmable horizontal gene transfer.

Guzmán et al. discuss @jem.org work (Luff et al. rupress.org/jem/article/...) showing cell-intrinsic signals from TACI drive marginal zone B cell development from T2 B cells thru. a mechanism involving activation of the PI3K–AKT pathway & inhibition of the FOXO1-KLF2 axis rupress.org/jem/article/...

MRL/lpr and TLR7 agonist-induced lupus nephritis mouse model study provides evidence the kidneys in lupus nephritis may act as sites of extramedullary hematopoiesis and contribute to disease progression through local myeloid cell expansion Arthritis & Rheumatology doi.org/10.1002/art....

Review The Neuroimmune Connectome: Understanding how the Peripheral Nervous System shapes Immunity academic.oup.com/immunohorizo...

Review: The adaptive immune receptors in a big data world academic.oup.com/immunohorizo...

we all know I have no life, so:

In totally unsurprising news, Richard Dawkins is developing AI psychosis. Paywall bypass: archive.is/6RdK9

The Foxp3 transcription factor integrates cell-intrinsic and environmental contexts with epigenetic programs to establish regulatory T cell identity @sciimmunology.bsky.social www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...

This paper was retracted from the @nejm.org because the images of bronchial branching after smoke inhalation were obviously and transparently manipulated by generative AI. Look at the ruler. I don't even know what lesson to draw from this. www.nejm.org/doi/10.1056/...

Awesome title! Living rent free in your head: resident memory T cells academic.oup.com/immunohorizo...

lol the shooter has a BLUE SKY ACCOUNT, well here’s one excuse that won’t work:

Later it works out because the man is a masochist. COMIC ◆ www.smbc-comics.com/comic/slap PATREON ◆ www.patreon.com/ZachWeinersm... STORE ◆ smbc-store.myshopify.com

Transient host-cell glycoengineering to reduce N-glycan trimming strengthens IgG-FcγRIIIa bond resilience under vascular flow forces & potentiates therapeutic antibody efficacy @cp-immunity.bsky.social @stanforduniversity.bsky.social @uwbioe.bsky.social www.cell.com/immunity/ful...

The Pentagon released its UFO videos – so I went to the US to chase aliens. This is what I found

WATCH: Researchers at Stanford University modeled how many people could die or be disabled in 25 years if vaccines for polio, measles, rubella or diphtheria were no longer available.

"Pancreatic cancer mRNA vaccine shows lasting results in an early trial: Scientists caution that more research is needed, but nearly all of the patients who responded to the personalized vaccine are still alive six years later."

a supposedly fun thing i'll never do again

Creating baby geniuses to thwart the AI threat? (Yes, really.) www.motherjones.com/politics/202... - smart people being really stupid about intelligence

They need to stop getting sycophantic feedback from their chatbots that makes them think they actually understand intelligence 🤦🏾‍♀️

Dr. Donna Farber presenting now as our third and final speaker: Immune memory to infection and vaccination in human tissues. #HIPC at #AAI2026

For scaling-laws aficionados (I am one), here are the graphs showing power-law behavior for vasculature for embryos (macaque, mouse, turtle). This means that the vasculature of developing embryos is scale free fractal. More here: www.biorxiv.org/content/10.6...

Man Who Threw Molotov Cocktail At Sam Altman’s Home Claims He Was Following ChatGPT Recipe For Risotto https://theonion.com/man-who-threw-molotov-cocktail-at-sam-altmans-home-claims-he-was-following-chatgpt-recipe-for-risotto/

When Trump urged pregnant women not to take Tylenol & RFK Jr falsely linked Tylenol in pregnancy with autism, 2 physicians, Jay Bhattacharya & Marty Makary, stood approvingly by their sides As the Lancet editor said, these 2 docs are “those one should not forgive” www.thelancet.com/journals/lan...

A humanoid robot chasing wild boars through Warsaw has become Poland’s latest viral sensation. “Edward Warchocki” has racked up hundreds of millions of views as he patrols streets, chats with locals, and turns heads across the capital.

Un altro paio di interventi di Trump su Papa e Vaticano e potremmo avere l'enciclica "Ma chittesaenculae".

Claude says humans contain theirs own kind of emotions

At a recent conference, a Senior Investigator sat next to me at dinner and asked who I was and what stage of my career I’m at 🙄🥳

Happy to see more recognition of this key idea The brain is not mental : frontiersin.org/journals/integ… And all cells in the body are key for what we usually call « mental » or « self » processes !

It’s time for my favorite cartoon of the year.

"i have two Microsoft Outlooks, and neither one of those are working." The Astronauts truly representing us all up there.

Local gene editing of #fibroblasts in tumors reveals a new cancer-associated fibroblast state. New study from Nicholas F. Kuhn, Matthew F. Krummel @maxkrummel.bsky.social @immunox.bsky.social and colleagues: rupress.org/jem/article/... #TumorImmunology #SolidTumors #TME #CAFs

DNA-PK interacts with cyclic dinucleotides and inhibits type I #interferon responses. From Isabelle K. Vila, Yasmine Messaoud-Nacer, Clara Taffoni, Dimitrios Vlachakis, Nadine Laguette @nadinelaguette.bsky.social @igmm-montpel.bsky.social and colleagues: rupress.org/jem/article/... #InnateImmunity

We need to read this in Italy. Nobody talks about it: that means it IS important

Data reveal that influenza-specific memory T cells formed under iron-deficient conditions are functionally impaired, most notably within the lung, indicating the critical effect of nutritional iron deficiency on T cell memory development and function: https://ow.ly/3hTR50Yyjch.

Discovery of potent and selective inhibitors of human #NLRP3 with a novel mechanism of action, from Kevin Wilhelmsen, Rebecca Coll @colllab.bsky.social and colleagues rupress.org/jem/article/... 📘 In our #InnateImmunity collection: rupress.org/jem/collecti... #KSInnateImmune26

If you do a lot of searching on the internet (as I do), this is a really useful article. Multiple things I didn’t know and will use going forward.

Statistical Rethinking 2026 is done: 20 new lectures emphasizing logical and critical statistical workflow, from basics of probability theory to causal inference to reliable computation to sensitivity. It's all free, made just for you. Lecture list and links: github.com/rmcelreath/s...

Big news about our thymus gland and extending healthspan www.nature.com/articles/d41... We thought our thymus gland involutes and has little function after teenage years But... As determined by AI, thymus health is adulthood is quantifiable and very importantly linked to MANY health outcomes

Over the past 5+ years I've had the honor of working with @wsdewitt.github.io @victora.bsky.social and many others on a project to "replay" affinity maturation evolution from a fixed starting point. matsen.group/general/2025...

I'd like to see this problem analysed at the single cell multi-omics level 'Advances in research technolo- gies are crucial for the scientific enterprise but have an unintended consequence: when pow- erful techniques become widely available, they tend to be applied without a good question in mind.'

We're proud to announce that infectious disease pioneer Jean-Laurent Casanova, MD, PhD, of @rockefeller.edu, @institutimagine.bsky.social, @hhmi-science.bsky.social, & @casanovalab.bsky.social, is the recipient of the 2026 Mechthild Esser #NemmersPrize in Medical Science: spr.ly/6008hCUaM

Indeed, we screen all severe cocci patients referred to UCLA (rare, yes ~ 2/month) for their Th2 ratio before starting dupilumab. As you'll see in an upcoming JCI Insight paper (!) we defined a threshold Th2/Th1 ratio of >1.27 as a useful cutoff for treatment. It's personalized therapy, indeed!

New paper out in Nature Communications: www.nature.com/articles/s41... We found >250 metabolic enzymes on chromatin. Only ~20 had been reported before. This means hundreds of metabolic enzymes may have unexplored nuclear roles.

Fontana thinking his 6000+ experiments may not have been enough to feel confident in his conclusions in the 18th century while we expect our singular experiments and their standalone replications to do wonders some 250 years later... (excerpt from the intro of Jutta Schickore's About Experiment)

Hey the guy that makes the deepfake generator and suicide machine is gonna get into the murderbot business sounds great what could go wrong

These results suggest that initial exposure to X’s algorithm has persistent effects on users’ current political attitudes and account-following behaviour, even in the absence of a detectable effect on partisanship. Don’t follow conservative political activist, those posting every incidence of crime

Something that probably you already know, but on Nature: www.nature.com/articles/s41...