1/ I’m very excited to share my postdoc work with @kseskv.bsky.social, in collaboration with @oligriffith.bsky.social. We explore embryonic DNA methylation reprogramming in the fat-tailed dunnart, an Australian marsupial 🦘🌏 www.biorxiv.org/content/10.1...

The Abstract submission and Earlybird registration deadlines have been extended! You now have until 𝐅𝐫𝐢𝐝𝐚𝐲 𝟐𝟏 𝐍𝐨𝐯𝐞𝐦𝐛𝐞𝐫 to submit and save! Do not forget to apply for awards if eligible! https://www.lornegenome.org/registrations Looking forward to seeing you at Lorne!

💥 Another fruitful collaboration! Along with @obog.bsky.social & Juan Tena’s teams we provide a multiomics study of zebrafish spermatogenesis 🐟#meiosis 👇 www.embopress.org/doi/full/10....

Did transposable elements shape brain evolution — and if so, which ones, and in which cell states and lineages? Led by @tyamadat.bsky.social, we explored this question in cerebellum development using sequence-based deep learning models! www.biorxiv.org/content/10.1...

Please join us for several days of fantastic science at Lorne Genome 2026! We're thrilled to welcome Prof Amander Clark, a renowned stem cell biologist whose work focuses on in vitro gametogenesis and ovarian reserve formation: https://www.lornegenome.org/amander-clark

Secure your early bird rate for Lorne Genome 2026 before Nov 7th! lornegenome.org We are excited to welcome Prof Duncan Odom as a speaker - a leading researcher in regulatory genomics and cancer genome evolution https://www.lornegenome.org/duncan-odum

Don't forget to register and submit an abstract for the 𝐋𝐨𝐫𝐧𝐞 𝐆𝐞𝐧𝐨𝐦𝐞 𝟐𝟎𝟐𝟔! 𝐓𝐡𝐢𝐬 𝐰𝐞𝐞𝐤'𝐬 𝐬𝐩𝐞𝐚𝐤𝐞𝐫 𝐬𝐩𝐨𝐭𝐥𝐢𝐠𝐡𝐭: 𝐏𝐫𝐨𝐟 𝐁𝐫𝐞𝐧𝐝𝐚 𝐀𝐧𝐝𝐫𝐞𝐰𝐬, a leading systems biologist whose research focuses on mapping genetic interaction networks and protein localisation patterns in yeast and human cells.

Just been reading this nice review. Taught someone who has never really done developmental biology a lot! Thanks and congrats to all involved. #epigenetics

How many chromosomes can an animal have? In our paper out now in @currentbiology.bsky.social we show that the Atlas blue butterfly has 229 chromosome pairs- the highest in diploid Metazoa! These arose by rapid autosome fragmentation while sex chromosomes stayed intact. www.cell.com/current-biol...

Earlybird registration & abstract submissions now open for the 𝟒𝟕𝐭𝐡 𝐋𝐨𝐫𝐧𝐞 𝐆𝐞𝐧𝐨𝐦𝐞 𝐂𝐨𝐧𝐟𝐞𝐫𝐞𝐧𝐜𝐞, 𝟏𝟓-𝟏𝟖𝐭𝐡 𝐅𝐞𝐛 𝟐𝟎𝟐𝟔: https://www.lornegenome.org/registrations (deadline 7th Nov 2025) Speakers: https://www.lornegenome.org/speakers We look forward to seeing you there!

ANZSCDB is pleased to launch our Zoom seminar series! Our first seminar kicks off on Thursday August 28th, 2025 at 12pm AEST with Professor Jose Polo and Dr Melanie White. Please register and attend to ensure the success and long-term sustainability of this initiative.

This is not a HiC map! Ever wondered if multiple enhancers get activated simultaneously? We measured chromatin accessibility on thousands of molecules by nanopore to create genome-wide co-accessibility maps. Proud of @mathias-boulanger.bsky.social @kasitc.bsky.social Biology in the thread👇

How do enhancer-gene contacts relate to transcription activation? In mouse embryonic stem cells, a combo of STED, oligoFISH & RNA FISH shows that 3% of Dppa3 alleles transcribe. For these, enhancers and promoters come closer (panel E). Stumberger ... Leonhardt & Harz www.biorxiv.org/content/10.1...

Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...

Our study on a male-essential microRNA and the evolution of other dosage compensation mechanisms in birds is now out in Nature! www.nature.com/articles/s41...

No new genes needed to fly - just rewire what you have! 🦇🧬 Great new paper from the labs of @fany-real.bsky.social @stemundi.bsky.social @dariloops.bsky.social doi.org/10.1038/s415... #EvoDevo #SingleCell #BatWings

OrthoFinder just dropped a major update It’s faster, more accurate, and ready for thousands of genomes Let’s break it down (1/10) github.com/OrthoFinder/... www.biorxiv.org/content/10.1...

I am very excited to share our latest work where we describe a new method to profile genome-wide chromatin transitions over time in single cells. Great collaborative effort with the van Oudenaarden group @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social www.nature.com/articles/s41....

Our work bridging enhancer-promoter proximity to phenotypic outcomes in vivo is out! Shout out to @olimpiabompadre.bsky.social, to Marie Kmita's lab, and to all the co-authors. www.nature.com/articles/s41...

Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁 Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5

Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/

How do non-coding variants in enhancers lead to disease? Happy to share our recent work, led by @ewholling.bsky.social, in which we discovered that poised chromatin sensitizes enhancers to aberrant activation by non-coding mutations, contributing to disease. www.biorxiv.org/content/10.1... 1/

⚠️ I am really excited to share the work of Anastasios Balaskas, an excellent PhD candidate in the lab, with the wider world. Tasos made a significant advance: generating a stem cell-based embryo model that contains both posterior and anterior neural tissues of the late-stage gastrulating embryo.

We are delighted to share our new preprint “The evolution of gene regulatory programs controlling gonadal development in primates” www.biorxiv.org/content/10.1...

Students (Master's/PhD), do not miss this fantastic Developmental Biology course of @sorbonne-universite.fr and @institutcurie.bsky.social - It is FREE and open to international students, however, room and board + travel are not included. training.institut-curie.org/courses/deve...

This is 1) great news and 2) I think I’m gonna sit on the multiome superenhancer story we were gonna submit now… 😂

One thing still missing in many GWAS pipelines: chrX analysis... In this study from @ajhgnews.bsky.social, Mefford et al. explore X-GWAS across 48 UKBB traits and as expected, ~3% of trait heritability comes from chrX. Looks like it’s time we start doing this! www.cell.com/ajhg/fulltex...

Neat thread. Following these ideas, Yaniv Brandvain & I spent some time thinking about the consequences of the fact that sperm alleles could alter the outcomes of female meiosis: pmc.ncbi.nlm.nih.gov/articles/PMC...

It was a pleasure to write a N&Vs on @danielibrahim.bsky.social's latest paper in @natgenet.nature.com. Enhancers tend to stay put even if their sequence changes beyond recognition. Quoting Il Gattopardo, everything must change so that everything can stay the same: www.nature.com/articles/s41...

How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭 Check out our paper - fresh off the press!!! We find widespread functional conservation of enhancers in absence of sequence homology Including: a bioinformatic tool to map sequence-diverged enhancers! rdcu.be/enVDN github.com/tobiaszehnde...

Transcriptional activity generates chromatin motion that drives nuclear blebbing https://www.biorxiv.org/content/10.1101/2025.05.20.655131v1

New paper from the lab: Our teeth arose as sensory organs on the outside of the body of ancient jawless fish.!! Congrats to Yara Haridy and the team! Background and video: phys.org/news/2025-05... Open Access Paper: www.nature.com/articles/s41... News and Views: www.nature.com/articles/d41...

We're excited to publish our latest study led by Bryony Leeke @bryonyleeke.bsky.social and Wazeer Varsally, now out in @nature.com 🍾This study focusses on the epigenome of marsupial embryos 🦘 mapping DNA methylation in embryo development to specific embryo events www.nature.com/articles/s41... 🧵

Massive findings for anyone interested in DNA methylation, development, and evolution! Can't wait to dig in, congrats to all the authors!

A tour de force study from Taipale&Yin labs. It expands the vocabulary of the Regulatory Code by adding 1131 TF:TF composite motifs that are different from the individual TF motifs. The new composite motifs are enriched in cell-type specific elements and active in vivo www.nature.com/articles/s41...

I am excited to share the latest paper from my lab where we leverage the selection bias of condensate-promoting oncofusions to uncover molecular rules governing condensate specificity and function. www.cell.com/cell/fulltex....

What did the two amino acid substitutions in #FOXP2 that occurred uniquely in the human lineage do? 🧪🧬 🧠 Fascinating new @cp-cell.bsky.social study by @shadys11.bsky.social D. Jarosz & J. Wysocka, uncovering a molecular function for these 2 substitutions in promoting the solubility of FOXP2. (1/n)

I am incredibly proud to share that my work has officially been published in Cell! @cp-cell.bsky.social This work was a product of years of dedication and countless hours of research in the labs of Joanna Wysocka and Dan Jarosz labs @stanfordmedicine.bsky.social www.cell.com/cell/fulltex...

we've put a Review together 👇 Just came out at www.nature.com/articles/s41... hoping it is useful for those in the field but also for those not in the field who would like an overview on chromatin/epigenetics/replication/nuclear organisation in early embryos Enjoy :) - feedback welcome

our work on the molecular differences between transcription factor isoforms is out now in Molecular Cell! key point: 2/3rds of TF isos differ in properties like DNA binding & transcriptional activity many are "negative regulators" & misexpressed in cancer www.sciencedirect.com/science/arti...

"The main fates after gene duplication are gene loss, redundancy, subfunctionalization and neofunctionalization". In our new review, @fedemantica.bsky.social and I argue we are missing the most prevalent one: specialization. And the same applies to alternative splicing! 1/7 tinyurl.com/45k7kbmp

Here’s a report by John Ross in @timeshighered.bsky.social on ARC Board’s proposal to change grant schemes ▶️ www.timeshighereducation.com/news/arc-gra... [Free login required] Both @scienceau.bsky.social's & I am worried about opportunities & unintended consequences for early-career researchers👇

Why can a human tolerate a drug that globally inhibits transcription? Why do transcription inhibitors not cure cancer? Our first paper of 2025 may help explain (some) of this! So incredibly proud of @tobiaswilliams.bsky.social & Ewa Michalak who led the work! www.cell.com/molecular-ce...

Quote from farther down the thread, "Fun fact: mSCD-B5 was discovered in an uncharacterized phage from a sewage microbiome" You never know where you're going to find the next tool to advance biomedical research and I love that.

Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. www.nature.com/articles/s41...

Very excited that our paper describing a critical role for the PNUTS-PP1 phosphatase complex in transcription pause release is up online! This was a massive team effort with @edimitrova.bsky.social and the rest of the @robklose.bsky.social lab www.cell.com/molecular-ce... A short thread: (1/8)

"Dark TFs": new manuscript mapped 166 uncharacterized human transcription factors, finding half bind genomic "dark matter," often closed chromatin rich in transposable elements. www.biorxiv.org/content/10.1...