Chris Hunter @kingofpathogens.bsky.social and colleagues review parasite and host immune factors that impact the development of a mucosal vaccine for #Cryptosporidium : www.mucosalimmunology.org/article/S193...

Quote Science knows no country, because knowledge belongs to humanity, and is the torch which illuminates the world. Science is the highest personification of the nation because that nation will remain the first which carries the furthest the works of thought and intelligence. Louis Pasteur

This is incredibly sad...I strongly believe that pivoting to different fields is a cornerstone of creativity and originality www.nature.com/articles/s41...

Incredible! Over the past 2 months, 5 independent manuscripts — from @TheColonnaLab, Dan Littman, @gardnerlabucsf.bsky.social and @chrysothemisbrown.bsky.social , and our own (now in @nature.com, www.nature.com/articles/s41...), reports that the dietary pTreg program is initiated by RORγt⁺ APCs. /1

#WeekendRead #NoTimeToDie! Matt, Better &co show @ Science Immunology that efferocytosis of apoptotic neutrophils (not epithelial cells) by alveolar macrophages reprograms their metabolism, boosting glutaminolysis & decreasing ROS, thus favoring repair but facilitating secondary bacterial infections

Bluetorial: Pathways to Independence: The K99-R00 award program NIH’s response to a 2005 National Academy report led to a new program based on its initial goal of reducing the age of investigators achieving research independence

#Bluetorial: In our latest paper on #gdTcells and #IBD in #ScienceImmunology we found that γδ IEL number and regulatory function are severely compromised BEFORE ileal inflammation occurs, suggesting that γδ IELs may maintain IEL homeostasis in response to a pro-inflammatory microenvironment. 1/n

So happy to see this story come together. Check it out! Kathleen Mills and many collaborators - GM-CSF–mediated epithelial-immune cell cross-talk orchestrates pulmonary immunity to Aspergillus fumigatus | Science Immunology www.science.org/doi/10.1126/...

Bluetorial: Women, courage, and leadership What follows will include some generalizations based on population averages of what I have experienced over the course of my career. There are, of course, exceptions in every group who are substantially more to one extreme or the other.

What do Pablo Picasso and Charles Janeway have in common? Both were interested in patterns of life. Janeway was focused on pathogen associated molecular patterns (PAMPs) that are detected by our immune system. But what are these patterns he refers to?

Thrilled for Johan Garaude’s @inserm.fr new work in Nature! I’m proud to see this Blander lab alumnus shine. His group shows bacterial cAMP accumulation signals death, fueling macrophage recycling—a fresh live-vs-dead immune twist. Stellar work with huge impact! www.nature.com/articles/s41...

NIH funding is frozen. @annikabarber.bsky.social is keeping score: 50%+ of study sections planned for this year (77/148) have been cancelled. I talked to Dr. Barber about why these delays are disastrous, and why scientists should be pooling info and speaking up: www.chronicle.com/article/nih-...

Dear TCR researchers of #immunosky, you may be interested to know that our tool Stitchr - for the automated production of full-length T cell receptor sequences - has just had a nice little update: jamieheather.github.io/stitchr/

Wondering if your study section cancelled? I update this sheet daily. As of today, 56/124 study sections that should have met since Jan 2, 2025 have "not met as scheduled." docs.google.com/spreadsheets...

Other than the brain, our immune system is the most complex part of the human body. For the first time, sequencing receptors of B and T cells, along w/ generative A.I., enabled diagnosis of medical conditions such as lupus. That's just for starters. erictopol.substack.com/p/the-first-...

Well said @dereklowe.bsky.social. Academia produces two vital products: (1) knowledge, and (2) human capital that knows how to use it. If we can’t train enough young creative US scientists to fulfill biopharma industry needs… “I think they're being short-sighted, because fear does that to you.”

To my friends and colleagues at UAB, IU, UF, FSU, UL, WashU, OSU, CWRU, etc, etc. Call both your senators and your representative. They listen. Emphasize the direct economic impact of NIH research, and the indirect impacts on pharmaceutical/biotech. Underscore its relevance to national security.

"... I ended up being reluctant to work with undergraduate researchers at all—until a new student helped me realize what is required to mentor undergraduates, and the rewards it can bring." #NationalMentoringMonth https://scim.ag/3E1bAYj

The NIH diversity supplement pages have all been pulled down. What is a diversity supplement and why should the public care? A diversity supplement is funding to help diversify the research workforce. You may be wondering, “so what?”. Let me explain. www.nigms.nih.gov/Pages/PageNo...

All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.

In toxic cultures, people get promoted for results even if they destroy relationships. Abuse is a price to pay for high performance. In healthy cultures, no level of individual excellence justifies undermining people. You’re not a high performer if you don't elevate others.

Looks like I’ll need to update my lymph node lectures. Very nice explanation for why there is preferential leukocyte recruitment to inflamed nodes. #immunosky

Ever wonder if the innate immune system protects against cancer in premalignancy? My lab reports that the inflammasome in bone marrow stroma suppresses Ras in preleukemic stem cells restraining lymphomagenesis. Happy to share here: www.nature.com/articles/s41...

One main pain point: interdisciplinary work is often judged by the highest standards in *both* disciplines. This creates an almost impossible burden, effectively extinguishing creative work. Sure, some standards are there for a reason, but more often than not, they are just stock critiques.

Expert's Dilemma: the more specialized you become, the less open you are to creative solutions from other fields. But the more you explore other fields, the more you risk losing credibility in your home field. Interdisciplinary work is still not really embraced by academia.

Important paper by Dave Masopust's group on defining CD8+ Trm cells in murine models. Heroic amount of work and must read for folks studying memory T cells. "Thus, current Trm-defining methodologies have implicit limitations, and a universal residence-specific signature may not exist." #ImmunoSky

Research involves day science and night science, requiring you to become good at both. Day science proceeds in logical steps and specializes in hypothesis testing, but to generate new ideas we pop out to the creative night science world, where leaps among ideas are made possible.

A great read - How to thank you lab mates: eight ways to show gratitude at the end of the year - www.nature.com/articles/d41...

#EveryCellIsAnImmuneCell!💥Thrilled for the final version of our paper @cp-cell.bsky.social! We show that type III #interferons control ZBP1 activation driving gasdermin C cleavage & delaying gut repair by inducing #pyroptosis in intestinal epithelial cells! 1/n www.cell.com/cell/abstrac...

The 90/10 rule of scientific discovery: 90% of your results come from 10% of your explorations, but it's not possible to know in advance what specific explorations those will be.

LIPSTIC to ID dietary Ag presenting cells under tolerizing & inflammatory conditions and how helminth infections disrupt tolerance induction www.science.org/doi/10.1126/... @science.org @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social

Real science: 1. Is not correlated with the amount of funding 2. Progresses slowly, usually taking many years 3. Leads to more questions than it answers 4. Advances when we disengage & in improvisational discussions 5. Is too important a thing to be done in a non-playful way

Delighted to share our paper on adipose gd T cells making IL-17 every night for homeostasis, coordinating lipid metabolism after eating @natureportfolio.bsky.social Huge effort by whole team and collaborators to work this out. www.nature.com/articles/s41...

Hot off the presses today is the 2024 NIH Public Access Policy. I read it so you don’t have t…Just kidding. You should still read it in full if you do NIH funded research. grants.nih.gov/grants/guide... Some highlights in the thread below

We made it among the BEST PICTURES OF THE YEAR by @natureportfolio.bsky.social www.nature.com/immersive/d4... Beautiful image representing in red the nuclear localization of MTHFD2 in pluripotent colon organoids by @NataliaPardoL Find the manuscript here: www.nature.com/articles/s41...

Science is not really happening when the goal is a paper, a presentation, a grant, or any product. It only really happens when the goal is a process of discovery.

Mirror Bacteria: The biggest future threat to life on Earth. Leading scientists are raising the alarm before it becomes reality. Honored to play a small role in evaluating this work prior to publication. www.science.org/doi/10.1126/...

Intestinal #organoid goes rogue and flips polarity 🤯 @vucellimaging.bsky.social #epithelial #cellbiology #microscopy

The birth of fruit fly's central nervous system imaged with multicolor #adaptive #lightsheet microscopy. The microscope self-aligns to a signal that appears during imaging. www.nature.com/articles/nbt...

How NINJ1 mediates plasma membrane rupture and why NINJ2 cannot www.cell.com/cell/fulltex...

Was inspired by NYT’s reporting about the Notre Dame cathedral rebuilding: buildings of this scale don't have individual’s names attached. “Time is the architect, the nation its builder.” Perhaps the best of science represents this too, a self-correcting force for good, shaped by fields over time.

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

When I try to explain how things are actually getting worse, people look at me like I'm crazy.This piece is spot on. #SIStem (senior #womeninSTEM)

Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies! Link: rdcu.be/d2mjm

I participated in a faculty panel a few weeks ago in which senior (ahem) faculty gave advice on careers in academia by pretending luck had very little to do with our success. One piece of advice riled me up, in which it was argued that a reason for their success was their ability to say no. 1/

Great story about mentorship, privilege, serendipity and more! 🧪

ᗪIᗪ YOᑌ KᑎOᗯ? BACITRACIN was named by Balbina Johnson, lab supervisor at Columbia Med School, since the producing (Baci)llus was isolated from compound fracture of a child Margaret (Trac)y where it was (in)hibiting pathogenic bacteria and helping her overcoming a septic infection? #IDSky 🦠 🧫 🧪

Building the body of an embryo or maintaining tissues in adults rely on cell migration. From neural crest cells leaving the neural tube to form our peripheral nervous system to migrating lateral line cells in a zebrafish to skin cells migrating to repair wounds, its key 1/n youtu.be/IqUs29Kz3HE?...

Highly recommend for wet-lab immunologists interested in bioinformatics analysis #ImmunoSky